Aurora Martinez is the leader of the research group Biorecognition that studies the relation between biomolecular structure and function to understand and develop new therapeutic options for genetic diseases, notably neurometabolic disorders such as phenylketonuria (PKU) and defects in dopamine synthesis.

Aurora is also a partner in the KG Jebsen Centre for neuropsychiatric disorders. In addition, she is also a partner in the project 'Molecular control of Arc protein: Decoding a master regulator of synaptic plasticity and cognition', coordinated by Clive Bramham, which received support from the Toppforsk Program (NFR).

MEDOD1

MEDOD2

2024

• K C, Kunwar Jung; Tristán-Noguero, Alba; Altankhuyag, Altanchimeg et al. (2024). Tetrahydrobiopterin (BH<inf>4</inf>) treatment stabilizes tyrosine hydroxylase: Rescue of tyrosine hydroxylase deficiency phenotypes in human neurons and in a knock-in mouse model. (external link)
• Thöny, B.; Ng, J.; Kurian, M.A. et al. (2024). Mouse models for inherited monoamine neurotransmitter disorders. (external link)
• Martin-Malpartida, Pau; Torner, Carles; Martinez, Aurora et al. (2024). TPPU_DSF: A Web Application to Calculate Thermodynamic Parameters Using DSF Data. (external link)
• Himmelreich, Nastassja; Ramón-Maiques, Santiago; Navarrete, Rosa et al. (2024). Significance of utilizing in silico structural analysis and phenotypic data to characterize phenylalanine hydroxylase variants: A PAH landscape. (external link)
• Tai, Mary Dayne Sia; Gamiz-Arco, Gloria; Martinez, Aurora (2024). Dopamine synthesis and transport: current and novel therapeutics for parkinsonisms. (external link)

2023

• Makris, Georgios; Kayhan, Semih; Kreuzer, Marvin et al. (2023). Impact of small molecule-mediated inhibition of ammonia detoxification on lung malignancies and liver metabolism. (external link)
• Wormdahl, Sofie Breisnes; Kleppe, Rune; Martinez, Aurora et al. (2023). Effect of simulated saturation diving on dopamine synthesis regulation. (external link)
• Mahmud, Md Ekhtear; Støve, Svein Isungset; Martinez, Aurora (2023). Towards the therapeutic correction of mitochondrial Complex I deficiency in dopaminergic cell models. (external link)
• Bustad, Helene J.; Sæter, Marthe Christie; Laitaoja, Mikko et al. (2023). One ring closer to a closure: the crystal structure of the ES<inf>3</inf> hydroxymethylbilane synthase intermediate. (external link)
• Brokstad, Kristine Kippersund; Støve, Svein Isungset; Martinez, Aurora (2023). Screening for VMAT2 chaperones and activity modulators. (external link)

See a complete overview of publications in Cristin.