Jeg er professor ved Institutt for biomedisin ved Universitetet i Bergen, og en av flere gruppeleder i Metabolisme og kreft-gruppen. Forskningen i vår gruppe har som mål å forstå molekylære interaksjoner på atomnivå og de nyanserte sammenhengene mellom struktur, dynamikk og funksjon av biomolekyler. Vi utvikler og anvender beregningsmetoder for å simulere molekylære bevegelser, som supplerer eksperimentelle observasjoner.

Gjennom samarbeid med grupper som utvikler Amber-programvaren for molekylære simuleringer, har vi utviklet Amber-kraftfeltet for å simulere molekylære interaksjoner i lipidkomplekser. Med Amber programvaren er vi nå i stand til å simulere komplekse molekylære systemer av hvilken som helst sammensetning. Vi anvender disse metodene for å forstå funksjonen til store molekylære systemer basert på intermolekylære krefter og iboende dynamikk.

Vår kraftfeltutvikling er også relevant for metoder for virtuell screening, der vi ønsker å finne små molekyler med potensiale til å utvikles til et medikament. Den virtuelle screeningen integreres med eksperimentell screening av små forbindelser utført av andre grupper ved Institutt for Biomedisin.

Jeg er medgründer og aksjonær i selskapet Pluvia Pharma AS, et oppstarts-biotec firma i Bergen som har som mål å utvikle molekyler med potensiale for å korrigere medfødte arvelige sykdommer som skyldes misfolding av proteiner.

Jeg er semesterstyreleder og har ansvar for innholdet i andre semester på medisinstudiet i Bergen og er medlem av Programutvalget i Medisin ved UiB. Jeg underviser i basalfagene for farmasi, tannlege og medisin og har i tillegg undervisning om strukturbiologi på master- og phd-emner ved instituttet. Jeg tilbyr masteroppgaver for studenter i farmasi, nanovitenskap, biomedisin og medisinsk teknologi i tillegg til prosjekter for forskerlinjen på medisin. Gjennom FEBS (Federation of European Biochemical Societies) er jeg involvert i utvikling av biokjemi-undervisning og deltar i FEBS-fora som Norges ambassadør for biokjemi-undervisning.

Når jeg ikke underviser i biokjemi, har jeg en lidenskap for ski og skikjøring. Som medlem av utdanningskomiteen i Den Norske Skiskole bidrar jeg med opplæring og internasjonal ISIA sertifisering av skilærere i Norge.

Vitenskapelig artikkel

• Frederico F. Miranda; Matthias Thorolfsson; Knut Teigen et al. (2004). Structural and stability effects of phosphorylation � Localized structural changes in phenylalanine hydroxylase. (ekstern lenke)
• Line Pedersen; Pouda Panahandeh; Muntequa Ishtiaq Siraji et al. (2020). Golgi-Localized PAQR4 Mediates Antiapoptotic Ceramidase Activity in Breast Cancer. (ekstern lenke)
• Olena Dobrovolska; Maxim Brilkov; Noëlly Madeleine et al. (2020). The Arabidopsis (ASHH2) CW domain binds monomethylated K4 of the histone H3 tail through conformational selection. (ekstern lenke)
• Nibal Betari; Kristoffer Sahlholm; Xavier Morató et al. (2020). Inhibition of Tryptophan Hydroxylases and Monoamine Oxidase-A by the Proton Pump Inhibitor, Omeprazole—In Vitro and In Vivo Investigations. (ekstern lenke)
• Angel Pey; Matthias Thorolfsson; Knut Teigen et al. (2004). Thermodynamic characterization of the binding of tetrahydropterins to phenylalanine hydroxylase. (ekstern lenke)
• Erlend Hodneland; Knut Teigen (2007). A simple method to calculate the accessible volume of protein-bound ligands: Application for ligand selectivity. (ekstern lenke)
• Åge Aleksander Skjevik; Mauro Mileni; Anne Baumann et al. (2014). The N-terminal sequence of tyrosine hydroxylase is a conformationally versatile motif that binds 14-3-3 proteins and membranes. (ekstern lenke)
• Knut Teigen; Vidar Remi Jensen; Aurora Martinez (2005). The reaction mechanism of phenylalanine hydroxylase. A question of coordination. (ekstern lenke)
• Åge Aleksander Skjevik; Benjamin D. Madej; Callum J. Dickson et al. (2015). All-atom lipid bilayer self-assembly with the AMBER and CHARMM lipid force fields. (ekstern lenke)
• Janne Molnes; Knut Teigen; Ingvild Aukrust et al. (2011). Binding of ATP at the active site of human pancreatic glucokinase - nucleotide-induced conformational changes with possible implications for its kinetic cooperativity. (ekstern lenke)
• Jessica Siltberg-Liberles; Marte Innselset Flydal; Knut Teigen et al. (2009). Evolution of regulation, structure and function in phenylalanine hydroxylase. (ekstern lenke)
• Marte Innselset Flydal; Trond-André Kråkenes; Mary Dayne Sia Tai et al. (2020). Levalbuterol lowers the feedback inhibition by dopamine and delays misfolding and aggregation in tyrosine hydroxylase. (ekstern lenke)
• Sara Elaine Olsson; Aurora Martinez; Knut Teigen et al. (2011). Formation of the Iron-Oxo Hydroxylating Species in the Catalytic Cycle of Aromatic Amino Acid Hydroxylases. (ekstern lenke)
• Åge Aleksander Skjevik; Bengt Erik Haug; Henning Lygre et al. (2011). Intramolecular hydrogen bonding in articaine can be related to superior bone tissue penetration: A molecular dynamics study. (ekstern lenke)
• Magnus Hole; Jarl Underhaug; Hector Diez et al. (2015). Discovery of compounds that protect tyrosine hydroxylase activity through different mechanisms. (ekstern lenke)
• Khanh Kim Dao; Knut Teigen; Reidun Kristin Kopperud et al. (2006). Epac1 and cAMP-dependent protein kinase holoenzyme have similar cAMP affinity, but their cAMP domains have distinct structural features and cyclic nucleotide recognition. (ekstern lenke)
• Lene Elisabeth Myhren; Gyrid Nygaard; Gro Gausdal et al. (2013). Iodinin (1,6-dihydroxyphenazine 5,10-dioxide) from streptosporangium sp. induces apoptosis selectively in myeloid leukemia cell lines and patient cells. (ekstern lenke)
• Knut Teigen; Nils Åge Frøystein; Aurora Martinez (1999). The structural Basis of the Recognition of Phenylalanine and Pterine Cofactors by Phenylalanine Hydroxylase. Implications for the Catalytic Mechanism. (ekstern lenke)
• Josephine Prener Holtan; Knut Teigen; Ingvild Aukrust et al. (2019). Dominant ARL3-related retinitis pigmentosa. (ekstern lenke)
• Ingeborg Winge; Knut Teigen; Agnete Fossbakk et al. (2015). Mammalian CSAD and GADL1 have distinct biochemical properties and patterns of brain expression. (ekstern lenke)
• Åge Aleksander Skjevik; Knut Teigen; Aurora Martinez (2009). Overview of computational methods employed in early-stage drug discovery. (ekstern lenke)
• Valentina L. Kouznetsova; Hannah Hu; Knut Teigen et al. (2017). Cripto stabilizes GRP78 on the cell membrane. (ekstern lenke)
• Knut Teigen; Khanh Kim Dao; Jeffrey Alan Mckinney et al. (2004). Tetrahydrobiopterin binding to aromatic amino acid hydroxylases. Ligand recognition and specificity. (ekstern lenke)
• Lars Herfindal; Camilla Krakstad; Lene Elisabeth Myhren et al. (2014). Introduction of aromatic ring-containing substituents in cyclic nucleotides is associated with inhibition of toxin uptake by the hepatocyte transporters OATP 1B1 and 1B3. (ekstern lenke)
• Svein Isungset Støve; Åge Aleksander Skjevik; Knut Teigen et al. (2022). Inhibition of VMAT2 by β2-adrenergic agonists, antagonists, and the atypical antipsychotic ziprasidone. (ekstern lenke)
• Ianire Martin; Jarl Underhaug; Garbiñe Celaya et al. (2013). Screening and evaluation of small organic molecules as ClpB inhibitors and potential antimicrobials. (ekstern lenke)
• João Leandro; Anne Jorunn Stokka; Knut Teigen et al. (2017). Substituting Tyr138 in the active site loop of human phenylalanine hydroxylase affects catalysis and substrate activation. (ekstern lenke)
• Sara Elaine Olsson; Aurora Martinez; Knut Teigen et al. (2011). Substrate Hydroxylation by the Oxido-Iron Intermediate in Aromatic Amino Acid Hydroxylases: A DFT Mechanistic Study. (ekstern lenke)
• Angel Pey; Aurora Martinez; Ramamurthy Charubala et al. (2006). Specific interaction of the diastereomers 7(R)- and 7(S)-tetrahydrobiopterin with phenylalanine hydroxylase: implications for understanding primapterinuria and vitiligo. (ekstern lenke)
• Callum J. Dickson; Benjamin D. Madej; Åge Aleksander Skjevik et al. (2014). Lipid14: The amber lipid force field. (ekstern lenke)
• María Teresa Bueno-Carrasco; Jorge Cuellar; Marte Innselset Flydal et al. (2022). Structural mechanism for tyrosine hydroxylase inhibition by dopamine and reactivation by Ser40 phosphorylation. (ekstern lenke)
• Nibal Betari; Kristoffer Sahlholm; Yuta Ishizuka et al. (2020). Discovery and biological characterization of a novel scaffold for potent inhibitors of peripheral serotonin synthesis. (ekstern lenke)
• Lars Skjærven; Barry Grant; Arturo Muga et al. (2011). Conformational sampling and nucleotide-dependent transitions of the GroEL subunit probed by unbiased molecular dynamics simulations. (ekstern lenke)
• Aidan Zhang; Knut Teigen; Valentina L. Kouznetsova et al. (2022). Modeling of mutant superoxide dismutase 1 octamers with cross-linked disulfide bonds. (ekstern lenke)
• Anu Humisto; Jouni Jokela; Knut Teigen et al. (2019). Characterization of the interaction of the antifungal and cytotoxic cyclic glycolipopeptide hassallidin with sterol-containing lipid membranes. (ekstern lenke)
• Nibal Betari; Knut Teigen; Kristoffer Sahlholm et al. (2021). Synthetic corticosteroids as tryptophan hydroxylase stabilizers. (ekstern lenke)
• Knut Teigen; Nils Åge Frøystein; Aurora Martinez (1999). The structural basis of the recognition of phenylalanine and pterin cofactors by phenylalanine hydroxylase. Implications for the catalytic mechanism. (ekstern lenke)
• Åge Aleksander Skjevik; Benjamin D. Madej; Ross C. Walker et al. (2012). LIPID11: A modular framework for lipid simulations using amber. (ekstern lenke)
• Åge Aleksander Skjevik; Benjamin D. Madej; Callum J. Dickson et al. (2016). Simulation of lipid bilayer self-assembly using all-atom lipid force fields. (ekstern lenke)
• Olena Dobrovolska; Øyvind Strømland; Ørjan Sele Handegård et al. (2021). Investigating the Disordered and Membrane-Active Peptide A-Cage-C Using Conformational Ensembles. (ekstern lenke)
• Marte Innselset Flydal; Tonje Cecilie Mohn; Rodroguez Angel Luis Pey et al. (2010). Superstoichiometric binding of L-Phe to phenylalanine hydroxylase from Caenorhabditis elegans: evolutionary implications. (ekstern lenke)
• Sara Elaine Olsson; Aurora Martinez; Knut Teigen et al. (2010). Water dissociation and dioxygen binding in phenylalanine hydroxylase. (ekstern lenke)
• Rune I. Lindstad; Knut Teigen; Lars Skjeldal (2013). Inhibition of sorbitol dehydrogenase by nucleosides and nucleotides. (ekstern lenke)
• Khanh Kim Dao; Angel L. Pey; Anja Underhaug Gjerde et al. (2011). The regulatory subunit of PKA-I remains partially structured and undergoes beta-aggregation upon thermal denaturation. (ekstern lenke)

Vitenskapelig bokkapittel

• Sara Elaine Olsson; Aurora Martinez; Knut Teigen et al. (2010). The aromatic amino acid hydroxylase mechanism: a perspective from computational chemistry. (ekstern lenke)
• Lars Skjærven; Knut Teigen; Aurora Martinez (2014). Structure–Function Relationships in the Aromatic Amino Acid Hydroxylases Enzyme Family: Evolutionary Insights. (ekstern lenke)

Masteroppgave

• Maria Teresa Bezem; Aurora Martinez; Knut Teigen (2012). Stabilisation of Tyrosine Hydroxylase in Nanoparticles for Enzyme Replacement Therapy. (ekstern lenke)
• Åge Aleksander Skjevik; Knut Teigen; Anja Underhaug Gjerde et al. (2008). INTERACTION OF A LOCAL ANAESTHETIC WITH MEMBRANE LIPIDS STUDIED COMPUTER MODELLING. (ekstern lenke)
• Marit Elisabet Aardal; Knut Teigen; Sonnich Meier et al. (2011). Interactions between polychlorinated biphenyls (PCBs) and a phospholipid bilayer: A molecular dynamics study. (ekstern lenke)
• Ellen Hovind Hjelmdal; Knut Teigen; Aurora Martinez (2016). Characterization of prevalent phenylketonuria mutations Effect of potential pharmacological chaperones. (ekstern lenke)
• Monica Hallem Akerholdt; Knut Teigen; Rune Kleppe (2015). Discovery of small-molecular disruptors of protein-protein inteactions A virtual screening approach applied to 14-3-3¿ and tyrosine hydroxylase. (ekstern lenke)
• Lea Francine J Longueville; Karl Johan Tronstad; Knut Teigen et al. (2024). Characterization of mutations detected in a family of severe cases of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). (ekstern lenke)
• Ida Benedikte Pedersen; Knut Teigen; Anja Underhaug Gjerde et al. (2008). BIOLOGICAL TARGETS OF LOCAL ANAESTHETICS – A MOLECULAR MODELLING STUDY. (ekstern lenke)
• Elise Skogheim; Knut Teigen; Rune Kleppe (2015). Identification of small molecular modulators of 14-3-3 functions. A virtual screening approach with experimental validation. (ekstern lenke)
• Magnus Hole; Knut Teigen; Aurora Martinez (2012). SEARCH AND ANALYSIS OF COMPOUNDS THAT STABILIZE TYROSINE HYDROXYLASE - IDENTIFICATION OF PHARMACOLOGICAL CHAPERONES. (ekstern lenke)
• Gerd Marie Eskerud Harris; Knut Teigen; Aurora Martinez (2014). Identification of pharmacological chaperones for Phenylalanine Hydroxylase. A virtual screening approach to discover novel drug candidates for treatment of phenylketonuria. (ekstern lenke)
• Rikke Landsvik Berg; Knut Teigen; Jan Haavik (2014). Identification of inhibitors of tryptophan hydroxylase 1. (ekstern lenke)

Konferanseposter

• Svein Isungset Støve; Åge Aleksander Skjevik; Knut Teigen et al. (2020). Searching for new inhibitors of vesicular monoamine transporter 2 by differential scanning fluorimetry. (ekstern lenke)
• Åge Aleksander Skjevik; Henning Lygre; Knut Teigen (2008). Interaction of a local anaesthetic with lipid membranes studied by computer modelling. (ekstern lenke)
• Åge Aleksander Skjevik; Svein Isungset Støve; Knut Teigen et al. (2020). Identification of VMAT2 inhibitory compounds. (ekstern lenke)
• Åge Aleksander Skjevik; Henning Lygre; Knut Teigen (2009). Molecular dynamics simulation: Interaction between the local anaesthetic articaine and membrane models. (ekstern lenke)
• Ida Benedikte Pedersen; Åge Aleksander Skjevik; Henning Lygre et al. (2008). Drug-membrane interactions. An explanation for the anti-inflammatory effect of local anesthetics?. (ekstern lenke)
• Åge Aleksander Skjevik; Henning Lygre; Knut Teigen (2010). Can intramolecular hydrogen bonding in articaine be related to superior bone tissue penetration? A molecular dynamics study. (ekstern lenke)
• Åge Aleksander Skjevik; Ida Benedikte Pedersen; Henning Lygre et al. (2008). Interactions between the local anesthetic articaine and membranes: A theoretical and experiemntal study. (ekstern lenke)
• Svein Isungset Støve; Åge Aleksander Skjevik; Knut Teigen et al. (2022). High-throughput screening for VMAT2 activity modulators. (ekstern lenke)
• Elaine Olsson; Aurora Martinez; Knut Teigen et al. (2010). Dioxygen Binding and Formation of the Hydroxylating FeIV=O Intermediate in Aromatic Amino Acid Hydroxylases. (ekstern lenke)
• Sara Elaine Olsson; Aurora Martinez; Knut Teigen et al. (2009). Catalytic cycle of phenylalanine hydroxylase. (ekstern lenke)
• Sara Elaine Olsson; Aurora Martinez; Knut Teigen et al. (2009). Catalytic cycle of phenylalanine hydroxylase. (ekstern lenke)

Konferanseforedrag

• Knut Teigen; Nils Åge Frøystein; Aurora Martínez (1998). NMR study on the conformation of L-phenylalanine and dihydrobiopterin bound to wild-type and mutant forms of recombinant human phenylalanine hydroxylase. (ekstern lenke)
• Sara Elaine Olsson; Aurora Martinez; Knut Teigen et al. (2009). Dioxygen in aromatic amino acid hydroxylases. (ekstern lenke)

Vitenskapelig litteraturgjennomgang

• Knut Teigen; Jeffrey Alan Mckinney; Jan Haavik et al. (2007). Selectivity and affinity determinants for ligand binding to the aromatic amino acid hydroxylases. (ekstern lenke)
• Elaine Olsson; Knut Teigen; Aurora Martinez et al. (2010). The aromatic amino acid hydroxylase mechanism: A perspective from computational chemistry. (ekstern lenke)
• Magnus Hole; Ana Jorge Finnigan; Jarl Underhaug et al. (2016). Pharmacological chaperones that protect Tetrahydrobiopterin dependent aromatic amino acid hydroxylases through different mechanisms. (ekstern lenke)
• Aurora Martinez; Ana C Calvo; Knut Teigen et al. (2009). Rescuing proteins of low kinetic stability by chaperones and natural ligands; phenylketonuria, a case study. (ekstern lenke)

Doktorgradsavhandling

• Magnus Hole; Knut Teigen (2015). A study of Structure-Function-Stability Relationships in Tyrosine Hydroxylase. (ekstern lenke)
• Knut Teigen (2004). Structural and Functional Aspects of Pterin-Binding Enzymes - A Nuclear Magnetic Resonance Spectroscopy and Molecular Modeling Study. (ekstern lenke)

Konferanseabstrakt

• Ross C. Walker; Åge Aleksander Skjevik; Knut Teigen (2012). Developing a comprehensive modular phospholipid force field for AMBER. (ekstern lenke)
• Benjamin D. Madej; Age Skjevik; Knut Teigen et al. (2012). AMBER-Lipid 11: A new modular lipid force field for molecular dynamics. (ekstern lenke)

Rettelse i tidsskrift

• Magnus Hole; Jarl Underhaug; Hector Diez et al. (2016). Erratum: Discovery of compounds that protect tyrosine hydroxylase activity through different mechanisms (Biochimica et Biophysica Acta - Proteins and Proteomics (2015) 1854:9 (1078-1089) DOI: 10.1016/j.bbapap.2015.04.030). (ekstern lenke)

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