Skiftarbeid og spesielt nattskift er assosiert med ulike helseplager, der søvnproblemer er mest uttalt. For lite søvn påvirker vår våkenhetsfunksjon, og evne til kognitiv ytelse og oppmerksomhet vil kunne bli redusert. Mitt PhD-prosjekt er translasjonelt og involverer simulert nattarbeid hos både rotter og mennesker. Jeg ønsker å undersøke hvordan nattarbeid påvirker våkenhetsfunksjon og kognitiv ytelse under nattskiftet, og søvnen etter arbeid. Jeg ønsker også se på hvordan ulike lysbetingelser under simulerte nattskift kan påvirke hjernens prosesseringsevne og søvnen etter nattskiftet.

Vitenskapelig artikkel

• Pedersen, Torhild Thue; Sunde, Erlend; Wisor, Jonathan P. et al. (2022). Sleep homeostasis and night work: a polysomnographic study of daytime sleep following three consecutive simulated night shifts. (ekstern lenke)
• Sunde, Erlend; Mrdalj, Jelena; Pedersen, Torhild Thue et al. (2022). Bright light exposure during simulated night work improves cognitive flexibility. (ekstern lenke)
• Sunde, Erlend; Pedersen, Torhild; Mrdalj, Jelena et al. (2020). Alerting and Circadian Effects of Short-Wavelength vs. Long-Wavelength Narrow-Bandwidth Light during a Simulated Night Shift. (ekstern lenke)
• Sunde, Erlend; Mrdalj, Jelena; Pedersen, Torhild et al. (2020). Role of nocturnal light intensity on adaptation to three consecutive night shifts: a counterbalanced crossover study. (ekstern lenke)
• Marti, Andrea Rørvik; Pedersen, Torhild; Wisor, Jonathan P. et al. (2020). Cognitive function and brain plasticity in a rat model of shift work: role of daily rhythms, sleep and glucocorticoids. (ekstern lenke)
• Sunde, Erlend; Pedersen, Torhild; Mrdalj, Jelena et al. (2020). Blue-enriched white light improves performance but not subjective alertness and circadian adaptation during three consecutive simulated night shifts. (ekstern lenke)
• Rempe, Michael J.; Grønli, Janne; Pedersen, Torhild et al. (2018). Mathematical modeling of sleep state dynamics in a rodent model of shift work. (ekstern lenke)
• Marti, Andrea Rørvik; Patil, Sudarshan; Mrdalj, Jelena et al. (2017). No escaping the rat race: simulated night shift work alters the time-of-day variation in BMAL1 translational activity in the prefrontal cortex. (ekstern lenke)
• Marti, Andrea Rørvik; Meerlo, Peter; Grønli, Janne et al. (2016). Shift in food intake and changes in metabolic regulation and gene expression during simulated night-shiftwork: A rat model. (ekstern lenke)
• Grønli, Janne; Meerlo, Peter; Pedersen, Torhild et al. (2016). A rodent model of night-shift work induces short-term and enduring sleep and electroencephalographic disturbances. (ekstern lenke)

Vitenskapelig foredrag

• Sunde, Erlend; Mrdalj, Jelena; Pedersen, Torhild Thue et al. (2022). Reversal learning and working memory scanning task performance improve with bright light exposure during simulated night work: a counterbalanced crossover study. (ekstern lenke)
• Sunde, Erlend; Mrdalj, Jelena; Pedersen, Torhild et al. (2019). Effects of Different Light Intensities on Adaptation to Simulated Night Shifts: A Randomized Counterbalanced Crossover Study. (ekstern lenke)

Poster

• Grønli, Janne; Marti, Andrea Rørvik; waslander, jorrit et al. (2018). Extended photoperiod alters sleep and expression of synaptic plasticity-associated genes. The impact of blue-enriched light.. (ekstern lenke)
• Mrdalj, Jelena; Sunde, Erlend; Pedersen, Torhild et al. (2018). Effects of bright light on sleepiness and cognitive performance during simulated night shift work.. (ekstern lenke)
• Bjerrum, Louise Haugen; Pedersen, Torhild; Mrdalj, Jelena et al. (2018). Prolonged photoperiod alters time in sleep and slow-wave activity. The impact of blue-enriched light.. (ekstern lenke)
• Pedersen, Torhild; Mrdalj, Jelena; Pallesen, Ståle et al. (2018). Bright light exposure during simulated night shift work- impact on daytime sleep.. (ekstern lenke)
• Pedersen, Torhild; Mrdalj, Jelena; Pallesen, Ståle et al. (2018). Daytime sleep following bright light exposure during simulated night shift work.. (ekstern lenke)
• Marti, Andrea Rørvik; Skrede, Silje; Mrdalj, Jelena et al. (2018). Extending the photoperiod impacts circadian rhythmicity and gene expression in prefrontal cortex and retina- Impact of exposure to blue-enriched light.. (ekstern lenke)
• Marti, Andrea Rørvik; waslander, jorrit; Skrede, Silje et al. (2018). Extended photoperiod alters circadian rhythmicity and expression of neuroplasticity markers. The impact of blue-enriched light.. (ekstern lenke)
• Pedersen, Torhild; Mrdalj, Jelena; Pallesen, Ståle et al. (2018). Daytime sleep following night shifts- impact of light intensity. (ekstern lenke)

Populærvitenskapelig artikkel

• Marti, Andrea Rørvik; Pedersen, Torhild (2018). Nattarbeid og den trøtte hjernen- kan lys hjelpe?. (ekstern lenke)

Intervju

• Pedersen, Torhild (2018). NRK Hordaland Morgensending- Hvordan få sove i sommervarmen?. (ekstern lenke)

Se en full oversikt over publikasjoner i Cristin

 

No Escaping the Rat Race: Simulated Night Shift Work Alters the Time-of-Day Variation in BMAL1 Translational Activity in the Prefrontal Cortex. Marti AR, Patil S, Mrdalj J, Meerlo P, Skrede S, Pallesen S, Pedersen TT, Bramham CR, Grønli J. Frontiers in Neural Circuits, 2017 11(70). doi: 10.3389/fncir.2017.00070.

A rodent model of night-shift work induces short-term and enduring sleep and electroencephalographic disturbances. Grønli J, Meerlo P, Pedersen TT, Pallesen S, Skrede S, Marti AR, Wisor JP, Murison R, Henriksen TEG, Rempe MJ, Mrdalj J. J Biol Rhythm, 2017 Feb;32(1):48-63. doi: 10.1177/0748730416675460.

Shift in food intake and changes in metabolic regulation and gene expression during simulated night-shift work. A rat model. Marti AR, Meerlo P, Grønli J, van Hasselt SJ, Mrdalj J, Pallesen S, Pedersen TT, Henriksen TEG, Skrede S.Nutrients, 2016 Nov 8;8(11). doi: 10.3390/nu8110712

Effekt av simulert nattarbeid på våkenhetsprestasjon, søvn, døgnrytmer og hjernefunksjon