Academic article

• Jouleh, Tæraneh; Kotopoulis, Spiros; Dimcevski, Georg et al. (2025). Comparison of two- and three-dimensional ultrasound for volume estimation of the meal-stimulated gallbladder. (external link)
• Mühlenpfordt, Melina; Olsen, Emma Bøe; Kotopoulis, Spiros et al. (2023). Real-Time Intravital Imaging of Acoustic Cluster Therapy–Induced Vascular Effects in the Murine Brain. (external link)
• Wamel, Annemieke van; Mühlenpfordt, Melina; Hansen, Rune et al. (2022). Ultrafast Microscopy Imaging of Acoustic Cluster Therapy Bubbles: Activation and Oscillation. (external link)
• Smalberger, Charl; Nathan, Malavika; Rubin, David M. et al. (2022). Experimental setup for the ultrasonic fractionation of flowing whole blood in a capillary. (external link)
• Kotopoulis, Spiros; Lam, Christina; Haugse, Ragnhild et al. (2022). Formulation and characterisation of drug-loaded antibubbles for image-guided and ultrasound-triggered drug delivery. (external link)
• Kotopoulis, Spiros; Popa, Mihaela-Lucia; Safont, Mireia Mayoral et al. (2022). SonoVue® vs. Sonazoid™ vs. Optison™: Which Bubble Is Best for Low-Intensity Sonoporation of Pancreatic Ductal Adenocarcinoma?. (external link)
• Poon, Charissa; Mühlenpfordt, Melina; Olsman, Marieke et al. (2022). Real-time intravital multiphoton microscopy to visualize focused ultrasound and microbubble treatments to increase blood-brain barrier permeability. (external link)
• Olsman, Marieke; Mühlenpfordt, Melina; Olsen, Emma Bøe et al. (2021). Acoustic Cluster Therapy (ACT®) increases blood-brain barrier permeability and enhances accumulation of core-crosslinked polymeric micelles. (external link)
• Schultz, Christopher W.; Garibay, Gorka Ruiz de; Langer, Anika et al. (2021). Selecting the optimal parameters for sonoporation of pancreatic cancer in a pre-clinical model. (external link)
• Eikrem, Øystein Solberg; Kotopoulis, Spiros; Popa, Mihaela-Lucia et al. (2021). Ultrasound and Microbubbles Enhance Uptake of Doxorubicin in Murine Kidneys. (external link)
• Bjånes, Tormod Karlsen; Kotopoulis, Spiros; Murvold, Elsa Thodesen et al. (2020). Ultrasound‐ and microbubble‐assisted gemcitabine delivery to pancreatic cancer cells. (external link)
• Bjånes, Tormod Karlsen; Jordheim, Lars Petter; Schjøtt, Jan et al. (2020). Intracellular cytidine deaminase regulates gemcitabine metabolism in pancreatic cancer cell lines. (external link)
• Castle, Jason; Kotopoulis, Spiros; Forsberg, Flemming (2020). Sonoporation for augmenting chemotherapy of pancreatic ductal adenocarcinoma. (external link)
• Bush, Nigel; Healey, Andrew; Shah, Anant et al. (2020). Theranostic attributes of acoustic cluster therapy and its use for enhancing the effectiveness of liposomal doxorubicin treatment of human triple negative breast cancer in mice. (external link)
• Haugse, Ragnhild; Langer, Anika; Murvold, Elisa Thodesen et al. (2020). Low-Intensity Sonoporation-Induced Intracellular Signalling of Pancreatic Cancer Cells, Fibroblasts and Endothelial Cells. (external link)
• Haugse, Ragnhild; Langer, Anika; Gullaksen, Stein-Erik et al. (2019). Intracellular signaling in key pathways is induced by treatment with ultrasound and microbubbles in a leukemia cell line, but not in healthy peripheral blood mononuclear cells. (external link)
• Bush, Nigel; Healey, Andrew; Shah, Anant et al. (2019). Acoustic Cluster Therapy displays theranostic capability in enhancing the effectiveness of liposomal doxorubicin treatment of human triple negative breast cancer in mice. (external link)
• Kotopoulis, Spiros; Stigen, Endre; Popa, Mihaela Lucia et al. (2017). Sonoporation with Acoustic Cluster Therapy (ACT®) induces transient tumour volume reduction in a subcutaneous xenograft model of pancreatic ductal adenocarcinoma. (external link)
• Retz, Kathinka; Kotopoulis, Spiros; Kiserud, Torvid et al. (2017). Measured acoustic intensities for clinical diagnostic ultrasound transducers and correlation with thermal index. (external link)
• Retz, Asta Kathinka H; Kotopoulis, Spiros; Kiserud, Torvid et al. (2016). Measured acoustic intensities for clinical diagnostic ultrasound transducers and correlation with thermal index. (external link)
• Dimcevski, Georg Gjorgji; Kotopoulis, Spiros; Bjånes, Tormod Karlsen et al. (2016). A human clinical trial using ultrasound and microbubbles to enhance gemcitabine treatment of inoperable pancreatic cancer. (external link)
• Kotopoulis, Spiros; Dimcevski, Georg Gjorgji; Cormack, Emmet Mc et al. (2016). Ultrasound- and microbubble-enhanced chemotherapy for treating pancreatic cancer: A phase I clinical trial. (external link)
• Johansen, Kristoffer; Kotopoulis, Spiros; Poortinga, Albert T. et al. (2016). Harmonic antibubbles. (external link)
• Yddal, Torstein; Gilja, Odd Helge; Cochran, Sandy et al. (2016). Glass-windowed ultrasound transducers. (external link)
• Kotopoulis, Spiros; Dimcevski, Georg Gjorgji; McCormack, Emmet et al. (2016). Ultrasound- and microbubble-enhanced chemotherapy for treating pancreatic cancer: a phase I clinical trial. (external link)
• Yddal, Torstein; Cochran, Sandy; Gilja, Odd Helge et al. (2015). Open source, high throughput, ultrasound treatment chamber. (external link)
• Johansen, Kristoffer; Kotopoulis, Spiros; Postema, Michiel (2015). Ultrasonically driven antibubbles encapsulated by Newtonian fluids for active leakage detection. (external link)
• Kotopoulis, Spiros; Johansen, Kristoffer; Gilja, Odd Helge et al. (2015). Acoustically active antibubbles. (external link)
• Johansen, Kristoffer; Kotopoulis, Spiros; Poortinga, Albert T. et al. (2015). Nonlinear echoes from encapsulated antibubbles. (external link)
• Johansen, Kristoffer; Yddal, Torstein; Kotopoulis, Spiros et al. (2014). Acoustic filtering of particles in a flow regime. (external link)
• Kotopoulis, Spiros; Dimcevski, Georg Gjorgji; Gjertsen, Bjørn Tore et al. (2014). Sonoporation: from the lab to human clinical trials. (external link)
• Kotopoulis, Spiros; Haugse, Ragnhild; Mujic, Maja et al. (2014). Evaluation of the effects of clinical diagnostic ultrasound in combination with ultrasound contrast agents on cell stress: Single cell analysis of intracellular phospho-signaling pathways in blood cancer cells and normal blood leukocytes. (external link)
• Yddal, Torstein; Kotopoulis, Spiros; Gilja, Odd Helge et al. (2014). Transparent glass-windowed ultrasound transducers. (external link)
• Kotopoulis, Spiros; Delalande, Anthony; Popa, Mihaela Lucia et al. (2014). Sonoporation-enhanced chemotherapy significantly reduces primary tumour burden in an orthotopic pancreatic cancer xenograft. (external link)
• Kotopoulis, Spiros; Eder, Sabrina Daniela; Greve, Martin Møller et al. (2013). Lab-on-a-chip device for fabrication of therapeutic microbubbles on demand. (external link)
• Kotopoulis, Spiros; Dimcevski, Georg Gjorgji; Gilja, Odd Helge et al. (2013). Treatment of human pancreatic cancer using combined ultrasound, microbubbles, and gemcitabine: a clinical case study. (external link)
• Viola, Ivan; Birkeland, Åsmund; Šoltészová, Veronika et al. (2013). High-quality 3D visualization of in-situ ultrasonography. (external link)
• Kotopoulis, Spiros; Delalande, Anthony; Pichon, Chantal et al. (2012). Real-time sonoporation through HeLa cells. (external link)
• Kotopoulis, Spiros; Wang, Han; Cochran, Sandy et al. (2012). High-frequency transducer for MR-guided FUS. (external link)
• Delalande, Anthony; Kotopoulis, Spiros; Rovers, Tijs et al. (2011). Sonoporation at a low mechanical index. (external link)
• Gerold, Bjoern; Kotopoulis, Spiros; McDougall, Craig et al. (2011). Laser-nucleated acoustic cavitation in focused ultrasound. (external link)
• Delalande, Anthony; Bouakaz, Ayache; Renault, Gilles et al. (2011). Ultrasound and microbubbles assisted gene delivery in Achilles tendons: long lasting gene expression and restoration of fibromodulin KO phenotype. (external link)
• Delalande, Anthony; Kotopoulis, Spiros; Pichon, Chantal et al. (2011). Sonoporation at a low MI. (external link)
• Kotopoulis, Spiros; Wang, Han; Cochran, Sandy et al. (2011). Lithium niobate transducers for MRI-guided ultrasonic microsurgery. (external link)
• Kotopoulis, Spiros; Postema, Michiel (2010). Microfoam formation in a capillary. (external link)
• Kotopoulis, Spiros; Wang, Han; Cochran, Sandy et al. (2010). Lithium niobate ultrasound transducers for high-resolution focused ultrasound surgery. (external link)
• Kotopoulis, Spiros; Schommartz, Antje; Postema, Michiel (2009). Sonic cracking of blue-green algae. (external link)
• Kotopoulis, Spiros; Schommartz, Antje; Postema, Michiel (2008). Safety radius for algae eradication at 200 kHz - 2.5 MHz. (external link)

Poster

• Jouleh, Tæraneh; Kotopoulis, Spiros; Dimcevski, Georg et al. (2024). Gallbladder Volumes Estimated by 2D Versus 3D Ultrasound. (external link)
• Mühlenpfordt, Melina; Olsman, Marieke; Olsen, Emma Bøe et al. (2022). Acoustic Cluster Therapy (ACT®) increases blood-brain barrier permeability and enhances accumulation of core-crosslinked polymeric micelles. (external link)
• Bjånes, Tormod Karlsen; Jordheim, Lars Petter; Schjøtt, Jan et al. (2019). Intracellular cytidine deaminase and gemcitabine metabolism in three pancreatic cancer cell lines. (external link)
• Bjånes, Tormod Karlsen; Schjøtt, Jan; Kotopoulis, Spiros et al. (2019). Sonoporation and gemcitabine delivery in pancreatic cancer cell lines. (external link)
• Bjånes, Tormod Karlsen; Jordheim, Lars Petter; Schjøtt, Jan et al. (2019). role of intracellular cytidine deaminase activity for gemcitabine metabolism in pancreatic cancer cell lines. (external link)
• Haugse, Ragnhild; Langer, Anika; Sundøy, Silje Maria et al. (2019). Molecular mechanisms of sonoporation in pancreatic ductal adenocarcinoma (PDAC). (external link)
• Bjånes, Tormod Karlsen; Jordheim, Lars Petter; Schjøtt, Jan et al. (2019). Intracellular cytidine deaminase and gemcitabine metabolism in three pancreatic cancer cell lines. (external link)
• Bjånes, Tormod Karlsen; Thodesen, Elisa Ulvøen; Schjøtt, Jan et al. (2019). Sonoporation and gemcitabine delivery in pancreatic cell lines. (external link)
• Thodesen, Elisa Ulvøen; Bjånes, Tormod Karlsen; Haugse, Ragnhild et al. (2019). in vitro optimisation of sonoporation conditions in pancreatic cancer. (external link)
• Bush, Nigel; Healey, Andrew; Shah, Anant et al. (2019). Acoustic Cluster Therapy displays theranostic capability in enhancing the effectiveness of liposomal doxorubicin treatment of human triple negative breast cancer in mice. (external link)
• Søvig, Karoline Kjellsdotter; Kotopoulis, Spiros; Nylund, Kim et al. (2015). Volume estimation of the Gallbladder - 2D vs 3D Ultrasound. (external link)

Academic lecture

• Skjaervold, Nils Kristian; Kotopoulis, Spiros; Løvskar, Sverre et al. (2023). Oxycate - utvikling av en trådløs engangs cerebral oksygenmonitor for prehospital bruk. (external link)
• Mühlenpfordt, Melina; Olsen, Emma Bøe; Kotopoulis, Spiros et al. (2022). Real-time intravital imaging of the vascular effects induced by Acoustic Cluster Therapy (ACT®) in a murine brain. (external link)
• Mühlenpfordt, Melina; Olsman, Marieke; Olsen, Emma Bøe et al. (2021). Acoustic Cluster Therapy (ACT®) enhances extravasation and parenchymal accumulation of core-crosslinked polymeric micelles in the brain. (external link)
• Kotopoulis, Spiros; Popa, Mihaela Lucia; Safont, MJ et al. (2015). Sonoporation using Acoustic Cluster Therapy in combination With chemotherapy transiently reduces tumour volume.. (external link)

Abstract

• Posey, James; Machado, Priscilla; Eisenbrey, John R. et al. (2023). Sonoporation for disrupting the pancreatic cancer microenvironment to enhance chemotherapy delivery and improve outcomes.. (external link)
• Dimcevski, Georg Gjorgji; Kotopoulis, Spiros; Bjånes, Tormod Karlsen et al. (2016). Ultrasound and microbubble enhanced treatment of inoperable pancreatic adeonocarcinoma. (external link)
• Kotopoulis, Spiros; Dimcevski, Georg Gjorgji; Hoem, Dag et al. (2015). Ultrasound sonoporation in pancreatic adenocarcinoma. (external link)
• Kotopoulis, Spiros; Postema, Michiel (2013). High-speed photography of encapsulated microbubbles. (external link)
• Kotopoulis, Spiros; Postema, Michiel (2011). Therapeutic ultrasound and sonoporation. (external link)

Academic chapter/article/Conference paper

• Nordaas, Ingrid Kvåle; Jouleh, Tæraneh; trelsgård, Audun Magerøy et al. (2021). Sonoporation in pancreatic cancer (PDAC). (external link)
• Kotopoulis, Spiros; Wang, Han; Yddal, Torstein et al. (2015). Novel multipurpose, low cost, modular, ultrasound transducers. (external link)
• Johansen, Kristoffer; Kotopoulis, Spiros; Postema, Michiel (2015). Active leakage detection by searching for antibubbles. (external link)
• Johansen, Kristoffer; Kotopoulis, Spiros; Postema, Michiel (2015). Ultrasonically driven antibubbles encapsulated by Newtonian fluids for active leakage detection. (external link)
• Johansen, Kristoffer; Kotopoulis, Spiros; Postema, Michiel (2015). Introduction to antibubbles. (external link)
• Søvig, Karoline Kjellsdotter; Kotopoulis, Spiros; Nylund, Kim et al. (2015). Volume estimation of the Gallbladder - 2D vs 3D Ultrasound. (external link)
• Kotopoulis, Spiros; Popa, Mihaela Lucia; Safont, MJ et al. (2015). Sonoporation using Acoustic Cluster Therapy in combination With chemotherapy transiently reduces tumour volume.. (external link)
• Johansen, Kristoffer; Kotopoulis, Spiros; Poortinga, Albert T. et al. (2015). Antibubbles. (external link)
• Kotopoulis, Spiros; Johansen, Kristoffer; Poortinga, Albert et al. (2014). Acoustically active antibubbles for ultrasound imaging and targeted drug delivery. (external link)
• Kotopoulis, Spiros; Postema, Michiel (2013). Using ultrasound to separate oil, gas, and water. (external link)
• Kotopoulis, Spiros; Delalande, Anthony; Popa, Mihaela et al. (2013). Ultrasound and microbubble enhanced therapy of orthotopic human pancreatic cancer in mice. (external link)
• Mujic, Maja; Haugse, Ragnhild; Kotopoulis, Spiros et al. (2013). Ultrasound combined with microbubbles modulates signal transduction pathways in blood cells. (external link)
• Dimcevski, Georg Gjorgji; Kotopoulis, Spiros; Hoem, Dag et al. (2013). Ultrasound-assisted treatment of an inoperable pancreatic cancer. (external link)
• Kotopoulis, Spiros; Haugse, Ragnhild; Postema, Michiel (2013). Sonoporation: the hurdles that need to be surpassed. (external link)
• Kotopoulis, Spiros; Delalande, Anthony; Pichon, Chantal et al. (2012). Biological and medical applications of low-intensity ultrasound. (external link)
• Gerold, Bjoern; Kotopoulis, Spiros; Cochran, Sandy et al. (2012). Hybrid laser-ultrasound cavitation for cloud evolution studies. (external link)
• Postema, Michiel; Kotopoulis, Spiros; Jenderka, Klaus-Vitold (2012). Basic Principles: Basic physical principles of medical ultrasound. (external link)
• Mujic, Maja; Kotopoulis, Spiros; Delalande, Anthony et al. (2012). Flow cytometic characterization and sorting of ultrasound contrast agents. (external link)
• Delalande, Anthony; Kotopoulis, Spiros; Midoux, Patrick et al. (2012). Ultrasound and microbubble-assisted gene delivery: insights for intracellular mechanism. (external link)
• Kotopoulis, Spiros; Delalande, Anthony; Pichon, Chantal et al. (2012). Nonlinear microbubble behaviour for enhanced drug uptake. (external link)
• Kotopoulis, Spiros; Delalande, Anthony; Pichon, Chantal et al. (2012). Real-time sonoporation through HeLa cells. (external link)
• Kotopoulis, Spiros; Delalande, Anthony; Pichon, Chantal et al. (2012). Sonoporation: using ultrasound for targeted drug delivery. (external link)
• Delalande, Anthony; Kotopoulis, Spiros; Pichon, Chantal et al. (2012). Microbubbles and cell interactions. (external link)
• Postema, Michiel; Kotopoulis, Spiros; Delalande, Anthony et al. (2011). Ultrasound-guided delivery and sonoporation. (external link)
• Kotopoulis, Spiros; Delalande, Anthony; Pichon, Chantal et al. (2011). On cells and sound. (external link)
• Kotopoulis, Spiros; Postema, Michiel (2011). Biomedical ultrasonics, cavitation, and sonoporation. (external link)
• Kotopoulis, Spiros; Postema, Michiel; Cochran, Sandy (2011). Ultrasound transducers made with lithium niobate for HF HIFU. (external link)
• Delalande, Anthony; Kotopoulis, Spiros; Midoux, Patrick et al. (2011). Cell-microbubble interaction and intracellular fate of plasmid DNA and microbubbles during the sonoporation process. (external link)
• Delalande, Anthony; Kotopoulis, Spiros; Pichon, Chantal et al. (2011). Cancer cell sonoporation at low acoustic amplitudes. (external link)
• Delalande, Anthony; Midoux, Patrick; Pichon, Chantal et al. (2011). Investigations of microbubble-cell interactions during the sonoporation process. (external link)
• Kotopoulis, Spiros; Postema, Michiel (2010). Forming morphing microfoam. (external link)

Lecture

• Bjånes, Tormod Karlsen; Schjøtt, Jan; Kotopoulis, Spiros et al. (2019). Sonoporation and gemcitabine delivery in pancreatic cancer cell lines. (external link)

Academic literature review

• Delalande, Anthony; Kotopoulis, Spiros; Postema, Michiel et al. (2013). Sonoporation: mechanistic insights and ongoing challenges for gene transfer. (external link)

Introduction

• Kotopoulis, Spiros; Delalande, Anthony; Godø, Olav Rune et al. (2012). Preface. (external link)

Encyclopaedia

• Kotopoulis, Spiros; Delalande, Anthony; Godø, Olav Rune et al. (2012). Micro-acoustics in marine and medical research. (external link)

Editorial

• Postema, Michiel; Kotopoulis, Spiros; Delalande, Anthony et al. (2012). Sonoporation: why microbubbles create pores. (external link)

See a complete overview of publications in Cristin.