Brystkreft; Molekylære endringer i ulike subgrupper (postdoc-prosjekt)

Genekspresjonsanalyser

Erfaring fra forskning på genekspresjonsforandringer ved endometriecancer (PhD)

PÅGÅENDE UNDERVISNING (2015):

Kordinator for PhD-kurset "CCBIO Junior Symposium" (CCBIO-901).

Timeundervisning ved PhD-kursene "Methods i Cancer Biomarker Research" (CCBIO-905) og "Biomarkers and Tumor Biology in Clinical Practice" (CCBIO-904).

Undervisning i patologi (obduksjon/makro) for medisinerstudenter.

TIDLIGERE UNDERVISNING:

Timeundervisning for medisinerstudenter i Gynekolog og obstetrikk.

Timeundervisning for masterstudenter i ernæringsfysiologi.

Vitenskapelig artikkel

• Astrid Andrine Syrtveit; Lise Martine Ingebriktsen; Amalie Fagerli Tegnander et al. (2025). Tumor necrosis associates with aggressive breast cancer features, increased hypoxia signaling and reduced patient survival. (ekstern lenke)
• Lise Martine Ingebriktsen; Kenneth Finne; Lars Andreas Akslen et al. (2022). A novel age-related gene expression signature associates with proliferation and disease progression in breast cancer. (ekstern lenke)
• Henrica Maria Johanna Werner; Anna Berg; Elisabeth Wik et al. (2013). ARID1A loss is prevalent in endometrial hyperplasia with atypia and low-grade endometrioid carcinomas. (ekstern lenke)
• Even Birkeland; Elisabeth Wik; Siv Mjøs et al. (2012). KRAS gene amplification and overexpression but not mutation associates with aggressive and metastatic endometrial cancer. (ekstern lenke)
• Ingunn Stefansson; Maria B Ræder; Elisabeth Wik et al. (2015). Increased angiogenesis is associated with a 32-gene expression signature and 6p21 amplification in aggressive endometrial cancer. (ekstern lenke)
• Magdalene A Earp; Linda E. Kelemen; Anthony M. Magliocco et al. (2014). Genome-wide association study of subtype-specific epithelial ovarian cancer risk alleles using pooled DNA. (ekstern lenke)
• Cecilie Askeland; Elisabeth Wik; Kenneth Finne et al. (2020). Stathmin expression associates with vascular and immune responses in aggressive breast cancer subgroups. (ekstern lenke)
• Elisabeth Wik; Maria B Ræder; Camilla Krakstad et al. (2013). Lack of estrogen receptor-alpha is associated with epithelial-mesenchymal transition and PI3K alterations in endometrial carcinoma. (ekstern lenke)
• Kristi Krüger; Laxmi Silwal-Pandit; Elisabeth Wik et al. (2021). Baseline microvessel density predicts response to neoadjuvant bevacizumab treatment of locally advanced breast cancer. (ekstern lenke)
• Sura Mohammed Aziz; Elisabeth Wik; Gøril Knutsvik et al. (2017). Extra-nodal extension is a significant prognostic factor in lymph node positive breast cancer. (ekstern lenke)
• Karen Klepsland Mauland; Jone Trovik; Elisabeth Wik et al. (2011). High BMI is significantly associated with positive progesterone receptor status and clinico-pathological markers for non-aggressive disease in endometrial cancer. (ekstern lenke)
• Elisabeth Wik; Jone Trovik; Ole-Erik Iversen et al. (2009). Deoxyribonucleic acid ploidy in endometrial carcinoma: a reproducible and valid prognostic marker in a routine diagnostic setting. (ekstern lenke)
• Camilla Krakstad; Jone Trovik; Elisabeth Wik et al. (2012). Loss of GPER identifies new targets for therapy among a subgroup of ER alpha-positive endometrial cancer patients with poor outcome. (ekstern lenke)
• Johannes Landskron; Sigrid M. Kraggerud; Elisabeth Wik et al. (2017). C77G in PTPRC (CD45) is no risk allele for ovarian cancer, but associated with less aggressive disease. (ekstern lenke)
• Anne Cathrine Staff; Jone Trovik; Ane Gerda Zahl Eriksson et al. (2011). Elevated plasma growth differentiation factor-15 correlates with lymph node metastases and poor survival in endometrial cancer. (ekstern lenke)
• Henrica Maria Johanna Werner; Jone Trovik; Mari Kyllesø Halle et al. (2014). Stathmin Protein Level, a Potential Peredictive Marker for Taxane Treatment Response in Endometrial Cancer. (ekstern lenke)
• Hui Shen; BL Fridley; HL Song et al. (2013). Epigenetic analysis leads to identification of HNF1B as a subtype-specific susceptibility gene for ovarian cancer. (ekstern lenke)
• Elise Klæstad; Signe Opdahl; Monica J Engstrøm et al. (2020). MRPS23 amplification and gene expression in breast cancer; association with proliferation and the non-basal subtypes. (ekstern lenke)
• Thomas E. Bartlett; Alison Jones; Ellen L. Goode et al. (2015). Intra-gene DNA methylation variability is a clinically independent prognostic marker in women's cancers. (ekstern lenke)
• Elisabeth Wik; Even Birkeland; Jone Trovik et al. (2013). High phospho-stathmin(Serine38) expression identifies aggressive endometrial cancer and suggests an association with PI3K inhibition. (ekstern lenke)
• Ingrid Vandenput; Jone Trovik; Karin Leunen et al. (2011). Evolution in endometrial cancer evidence from an immunohistochemical study. (ekstern lenke)
• Amalie Abrahamsen Svanøe; Rasmus Olai Collett Humlevik; Gøril Knutsvik et al. (2024). Age-related phenotypes in breast cancer: A population-based study. (ekstern lenke)
• Elisabeth Wik; Jone Trovik; Kanthida Kusonmano et al. (2014). Endometrial Carcinoma Recurrence Score (ECARS) validates to identify aggressive disease and associates with markers of epithelial-mesenchymal transition and PI3K alterations. (ekstern lenke)
• Tor Audun Klingen; Ying Chen; Ingunn Stefansson et al. (2016). Tumour cell invasion into blood vessels is significantly related to breast cancer subtypes and decreased survival. (ekstern lenke)
• Kristi Krüger; Elisabeth Wik; Gøril Knutsvik et al. (2017). Expression of Nestin associates with BRCA1 mutations, a basal-like phenotype and aggressive breast cancer. (ekstern lenke)
• Lise Martine Ingebriktsen; Amalie Abrahamsen Svanøe; Anna Kristine Myrmel Sæle et al. (2024). Age-Related Clusters and Favorable Immune Phenotypes in Breast Cancer of the Young Patients. (ekstern lenke)
• Sura Mohammed Aziz; Elisabeth Wik; Gøril Knutsvik et al. (2016). Evaluation of Tumor Cell Proliferation by Ki-67 Expression and Mitotic Count in Lymph Node Metastases from Breast Cancer. (ekstern lenke)
• Silje Kjølle; Kenneth Finne; Even Birkeland et al. (2023). Hypoxia induced responses are reflected in the stromal proteome of breast cancer. (ekstern lenke)
• Konstantinos Doufekas; Richard B.M. Hadwin; Raju Kandimalla et al. (2013). GALR1 methylation in vaginal swabs is highly accurate in identifying women with endometrial cancer. (ekstern lenke)
• Rasmus Olai Collett Humlevik; Amalie Abrahamsen Svanøe; Turid Aas et al. (2025). Distinct clinicopathological features and treatment differences in breast cancer patients of young age. (ekstern lenke)
• Karen Klepsland Mauland; Elisabeth Wik; Erling Andre Høivik et al. (2016). Aneuploidy related transcriptional changes in endometrial cancer link low expression of chromosome 15q genes to poor survival. (ekstern lenke)
• Geir Bredholt; Monica Mannelqvist; Ingunn Stefansson et al. (2015). Tumor necrosis is an important hallmark of aggressive endometrial cancer and associates with hypoxia, angiogenesis and inflammation responses. (ekstern lenke)
• Jennifer Permuth-Wey; K Lawrenson; HC Shen et al. (2013). Identification and molecular characterization of a new ovarian cancer susceptibility locus at 17q21.31. (ekstern lenke)
• Paul D.P. Pharoah; Mari Kyllesø Halle; Camilla Krakstad et al. (2013). GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer. (ekstern lenke)
• Grethe Albrektsen; Ivar Heuch; Elisabeth Wik et al. (2009). Parity and time interval since childbirth influence survival in endometrial cancer patients. (ekstern lenke)
• Ingvild Kathrin Lokøy; Inga Sofie Bakken; Elisabeth Wik et al. (2024). Brystkreft hos menn – histopatologi og biomarkører. (ekstern lenke)
• Monica Mannelqvist; Ingunn Marie Stefansson; Elisabeth Wik et al. (2012). Lipocalin 2 expression is associated with aggressive features of endometrial cancer. (ekstern lenke)
• Jone Trovik; Karen Klepsland Mauland; Henrica Maria Johanna Werner et al. (2012). Improved survival related to changes in endometrial cancer treatment, a 30-year population based perspective. (ekstern lenke)
• Jone Trovik; Elisabeth Wik; Ingunn Marie Stefansson et al. (2011). Stathmin Overexpression Identifies High-Risk Patients and Lymph Node Metastasis in Endometrial Cancer. (ekstern lenke)
• Anna Kristine Myrmel Sæle; Amalie Abrahamsen Svanøe; Cecilie Askeland et al. (2025). Reduced GATA3 expression associates with immuno-metabolic alterations and aggressive features in breast cancer. (ekstern lenke)
• Maren Høibø; Andre Pedersen; Vibeke Grotnes Dale et al. (2025). Immunohistochemistry guided segmentation of benign epithelial cells, in situ lesions, and invasive epithelial cells in breast cancer slides. (ekstern lenke)
• Hannah Ni Bhriain; Jone Trovik; Elisabeth Wik et al. (2009). Plasma calprotectin concentrations in women with endometrial carcinoma. (ekstern lenke)
• Elisabeth Wik; Sura Mohammed Aziz; Heidrun Vethe et al. (2022). Neurogenesis and angiogenesis are associated features of aggressive breast cancer. (ekstern lenke)
• Kanthida Kusonmano; Mari Kyllesø Halle; Elisabeth Wik et al. (2018). Identification of highly connected and differentially expressed gene subnetworks in metastasizing endometrial cancer. (ekstern lenke)
• Allison Jones; Andrew E. Teschendorff; Quanxi Li et al. (2013). Role of DNA methylation and epigenetic silencing of HAND2 in endometrial cancer development. (ekstern lenke)
• Helga Birgitte Salvesen; Scott L. Carter; Monica Mannelqvist et al. (2009). Integrated genomic profiling of endometrial carcinoma associates aggressive tumors with indicators of PI3 kinase activation. (ekstern lenke)
• Akinyemi Ojesina; Lee Lichtenstein; Samuel S. Freeman et al. (2014). Landscape of genomic alterations in cervical carcinomas. (ekstern lenke)
• Maria B Ræder; Even Birkeland; Jone Trovik et al. (2013). Integrated genomic analysis of the 8q24 amplification in endometrial cancers identifies ATAD2 as essential to MYC-dependent cancers. (ekstern lenke)
• Bridget Charbonneau; MS Block; WR Bamlet et al. (2014). Risk of ovarian cancer and the NF-kB pathway: Genetic association with IL1A and TNFSF10. (ekstern lenke)
• Tor Audun Klingen; Ying Chen; Hans Aas et al. (2017). Tumor-associated macrophages are strongly related to vascular invasion, non-luminal subtypes, and interval breast cancer. (ekstern lenke)
• Maren Høibø; Ute Spiske; Andre Pedersen et al. (2025). Predicting estrogen receptor status from HE-stained breast cancer slides using artificial intelligence. (ekstern lenke)
• Kurt Hanevik; Elisabeth Wik; Nina Langeland et al. (2018). Transient elevation of anti-transglutaminase and anti-endomysium antibodies in Giardia infection. (ekstern lenke)
• Grethe Albrektsen; Ivar Heuch; Elisabeth Wik et al. (2009). Prognostic Impact of Parity in 493 Uterine Sarcoma Patients. (ekstern lenke)
• Vladan Milosevic; Reidunn Jetne Edelmann; Ingeborg Winge et al. (2023). Vessel size as a marker of survival in estrogen receptor positive breast cancer. (ekstern lenke)
• Camilla Krakstad; Even Birkeland; Danila Seidel et al. (2012). High-throughput mutation profiling of primary and metastatic endometrial cancers identifies KRAS, FGFR2 and PIK3CA to be frequently mutated. (ekstern lenke)
• Stig E. Bojesen; Karen A Pooley; Sharon E Johnatty et al. (2013). Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer. (ekstern lenke)
• Frederik Holst; Henrica Maria Johanna Werner; Siv Mjøs et al. (2019). PIK3CA amplification associates with aggressive phenotype but not markers of AKT-mTOR signaling in endometrial carcinoma. (ekstern lenke)
• Erling Andre Høivik; Kanthida Kusonmano; Mari Kyllesø Halle et al. (2014). Hypomethylation of the CTCFL/BORIS promoter and aberrant expression during endometrial cancer progression suggests a role as an Epi-driver gene. (ekstern lenke)
• Hilde Ytre-Hauge Smeland; Cecilie Askeland; Elisabeth Wik et al. (2019). Integrin α11β1 is expressed in breast cancer stroma and associates with aggressive tumor phenotypes.. (ekstern lenke)
• Anna Berg; Erling Andre Høivik; Siv Mjøs et al. (2015). Molecular profiling of endometrial carcinoma precursor, primary and metastatic lesions suggests different targets for treatment in obese compared to non-obese patients. (ekstern lenke)
• Ying Chen; Tor Audun Klingen; Elisabeth Wik et al. (2014). Breast cancer stromal elastosis is associated with mammography screening detection, low Ki67 expression and favourable prognosis in a population-based study. (ekstern lenke)
• Tor Audun Klingen; Ying Chen; Hans Aas et al. (2021). Fibulin-2 expression associates with vascular invasion and patient survival in breast cancer. (ekstern lenke)
• Jessica Furriol Palmer; Elisabeth Wik; Sura Mohammed Aziz et al. (2024). VEGFA gene variants are associated with breast cancer progression. (ekstern lenke)
• Konstantina Dimitrakopoulou; Elisabeth Wik; Lars A. Akslen et al. (2018). Deblender: A semi-/unsupervised multi-operational computational method for complete deconvolution of expression data from heterogeneous samples. (ekstern lenke)
• Lorena Alonso-Alconada; Laura Muinelo-Romay; Kadri Madissoo et al. (2014). Molecular profiling of circulating tumor cells links plasticity to the metastatic process in endometrial cancer. (ekstern lenke)
• Monica Mannelqvist; Elisabeth Wik; Ingunn Stefansson et al. (2014). An 18-Gene signature for vascular invasion is associated with aggressive features and reduced survival in breast cancer. (ekstern lenke)
• Jone Trovik; Elisabeth Wik; Henrica Maria Johanna Werner et al. (2013). Hormone receptor loss in endometrial carcinoma curettage predicts lymph node metastasis and poor outcome in prospective multicentre trial. (ekstern lenke)
• Andrew E. Teschendorff; Shih-Han Lee; Allison Jones et al. (2015). HOTAIR and its surrogate DNA methylation signature indicate carboplatin resistance in ovarian cancer. (ekstern lenke)
• Ying Chen; Tor Audun Klingen; Hans Aas et al. (2021). Tumor-associated lymphocytes and macrophages are related to stromal elastosis and vascular invasion in breast cancer. (ekstern lenke)
• Lise Martine Ingebriktsen; Rasmus Olai Collett Humlevik; Amalie Abrahamsen Svanøe et al. (2024). Elevated expression of Aurora-A/AURKA in breast cancer associates with younger age and aggressive features. (ekstern lenke)
• Ying Chen; Tor Audun Klingen; Hans Aas et al. (2023). CD47 and CD68 expression in breast cancer is associated with tumor-infiltrating lymphocytes, blood vessel invasion, detection mode, and prognosis. (ekstern lenke)

Konferanseposter

• Kanthida Kusonmano; Elisabeth Wik; Helga Birgitte Salvesen et al. (2012). An ensemble-based feature selection algorithm for identifying candidate metastasis marker genes in endometrial cancer. (ekstern lenke)
• Jone Trovik; Elisabeth Wik; Ingunn Marie Stefansson et al. (2009). Stathmin is superior to AKT and Phospho-AKT staining to detect PI3Kinase activation and aggressive endometrial cancer. (ekstern lenke)
• Kanthida Kusonmano; Elisabeth Wik; Helga Birgitte Salvesen et al. (2012). Identification of metastasis subnetworks in endometrial cancer. (ekstern lenke)

Antologi

• Anne Bremer; Roger Strand; John Alexander Cairns et al. (2017). Cancer Biomarkers: Ethics, Economics and Society. (ekstern lenke)

Vitenskapelig bokkapittel

• Anne Bremer; Elisabeth Wik; Lars Andreas Akslen (2022). HER2 Revisited: Reflections on the Future of Cancer Biomarker Research. (ekstern lenke)
• Elisabeth Wik; Lars A. Akslen (2017). Gene expression signatures of the tumor microenvironment: relation to tumor progress in breast cancer. (ekstern lenke)

Doktorgradsavhandling

• Elisabeth Wik (2013). Endometrial carcinoma: a step closer to individualized therapy? Exploring transcriptional alterations in relation to prognostic biomarkers. (ekstern lenke)

Vitenskapelig litteraturgjennomgang

• Karen Klepsland Mauland; Elisabeth Wik; Helga Salvesen (2014). Clinical value of DNA content assessment in endometrial cancer. (ekstern lenke)

Kapittel i fagbok

• Elisabeth Wik; Lise Martine Ingebriktsen; Lars Andreas Akslen (2022). Gene Expression Signatures of the Tumor Micoenvironment: Relation to Tumor Phenotypes and Progress in Breast Cancer. (ekstern lenke)

Medieintervju

• Elisabeth Wik; Sonja Eriksson Steigen (2017). Med forskning som ståsted i patologien. (ekstern lenke)

Konferanseabstrakt

• Elisabeth Wik; Maria Rader; Camilla Krakstad et al. (2012). Estrogen receptor a loss in endometrial carcinoma is associated with epithelial-to-mesenchymal transition and a potential for PI3Kinase inhibition. (ekstern lenke)
• Elisabeth Wik; Maria Rader; Camilla Krakstad et al. (2012). Estrogen receptor a loss in endometrial carcinoma is associated with epithelial-to-mesenchymal transition and a potential for PI3Kinase inhibition. (ekstern lenke)

Leserbrev

• Jone Trovik; Elisabeth Wik; Ingunn Marie Stefansson et al. (2010). Stathmin is superior to AKT and phospho-AKT staining for the detection of phosphoinositide 3-kinase activation and aggressive endometrial cancer. (ekstern lenke)
• Mari Kyllesø Halle; Henrica Maria Johanna Werner; Camilla Krakstad et al. (2012). Stratification based on high tumour cell content in fresh frozen tissue promotes selection of aggressive endometrial carcinomas. (ekstern lenke)

Se en full oversikt over publikasjoner i Cristin

Endometrial Carcinoma Recurrence Score (ECARS) validates to identify aggressive disease and associates with markers of epithelial-mesenchymal transition and PI3K alterations.
Wik E, Trovik J, Kusonmano K, Birkeland E, Raeder MB, Pashtan I, Hoivik EA, Krakstad C, Werner HM, Holst F, Mjøs S, Halle MK, Mannelqvist M, Mauland KK, Oyan AM, Stefansson IM, Petersen K, Simon R, Cherniack AD, Meyerson M, Kalland KH, Akslen LA, Salvesen HB.
Gynecol Oncol. 2014 Sep;134(3):599-606. PMID: 24995579

High phospho-Stathmin(Serine38) expression identifies aggressive endometrial cancer and suggests an association with PI3K inhibition.
Wik E, Birkeland E, Trovik J, Werner HM, Hoivik EA, Mjos S, Krakstad C, Kusonmano K, Mauland K, Stefansson IM, Holst F, Petersen K, Oyan AM, Simon R, Kalland KH, Ricketts W, Akslen LA, Salvesen HB.
Clin Cancer Res. 2013 May 1;19(9):2331-41. PMID: 23538402

Lack of estrogen receptor-α is associated with epithelial-mesenchymal transition and PI3K alterations in endometrial carcinoma.
Wik E, Ræder MB, Krakstad C, Trovik J, Birkeland E, Hoivik EA, Mjos S, Werner HM, Mannelqvist M, Stefansson IM, Oyan AM, Kalland KH, Akslen LA, Salvesen HB.
Clin Cancer Res. 2013 Mar 1;19(5):1094-105. PMID: 23319822

An 18-gene signature for vascular invasion is associated with aggressive features and reduced survival in breast cancer.
Mannelqvist M, Wik E, Stefansson IM, Akslen LA.
PLoS One. 2014 Jun 6;9(6):e98787.
PMID: 24905342

Increased angiogenesis is associated with a 32-gene expression signature and 6p21 amplification in aggressive endometrial cancer.
Stefansson IM, Raeder M, Wik E, Mannelqvist M, Kusonmano K, Knutsvik G, Haldorsen I, Trovik J, Øyan AM, Kalland KH, Staff AC, Salvesen HB, Akslen LA.
Oncotarget. 2015 Mar 10. PMID: 25860936

Breast cancer stromal elastosis is associated with mammography screening detection, low Ki67 expression and favourable prognosis in a population-based study.
Chen Y, Klingen TA, Wik E, Aas H, Vigeland E, Liestøl K, Garred Ø, Mæhlen J, Akslen LA, Lømo J. Diagn Pathol. 2014 Dec 19;9(1):230. PMID: 25522915

 

For other publications, see: http://www.ncbi.nlm.nih.gov/pubmed/?term=wik+e

 

 

 

 

Postdoc prosjekt:

Biomarkers and gene expression profiles for disease progression across different molecular subtypes of breast cancer