Mette Vesterhus er ansatt som professor ved UiB (100%) og er undervisningsgruppeleder for propedeutikk ved K2. Hun er spesialist i fordøyelsessykdommer med spesiell interesse for leversykdommer og har en bistilling som overlege ved Haraldsplass diakonale sykehus. Forskningen hennes fokuserer på autoimmune leversykdommer, med særlig vekt på leverelastografi og biomarkører for sykdomsaktivitet og prognose ved primær skleroserende cholangitt. Hun leder Forskningsgruppe for leversykdommer ved Haraldsplass, NoPSC Bergen Clinical Research Group, og er prosjektleder for ScandPSC - Strategic Prospective Scandinavian PSC Biobank & Cohort og Nasjonalt nettverk for autoimmune leversykdommer.

Vi trenger en ny strategi for leversykdom | Tidsskrift for Den norske legeforening

– Forventer en dobling av sykdomsbyrden for alvorlig leversykdom

Leveren har et image-problem

• Leversykdommer (MED6, MED11; masterstudiet i ernæringsfysiologi)
• Propedeutikk (MED5)

Doktorgradsavhandling

• Mette Vesterhus (2009). Monogenic diabetes and pancreatic exocrine dysfunction in mouse and man. (ekstern lenke)

Fagartikkel

• Nasir Hussain; Christopher Ma; Gideon Hirschfield et al. (2024). Protocol for the development of a core outcome set for clinical trials in primary sclerosing cholangitis. (ekstern lenke)
• Holmfridur Helgadottir; Trine Folseraas; Gunter Kemmerich et al. (2023). Primær skleroserende kolangitt. (ekstern lenke)
• Eivind Ness-Jensen; Birgitte Karen Berggreen Seip; Mette Vesterhus (2020). Prioriteringsråd for fordøyelsessykdommer under korona-pandemien. (ekstern lenke)

Forelesning

• Mette Nåmdal Vesterhus (2021). ELF Test in PSC - should we start using it?. (ekstern lenke)
• Mette Nåmdal Vesterhus (2021). 2.linjebehandling ved PBC og AIH. (ekstern lenke)
• Mette Nåmdal Vesterhus (2021). Juvenile PSC/ASC: The adult side.. (ekstern lenke)
• Mette Nåmdal Vesterhus (2021). ULTRASOUND EVALUATION OF PSC. (ekstern lenke)
• Mette Nåmdal Vesterhus (2021). PSC - What is that disease exactly?. (ekstern lenke)
• Anesa Mulabecirovic; Mette Vesterhus; Odd Helge Gilja et al. (2017). Ultralyd Elastografi. (ekstern lenke)
• Anesa Mulabecirovic; Anders Batman Mjelle; Odd Helge Gilja et al. (2017). Måling av vevsstivhet på fantomer med fire ulike «shear wave» elastografisystemer. (ekstern lenke)

Fremhevet artikkel i media

• Mette Nåmdal Vesterhus; Kristin Kaasen Jørgensen; Svein Oskar Frigstad et al. (2022). Vi trenger en ny strategi for leversykdom. (ekstern lenke)

Konferanseabstrakt

• Roald Flesland Havre; Anesa Mulabecirovic; Mette Vesterhus et al. (2015). Elasticity Mearsurements Using Four Different Ultrasound Scanners. (ekstern lenke)
• Mette Vesterhus; Stefan Johansson; Helge Ræder et al. (2007). Pancreatic exocrine deficiency is common in MODY 3. (ekstern lenke)

Konferanseforedrag

• Anesa Mulabecirovic; Anders Batman Mjelle; Roald Flesland Havre et al. (2016). Quantification of tissue elasticity in vitro using three clinical shear wave elastography platforms on liver fibrosis phantoms. (ekstern lenke)
• Anders Batman Mjelle; Anesa Mulabecirovic; Trygve Hausken et al. (2016). Elastography of the Liver in Primary Sclerosing Cholangitis. (ekstern lenke)
• Martin Kummen; Kristian Holm; Jarl Andreas Anmarkrud et al. (2015). O082 : THE GUT MICROBIOTA IN PRIMARY SCLEROSING CHOLANGITIS DIFFERS FROM THAT OF HEALTHY CONTROLS AND ULCERATIVE COLITIS PATIENTS WITHOUT BILIARY DISEASE. (ekstern lenke)
• Anesa Mulabecirovic; Mette Vesterhus; Odd Helge Gilja et al. (2015). In vitro quantification and reproducibility of elasticity measurements using five different elastography systems. (ekstern lenke)

Konferanseposter

• Joachim Høg Mortensen; Aida Kapic Lunder; Tina Manon-Jensen et al. (2020). P117 Biomarkers of extracellular matrix remodelling are associated with intestinal fibrosis assessed by magnetic resonance enterography and accumulated intestinal damage (Lémann index): the IBSEN study. (ekstern lenke)
• Anesa Mulabecirovic; Felix Bende; I Sporea et al. (2017). ASSESSING LIVER STIFFNESS USING 2D-SHEAR WAVE ELASTOGRAPHY IN A HEALTHY COHORT. (ekstern lenke)
• Anders Batman Mjelde; Trygve Hausken; Tom Hemming Karlsen et al. (2015). Point shear wave elastography of the liver in primary sclerosing cholangitis.. (ekstern lenke)
• Martin Kummen; Mette Vesterhus; Marius Trøseid et al. (2015). P1174: Microbiota-dependent marker trimethylamine-N-oxide (TMAO) is associated with the severity of primary sclerosing cholangitis.. (ekstern lenke)
• Anesa Mulabecirovic; Mette Vesterhus; Odd Helge Gilja et al. (2015). In vitro quantification and reproducibility of elasticity measurements using four different ultrasound scanners. (ekstern lenke)
• Martin Kummen; Mette Vesterhus; Marius Trøseid et al. (2015). MICROBIOTA-DEPENDENT MARKER TRIMETHYLAMINE-N-OXIDE (TMAO) IS ASSOCIATED WITH THE SEVERITY OF PRIMARY SCLEROSING CHOLANGITIS. (ekstern lenke)

Lederartikkel

• Mette Nåmdal Vesterhus (2022). Gode TIPS ved alvorlig leversykdom. (ekstern lenke)

Leserbrev

• John Willy Haukeland; Mette Nåmdal Vesterhus; Kristin Kaasen Jørgensen et al. (2023). FIB-4-testen som beslutningsverktøy. (ekstern lenke)
• Ansgar W. Lohse; Marcial Sebode; Mette Nåmdal Vesterhus (2021). Reply to: "Both tacrolimus and mycophenylate mophetil should be considered second-line therapy for autoimmune hepatitis". (ekstern lenke)

Vitenskapelig artikkel

• Antonio Molinaro; Peder Rustøen Braadland; Guido Carpino et al. (2026). Gut microbiota-derived imidazole propionate promotes primary sclerosing cholangitis via p38 signalling. (ekstern lenke)
• Peder Rustøen Braadland; Ahmad H. Ali; Philip Puchas et al. (2026). Vitamin B6 predicts poor outcomes in geographically distinct populations with primary sclerosing cholangitis. (ekstern lenke)
• Bregje Mol; Moyrha van Nieuwamerongen; Kim N. van Munster et al. (2025). Proctocolectomy with permanent ileostomy is associated with improved transplant-free survival in patients with PSC. (ekstern lenke)
• Yashbir Singh; John E. Eaton; Sudhakar K. Venkatesh et al. (2025). Deep learning analysis of MRI accurately detects early-stage perihilar cholangiocarcinoma in patients with primary sclerosing cholangitis. (ekstern lenke)
• Guri Fossdal; Peder Rustøen Braadland; Johannes Espolin Roksund Hov et al. (2025). Mitochondrial dysfunction and lipid alterations in primary sclerosing cholangitis. (ekstern lenke)
• Peder Rustøen Braadland; Annika Bergquist; Martin Kummen et al. (2023). Clinical and biochemical impact of vitamin B6 deficiency in primary sclerosing cholangitis before and after liver transplantation. (ekstern lenke)
• Ainhoa Lapitz; Mikel Azkargorta; Piotr Milkiewicz et al. (2023). Liquid biopsy-based protein biomarkers for risk prediction, early diagnosis, and prognostication of cholangiocarcinoma. (ekstern lenke)
• Jeffrey V. Lazarus; Henry E. Mark; Alina M. Allen et al. (2023). A global action agenda for turning the tide on fatty liver disease. (ekstern lenke)
• Eike Matthias Wacker; Florian Uellendahl-Werth; Saptarshi Bej et al. (2023). Whole blood RNA sequencing identifies transcriptional differences between primary sclerosing cholangitis and ulcerative colitis. (ekstern lenke)
• Kevin De Muynck; Lander Heyerick; Federico F. De Ponti et al. (2023). Osteopontin characterizes bile duct-associated macrophages and correlates with liver fibrosis severity in primary sclerosing cholangitis. (ekstern lenke)
• Annika Bergquist; Tobias J. Weismüller; Cynthia Levy et al. (2022). Impact on follow-up strategies in patients with primary sclerosing cholangitis. (ekstern lenke)
• Peder Rustøen Braadland; Kai Markus Schneider; Annika Bergquist et al. (2022). Suppression of bile acid synthesis as a tipping point in the disease course of primary sclerosing cholangitis. (ekstern lenke)
• Yashbir Singh; William A. Jons; John E. Eaton et al. (2022). Algebraic topology-based machine learning using MRI predicts outcomes in primary sclerosing cholangitis. (ekstern lenke)
• Holmfridur Helgadottir; Geir Folvik; Mette Nåmdal Vesterhus (2022). Improvement of cholestatic episodes in patients with benign recurrent intrahepatic cholestasis (BRIC) treated with rifampicin. A long-term follow-up. (ekstern lenke)
• Tea Lund Laursen; Lars Bossen; Rasmus Pihl et al. (2022). Highly Increased Levels of Inter-α-inhibitor Heavy Chain 4 (ITIH4) in Autoimmune Cholestatic Liver Diseases. (ekstern lenke)
• Amandeep Kaur Dhillon; Christian Rupp; Annika Bergquist et al. (2021). Associations of neopterin and kynurenine–tryptophan ratio with survival in primary sclerosing cholangitis. (ekstern lenke)
• Mette Vesterhus; Mette Juul Nielsen; Johannes Roksund Hov et al. (2021). Comprehensive assessment of ECM turnover using serum biomarkers establishes PBC as a high-turnover autoimmune liver disease. (ekstern lenke)
• Guri Fossdal; Anders Batman Mjelle; Kristine Wiencke et al. (2021). Fluctuating biomarkers in primary sclerosing cholangitis: A longitudinal comparison of alkaline phosphatase, liver stiffness, and ELF. (ekstern lenke)
• Lars Bossen; Mette Nåmdal Vesterhus; Johannes Espolin Roksund Hov et al. (2021). Circulating Macrophage Activation Markers Predict Transplant-Free Survival in Patients With Primary Sclerosing Cholangitis. (ekstern lenke)
• Anders Batman Mjelle; Anesa Mulabecirovic; Edda Jonina Olafsdottir et al. (2021). Controlled Attenuation Parameter in Healthy Individuals Aged 8-70 Years. (ekstern lenke)
• Anders Batman Mjelle; Anesa Mulabecirovic; Roald Flesland Havre et al. (2020). Liver elastography in healthy children using three different systems - how many measurements are necessary?. (ekstern lenke)
• Martin Kummen; Louise B. Thingholm; Malte C. Rühlemann et al. (2020). Altered Gut Microbial Metabolism of Essential Nutrients in Primary Sclerosing Cholangitis. (ekstern lenke)
• Omar Y Mousa; Brian D Juran; Bryan M. McCauley et al. (2020). Bile Acid Profiles in Primary Sclerosing Cholangitis and their Ability to Predict Hepatic Decompensation. (ekstern lenke)
• Victoria Resvik Taraldsen; Sunneva Tomasgard; Margrethe Thune Rudlang et al. (2020). Point shear wave elastography and the effect of physical exercise, alcohol consumption, and respiration in healthy adults. (ekstern lenke)
• Charlotte Rose Hawkey Hedin; Gina Sado; Nelson Ndegwa et al. (2020). Effects of Tumor Necrosis Factor Antagonists in Patients With Primary Sclerosing Cholangitis. (ekstern lenke)
• Anders Batman Mjelle; Guri Fossdal; Odd Helge Gilja et al. (2020). Liver Elastography in Primary Sclerosing Cholangitis Patients Using Three Different Scanner Systems. (ekstern lenke)
• Francesca Saffioti; Davide Roccarina; Mette Vesterhus et al. (2019). Cholangiocarcinoma is associated with a raised enhanced liver fibrosis score independent of primary sclerosing cholangitis. (ekstern lenke)
• Amandeep Kaur Dhillon; Andreas E. Kremer; Martin Kummen et al. (2019). Autotaxin activity predicts transplant-free survival in primary sclerosing cholangitis. (ekstern lenke)
• Anders Batman Mjelle; Anesa Mulabecirovic; Roald Flesland Havre et al. (2019). Normal Liver Stiffness Values in Children: A Comparison of Three Different Elastography Methods. (ekstern lenke)
• Amandeep Kaur Dhillon; Martin Kummen; Marius Trøseid et al. (2019). Circulating markers of gut barrier function associated with disease severity in primary sclerosing cholangitis. (ekstern lenke)
• Roman Zenouzi; T Liwinski; J Yamamura et al. (2018). Follow-up magnetic resonance imaging/3D-magnetic resonance cholangiopancreatography in patients with primary sclerosing cholangitis: challenging for experts to interpret. (ekstern lenke)
• JE Eaton; Mette Vesterhus; Bryan M. McCauley et al. (2018). Primary sclerosing cholangitis risk estimate tool (PREsTo) predicts outcomes of the disease: A derivation and validation study using machine learning. (ekstern lenke)
• Anesa Mulabecirovic; Anders Batman Mjelle; Odd Helge Gilja et al. (2018). Liver elasticity in healthy individuals by two novel shear-wave elastography systems-Comparison by age, gender, BMI and number of measurements. (ekstern lenke)
• MJ Nielsen; Douglas Thorburn; DJ Leeming et al. (2018). Serological markers of extracellular matrix remodeling predict transplant-free survival in primary sclerosing cholangitis. (ekstern lenke)
• EC Goode; AB Clark; GM Melis et al. (2018). Factors Associated With Outcomes of Patients With Primary Sclerosing Cholangitis and Development and Validation of a Risk Scoring System. (ekstern lenke)
• Felix Bende; Anesa Mulabecirovic; Alina Popescu et al. (2017). Assessing liver stiffness by 2-D shear wave elastography in a healthy cohort. (ekstern lenke)
• Anesa Mulabecirovic; Anders Batman Mjelle; Odd Helge Gilja et al. (2017). Repeatability of shear wave elastography in liver fibrosis phantoms—Evaluation of five different systems. (ekstern lenke)
• PJ Trivedi; J Tickle; Mette Vesterhus et al. (2017). Vascular adhesion protein-1 is elevated in primary sclerosing cholangitis, is predictive of clinical outcome and facilitates recruitment of gut-tropic lymphocytes to liver in a substrate-dependent manner. (ekstern lenke)
• Elisabeth M.G. de Vries; Martti Färkkilä; Piotr Milkiewicz et al. (2017). Enhanced liver fibrosis test predicts transplant-free survival in primary sclerosing cholangitis, a multi-centre study. (ekstern lenke)
• Mette Vesterhus; Anders Holm; Johannes Espolin Roksund Hov et al. (2017). Novel serum and bile protein markers predict primary sclerosing cholangitis disease severity and prognosis. (ekstern lenke)
• Johannes Espolin Roksund Hov; Kirsten Muri Boberg; Eli Taraldsrud et al. (2017). Antineutrophil antibodies define clinical and genetic subgroups in primary sclerosing cholangitis. (ekstern lenke)
• Sebastian Torben Jendrek; Daniel Gotthardt; Thomas Nitzsche et al. (2017). Anti-GP2 IgA autoantibodies are associated with poor survival and cholangiocarcinoma in primary sclerosing cholangitis. (ekstern lenke)
• Silje Fjellgård Jørgensen; Marius Trøseid; Martin Kummen et al. (2016). Altered gut microbiota profile in common variable immunodeficiency associates with levels of lipopolysaccharide and markers of systemic immune activation. (ekstern lenke)
• Martin Kummen; Mette Vesterhus; Marius Trøseid et al. (2016). Elevated trimethylamine-N-oxide (TMAO) is associated with poor prognosis in primary sclerosing cholangitis patients with normal liver function. (ekstern lenke)
• Anesa Mulabecirovic; Anders Batman Mjelle; Mette Vesterhus et al. (2016). In Vitro Comparison of Five Different Elastography Systems for Clinical Applications, Using Strain and Shear Wave Technology. (ekstern lenke)
• Anders Batman Mjelle; Anesa Mulabecirovic; Trygve Hausken et al. (2016). Ultrasound and point shear wave elastography in livers of patients with primary sclerosing cholangitis. (ekstern lenke)
• Anesa Mulabecirovic; Mette Vesterhus; Odd Helge Gilja et al. (2016). In vitro comparison of five different elastography systems for clinical applications, using strain and shear wave technology. (ekstern lenke)
• Martin Kummen; Kristian Holm; Jarl Andreas Anmarkrud et al. (2016). The gut microbial profile in patients with primary sclerosing cholangitis is distinct from patients with ulcerative colitis without biliary disease and healthy controls. (ekstern lenke)
• Mette Vesterhus; Espen Melum (2016). Prognostic biomarkers and surrogate end points in PSC.. (ekstern lenke)
• Serge J. Zweers; Alexey Shiryaev; Mina Komuta et al. (2016). Elevated interleukin-8 in bile of patients with primary sclerosing cholangitis. (ekstern lenke)
• Mette Vesterhus; Johannes Espolin Roksund Hov; Anders Holm et al. (2015). Enhanced liver fibrosis score predicts transplant-free survival in primary sclerosing cholangitis. (ekstern lenke)
• Helge Ræder; Fiona E. McAllister; Erling Tjora et al. (2014). Carboxyl-ester lipase maturity-onset diabetes of the young is associated with development of pancreatic cysts and upregulated MAPK signaling in secretin-stimulated duodenal fluid. (ekstern lenke)
• Tom Hemming Karlsen; Mette Vesterhus; Kirsten Muri Boberg (2014). Review article: Controversies in the management of primary biliary cirrhosis and primary sclerosing cholangitis. (ekstern lenke)
• Helge Ræder; Mette Vesterhus; Abdelfattah El Ouaamari et al. (2013). Absence of diabetes and pancreatic exocrine dysfunction in a transgenic model of carboxyl-ester lipase-MODY (Maturity-Onset Diabetes of the young). (ekstern lenke)
• Bente Berg Johansson; Janniche Torsvik; Lise Bjørkhaug et al. (2011). Diabetes and pancreatic exocrine dysfunction due to mutations in the carboxyl ester lipase gene-maturity onset diabetes of the young (CEL-MODY) A PROTEIN MISFOLDING DISEASE. (ekstern lenke)
• Ingfrid S. Haldorsen; Helge Ræder; Mette Vesterhus et al. (2011). The role of pancreatic imaging in monogenic diabetes. (ekstern lenke)
• Mette Vesterhus; Helge Ræder; Amarnath J Kurpad et al. (2010). Pancreatic Function in Carboxyl-Ester Lipase Knockout Mice. (ekstern lenke)
• Mette Vesterhus; Ingfrid Salvesen Haldorsen; Helge Ræder et al. (2008). Reduced pancreatic volume in hepatocyte nuclear factor 1A-maturity-onset diabetes of the young. (ekstern lenke)
• Mette Vesterhus; Helge Ræder; Stefan Johansson et al. (2008). Pancreatic Exocrine Dysfunction in Maturity-Onset Diabetes of the Young Type 3. (ekstern lenke)
• Ingfrid Salvesen Haldorsen; Mette Vesterhus; Helge Ræder et al. (2008). Lack of pancreatic body and tail in HNF1B mutation carriers. (ekstern lenke)
• Mette Vesterhus; Helge Ræder; Harald Aurlien et al. (2008). Neurological features and enzyme therapy in patients with endocrine and exocrine pancreas dysfunction due to CEL mutations. (ekstern lenke)

Vitenskapelig bokkapittel

• Anders Batman Mjelde; Trygve Hausken; Tom Hemming Karlsen et al. (2015). Point shear wave elastography of the liver in primary sclerosing cholangitis.. (ekstern lenke)

Vitenskapelig litteraturgjennomgang

• Holmfridur Helgadottir; Mette Nåmdal Vesterhus (2023). Noninvasive evaluation of fibrosis in adult biliary diseases. (ekstern lenke)
• Jeffrey V. Lazarus; Henry E. Mark; Quentin M. Anstee et al. (2021). Advancing the global public health agenda for NAFLD: a consensus statement. (ekstern lenke)
• Mette Nåmdal Vesterhus; Kristine Wiencke; John Willy Haukeland et al. (2021). Klinisk oversiktsartikkel: Diagnostikk og behandling av autoimmun hepatitt. (ekstern lenke)
• Ansgar W. Lohse; Marcial Sebode; Marianne H. Jørgensen et al. (2020). Second-line and third-line therapy for autoimmune hepatitis: A position statement from the European Reference Network on Hepatological Diseases and the International Autoimmune Hepatitis Group. (ekstern lenke)
• Mette Vesterhus; Tom Hemming Karlsen (2020). Emerging therapies in primary sclerosing cholangitis: pathophysiological basis and clinical opportunities. (ekstern lenke)
• Tom Hemming Karlsen; Trine Folseraas; Douglas Thorburn et al. (2017). Primary sclerosing cholangitis - a comprehensive review. (ekstern lenke)
• Ingfrid S. Haldorsen; Helge Ræder; Mette Vesterhus et al. (2012). The role of pancreatic imaging in monogenic diabetes mellitus. (ekstern lenke)

Se en fullstendig oversikt over publikasjoner i NVA.

• Strategic Prospective Scandinavian PSC Biobank (National PI)
• Nasjonalt nettverk for autoimmune leversykdommer (PI)
• Biomarkers of prognosis and disease activity in primary sclerosing cholangitis