Vitenskapelig artikkel

• Jouleh, Tæraneh; Kotopoulis, Spiros; Dimcevski, Georg et al. (2025). Comparison of two- and three-dimensional ultrasound for volume estimation of the meal-stimulated gallbladder. (ekstern lenke)
• Mühlenpfordt, Melina; Olsen, Emma Bøe; Kotopoulis, Spiros et al. (2023). Real-Time Intravital Imaging of Acoustic Cluster Therapy–Induced Vascular Effects in the Murine Brain. (ekstern lenke)
• Wamel, Annemieke van; Mühlenpfordt, Melina; Hansen, Rune et al. (2022). Ultrafast Microscopy Imaging of Acoustic Cluster Therapy Bubbles: Activation and Oscillation. (ekstern lenke)
• Smalberger, Charl; Nathan, Malavika; Rubin, David M. et al. (2022). Experimental setup for the ultrasonic fractionation of flowing whole blood in a capillary. (ekstern lenke)
• Kotopoulis, Spiros; Lam, Christina; Haugse, Ragnhild et al. (2022). Formulation and characterisation of drug-loaded antibubbles for image-guided and ultrasound-triggered drug delivery. (ekstern lenke)
• Kotopoulis, Spiros; Popa, Mihaela-Lucia; Safont, Mireia Mayoral et al. (2022). SonoVue® vs. Sonazoid™ vs. Optison™: Which Bubble Is Best for Low-Intensity Sonoporation of Pancreatic Ductal Adenocarcinoma?. (ekstern lenke)
• Poon, Charissa; Mühlenpfordt, Melina; Olsman, Marieke et al. (2022). Real-time intravital multiphoton microscopy to visualize focused ultrasound and microbubble treatments to increase blood-brain barrier permeability. (ekstern lenke)
• Olsman, Marieke; Mühlenpfordt, Melina; Olsen, Emma Bøe et al. (2021). Acoustic Cluster Therapy (ACT®) increases blood-brain barrier permeability and enhances accumulation of core-crosslinked polymeric micelles. (ekstern lenke)
• Schultz, Christopher W.; Garibay, Gorka Ruiz de; Langer, Anika et al. (2021). Selecting the optimal parameters for sonoporation of pancreatic cancer in a pre-clinical model. (ekstern lenke)
• Eikrem, Øystein Solberg; Kotopoulis, Spiros; Popa, Mihaela-Lucia et al. (2021). Ultrasound and Microbubbles Enhance Uptake of Doxorubicin in Murine Kidneys. (ekstern lenke)
• Bjånes, Tormod Karlsen; Kotopoulis, Spiros; Murvold, Elsa Thodesen et al. (2020). Ultrasound‐ and microbubble‐assisted gemcitabine delivery to pancreatic cancer cells. (ekstern lenke)
• Bjånes, Tormod Karlsen; Jordheim, Lars Petter; Schjøtt, Jan et al. (2020). Intracellular cytidine deaminase regulates gemcitabine metabolism in pancreatic cancer cell lines. (ekstern lenke)
• Castle, Jason; Kotopoulis, Spiros; Forsberg, Flemming (2020). Sonoporation for augmenting chemotherapy of pancreatic ductal adenocarcinoma. (ekstern lenke)
• Bush, Nigel; Healey, Andrew; Shah, Anant et al. (2020). Theranostic attributes of acoustic cluster therapy and its use for enhancing the effectiveness of liposomal doxorubicin treatment of human triple negative breast cancer in mice. (ekstern lenke)
• Haugse, Ragnhild; Langer, Anika; Murvold, Elisa Thodesen et al. (2020). Low-Intensity Sonoporation-Induced Intracellular Signalling of Pancreatic Cancer Cells, Fibroblasts and Endothelial Cells. (ekstern lenke)
• Haugse, Ragnhild; Langer, Anika; Gullaksen, Stein-Erik et al. (2019). Intracellular signaling in key pathways is induced by treatment with ultrasound and microbubbles in a leukemia cell line, but not in healthy peripheral blood mononuclear cells. (ekstern lenke)
• Bush, Nigel; Healey, Andrew; Shah, Anant et al. (2019). Acoustic Cluster Therapy displays theranostic capability in enhancing the effectiveness of liposomal doxorubicin treatment of human triple negative breast cancer in mice. (ekstern lenke)
• Kotopoulis, Spiros; Stigen, Endre; Popa, Mihaela Lucia et al. (2017). Sonoporation with Acoustic Cluster Therapy (ACT®) induces transient tumour volume reduction in a subcutaneous xenograft model of pancreatic ductal adenocarcinoma. (ekstern lenke)
• Retz, Kathinka; Kotopoulis, Spiros; Kiserud, Torvid et al. (2017). Measured acoustic intensities for clinical diagnostic ultrasound transducers and correlation with thermal index. (ekstern lenke)
• Retz, Asta Kathinka H; Kotopoulis, Spiros; Kiserud, Torvid et al. (2016). Measured acoustic intensities for clinical diagnostic ultrasound transducers and correlation with thermal index. (ekstern lenke)
• Dimcevski, Georg Gjorgji; Kotopoulis, Spiros; Bjånes, Tormod Karlsen et al. (2016). A human clinical trial using ultrasound and microbubbles to enhance gemcitabine treatment of inoperable pancreatic cancer. (ekstern lenke)
• Kotopoulis, Spiros; Dimcevski, Georg Gjorgji; Cormack, Emmet Mc et al. (2016). Ultrasound- and microbubble-enhanced chemotherapy for treating pancreatic cancer: A phase I clinical trial. (ekstern lenke)
• Johansen, Kristoffer; Kotopoulis, Spiros; Poortinga, Albert T. et al. (2016). Harmonic antibubbles. (ekstern lenke)
• Yddal, Torstein; Gilja, Odd Helge; Cochran, Sandy et al. (2016). Glass-windowed ultrasound transducers. (ekstern lenke)
• Kotopoulis, Spiros; Dimcevski, Georg Gjorgji; McCormack, Emmet et al. (2016). Ultrasound- and microbubble-enhanced chemotherapy for treating pancreatic cancer: a phase I clinical trial. (ekstern lenke)
• Yddal, Torstein; Cochran, Sandy; Gilja, Odd Helge et al. (2015). Open source, high throughput, ultrasound treatment chamber. (ekstern lenke)
• Johansen, Kristoffer; Kotopoulis, Spiros; Postema, Michiel (2015). Ultrasonically driven antibubbles encapsulated by Newtonian fluids for active leakage detection. (ekstern lenke)
• Kotopoulis, Spiros; Johansen, Kristoffer; Gilja, Odd Helge et al. (2015). Acoustically active antibubbles. (ekstern lenke)
• Johansen, Kristoffer; Kotopoulis, Spiros; Poortinga, Albert T. et al. (2015). Nonlinear echoes from encapsulated antibubbles. (ekstern lenke)
• Johansen, Kristoffer; Yddal, Torstein; Kotopoulis, Spiros et al. (2014). Acoustic filtering of particles in a flow regime. (ekstern lenke)
• Kotopoulis, Spiros; Dimcevski, Georg Gjorgji; Gjertsen, Bjørn Tore et al. (2014). Sonoporation: from the lab to human clinical trials. (ekstern lenke)
• Kotopoulis, Spiros; Haugse, Ragnhild; Mujic, Maja et al. (2014). Evaluation of the effects of clinical diagnostic ultrasound in combination with ultrasound contrast agents on cell stress: Single cell analysis of intracellular phospho-signaling pathways in blood cancer cells and normal blood leukocytes. (ekstern lenke)
• Yddal, Torstein; Kotopoulis, Spiros; Gilja, Odd Helge et al. (2014). Transparent glass-windowed ultrasound transducers. (ekstern lenke)
• Kotopoulis, Spiros; Delalande, Anthony; Popa, Mihaela Lucia et al. (2014). Sonoporation-enhanced chemotherapy significantly reduces primary tumour burden in an orthotopic pancreatic cancer xenograft. (ekstern lenke)
• Kotopoulis, Spiros; Eder, Sabrina Daniela; Greve, Martin Møller et al. (2013). Lab-on-a-chip device for fabrication of therapeutic microbubbles on demand. (ekstern lenke)
• Kotopoulis, Spiros; Dimcevski, Georg Gjorgji; Gilja, Odd Helge et al. (2013). Treatment of human pancreatic cancer using combined ultrasound, microbubbles, and gemcitabine: a clinical case study. (ekstern lenke)
• Viola, Ivan; Birkeland, Åsmund; Šoltészová, Veronika et al. (2013). High-quality 3D visualization of in-situ ultrasonography. (ekstern lenke)
• Kotopoulis, Spiros; Delalande, Anthony; Pichon, Chantal et al. (2012). Real-time sonoporation through HeLa cells. (ekstern lenke)
• Kotopoulis, Spiros; Wang, Han; Cochran, Sandy et al. (2012). High-frequency transducer for MR-guided FUS. (ekstern lenke)
• Delalande, Anthony; Kotopoulis, Spiros; Rovers, Tijs et al. (2011). Sonoporation at a low mechanical index. (ekstern lenke)
• Gerold, Bjoern; Kotopoulis, Spiros; McDougall, Craig et al. (2011). Laser-nucleated acoustic cavitation in focused ultrasound. (ekstern lenke)
• Delalande, Anthony; Bouakaz, Ayache; Renault, Gilles et al. (2011). Ultrasound and microbubbles assisted gene delivery in Achilles tendons: long lasting gene expression and restoration of fibromodulin KO phenotype. (ekstern lenke)
• Delalande, Anthony; Kotopoulis, Spiros; Pichon, Chantal et al. (2011). Sonoporation at a low MI. (ekstern lenke)
• Kotopoulis, Spiros; Wang, Han; Cochran, Sandy et al. (2011). Lithium niobate transducers for MRI-guided ultrasonic microsurgery. (ekstern lenke)
• Kotopoulis, Spiros; Postema, Michiel (2010). Microfoam formation in a capillary. (ekstern lenke)
• Kotopoulis, Spiros; Wang, Han; Cochran, Sandy et al. (2010). Lithium niobate ultrasound transducers for high-resolution focused ultrasound surgery. (ekstern lenke)
• Kotopoulis, Spiros; Schommartz, Antje; Postema, Michiel (2009). Sonic cracking of blue-green algae. (ekstern lenke)
• Kotopoulis, Spiros; Schommartz, Antje; Postema, Michiel (2008). Safety radius for algae eradication at 200 kHz - 2.5 MHz. (ekstern lenke)

Poster

• Jouleh, Tæraneh; Kotopoulis, Spiros; Dimcevski, Georg et al. (2024). Gallbladder Volumes Estimated by 2D Versus 3D Ultrasound. (ekstern lenke)
• Mühlenpfordt, Melina; Olsman, Marieke; Olsen, Emma Bøe et al. (2022). Acoustic Cluster Therapy (ACT®) increases blood-brain barrier permeability and enhances accumulation of core-crosslinked polymeric micelles. (ekstern lenke)
• Bjånes, Tormod Karlsen; Jordheim, Lars Petter; Schjøtt, Jan et al. (2019). Intracellular cytidine deaminase and gemcitabine metabolism in three pancreatic cancer cell lines. (ekstern lenke)
• Bjånes, Tormod Karlsen; Schjøtt, Jan; Kotopoulis, Spiros et al. (2019). Sonoporation and gemcitabine delivery in pancreatic cancer cell lines. (ekstern lenke)
• Bjånes, Tormod Karlsen; Jordheim, Lars Petter; Schjøtt, Jan et al. (2019). role of intracellular cytidine deaminase activity for gemcitabine metabolism in pancreatic cancer cell lines. (ekstern lenke)
• Haugse, Ragnhild; Langer, Anika; Sundøy, Silje Maria et al. (2019). Molecular mechanisms of sonoporation in pancreatic ductal adenocarcinoma (PDAC). (ekstern lenke)
• Bjånes, Tormod Karlsen; Jordheim, Lars Petter; Schjøtt, Jan et al. (2019). Intracellular cytidine deaminase and gemcitabine metabolism in three pancreatic cancer cell lines. (ekstern lenke)
• Bjånes, Tormod Karlsen; Thodesen, Elisa Ulvøen; Schjøtt, Jan et al. (2019). Sonoporation and gemcitabine delivery in pancreatic cell lines. (ekstern lenke)
• Thodesen, Elisa Ulvøen; Bjånes, Tormod Karlsen; Haugse, Ragnhild et al. (2019). in vitro optimisation of sonoporation conditions in pancreatic cancer. (ekstern lenke)
• Bush, Nigel; Healey, Andrew; Shah, Anant et al. (2019). Acoustic Cluster Therapy displays theranostic capability in enhancing the effectiveness of liposomal doxorubicin treatment of human triple negative breast cancer in mice. (ekstern lenke)
• Søvig, Karoline Kjellsdotter; Kotopoulis, Spiros; Nylund, Kim et al. (2015). Volume estimation of the Gallbladder - 2D vs 3D Ultrasound. (ekstern lenke)

Vitenskapelig foredrag

• Skjaervold, Nils Kristian; Kotopoulis, Spiros; Løvskar, Sverre et al. (2023). Oxycate - utvikling av en trådløs engangs cerebral oksygenmonitor for prehospital bruk. (ekstern lenke)
• Mühlenpfordt, Melina; Olsen, Emma Bøe; Kotopoulis, Spiros et al. (2022). Real-time intravital imaging of the vascular effects induced by Acoustic Cluster Therapy (ACT®) in a murine brain. (ekstern lenke)
• Mühlenpfordt, Melina; Olsman, Marieke; Olsen, Emma Bøe et al. (2021). Acoustic Cluster Therapy (ACT®) enhances extravasation and parenchymal accumulation of core-crosslinked polymeric micelles in the brain. (ekstern lenke)
• Kotopoulis, Spiros; Popa, Mihaela Lucia; Safont, MJ et al. (2015). Sonoporation using Acoustic Cluster Therapy in combination With chemotherapy transiently reduces tumour volume.. (ekstern lenke)

Sammendrag/Abstract

• Posey, James; Machado, Priscilla; Eisenbrey, John R. et al. (2023). Sonoporation for disrupting the pancreatic cancer microenvironment to enhance chemotherapy delivery and improve outcomes.. (ekstern lenke)
• Dimcevski, Georg Gjorgji; Kotopoulis, Spiros; Bjånes, Tormod Karlsen et al. (2016). Ultrasound and microbubble enhanced treatment of inoperable pancreatic adeonocarcinoma. (ekstern lenke)
• Kotopoulis, Spiros; Dimcevski, Georg Gjorgji; Hoem, Dag et al. (2015). Ultrasound sonoporation in pancreatic adenocarcinoma. (ekstern lenke)
• Kotopoulis, Spiros; Postema, Michiel (2013). High-speed photography of encapsulated microbubbles. (ekstern lenke)
• Kotopoulis, Spiros; Postema, Michiel (2011). Therapeutic ultrasound and sonoporation. (ekstern lenke)

Vitenskapelig Kapittel/Artikkel/Konferanseartikkel

• Nordaas, Ingrid Kvåle; Jouleh, Tæraneh; trelsgård, Audun Magerøy et al. (2021). Sonoporation in pancreatic cancer (PDAC). (ekstern lenke)
• Kotopoulis, Spiros; Wang, Han; Yddal, Torstein et al. (2015). Novel multipurpose, low cost, modular, ultrasound transducers. (ekstern lenke)
• Johansen, Kristoffer; Kotopoulis, Spiros; Postema, Michiel (2015). Active leakage detection by searching for antibubbles. (ekstern lenke)
• Johansen, Kristoffer; Kotopoulis, Spiros; Postema, Michiel (2015). Ultrasonically driven antibubbles encapsulated by Newtonian fluids for active leakage detection. (ekstern lenke)
• Johansen, Kristoffer; Kotopoulis, Spiros; Postema, Michiel (2015). Introduction to antibubbles. (ekstern lenke)
• Søvig, Karoline Kjellsdotter; Kotopoulis, Spiros; Nylund, Kim et al. (2015). Volume estimation of the Gallbladder - 2D vs 3D Ultrasound. (ekstern lenke)
• Kotopoulis, Spiros; Popa, Mihaela Lucia; Safont, MJ et al. (2015). Sonoporation using Acoustic Cluster Therapy in combination With chemotherapy transiently reduces tumour volume.. (ekstern lenke)
• Johansen, Kristoffer; Kotopoulis, Spiros; Poortinga, Albert T. et al. (2015). Antibubbles. (ekstern lenke)
• Kotopoulis, Spiros; Johansen, Kristoffer; Poortinga, Albert et al. (2014). Acoustically active antibubbles for ultrasound imaging and targeted drug delivery. (ekstern lenke)
• Kotopoulis, Spiros; Postema, Michiel (2013). Using ultrasound to separate oil, gas, and water. (ekstern lenke)
• Kotopoulis, Spiros; Delalande, Anthony; Popa, Mihaela et al. (2013). Ultrasound and microbubble enhanced therapy of orthotopic human pancreatic cancer in mice. (ekstern lenke)
• Mujic, Maja; Haugse, Ragnhild; Kotopoulis, Spiros et al. (2013). Ultrasound combined with microbubbles modulates signal transduction pathways in blood cells. (ekstern lenke)
• Dimcevski, Georg Gjorgji; Kotopoulis, Spiros; Hoem, Dag et al. (2013). Ultrasound-assisted treatment of an inoperable pancreatic cancer. (ekstern lenke)
• Kotopoulis, Spiros; Haugse, Ragnhild; Postema, Michiel (2013). Sonoporation: the hurdles that need to be surpassed. (ekstern lenke)
• Kotopoulis, Spiros; Delalande, Anthony; Pichon, Chantal et al. (2012). Biological and medical applications of low-intensity ultrasound. (ekstern lenke)
• Gerold, Bjoern; Kotopoulis, Spiros; Cochran, Sandy et al. (2012). Hybrid laser-ultrasound cavitation for cloud evolution studies. (ekstern lenke)
• Postema, Michiel; Kotopoulis, Spiros; Jenderka, Klaus-Vitold (2012). Basic Principles: Basic physical principles of medical ultrasound. (ekstern lenke)
• Mujic, Maja; Kotopoulis, Spiros; Delalande, Anthony et al. (2012). Flow cytometic characterization and sorting of ultrasound contrast agents. (ekstern lenke)
• Delalande, Anthony; Kotopoulis, Spiros; Midoux, Patrick et al. (2012). Ultrasound and microbubble-assisted gene delivery: insights for intracellular mechanism. (ekstern lenke)
• Kotopoulis, Spiros; Delalande, Anthony; Pichon, Chantal et al. (2012). Nonlinear microbubble behaviour for enhanced drug uptake. (ekstern lenke)
• Kotopoulis, Spiros; Delalande, Anthony; Pichon, Chantal et al. (2012). Real-time sonoporation through HeLa cells. (ekstern lenke)
• Kotopoulis, Spiros; Delalande, Anthony; Pichon, Chantal et al. (2012). Sonoporation: using ultrasound for targeted drug delivery. (ekstern lenke)
• Delalande, Anthony; Kotopoulis, Spiros; Pichon, Chantal et al. (2012). Microbubbles and cell interactions. (ekstern lenke)
• Postema, Michiel; Kotopoulis, Spiros; Delalande, Anthony et al. (2011). Ultrasound-guided delivery and sonoporation. (ekstern lenke)
• Kotopoulis, Spiros; Delalande, Anthony; Pichon, Chantal et al. (2011). On cells and sound. (ekstern lenke)
• Kotopoulis, Spiros; Postema, Michiel (2011). Biomedical ultrasonics, cavitation, and sonoporation. (ekstern lenke)
• Kotopoulis, Spiros; Postema, Michiel; Cochran, Sandy (2011). Ultrasound transducers made with lithium niobate for HF HIFU. (ekstern lenke)
• Delalande, Anthony; Kotopoulis, Spiros; Midoux, Patrick et al. (2011). Cell-microbubble interaction and intracellular fate of plasmid DNA and microbubbles during the sonoporation process. (ekstern lenke)
• Delalande, Anthony; Kotopoulis, Spiros; Pichon, Chantal et al. (2011). Cancer cell sonoporation at low acoustic amplitudes. (ekstern lenke)
• Delalande, Anthony; Midoux, Patrick; Pichon, Chantal et al. (2011). Investigations of microbubble-cell interactions during the sonoporation process. (ekstern lenke)
• Kotopoulis, Spiros; Postema, Michiel (2010). Forming morphing microfoam. (ekstern lenke)

Faglig foredrag

• Bjånes, Tormod Karlsen; Schjøtt, Jan; Kotopoulis, Spiros et al. (2019). Sonoporation and gemcitabine delivery in pancreatic cancer cell lines. (ekstern lenke)

Vitenskapelig oversiktsartikkel/review

• Delalande, Anthony; Kotopoulis, Spiros; Postema, Michiel et al. (2013). Sonoporation: mechanistic insights and ongoing challenges for gene transfer. (ekstern lenke)

Innledning

• Kotopoulis, Spiros; Delalande, Anthony; Godø, Olav Rune et al. (2012). Preface. (ekstern lenke)

Leksikon

• Kotopoulis, Spiros; Delalande, Anthony; Godø, Olav Rune et al. (2012). Micro-acoustics in marine and medical research. (ekstern lenke)

Leder

• Postema, Michiel; Kotopoulis, Spiros; Delalande, Anthony et al. (2012). Sonoporation: why microbubbles create pores. (ekstern lenke)

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