Eg har doktorgrad (PhD) frå UiB (2004) der eg undersøkte molekylære mekanismar for hormonproduksjon og cellevekstkontroll. Eg har sidan jobba for å finne ut av molekylære mekanismar som ligg til grunn for cellevekst og legemiddelresistens, og for å utvikle betre behandlingar mot ulike former av kreft. Eg er for tida forskar i gruppa til professor Lars Herfindal ved Senter for farmasi. Gruppa arbeider i hovudsak med legemiddelutvikling, med fokus på nye kreftlegemiddel, ved mellom anna å nytte seg av nanobærarar.

Mitt hovudfokus er utvikling av nye terapiar spesielt retta mot born med kreft. Gjennom prosjektet PICCA2 bidreg eg med å identifisere molekylære kjenneteikn til kreftsjukdomen, følgje korleis sjukdomen utviklar seg og til å identifisere nye terapiar. Hovudmålet for prosjektet er å utvikle nye terapiar som tek sikte på å gje kvar enkelt pasient den mest effektive og skånsame behandlinga.

Vitenskapelig artikkel

• Frazier, Théo; Pereira, Elisabeth; Aesoy, Reidun et al. (2024). Synthesis, kinase inhibition and anti-leukemic activities of diversely substituted indolopyrazolocarbazoles. (ekstern lenke)
• Slimestad, Rune; Rathe, Bendik Auran; Aesoy, Reidun et al. (2022). A novel bicyclic lactone and other polyphenols from the commercially important vegetable Anthriscus cerefolium. (ekstern lenke)
• Auvert, Etienne; Aesoy, Reidun; Giraud, Francis et al. (2022). Synthesis of new pyrazolo[4,3-a]phenanthridine Pim-1 inhibitors and evaluation of their cytotoxic activity towards the MOLM-13 acute myeloid leukemia cell line. (ekstern lenke)
• Skjånes, Kari; Aesoy, Reidun; Herfindal, Lars et al. (2021). Bioactive peptides from microalgae: Focus on anti-cancer and immunomodulating activity. (ekstern lenke)
• Viktorsson, Elvar Örn; Aesoy, Reidun; Støa, Sindre et al. (2021). New prodrugs and analogs of the phenazine 5,10-dioxide natural products iodinin and myxin promote selective cytotoxicity towards human acute myeloid leukemia cells. (ekstern lenke)
• Solum, Eirik Johansson; Hansen, Trond Vidar; Aesoy, Reidun et al. (2020). New CDK8 inhibitors as potential anti-leukemic agents – Design, synthesis and biological evaluation. (ekstern lenke)
• Bjørnstad, Ronja; Aesoy, Reidun; Bruserud, Øystein et al. (2019). A kinase inhibitor with anti-Pim kinase activity is a potent and selective cytotoxic agent toward acute myeloid leukemia. (ekstern lenke)
• Åsrud, Kathrine Sivertsen; Pedersen, Line; Aesoy, Reidun et al. (2019). Mice depleted for Exchange Proteins Directly Activated by cAMP (Epac) exhibit irregular liver regeneration in response to partial hepatectomy. (ekstern lenke)
• Aesoy, Reidun; Muwonge, Haruna; Sivertsen Åsrud, Kathrine et al. (2018). Deletion of exchange proteins directly activated by cAMP (Epac) causes defects in hippocampal signaling in female mice. (ekstern lenke)
• Viktorsson, Elvar Örn; Grøthe, Bendik Melling; Aesoy, Reidun et al. (2017). Total synthesis and antileukemic evaluations of the phenazine 5,10-dioxide natural products iodinin, myxin and their derivatives. (ekstern lenke)
• Edland, Ravn Fritdtjov; Wergeland, Anita; Kopperud, Reidun Kristin et al. (2016). Long-term consumption of an obesogenic high fat diet prior to ischemia-reperfusion mediates cardioprotection via Epac1-dependent signaling. (ekstern lenke)
• Lewis, Aurelia Eva; Aesoy, Reidun; Bakke, Marit (2016). Role of EPAC in cAMP-mediated actions in adrenocortical cells. (ekstern lenke)
• Æsøy, Reidun; Gradin, Katarina; Åsrud, Kathrine Sivertsen et al. (2014). Regulation of CDKN2B expression by interaction of Arnt with Miz-1 - a basis for functional integration between the HIF and Myc gene regulatory pathways. (ekstern lenke)
• Wickström, Malin; Viktorsson, Kristina; Lundholm, Lovisa et al. (2010). The alkylating prodrug J1 can be activated by aminopeptidase N, leading to a possible target directed release of melphalan. (ekstern lenke)
• Høivik, Erling Andre; Aumo, Linda; Æsøy, Reidun et al. (2008). Deoxyribonucleic acid methylation controls cell type-specific expression of steroidogenic factor 1. (ekstern lenke)
• Æsøy, Reidun; Chavez Sanchez, Betzabe; Norum, Jens Henrik et al. (2008). An autocrine VEGF/VEGFR2 and p38 signaling loop confers resistance to 4-hydroxytamoxifen in MCF-7 breast cancer cells. (ekstern lenke)
• Æsøy, Reidun; Mellgren, Gunnar; Morohashi, Ken-Ichirou et al. (2002). Activation of cAMP-dependent protein kinase increases the protein level of steroidogenic factor-1. (ekstern lenke)
• Lund, Johan; Jacob, Anne L.; Æsøy, Reidun et al. (1998). Biochemical and functional analysis of nuclear receptors as targets in cAMP-dependent control of bovine CYP17. (ekstern lenke)

Poster

• Montlaur, Constance De; Æsøy, Reidun; Brenner, Annette et al. (2022). Precision medicine in childhood cancer - a representative case of neuroblastoma. (ekstern lenke)

Vitenskapelig oversiktsartikkel/review

• Fewer, David P.; Jokela, Jouni; Heinilä, Lassi et al. (2021). Chemical diversity and cellular effects of antifungal cyclic lipopeptides from cyanobacteria . (ekstern lenke)
• Æsøy, Reidun; Clyne, Colin D.; Chand, Ashwini L. (2015). Insights into Orphan Nuclear Receptors as Prognostic Markers and Novel Therapeutic Targets for Breast Cancer.. (ekstern lenke)
• Lund, Johan; Børud, Bente; Mellgren, Gunnar et al. (2002). Differential regulation of SF-1-cofactor interactions. (ekstern lenke)

Doktorgradsavhandling

• Æsøy, Reidun (2004). Modifications of transcriptional regulation by protein-protein interactions and signal transduction. (ekstern lenke)

Se en full oversikt over publikasjoner i Cristin