Henriette Aksnes
Stilling
forsker, Forskningsgruppeleder med professorkompetanse
Tilhørighet
- E-post
- henriette.aksnes@uib.no
- Besøksadresse
-
Jonas Lies ve 91 6. etg BB-bygget
5009 Bergen - Postadresse
-
Postboks 7804
5020 Bergen
Henriette Aksnes
Stilling
forsker, Forskningsgruppeleder med professorkompetanse
Tilhørighet
Forskergrupper
- MemBrain - Membrane proteins in the brain
- Molecular Imaging Center (MIC)
- Systems Biology and Translational Cell Signaling
Kort info
Doktorgrad i molekylær cellebiolog og mastergrad i molekylær nevrovitenskap.
PI/leder for prosjekter på molekylære mekanismer ved nevrodegenerative sykdom og co-PI for prosjekt om regulering av aktin cytoskjelettet.
Vitenskapelig leder lysmikroskopi ved MIC.
Forskning
AKTIVE PROSJEKTER
Hvordan påvirker proteinmodifikasjoner hjernen vår?
Et av proteinene som jeg karakteriserte i løpet av doktorgraden i Arnesen lab var relativt lite studert da jeg startet. Det ble tydelig at dette enzymet hadde en rolle i cellenes sekretoriske system og i tillegg var det noen vage antydninger på at det kunne være svært viktig for nerveceller, noe jeg fattet spesiell interesse for siden jeg har en bakgrunn i molekylær nevrobiologi fra Bramham lab. Gjennom et nytt samarbeid med nevrologer på UCL holder jeg nå på å avdekke klare beviser for at dette proteinet har en kritisk funksjon i hjernen. For tiden studerer jeg celler som er isolert fra pasienter. Disse pasientene er rammet av arvelig nevrologisk sykdom fordi de mangler en bestemt type proteinmodifikasjon. Dette er utrolig spennende fordi vi er inne på et spor hvor det kan bli mulig å beskrive hvordan molekylære mekanismer forårsaket av et protein inni hjernecellene har en avgjørende nevrobiologisk betydning. Det er grunnlag for å tro at det kan være en kobling mellom NAT enzymer og nevrodegenerative sykdommer som Parkinsons. Dette er noe jeg brenner for å studere videre. Forekomsten av nevrodegenerative sykdommer øker, mens behandlingen har store utfordringer. Det er derfor et trykkende behov for forskning på dette området. Jeg håper at jeg gjennom kombinert spesialkunnskap om NAT enzymfamilien og molekylær nevrobiologi vil kunne bidra til å fylle dette kunnskapsgapet.
Kan mangel på aktin N-terminal modifikasjon i kreft være knyttet til økt risiko for metastase?
Iløpet av postdoktor perioden var jeg med på å karakterisere et enzym, kalt NAA80, som modifiserer aktins N-terminal. Aktin er et av de proteinene det finnes mest av i cellene våre og det er byggesteinen i mikrofilament celleskjelett. Dette celleskjelettet er ikke stivt og statisk sånn som navnet kanskje skulle tilsi, men er ekstremt dynamisk og denne konstante endringen er bl.a. grunnlaget for cellers bevegelighet. Normalt sett i en ferdig utviklet organisme er cellenes bevegelighet holdt i sjakk slik at en levercelle holder posisjonen sin i leveren og en nyrecelle holder posisjonen sin i nyren. Men i kreft kan reguleringen være forstyrret og det kan medføre at kreftceller begynner å invadere nabovev og migrere til andre steder i kroppen, såkalt metastase. Denne prosessen fattet jeg spesielt interesse for da vi oppdaget at når vi fjernet NAA80 enzymet, så ble cellene hypermobile. Videre har jeg nå sammen med studenter fintunet verktøy for å studere denne prosessen, samt beskrevet videre at Golgi-apparatet er fragmentert i celler som mangler NAA80.
I 2022 er jeg medarrangør og foredragsholder på en stor internalsjonal vitenskapelig konferanse i Bergen 8.-11. Juni. Se vårt spennende program: EMBO conference "Protein termini: from mechanisms to biological impact".
Formidling
Henriettes forskningsformidling og medieomtale
- Aksnes nominert av NBS til å intervjues for eBok WOMEN’S CAREERS IN SCIENCE EBOOK av FEBS’ Women in science initiativ.
- Tildelt Trond Mohn Starting grant.
- Oppdagelse av et nytt hjerneforkalknings-gen. UiB populærvitenskapelig artikkel tilhørende vitenskapelig publikasjon.
- Fjerning av protein N-terminal acetylering gir degradering av ribosomale proteiner. UiB populærvitenskapelig artikkel tilhørende vitenskapelig publikasjon.
- Tildelt Meltzer prisen for fremragende yngre forskere 2022. UiB annonsering og intervju.
- Diving into the microscopic world. Sci Snapshot forskerportrett i NatureVolve Magazine.
- Gjær og proteomikk definerer protein N-terminal acetylering. UiB populærvitenskapelig artikkel tilhørende vitenskapelig publikasjon.
- Poster pris til Alessia Caiella basert på vårt arbeid, EMBO/ISPT konferansen 2022.
- Feil ved nytt gen årsak til utviklingshemming. UiB populærvitenskapelig artikkel tilhørende vitenskapelig publikasjon.
- Application note, nytt bruksområde for det digtale holografiske mikroskopet HoloMonitor M4, basert på vårt arbeid.
- Horizon Discovery blog skriver om Hvordan lykkes med HAP1 celler, basert på vårt arbeid.
- First-person interview i Biology Open med studentene Tobias B. Beigl, Ine Kjosås and Emilie Seljeseth basert på vårt arbeid.
- Fra prosjektoppgave i MOL231 til publikasjon, UiB nyhetsartikkel av studentene Ine Kjosås og Emilie Seljeseth.
- Vinner av Falch junior award 2019, UiB annonsering, UiB artikkel intervju.
- Å forske fra hjemmekontor, UiB artikkel om arbeid sammen med MSc studenter Monica Hellsevik og Hanne Øye.
- Fra ERASMUS utveksling til publisert artikkel, UiB artikkel om arbeid sammen med MSc student Tobias B. Beigl.
- A Jack of all Trades in Cancer Cells, UiB artikkel i anledning review i MolCel 2019.
- Avdekker hemmelighetene bak cellers bevegelighet, InCyte blog intervju.
- Hyper-bevegelige celler avslørt med IncuCyte, InCytes Publication newsletter.
- Setter brems på cellebevegelighet, UiB artikkel.
- Masteravhandlingen ble TIRFet i land (som hovedveileder for Monica Hellesvik), UiB artikkel
- Trener forskingsformidling foran kamera i Momentum karriereprogram for fremragende yngre forskere, UiB artikkel
- Fakultetets dag Medisinsk fakultet - Mottok på vegne av alle medforfattere i Arnesen lab, pris for beste publikasjon i 2018 for back-to-back artikler i PNAS 2018 UiB artikkel, MedFak og UiB artikkel, IBM
- Cellespionasje i NAT laboratoriet, UiB artikkel
- Protein acetylation gets some respect—A commentary by Henriette Aksnes, Cell Reports blog
- Actin acetylation, NBS Nytt 2 2018
- Protein function can be revealed by microscopy, UiB artikkel
- Hangin’ out at the Golgi, UiB artikkel
- Cellular GPS-system reveals new territory for an influential enzyme family, UiB artikkel
- ZONA award for beste PhD 2014, UiB artikkel
- Ny doktorgrad PhD, UiB pressemelding
Undervisning
Kurs
BMED320 - Metoder i Medisinsk Cellebiologi
Forskning- og laboratorieopplæring for prosjektoppgaver på Master nivå.
Gjesteforelseser i tema Mikroskopi.
Gjesteforeleser i tema Modelorganismer.
MOL231 - Prosjektoppgave i Molekylærbiologi
Forskning- og laboratorieopplæring for prosjektoppgaver på Bachelor nivå.
Studentveiledning
2025- Hovedveileder for Erasmus praksis student fra Utrecht University of applied sciences Cheryl Oortwijn
2024- Hovedveileder for MSc stud., Dept. of Biological sciences, UiB. Anton R. Melbye
2023- Hovedveileder for forskerlinjestudent, MED, UiB. Christina W. Leerink
2023-24 Hovedveileder for Masterstud., Dept. of Biomedicine, UiB. Åse K. Bekkelund
2023- Hovedveileder for PhD candidate, Dept. of Biomedicine, UiB. Alessia Caiella
2022-23 Hovedveileder for Masterstud., Dept. of Biomedicine, UiB. Anette Siggervåg
2022-23 Medveileder for Masterstud., Dept. of Biomedicine, UiB. Inger Johanne Hellerud
2021–22 Main supervisor for MSc thesis stud., Dept. of Biomedicine, UiB. Therese S. Hjellvoll
2021–22 Main supervisor for MSc thesis stud., Dept. of Biomedicine, UiB. Ajia R. Pennavaria
2021–22 Co-supervisor for MSc stud., Dept. of Biological sciences, UiB. Camilla H. Nundal
2021-22 Co-supervisor for MSc thesis stud., Dept. of Biomedicine, UiB. Birger H. Furnes
2021– Main supervisor for PhD candidate, Dept. of Biomedicine, UiB. Hanne Øye
2020– Co-supervisor for PhD candidate, Dept. of Biomedicine, UiB. Monica Hellesvik
2020–21 Main supervisor for MSc thesis stud., Dept. of Biomedicine, UiB. Alessia Caiella
2020–21 Main supervisor for MSc thesis stud., Dept. of Biomedicine, UiB. Liv S. Krogstad
2020–21 Co-supervisor for MSc thesis stud., Dept. of Biological sciences, UiB. Ine Kjosås
2019–20 Main supervisor for MSc thesis stud., Dept. of Biomedicine, UiB. Kristine H. Furre
2019–20 Main supervisor for MSc thesis stud., Dept. of Biomedicine, UiB. Hanne Øye
2018–19 Main supervisor for MSc thesis stud., Dept. of Biological Sciences, UiB, Monica Hellesvik
2019–19 Main supervisor for MSc thesis stud., UiB/Universität Stuttgart, Tobias B. Beigl
2019–19 Main supervisor for 2 BSc students in MOL231 project course, Dept. of Biological Sciences, UiB, Ine Kjosås and Emilie Seljeseth
2018–18 Main supervisor for 2 MSc students in BMED320 project course, Dept. of Biomedicine, UiB. Atefeh Kianian and Kristine H. Furre
2018–18 Main supervisor for MSc ERASMUS stud., Dept. of Biomedicine, UiB, Tobias B. Beigl
2014–17 Co-supervisor for PhD candidate, Dept. of Molecular biology, UiB, Marianne Goris
2013–16 Co-supervisor for PhD candidate, Dept. of Molecular biology, UiB, Sylvia Varland
2012–16 Co-supervisor for PhD candidate, Dept. of Molecular biology, UiB, Camilla Osberg
2011–12 Co-supervisor for MSc thesis stud., Dept. of Molecular biology, UiB, Camilla Osberg
2011–12 Co-supervisor for MSc thesis stud., Dept. of Molecular biology, UiB, Sylvia Varland
2011–12 Co-supervisor for BSc stud., Dept. of Molecular biology, UiB, Eilen Henriksen
Publikasjoner
Doktorgradsavhandling
Vitenskapelig artikkel
- Ulises H. Guzman; Henriette Aksnes; Rasmus Ree et al. (2023). Loss of N-terminal acetyltransferase A activity induces thermally unstable ribosomal proteins and increases their turnover in Saccharomyces cerevisiae. (ekstern lenke)
- Henriette Aksnes; Michaël Bruno Eric Marie; Thomas Arnesen et al. (2018). Actin polymerization and cell motility are affected by NAA80-mediated posttranslational N-terminal acetylation of actin. (ekstern lenke)
- Henriette Aksnes; Camilla Osberg; Thomas Arnesen (2013). N-Terminal Acetylation by NatC Is Not a General Determinant for Substrate Subcellular Localization in Saccharomyces cerevisiae. (ekstern lenke)
- Adrian Drazic; Henriette Aksnes; Michael Bruno Eric Marie et al. (2018). NAA80 is actin’s N-terminal acetyltransferase and regulates cytoskeleton assembly and cell motility. (ekstern lenke)
- Tobias Beigl; Monica Hellesvik; Jaakko Saraste et al. (2020). N-terminal acetylation of actin by NAA80 is essential for structural integrity of the Golgi apparatus. (ekstern lenke)
- Henriette Aksnes; Petra Van Damme; Marianne Goris et al. (2015). An organellar Nα-acetyltransferase, Naa60, acetylates cytosolic n termini of transmembrane proteins and maintains golgi integrity. (ekstern lenke)
- Kristine Hole; Petra Van Damme; Monica Dalva et al. (2011). The human N-Alpha-Acetyltransferase 40 (hNaa40p/hNatD) is conserved from yeast and N-terminally acetylates histones H2A and H4. (ekstern lenke)
- Henriette Aksnes; Nina McTiernan; Thomas Arnesen (2023). NATs at a glance. (ekstern lenke)
- Henriette Aksnes; Kristine Hole; Thomas Arnesen (2015). Molecular, cellular, and physiological significance of N-terminal acetylation. (ekstern lenke)
- Jennifer Morrison; Norah Altuwaijri; Kirsten Marie Brønstad et al. (2021). Missense NAA20 variants impairing the NatB protein N-terminal acetyltransferase cause autosomal recessive developmental delay, intellectual disability, and microcephaly. (ekstern lenke)
- Monica Hellesvik; Hanne Øye; Henriette Aksnes (2020). Exploiting the potential of commercial digital holographic microscopy by combining it with 3D matrix cell culture assays. (ekstern lenke)
- Silje Kathrine Larsen; Åse Karine Bekkelund; Nina Glomnes et al. (2024). Assessing N-terminal acetylation status of cellular proteins via an antibody specific for acetylated methionine. (ekstern lenke)
- Camilla Osberg; Henriette Aksnes; Sandra Ninzima et al. (2016). Microscopy-based Saccharomyces cerevisiae complementation model reveals functional conservation and redundancy of N-terminal acetyltransferases. (ekstern lenke)
- Viorica Chelban; Henriette Aksnes; Reza Maroofian et al. (2024). Biallelic NAA60 variants with impaired n-terminal acetylation capacity cause autosomal recessive primary familial brain calcifications. (ekstern lenke)
- Sylvia Varland; Henriette Aksnes; Fedor Kryuchkov et al. (2018). N-terminal acetylation levels are maintained during acetyl-CoA deficiency in Saccharomyces cerevisiae. (ekstern lenke)
- Henriette Aksnes; Michael Bruno Eric Marie; Thomas Arnesen (2015). Holding it together: Naa60 at the Golgi. (ekstern lenke)
- Petra Van Damme; Camilla Osberg; Veronique Jonckheere et al. (2022). Expanded in vivo substrate profile of the yeast N-terminal acetyltransferase NatC. (ekstern lenke)
- Henriette Aksnes; Marianne Goris; Øyvind Strømland et al. (2017). Molecular determinants of the N-Terminal acetyltransferase Naa60 anchoring to the Golgi membrane. (ekstern lenke)
- Tobias Beigl; Ine Kjosås; Emilie Seljeseth et al. (2020). Efficient and crucial quality control of HAP1 cell ploidy status. (ekstern lenke)
Konferanseposter
- Henriette Aksnes; Rajeevkumar Raveendran Nair; Clive R. Bramham (2009). Time-lapse imaging of Arc protein degradation and synthesis in hippocampal neurons. (ekstern lenke)
- Viorica Chelban; Henriette Aksnes; Ajia Rae Pennavaria et al. (2022). NAA60 Variants associated with neurological disease have impaired N-terminal acetylation capacity. (ekstern lenke)
- Monica Hellesvik; Thomas Arnesen; Henriette Aksnes (2019). NAA80 KO cells – Fast and Furious? Actin N-terminal acetylation by NatH/NAA80 affects cell adhesion and early cell spreading. (ekstern lenke)
- Tobias B. Beigl; Nina Glomnes; Thomas Arnesen et al. (2019). Actin N-terminal acetylation impacts Golgi structural integrity. (ekstern lenke)
- Monica Hellesvik; Tobias B. Beigl; Thomas Arnesen et al. (2020). Spying on the cells using holographic live cell imaging - revealing increased metastatic potential for cancer cells lacking NAA80. (ekstern lenke)
- Camilla Osberg; Sandra Ninzima; Henriette Aksnes et al. (2015). Targeting of membrane proteins by means of N-terminal acetylation. (ekstern lenke)
- Henriette Aksnes; Marianne Goris; Petra Van Damme et al. (2015). N-terminal acetylation meets the organelles. (ekstern lenke)
- Henriette Aksnes; Adrian Drazic; Michaël Bruno Eric Marie et al. (2018). N-terminal acetylation of actin by NAA80 impacts cell migration. (ekstern lenke)
- Åse Karine Bekkelund; Anton Riksheim Melbye; Anette Siggervåg et al. (2024). Aberrant NAA60 disrupts Golgi and cause primary familial brain calcification. (ekstern lenke)
- Tobias B. Beigl; Ine Kjosås; Emilie Seljeseth et al. (2020). Efficient and crucial quality control of HAP1 cell ploidy status. (ekstern lenke)
- Henriette Aksnes; Kristine Hole; Petra Van Damme et al. (2012). ISOLATION OF SECRETED PROTEINS FROM YEAST AND MAMMALIAN CELL CULTURE. (ekstern lenke)
- Alessia Caiella; Therese Soltvedt Hjellvoll; Thomas Arnesen et al. (2022). α-Synuclein N-terminal acetylation affects aggregation and membrane binding properties in cell models. (ekstern lenke)
- Sylvia Varland; Henriette Aksnes; Veronique Jonckheere et al. (2016). Dynamic aspects of protein N-terminal acetylation in response to changes in nutrient availability. (ekstern lenke)
- Adrian Drazic; Henriette Aksnes; Michael Bruno Eric Marie et al. (2018). Discovery of NAA80 as actin’s N-terminal acetyltransferase – a novel regulator of cytoskeleton dynamics. (ekstern lenke)
- Hanne Øye; Thomas Arnesen; Henriette Aksnes (2020). Impact of N‐terminal acetylation on cancer cell invasiveness. (ekstern lenke)
- Sylvia Varland; Henriette Aksnes; Petra Van Damme et al. (2012). GLUCOSE DEPENDENT DYNAMIC N-TERMINAL ACETYLATION IN SACCHAROMYCES CEREVISIAE. (ekstern lenke)
- Henriette Aksnes; Camilla Osberg; Nina Glomnes et al. (2012). N-terminal acetyltransferase 30 (Naa30p/NatC) - Phenotypes of S. Cerevisiae naa30Δ strains. (ekstern lenke)
- Camilla Osberg; Henriette Aksnes; Petra Van Damme et al. (2018). Saccharomyces cerevisiae growth assays and proteomics reveal functional conservation, redundancy and substrates of N-terminal acetyltransferases. (ekstern lenke)
- Monica Hellesvik; Birger Hjønnevåg Furnes; Kristine Haugen Furre et al. (2022). Cellular actin properties depending on NAA80-mediated N-terminal acetylation. (ekstern lenke)
- Henriette Aksnes; Monica Hellesvik; Tobias B. Beigl et al. (2019). Impact of actin N-terminal acetylation. (ekstern lenke)
- Camilla Osberg; Sandra Ninzima; Henriette Aksnes et al. (2015). Evolutionary conservation of N-terminal acetyltransferase C (NatC) from yeast to human. (ekstern lenke)
- Kristine Haugen Furre; Atefeh Kianian; Thomas Arnesen et al. (2020). The Impact of NAA80 and Actin N-terminal Acetylation on Drug Sensitivity. (ekstern lenke)
- Hanne Øye; Camilla Nundal; Henriette Aksnes et al. (2022). Actin’s N-terminal acetyltransferase NAA80 regulates cytoskeleton morphology. (ekstern lenke)
- Tobias B. Beigl; Nina Glomnes; Thomas Arnesen et al. (2019). Knockout of the posttranslational actin modifier NAA80/NatH cause Golgi fragmentation. (ekstern lenke)
- Henriette Aksnes; Adrian Drazic; Michaël Bruno Eric Marie et al. (2018). Actin Acetylation. (ekstern lenke)
- Åse Karine Bekkelund; Alessia Caiella; Anette Siggervåg et al. (2024). Mechanistic investigation of PFBC in NAA60 loss of function cases. (ekstern lenke)
- Henriette Aksnes; Camilla Osberg; Sylvia Varland et al. (2012). Dynamicity and functional implications of N-terminal acetylation in S. cerevisiae. (ekstern lenke)
- Sylvia Varland; Petra Van Damme; Jolien Hollebeke et al. (2015). Metabolic Regulation of Protein N-terminal Acetylation. (ekstern lenke)
- Kristian Kobbenes Starheim; Thomas Vikestad Kalvik; Kristine Hole et al. (2012). Depletion of the N-terminal acetyltransferase hNaa30p disrupts Golgi integrity. (ekstern lenke)
Masteroppgave
- Ajia Rae Pennavaria; Henriette Aksnes; Thomas Arnesen (2022). Molecular roles of NAA60 in neurodegeneration. (ekstern lenke)
- Therese Soltvedt Hjellvoll; Henriette Aksnes; Thomas Arnesen (2022). Defining properties of α-synuclein using human NatB knockout cells. (ekstern lenke)
- Hanne Øye; Henriette Aksnes; Thomas Arnesen (2020). Impact of Actin N-terminal Acetylation on Small Cell Lung Carcinoma Cell Invasiveness. (ekstern lenke)
- Liv Svenningsson Krogstad; Henriette Aksnes; Thomas Arnesen (2021). Uncovering NAA60’s Role in the Nervous System. (ekstern lenke)
- Inger Johanne Hellerud; Thomas Arnesen; Henriette Aksnes (2023). Investigating the biological role of human NAT14 (probable N-acetyltransferase 14). (ekstern lenke)
- Anette Siggervåg; Henriette Aksnes; Thomas Arnesen (2023). NAA60 in neurodegenerative disease. (ekstern lenke)
- Åse Karine Bekkelund; Thomas Arnesen; Henriette Aksnes et al. (2024). The Mechanism of NAA60 in Genetically Rooted Brain Calcification. (ekstern lenke)
- Birger Hjønnevåg Furnes; Thomas Arnesen; Monica Hellesvik et al. (2022). The mechanisms by which actin Nt-acetylation steers cell migration. (ekstern lenke)
- Clive R. Evjen Bramham; Henriette Aksnes (2009). Time-lapse imaging of Arc/Arg3.1 protein degradation in hippocampal neurons using the novel photoconvertible fluorescent protein Dendra2. (ekstern lenke)
- Alessia Caiella; Henriette Aksnes; Thomas Arnesen (2021). The effect of N-terminal acetylation on α-Synuclein’s pathogenicity in Parkinson’s disease. (ekstern lenke)
- Kristine Haugen Furre; Henriette Aksnes; Thomas Arnesen (2020). The Impact of N-terminal Acetylation on Actin Polymerization and Cell Migration. (ekstern lenke)
Vitenskapelig litteraturgjennomgang
- Henriette Aksnes; Adrian Drazic; Thomas Arnesen (2015). (Hyper)tension release by N-terminal acetylation. (ekstern lenke)
- Henriette Aksnes; Rasmus Moen Ree; Thomas Arnesen (2019). Co-translational, post-translational, and non-catalytic roles of N-terminal acetyltransferases. (ekstern lenke)
- Åse Karine Bekkelund; Anette Siggervåg; Henriette Aksnes (2025). Pi-ecing together brain calcification mechanisms for therapeutic advancement. (ekstern lenke)
- Anette Siggervåg; Åse Karine Bekkelund; Jaakko Saraste et al. (2025). Understanding brain calcification via N-terminal acetylation at the Golgi apparatus. (ekstern lenke)
- Henriette Aksnes; Adrian Drazic; Michael Bruno Eric Marie et al. (2016). First things first: Vital protein marks by N-terminal acetyltransferases. (ekstern lenke)
- Thomas Arnesen; Henriette Aksnes (2023). Actin finally matures: uncovering machinery and impact. (ekstern lenke)
- Thomas Arnesen; Henriette Aksnes; Carmela Giglione (2023). Protein Termini 2022: central roles of protein ends. (ekstern lenke)
Konferanseforedrag
- Tobias B. Beigl; Henriette Aksnes (2019). Actin N-terminal acetylation impacts Golgi structural integrity (Talk by Tobias B. Beigl selected from abstracts). (ekstern lenke)
- Henriette Aksnes (2020). Efficient and crucial quality control of HAP1 cell ploidy status (Talk selected from abstracts). (ekstern lenke)
- Monica Hellesvik; Henriette Aksnes (2020). Spying on the cells using holographic live cell imaging - revealing increased metastatic potential for cancer cells lacking NAA80 (Talk by Monica Hellesvik selected from Abstracts). (ekstern lenke)
- Henriette Aksnes (2019). Knockout of the posttranslational actin modifier NAA80/NatH cause Golgi fragmentation (Talk selected from abstract). (ekstern lenke)
- Henriette Aksnes (2022). Protein N-terminal modifications and neurodegenerative disease. (ekstern lenke)
- Henriette Aksnes (2022). Membrane protein modifications in neurodegenerative disease. (ekstern lenke)
Se en full oversikt over publikasjoner i Cristin
FAGFELLEVURDERTE VITENSKAPELIGE PUBLIKASJONER (PubMed)
Caiella A, McTiernan N, Aksnes H✉️.
Methods Enzymol. 2025;718:129-165. doi: 10.1016/bs.mie.2025.06.028. Epub 2025 Aug 11.PMID: 40887156
Understanding brain calcification via N-terminal acetylation at the Golgi apparatus.
Siggervåg A, Bekkelund ÅK, Saraste J, Aksnes H✉️.
Brain. 2025 May 9:awaf175. doi: 10.1093/brain/awaf175. Online ahead of print.PMID: 40344186
Pi-ecing together brain calcification mechanisms for therapeutic advancement.
Bekkelund ÅK, Siggervåg A, Aksnes H✉️.
Trends Mol Med. 2025 Mar;31(3):206-208. doi: 10.1016/j.molmed.2024.12.003. Epub 2025 Jan 4.PMID: 39755442 Free article.
Larsen SK, Bekkelund ÅK, Glomnes N, Arnesen T, Aksnes H✉️.
Biochimie. 2024 Jul 20:S0300-9084(24)00166-4. doi: 10.1016/j.biochi.2024.07.007. Online ahead of print.PMID: 39038730 Free article.
Chelban V✉️, Aksnes H✉️, Maroofian R, LaMonica LC, Seabra L, Siggervåg A, Devic P, Shamseldin HE, Vandrovcova J, Murphy D, Richard AC, Quenez O, Bonnevalle A, Zanetti MN, Kaiyrzhanov R, Salpietro V, Efthymiou S, Schottlaender LV, Morsy H, Scardamaglia A, Tariq A, Pagnamenta AT, Pennavaria A, Krogstad LS, Bekkelund ÅK, Caiella A, Glomnes N, Brønstad KM, Tury S, Moreno De Luca A, Boland-Auge A, Olaso R, Deleuze JF, Anheim M, Cretin B, Vona B, Alajlan F, Abdulwahab F, Battini JL, İpek R, Bauer P, Zifarelli G, Gungor S, Kurul SH, Lochmuller H, Da'as SI, Fakhro KA, Gómez-Pascual A, Botía JA, Wood NW, Horvath R, Ernst AM, Rothman JE, McEntagart M, Crow YJ, Alkuraya FS, Nicolas G; SYNaPS Study Group; Arnesen T✉️, Houlden H✉️.
Nat Commun. 2024 Mar 13;15(1):2269. doi: 10.1038/s41467-024-46354-0.PMID: 38480682 Free PMC article.
Guzman UH, Aksnes H, Ree R, Krogh N, Jakobsson ME, Jensen LJ, Arnesen T, Olsen JV.
Nat Commun. 2023 Jul 27;14(1):4517. doi: 10.1038/s41467-023-40224-x. PMID: 37500638 Free PMC article.
Aksnes H✉️, McTiernan N, Arnesen T✉️.
J Cell Sci. 2023 Jul 15;136(14):jcs260766. doi: 10.1242/jcs.260766. Epub 2023 Jul 18. PMID: 37462250 Review.
Protein Termini 2022: central roles of protein ends.
Arnesen T✉️, Aksnes H✉️, Giglione C✉️.
Trends Biochem Sci. 2023 Jun;48(6):495-499. doi: 10.1016/j.tibs.2023.02.008. Epub 2023 Mar 29. PMID: 36997368
Actin finally matured – uncovering the machinery and the impact
Arnesen T✉️ and Aksnes H✉️
Trends Biochem Sci 2023 PMID: 36804256
Commentary on: Haahr P et al., Science 2022 10.1126/science.abq5082
Expanded in vivo substrate profile of the yeast N-terminal acetyltransferase NatC
Van Damme P✉️, Osberg C S, Jonckheere V, Glomnes N, Gevaert K, Arnesen T and Aksnes H✉️
J Biol Chem, 2023 299(2):102824. PMID: 36567016
Missense NAA20 variants impairing the NatB protein N-terminal acetyltransferase cause autosomal recessive developmental delay, intellectual disability, and microcephaly.
Morrison J*, Altuwaijri NK*, Brønstad K*, Aksnes H*, Alsaif HS, Evans A, Hashem M, Wheeler PG, Webb BD, Alkuraya FS, Arnesen T.
Genet Med. 2021 Nov;23(11):2213-2218. doi: 10.1038/s41436-021-01264-0. Epub 2021 Jul 6. PMID: 34230638
*Shared first authorship
Efficient and crucial quality control of HAP1 cell ploidy status.
Beigl TB, Kjosås I, Seljeseth E, Glomnes N, Aksnes H✉️.
Biol Open. 2020 Nov 12;9(11):bio057174. doi: 10.1242/bio.057174. PMID: 33184093
✉️Corresponding author
Exploiting the potential of commercial digital holographic microscopy by combining it with 3D matrix cell culture assays
Hellesvik M, Øye H, Aksnes H✉️.
Sci Rep. 2020 Sep 7;10(1):14680. doi: 10.1038/s41598-020-71538-1. PMID: 32895419
✉️Corresponding author
N-terminal acetylation of actin by NAA80 is essential for structural integrity of the Golgi apparatus
Beigl TB, Hellesvik M, Saraste J, Arnesen T, Aksnes H✉️.
Exp Cell Res. 2020 May 15;390(2):111961. doi: 10.1016/j.yexcr.2020.111961. Epub 2020 Mar 21. PMID: 32209306
✉️Corresponding author
Co-translational, Post-translational, and Non-catalytic Roles of N-Terminal Acetyltransferases
Aksnes H✉️, Ree R, Arnesen T*.
Mol Cell. 2019 Mar 21;73(6):1097-1114. Review. PMID: 30878283
✉️Corresponding author
Actin polymerization and cell motility are affected by NAA80-mediated posttranslational N-terminal acetylation of actin
Aksnes H✉️, Marie M, Arnesen T, Drazic A.
Commun Integr Biol. 2018 Oct 21;11(4):e1526572. PMID: 30534344
✉️Corresponding author
N-terminal Acetylation Levels Are Maintained During Acetyl-CoA Deficiency in Saccharomyces cerevisiae
Varland S, Aksnes H, Kryuchkov F, Impens F, Van Haver D, Jonckheere V, Ziegler M, Gevaert K, Van Damme P, Arnesen T.
Mol Cell Proteomics. 2018 Dec;17(12):2309-2323. PMID: 30150368
NAA80 is actin's N-terminal acetyltransferase and regulates cytoskeleton assembly and cell motility
Drazic A#, Aksnes H#, Marie M#, Boczkowska M, Varland S, Timmerman E, Foyn H, Glomnes N, Rebowski G, Impens F, Gevaert K, Dominguez R, Arnesen T.
Proc Natl Acad Sci U S A. 2018 Apr 24;115(17):4399-4404. PMID: 29581253
# Shared first authorship
Best paper of the year, Faculty of Medicine, UiB
Received attention:
- From the cover Proc Natl Acad Sci USA 2018; vol. 115 no. 17.
- Commented in: NATure of actin amino-terminal acetylation Proc Natl Acad Sci USA 115(17):4314-16.
- Commented in: Actin's N-terminal acetyltransferase uncovered Cytoskeleton 75(7):318-22.
Molecular determinants of the N-terminal acetyltransferase Naa60 anchoring to the Golgi membrane
Aksnes H, Goris M, Strømland Ø, Drazic A, Waheed Q, Reuter N, Arnesen T.
J Biol Chem. 2017 Apr 21;292(16):6821-6837. PMID: 28196861
Microscopy-based Saccharomyces cerevisiae complementation model reveals functional conservation and redundancy of N-terminal acetyltransferases
Osberg C, Aksnes H, Ninzima S, Marie M, Arnesen T.
Sci Rep. 2016 Aug 24;6:31627. PMID: 27555049
First Things First: Vital Protein Marks by N-Terminal Acetyltransferases
Aksnes H, Drazic A, Marie M, Arnesen T.
Trends Biochem Sci. 2016 Sep;41(9):746-760. Review. PMID: 27498224
Holding it together: Naa60 at the Golgi
Aksnes H, Marie M, Arnesen T.
Oncotarget. 2015 Jun 30;6(18):15726-7. PMID: 26164078
(Hyper)tension release by N-terminal acetylation
Aksnes H, Drazic A, Arnesen T.
Trends Biochem Sci. 2015 Aug;40(8):422-4. PMID: 26027460
Molecular, cellular, and physiological significance of N-terminal acetylation
Aksnes H, Hole K, Arnesen T.
Int Rev Cell Mol Biol. 2015;316:267-305. Review. PMID: 25805127
An organellar Nα-acetyltransferase, Naa60, acetylates cytosolic N termini of transmembrane proteins and maintains Golgi integrity
Aksnes H, Van Damme P, Goris M, Starheim KK, Marie M, Støve SI, Hoel C, Kalvik TV, Hole K, Glomnes N, Furnes C, Ljostveit S, Ziegler M, Niere M, Gevaert K, Arnesen T.
Cell Rep. 2015 Mar 3;10(8):1362-74. PMID: 25732826
Best paper of the year, Dept. of Molecular Biology, UiB
N-terminal acetylation by NatC is not a general determinant for substrate subcellular localization in Saccharomyces cerevisiae.
Aksnes H, Osberg C, Arnesen T.
PLoS One. 2013 Apr 15;8(4):e61012. doi: 10.1371/journal.pone.0061012. Print 2013.
PMID: 23613772
The human N-alpha-acetyltransferase 40 (hNaa40p/hNatD) is conserved from yeast and N-terminally acetylates histones H2A and H4.
Hole K, Van Damme P, Dalva M, Aksnes H, Glomnes N, Varhaug JE, Lillehaug JR, Gevaert K, Arnesen T.
PLoS One. 2011;6(9):e24713. doi: 10.1371/journal.pone.0024713. Epub 2011 Sep 15.
PMID: 21935442
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