Eg har doktorgrad (PhD) frå UiB (2004) der eg undersøkte molekylære mekanismar for hormonproduksjon og cellevekstkontroll. Eg har sidan jobba for å finne ut av molekylære mekanismar som ligg til grunn for cellevekst og legemiddelresistens, og for å utvikle betre behandlingar mot ulike former av kreft. Eg er for tida forskar i gruppa til professor Lars Herfindal ved Senter for farmasi. Gruppa arbeider i hovudsak med legemiddelutvikling, med fokus på nye kreftlegemiddel, ved mellom anna å nytte seg av nanobærarar.

Mitt hovudfokus er utvikling av nye terapiar spesielt retta mot born med kreft. Gjennom prosjektet PICCA2 bidreg eg med å identifisere molekylære kjenneteikn til kreftsjukdomen, følgje korleis sjukdomen utviklar seg og til å identifisere nye terapiar. Hovudmålet for prosjektet er å utvikle nye terapiar som tek sikte på å gje kvar enkelt pasient den mest effektive og skånsame behandlinga.

Vitenskapelig artikkel

• Aurelia Eva Lewis; Reidun Aesoy; Marit Bakke (2016). Role of EPAC in cAMP-mediated actions in adrenocortical cells. (ekstern lenke)
• Etienne Auvert; Reidun Aesoy; Francis Giraud et al. (2022). Synthesis of new pyrazolo[4,3-a]phenanthridine Pim-1 inhibitors and evaluation of their cytotoxic activity towards the MOLM-13 acute myeloid leukemia cell line. (ekstern lenke)
• Elvar Örn Viktorsson; Reidun Aesoy; Sindre Støa et al. (2021). New prodrugs and analogs of the phenazine 5,10-dioxide natural products iodinin and myxin promote selective cytotoxicity towards human acute myeloid leukemia cells. (ekstern lenke)
• Ingeborg Nerbø Reiten; Reidun Æsøy; Jan-Lukas Førde et al. (2025). Phenazine 5,10-dioxide analogues as potential therapeutics in AML: Efficacy on patient-derived blasts, in zebrafish larvae xenografts and synergy with venetoclax. (ekstern lenke)
• Elvar Örn Viktorsson; Bendik Melling Grøthe; Reidun Aesoy et al. (2017). Total synthesis and antileukemic evaluations of the phenazine 5,10-dioxide natural products iodinin, myxin and their derivatives. (ekstern lenke)
• Eirik Johansson Solum; Trond Vidar Hansen; Reidun Aesoy et al. (2020). New CDK8 inhibitors as potential anti-leukemic agents – Design, synthesis and biological evaluation. (ekstern lenke)
• Reidun Æsøy; Betzabe Chavez Sanchez; Jens Henrik Norum et al. (2008). An autocrine VEGF/VEGFR2 and p38 signaling loop confers resistance to 4-hydroxytamoxifen in MCF-7 breast cancer cells. (ekstern lenke)
• Kathrine Sivertsen Åsrud; Line Pedersen; Reidun Aesoy et al. (2019). Mice depleted for Exchange Proteins Directly Activated by cAMP (Epac) exhibit irregular liver regeneration in response to partial hepatectomy. (ekstern lenke)
• Erling Andre Høivik; Linda Aumo; Reidun Æsøy et al. (2008). Deoxyribonucleic acid methylation controls cell type-specific expression of steroidogenic factor 1. (ekstern lenke)
• Goraksha Machhindra Khose; Siva Krishna Vagolu; Reidun Aesoy et al. (2025). Functionalized regioisomers of the natural product phenazines myxin and iodinin as potent inhibitors of Mycobacterium tuberculosis and human acute myeloid leukemia cells. (ekstern lenke)
• Reidun Aesoy; Haruna Muwonge; Kathrine Sivertsen Åsrud et al. (2018). Deletion of exchange proteins directly activated by cAMP (Epac) causes defects in hippocampal signaling in female mice. (ekstern lenke)
• Johan Lund; Anne L. Jacob; Reidun Æsøy et al. (1998). Biochemical and functional analysis of nuclear receptors as targets in cAMP-dependent control of bovine CYP17. (ekstern lenke)
• Théo Frazier; Elisabeth Pereira; Reidun Aesoy et al. (2024). Synthesis, kinase inhibition and anti-leukemic activities of diversely substituted indolopyrazolocarbazoles. (ekstern lenke)
• Ronja Bjørnstad; Reidun Aesoy; Øystein Bruserud et al. (2019). A kinase inhibitor with anti-Pim kinase activity is a potent and selective cytotoxic agent toward acute myeloid leukemia. (ekstern lenke)
• Kari Skjånes; Reidun Aesoy; Lars Herfindal et al. (2021). Bioactive peptides from microalgae: Focus on anti-cancer and immunomodulating activity. (ekstern lenke)
• Edvin Tang Gundersen; Zhiqiang Wang; Jan-Lukas Førde et al. (2025). Repurposing chlorpromazine for anti-leukaemic therapy with the drug-in-cyclodextrin-in-liposome nanocarrier platform. (ekstern lenke)
• Reidun Æsøy; Katarina Gradin; Kathrine Sivertsen Åsrud et al. (2014). Regulation of CDKN2B expression by interaction of Arnt with Miz-1 - a basis for functional integration between the HIF and Myc gene regulatory pathways. (ekstern lenke)
• Ravn Fritdtjov Edland; Anita Wergeland; Reidun Kristin Kopperud et al. (2016). Long-term consumption of an obesogenic high fat diet prior to ischemia-reperfusion mediates cardioprotection via Epac1-dependent signaling. (ekstern lenke)
• Malin Wickström; Kristina Viktorsson; Lovisa Lundholm et al. (2010). The alkylating prodrug J1 can be activated by aminopeptidase N, leading to a possible target directed release of melphalan. (ekstern lenke)
• Rune Slimestad; Bendik Auran Rathe; Reidun Aesoy et al. (2022). A novel bicyclic lactone and other polyphenols from the commercially important vegetable Anthriscus cerefolium. (ekstern lenke)
• Reidun Æsøy; Gunnar Mellgren; Ken-Ichirou Morohashi et al. (2002). Activation of cAMP-dependent protein kinase increases the protein level of steroidogenic factor-1. (ekstern lenke)

Doktorgradsavhandling

• Reidun Æsøy (2004). Modifications of transcriptional regulation by protein-protein interactions and signal transduction. (ekstern lenke)

Vitenskapelig litteraturgjennomgang

• Reidun Æsøy; Colin D. Clyne; Ashwini L. Chand (2015). Insights into Orphan Nuclear Receptors as Prognostic Markers and Novel Therapeutic Targets for Breast Cancer.. (ekstern lenke)
• David P. Fewer; Jouni Jokela; Lassi Heinilä et al. (2021). Chemical diversity and cellular effects of antifungal cyclic lipopeptides from cyanobacteria. (ekstern lenke)
• Johan Lund; Bente Børud; Gunnar Mellgren et al. (2002). Differential regulation of SF-1-cofactor interactions. (ekstern lenke)

Konferanseposter

• Constance De Montlaur; Reidun Æsøy; Annette Brenner et al. (2022). Precision medicine in childhood cancer - a representative case of neuroblastoma. (ekstern lenke)

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