Vitenskapelig litteraturgjennomgang

• Peter Celec; Barbora Vlková; Lucia Laukova et al. (2018). Cell-free DNA: the role in pathophysiology and as a biomarker in kidney diseases. (ekstern lenke)
• Marianna Gyurászová; Radana Gurecká; Janka Babickova et al. (2020). Oxidative stress in the pathophysiology of kidney disease: Implications for noninvasive monitoring and identification of biomarkers. (ekstern lenke)
• Janka Babickova; Hai-Chun Yang; Agnes B. Fogo (2024). Adverse effects of acute tubular injury on the glomerulus: contributing factors and mechanisms. (ekstern lenke)
• Marianna Gyuraszova; Alexandra Kovalcikova; Janka Babickova et al. (2018). Cell-free nucleic acids in urine as potential biomarkers of kidney disease. (ekstern lenke)

Vitenskapelig artikkel

• Lea Zoe Landolt; Jessica Furriol; Janka Babickova et al. (2019). AXL targeting reduces fibrosis development in experimental unilateral ureteral obstruction. (ekstern lenke)
• Hassan Osman Alhassan Elsaid; Jessica Furriol; Maria Blomqvist et al. (2022). Reduced α-galactosidase A activity in zebrafish (Danio rerio) mirrors distinct features of Fabry nephropathy phenotype. (ekstern lenke)
• Jana Tulinska; Zora Krivosikova; Aurelia Liskova et al. (2022). Six-week inhalation of lead oxide nanoparticles in mice affects antioxidant defense, immune response, kidneys, intestine and bones. (ekstern lenke)
• Zuzana Vrablicova; Kristina Tomova; Lubomira Tothova et al. (2020). Nuclear and Mitochondrial Circulating Cell-Free DNA Is Increased in Patients With Inflammatory Bowel Disease in Clinical Remission. (ekstern lenke)
• Anne Christina Kipp; Hans Peter Marti; Janka Babickova et al. (2023). Glomerular proteomic profiling reveals early differences between preexisting and de novo type 2 diabetes in human renal allografts. (ekstern lenke)
• Barbora Konečná; Paulína Chobodová; Jakub Janko et al. (2021). The Effect of Melatonin on Periodontitis. (ekstern lenke)
• Alexander Jančuška; Alena Potočárová; Alexandra Gaál Kovalčíková et al. (2022). Dynamics of Plasma and Urinary Extracellular DNA in Acute Kidney Injury. (ekstern lenke)
• August Hoel; Tarig Osman; Fredrik Hoel et al. (2021). Axl-inhibitor bemcentinib alleviates mitochondrial dysfunction in the unilateral ureter obstruction murine model. (ekstern lenke)
• Alexandra Gaál Kovalčíková; Ľubica Janovičová; Július Hodosy et al. (2022). Extracellular DNA concentrations in various aetiologies of acute kidney injury. (ekstern lenke)
• Jana Tulinska; Vlasta Masanova; Aurelia Liskova et al. (2019). Six-week inhalation of CdO nanoparticles in mice: The effects on immune response, oxidative stress, antioxidative defense, fibrotic response, and bones. (ekstern lenke)
• Marta Kaminska; Urszula Zofia Kalucka; Janka Babickova et al. (2025). Bradykinin’s carbamylation as a mechanistic link to impaired wound healing in patients with kidney dysfunction. (ekstern lenke)
• Øystein Solberg Eikrem; Spiros Kotopoulis; Mihaela-Lucia Popa et al. (2021). Ultrasound and Microbubbles Enhance Uptake of Doxorubicin in Murine Kidneys. (ekstern lenke)
• Mariell Lossius Rivedal; Håvard Mikkelsen; Hans Peter Marti et al. (2023). Glomerular transcriptomics predicts long term outcome and identifies therapeutic strategies for patients with assumed benign IgA nephropathy. (ekstern lenke)
• Jordanka Homolová; L'ubica Janovičová; Barbora Konečná et al. (2020). Plasma Concentrations of Extracellular DNA in Acute Kidney Injury. (ekstern lenke)
• Maike Baues; Barbara M Klinkhammer; Josef Ehling et al. (2020). A collagen-binding protein enables molecular imaging of kidney fibrosis in vivo. (ekstern lenke)
• Hassan Osman Alhassan Elsaid; Mariell Lossius Rivedal; Eleni Skandalou et al. (2023). Proteomic analysis unveils Gb3-independent alterations and mitochondrial dysfunction in a gla ^−/− zebrafish model of Fabry disease. (ekstern lenke)
• Hassan Osman Alhassan Elsaid; Håkon Tjeldnes; Mariell Lossius Rivedal et al. (2022). Gene Expression Analysis in gla-Mutant Zebrafish Reveals Enhanced Ca²⁺ Signaling Similar to Fabry Disease. (ekstern lenke)
• Janka Babickova; Jozef Conka; L Janovicova et al. (2018). Extracellular DNA as a prognostic and therapeutic target in mouse colitis under DNase I treatment. (ekstern lenke)
• Janka Babickova; Urszula Zofia Kalucka; Alicja Sochaj-Grzegorczyk et al. (2025). Carbamylation is Instrumental in End-Stage Kidney Disease Coagulopathies: The Impact on von Willebrand Factor and Platelet Functionality. (ekstern lenke)
• Marianna Gyuraszova; Alexandra Gaal Kovalcikova; Emese Renczes et al. (2019). Oxidative Stress in Animal Models of Acute and Chronic Renal Failure. (ekstern lenke)

Konferanseposter

• Øystein Solberg Eikrem; Philipp Strauss; Miroslav Sekulic et al. (2018). Fabry nephropathy: Transcriptome sequencing of microdissected renal compartments from archival kidney biopsies at baseline, and after 5 & 10 years of enzyme replacement therapy. (ekstern lenke)

Se en full oversikt over publikasjoner i Cristin

Publications

European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement (No. 842619-DIE_CKD).

About the project:

Chronic kidney disease (CKD) is a major cause of morbidity and mortality, affecting over 10 % of the adult population. Regardless of the primary case, the progressed stage is characterized by scarring of all anatomical elements of the kidney - glomeruli, tubulointerstitium, and vasculature referred to as renal fibrosis. Tubulointerstitial fibrosis has largely been viewed as a consequence of glomerular scarring, reflecting hypoxia downstream from the scarred glomeruli. Novel data suggest that ongoing communication between the glomerular and tubular compartments (tubuloglomerular feedback) plays an important role in the progression of renal fibrosis. Particularly, injury to the tubular compartments leads to more pronounced glomerular injury in the future. DIE_CKD is designed to uncover the range and mechanisms of tubular injuries involved in the pathogenic tubuloglomerular feedback. To achieve the project objectives, double/quadruple transgenic mice with the possibility of time-dependent, subsequent injury to different compartments of the kidney will be used. This unique approach will enable a direct study of how the injury to tubular compartments predisposes glomeruli to more severe injury. Detailed analysis of the mechanisms behind these effects will be performed. The experimental data will be further confirmed in human renal biopsies of patients with Fabry disease with progressed CKD and renal fibrosis. A comprehensive histopathological assessment of long-term prognosis of sequential biopsies will be performed to analyze the involvement of individual compartments over time.

Publications:

https://www.asn-online.org/education/kidneyweek/2021/program-abstract.aspx?controlId=3612468

https://www.asn-online.org/education/kidneyweek/2020/program-abstract.aspx?controlId=3446652

https://pubmed.ncbi.nlm.nih.gov/36207374/

https://pubmed.ncbi.nlm.nih.gov/35328821/

https://pubmed.ncbi.nlm.nih.gov/32082479/

https://pubmed.ncbi.nlm.nih.gov/32168933/

https://pubmed.ncbi.nlm.nih.gov/36613802/

 

Dissemination:

https://cordis.europa.eu/article/id/442761-molecular-breakthrough-gives-hope-to-kidney-disease-patients?WT.mc_id=exp