Gjertsen is Director at KG Jebsen Centre of Myeloid Blood Cancer. He served as co-Director for Centre for Cancer Biomarkers (CCBIO) Norwegian Centre of Excellence, University of Bergen, 2016–2022. In 2010-2018, he developed the phase I clinical trials unit at Haukeland University Hospital. His clinical practice is focused on clinical trials in CML and AML, and several early phase clinical trials in AML has been established with single cell biomarker programs for disease profiling and response evaluation. His laboratory is working on intracellular signal transduction, single cell analysis and immune cell profiling for early response evaluation. In 2024 Gjertsen was awarded a five-year KG Jebsen Centre for Myeloid Blood Cancer, focused on signalling targeted therapy guided by single cell signalling profiles tumor and immune cells. Funding support: Norwegian Cancer Society, the Helse Vest Health Trust, the Research Council of Norway, EU TRANSCAN-3 and ERA PerMed. Dr. Gjertsen is founding member and chair of the Norwegian AML Group and the Nordic AML Group, and is member of the Nordic CML Study Group.

2025

• Gullaksen, Stein-Erik; Omsland, Maria; Brevik, Mathias et al. (2025). CML stem cells and their interactions and adaptations to tyrosine kinase inhibitors. (external link)
• Gavasso, Sonia; Haugsøen, Jonas Bull; Kleftogiannis, Dimitrios et al. (2025). High-dimensional Immune Profiling Following Autologous Hematopoietic Stem Cell Transplantation in Relapsing-Remitting Multiple Sclerosis. (external link)
• Loges, Sonja; Heuser, Michael; Chromik, Jörg et al. (2025). Bemcentinib as monotherapy and in combination with low-dose cytarabine in acute myeloid leukemia patients unfit for intensive chemotherapy: a phase 1b/2a trial. (external link)
• Gladkauskas, Titas; Cristea, Ileana; Mehrasa, Roya et al. (2025). Temperature as a Key Modulator: Investigating Phosphorylation Patterns of p.Asn666 PDGFRB Variants and Their Role in Downstream Signaling. (external link)

2024

• Caulier, Benjamin William; Joaquina, Sandy; Gelebart, Pascal Francois et al. (2024). CD37 is a safe chimeric antigen receptor target to treat acute myeloid leukemia. (external link)
• Flygt, Hjalmar; Söderlund, Stina; Richter, Johan et al. (2024). Correction to: Treatment-free remission after a second TKI discontinuation attempt in patients with Chronic Myeloid Leukemia re-treated with dasatinib – interim results from the DAstop2 trial (Leukemia, (2024), 10.1038/s41375-024-02145-6). (external link)
• Kleftogiannis, Dimitrios; Gavasso, Sonia; Tislevoll, Benedicte Sjo et al. (2024). Automated cell type annotation and exploration of single-cell signaling dynamics using mass cytometry. (external link)
• Cuminetti, Vincent; Konieczny, Joanna; Mera, Aurora Bernal et al. (2024). Succinate receptor 1 signaling regulates hematopoiesis via S100/a8 and S100/a9 in health and malignancy. (external link)
• Hemminki, Kari; Zitricky, Frantisek; Försti, Asta et al. (2024). Age-specific survival in acute myeloid leukemia in the Nordic countries through a half century. (external link)
• Helland, Åslaug; Steinskog, Eli Sihn Samdal; Blix, Egil Støre et al. (2024). Hever kvaliteten på behandling av kreft. (external link)
• Flygt, Hjalmar; Söderlund, Stina; Richter, Johan et al. (2024). Treatment-free remission after a second TKI discontinuation attempt in patients with Chronic Myeloid Leukemia re-treated with dasatinib – interim results from the DAstop2 trial. (external link)
• Venanzi, Alessandra; Cardinali, Valeria; Perriello, Vincenzo et al. (2024). Starry sky pattern predicts RAS pathway activation in NPM1-mutated acute myeloid leukemia. (external link)
• Lygre, Kristin Bentung; Forthun, Rakel Brendsdal; Høysæter, Trude et al. (2024). Assessment of postoperative circulating tumour DNA to predict early recurrence in patients with stage I–III right-sided colon cancer: prospective observational study. (external link)
• Ha, Trung Quang; Andresen, Vibeke; Erikstein, Bjarte Skoe et al. (2024). Preclinical activity of resazurin in acute myeloid leukaemia. (external link)
• Eldfors, Samuli; Saad, Joseph; Ikonen, Nemo et al. (2024). Monosomy 7/del(7q) cause sensitivity to inhibitors of nicotinamide phosphoribosyltransferase in acute myeloid leukemia. (external link)
• Sefland, Øystein; Gullaksen, Stein-Erik; Omsland, Maria et al. (2024). Mass cytometric single cell immune profiles of peripheral blood from acute myeloid leukemia patients in complete remission with measurable residual disease. (external link)
• Khan, Alesia A.; James, Daniel; Andresen, Vibeke et al. (2024). Pre-B acute lymphoblastic leukemia presenting with NPM1 and FLT3 mutations. (external link)

2023

• Falini, Brunangelo; Gjertsen, Bjørn Tore; Andresen, Vibeke (2023). The acidic stretch and the C-terminal nuclear export signal motif of NPM1 mutant: are they druggable in AML?. (external link)
• Skarstein, Andreas Tvedt; Hoang, Tuyen; Haugen, Hallvard et al. (2023). In vitro Study of STAT3-inhibitors in Drug-Resistant Chronic Myeloid Leukemia (CML). (external link)
• Thomsen, Liv Cecilie Vestrheim; Honore, Alfred; Gjertsen, Bjørn Tore et al. (2023). A prospective non-randomized phase I trial of dendritic cell–based cryoimmunotherapy combined with checkpoint inhibitors in mCRPC.. (external link)
• Thomsen, Liv Cecilie Vestrheim; Honore, Alfred; Reisæter, Lars Anders Rokne et al. (2023). Survival and biomarkers in a prospective non-randomized phase I trial of dendritic cell-based cryoimmunotherapy combined with checkpoint inhibitors in metastatic castration-resistant prostate cancer (mCRPC). (external link)
• Tettero, Jesse M.; Buisman, Yara; Ngai, Lok Lam et al. (2023). Prognostic Significance of Measurable Residual Disease Detection by Flow Cytometry in Autologous Stem Cell Apheresis Products in AML. (external link)
• Geelen, Inge G.P.; Gullaksen, Stein-Erik; Ilander, Mette M. et al. (2023). Switching from imatinib to nilotinib plus pegylated interferon-α2b in chronic phase CML failing to achieve deep molecular response: clinical and immunological effects. (external link)
• Hokland, Peter; Fernández, Isolda I.; Freeman, Sylvie D. et al. (2023). AML in the elderly—A global view. (external link)
• Thomsen, Liv Cecilie Vestrheim; Honore, Alfred; Reisæter, Lars Anders Rokne et al. (2023). A phase I prospective, non-randomized trial of autologous dendritic cell-based cryoimmunotherapy in patients with metastatic castration-resistant prostate cancer. (external link)
• Fløisand, Yngvar; Remberger, Mats; Bigalke, Iris et al. (2023). WT1 and PRAME RNA-loaded dendritic cell vaccine as maintenance therapy in de novo AML after intensive induction chemotherapy. (external link)
• Thomsen, Liv Cecilie Vestrheim; Honore, Alfred; Reisæter, Lars Anders Rokne et al. (2023). Survival and biomarkers in a prospective non-randomized phase I trial of dendritic cell-based cryoimmunotherapy combined with checkpoint inhibitors in metastatic castration-resistant prostate cancer (mCRPC). (external link)
• Rosti, Gianantonio; Brümmendorf, Tim H.; Gjertsen, Bjørn Tore et al. (2023). Impact of age and comorbidities on the efficacy and tolerability of bosutinib in previously treated patients with chronic myeloid leukemia: results from the phase 4 BYOND study. (external link)
• Ngai, Lok Lam; Hanekamp, Diana; Janssen, Fleur et al. (2023). Prospective validation of the prognostic relevance of CD34⁺CD38^– AML stem cell frequency in the HOVON-SAKK132 trial. (external link)
• Tettero, Jesse M.; Ngai, Lok Lam; Bachas, Costa et al. (2023). Measurable residual disease-guided therapy in intermediate-risk acute myeloid leukemia patients is a valuable strategy in reducing allogeneic transplantation without negatively affecting survival. (external link)
• Falini, Brunangelo; Martelli, Maria Paola; Brunetti, Lorenzo et al. (2023). The NPM1 mutant defines AML irrespective of blast count. (external link)
• Tislevoll, Benedicte Sjo; Hellesøy, Monica; Fagerholt, Oda Helen Eck et al. (2023). Author Correction: Early response evaluation by single cell signaling profiling in acute myeloid leukemia (Nature Communications, (2023), 14, 1, (115), 10.1038/s41467-022-35624-4). (external link)
• Othman, Jad; Meggendorfer, Manja; Tiacci, Enrico et al. (2023). Overlapping features of therapy-related and de novo NPM1-mutated AML. (external link)
• Tislevoll, Benedicte Sjo; Hellesøy, Monica; Fagerholt, Oda Helen Eck et al. (2023). Early response evaluation by single cell signaling profiling in acute myeloid leukemia. (external link)

2022

• Pianigiani, Giulia; Rocchio, Francesca; Peruzzi, Sara et al. (2022). The absent/low expression of CD34 in NPM1-mutated AML is not related to cytoplasmic dislocation of NPM1 mutant protein. (external link)
• Kleftogiannis, Dimitrios; Tislevoll, Benedicte Sjo; Hellesøy, Monica et al. (2022). Identifying predictors of survival in patients with leukemia using single-cell mass cytometry and machine learning. (external link)
• Tasken, Kjetil; Russnes, Hege Elisabeth Giercksky; Aas, Eline et al. (2022). A national precision cancer medicine implementation initiative for Norway. (external link)
• Tislevoll, Benedicte Sjo; Hellesøy, Monica; Fagerholt, Oda Helen Eck et al. (2022). Early response evaluation by single cell signaling profiling in acute myeloid leukemia. (external link)
• Tettero, Jesse M.; Al-Badri, Waleed K. W.; Ngai, Lok Lam et al. (2022). Concordance in measurable residual disease result after first and second induction cycle in acute myeloid leukemia: An outcome- and cost-analysis. (external link)
• Jenssen, Astrid Bjørke; Mohamed-Ahmed, Samih Salah Eldin Mahgoub; Kankuri, Esko et al. (2022). Administration Methods of Mesenchymal Stem Cells in the Treatment of Burn Wounds. (external link)
• Helland, Åslaug; Russnes, Hege Elisabeth Giercksky; Fagereng, Gro Live et al. (2022). Correction to: Improving public cancer care by implementing precision medicine in Norway: IMPRESS-Norway (Journal of Translational Medicine, (2022), 20, 1, (225), 10.1186/s12967-022-03432-5). (external link)
• Helland, Åslaug; Russnes, Hege Elisabeth Giercksky; Fagereng, Gro Live et al. (2022). Improving public cancer care by implementing precision medicine in Norway: IMPRESS-Norway. (external link)
• Huuhtanen, Jani; Ilander, Mette; Yadav, Bhagwan et al. (2022). IFN-α with dasatinib broadens the immune repertoire in patients with chronic-phase chronic myeloid leukemia. (external link)

2021

• Kreitman, Robert J.; Dearden, Claire; Zinzani, Pier Luigi et al. (2021). Moxetumomab pasudotox in heavily pre-treated patients with relapsed/refractory hairy cell leukemia (HCL): long-term follow-up from the pivotal trial. (external link)
• Jaffredo, Thierry; Balduini, Alessandra; Bigas, Anna et al. (2021). The eha research roadmap: normal hematopoiesis. (external link)
• Johansen, Silje; Lægreid, Ingvild Jenssen; Ernstsen, Siw Leiknes et al. (2021). Thrombosis and thrombocytopenia after HPV vaccination. (external link)
• Bakunina, Katerina; Putter, Hein; Versluis, Jurjen et al. (2021). The added value of multi-state modelling in a randomized controlled trial: The HOVON 102 study re-analyzed. (external link)
• Mosleth, Ellen Færgestad; Vedeler, Christian Alexander; Liland, Kristian Hovde et al. (2021). Cerebrospinal fluid proteome shows disrupted neuronal development in multiple sclerosis. (external link)
• Shafiee, Sahba; Gelebart, Pascal Francois; Popa, Mihaela-Lucia et al. (2021). Preclinical characterisation and development of a novel myelodysplastic syndrome-derived cell line. (external link)
• Janssen, Jeroen; Löwenberg, Bob; Manz, Markus et al. (2021). Inferior outcome of addition of the aminopeptidase inhibitor tosedostat to standard intensive treatment for elderly patients with aml and high risk mds. (external link)
• Rana, Neha; Suliman, Salwa; Mohamed-Ahmed, Samih Salah Eldin Mahgoub et al. (2021). Systemic monocyte-macrophage response to co-transplanting mesenchymal stromal cells and biphasic calcium phosphate biomaterial for bone regeneration. (external link)
• Löwenberg, Bob; Pabst, Thomas; Maertens, Johan et al. (2021). Addition of lenalidomide to intensive treatment in younger and middle-aged adults with newly diagnosed AML: The HOVON-SAKK-132 trial. (external link)
• Ngai, Lok Lam; Ma, Connie Y.; Maguire, Orla et al. (2021). Bimodal expression of potential drug target CLL-1 (CLEC12A) on CD34+ blasts of AML patients. (external link)
• Anandan, Shamundeeswari; Thomsen, Liv Cecilie Vestrheim; Gullaksen, Stein-Erik et al. (2021). Phenotypic Characterization by Mass Cytometry of the Microenvironment in Ovarian Cancer and Impact of Tumor Dissociation Methods. (external link)
• Bredrup, Cecilie; Cristea, Ileana; Safieh, Leen Abu et al. (2021). Temperature-dependent autoactivation associated with clinical variability of PDGFRB Asn666 substitutions. (external link)
• Hellesøy, Monica; Engen, Caroline Benedicte Nitter; Grob, Tim et al. (2021). Sex disparity in acute myeloid leukaemia with FLT3 internal tandem duplication mutations: implications for prognosis. (external link)
• Flygt, Hjalmar; Söderlund, Stina; Stentoft, Jesper et al. (2021). Long-term tolerability and efficacy after initial PegIFN-α addition to dasatinib in CML-CP: Five-year follow-up of the NordCML007 study. (external link)
• Rana, Neha; Suliman, Salwa; Mohamed-Ahmed, Samih Salah Eldin Mahgoub et al. (2021). Systemic and local innate immune responses to surgical co-transplantation of mesenchymal stromal cells and biphasic calcium phosphate for bone regeneration. (external link)
• Haaland, Ingvild; Hjelle, Sigrun Margrethe; Reikvam, Håkon et al. (2021). p53 Protein Isoform Profiles in AML: Correlation with Distinct Differentiation Stages and Response to Epigenetic Differentiation Therapy. (external link)
• Malani, Disha; Kumar, Kumar Adish; Brück, Oscar et al. (2021). Implementing a Functional Precision Medicine Tumor Board for Acute Myeloid Leukemia. (external link)
• Nordgård, Oddmund; Forthun, Rakel Brendsdal; Lapin, Morten et al. (2021). Liquid Biopsies in Solid Cancers: Implementation in a Nordic Healthcare System. (external link)
• Engen, Caroline; Hellesøy, Monica; Grob, Tim et al. (2021). FLT3-ITD mutations in acute myeloid leukaemia – molecular characteristics, distribution and numerical variation. (external link)
• Sletta, Kristine Yttersian; Marin, Oriol Castells; Gjertsen, Bjørn Tore (2021). Colony stimulating factor 1 receptor in acute myeloid leukemia. (external link)
• Gundersen, Edvin Tang; Førde, Jan-Lukas; Tislevoll, Benedicte Sjo et al. (2021). Repurposing chlorpromazine for anti-leukaemic therapy by nanoparticle encapsulation. (external link)

2020

• Fagerholt, Oda Helen Eck; Hellesøy, Monica; Gullaksen, Stein-Erik et al. (2020). Single cell detection of the p53 protein by mass cytometry. (external link)
• Kleinmanns, Katrin; Bischof, Katharina; Anandan, Shamundeeswari et al. (2020). CD24-targeted fluorescence imaging in patient-derived xenograft models of high-grade serous ovarian carcinoma. (external link)
• Kuusanmäki, Heikki; Leppä, Aino-Maija; Pölönen, Petri et al. (2020). Phenotype-based drug screening reveals association between venetoclax response and differentiation stage in acute myeloid leukemia. (external link)
• Bjånes, Tormod Karlsen; Kotopoulis, Spiros; Murvold, Elsa Thodesen et al. (2020). Ultrasound‐ and microbubble‐assisted gemcitabine delivery to pancreatic cancer cells. (external link)
• Mercatelli, Daniele; Bortolotti, Massimo; Andresen, Vibeke et al. (2020). Early Response to the Plant Toxin Stenodactylin in Acute Myeloid Leukemia Cells Involves Inflammatory and Apoptotic Signaling. (external link)
• Alme, Eirin; Törnroos, Karl Wilhelm; Gjertsen, Bjørn Tore et al. (2020). Synthesis of N-aryl- and N-alkyl-substituted imidazolium silver complexes: Cytotoxic screening by using human cell lines modelling acute myeloid leukaemia. (external link)
• Engen, Caroline Benedicte Nitter; Gjertsen, Bjørn Tore; Bruserud, Øystein et al. (2020). Exploring the boundaries of precision haemato-oncology : The case of FLT3 length mutated acute myeloid leukaemia. (external link)
• Ossenkoppele, G.J.; Breems, D.A.; Stuessi, G. et al. (2020). Correction: Lenalidomide added to standard intensive treatment for older patients with AML and high-risk MDS (Leukemia, (2020), 34, 7, (1751-1759), 10.1038/s41375-020-0725-0). (external link)
• Tambe, Mahesh; Karjalainen, Ella; Vähä-Koskela, Markus et al. (2020). Pan-RAF inhibition induces apoptosis in acute myeloid leukemia cells and synergizes with BCL2 inhibition. (external link)
• Wang, Xiang; Deng, Linhong; Gjertsen, Bjørn Tore (2020). A microfluidic device for differential capture of heterogeneous rare tumor cells with epithelial and mesenchymal phenotypes. (external link)
• Bjørsvik, Hans-René; Gjertsen, Bjørn Tore; Elumalai, Vijayaragavan (2020). Hit to leads with cytotoxic effect in leukemic cells: Total synthesis intermediates as a molecule treasure chest. (external link)
• Tadele, Dagim Shiferaw; Robertson, Joseph; Crispin, Richard et al. (2020). A cell competition-based small molecule screen identifies a novel compound that induces dual c-Myc depletion and p53 activation. (external link)
• Majumder, Muntasir M.; Leppä, Aino-Maija; Hellesøy, Monica et al. (2020). Multi-parametric single cell evaluation defines distinct drug responses in healthy hematologic cells that are retained in corresponding malignant cell types. (external link)
• Haugse, Ragnhild; Langer, Anika; Murvold, Elisa Thodesen et al. (2020). Low-Intensity Sonoporation-Induced Intracellular Signalling of Pancreatic Cancer Cells, Fibroblasts and Endothelial Cells. (external link)
• Onyango, Therese Bredholt; Hjelle, Sigrun Margrethe; Haaland, Ingvild et al. (2020). A comparison of p53 isoform profiles and apoptosis induced by camptothecin or a herbal khat extract (Catha edulis (vahl) forssk. ex endl.) in leukemic cell lines: Exploring cellular responses in therapy development. (external link)
• Omsland, Maria; Andresen, Vibeke; Gullaksen, Stein-Erik et al. (2020). Tyrosine kinase inhibitors and interferon‐α increase tunneling nanotube (TNT) formation and cell adhesion in chronic myeloid leukemia (CML) cell lines (. (external link)
• Ossenkoppele, G.J.; Breems, D.A.; Stuessi, G. et al. (2020). Lenalidomide added to standard intensive treatment for older patients with AML and high-risk MDS. (external link)
• Hochhaus, Andreas; Gambacorti-Passerini, Carlo; Abboud, Camille et al. (2020). Bosutinib for pretreated patients with chronic phase chronic myeloid leukemia: primary results of the phase 4 BYOND study. (external link)

2019

• Forthun, Rakel Brendsdal; Hellesøy, Monica; Sulen, Andre et al. (2019). Modulation of phospho-proteins by interferon-alpha and valproic acid in acute myeloid leukemia. (external link)
• Navarro, Andrea Gras; Espedal, Heidi; Joseph, Justin Vareecal et al. (2019). Pretreatment of glioblastoma with bortezomib potentiates natural killer cell cytotoxicity through TRAIL/DR5 mediated apoptosis and prolongs animal survival. (external link)
• Haugse, Ragnhild; Langer, Anika; Gullaksen, Stein-Erik et al. (2019). Intracellular signaling in key pathways is induced by treatment with ultrasound and microbubbles in a leukemia cell line, but not in healthy peripheral blood mononuclear cells. (external link)
• Bischof, Katharina; Knappskog, Stian; Hjelle, Sigrun Margrethe et al. (2019). Influence of p53 isoform expression on survival in high-grade serous ovarian cancers. (external link)
• Bischof, Katharina; Bjørge, Line; Gjertsen, Bjørn Tore et al. (2019). Rethinking Gynecological High- Grade Serous Carcinoma. Portraying the p53 isoform landscape and development of a new preclinical for optical imaging in xenograft models. (external link)
• Lundevall, Frida Johanne; Bedringaas, Siv Lise; Törnroos, Karl Wilhelm et al. (2019). Synthesis and investigation of Ag-NHC complexes with cytotoxic properties towards cell lines modelling acute myeloid leukemia. (external link)
• Andresen, Vibeke; Gjertsen, Bjørn Tore (2019). Clinical trials of repurposing medicines in acute myeloid leukemia: Limitations and possibilities in the age of precision therapy. (external link)
• Zhang, Beibei; Ayuda-Duran, Maria del Pilar; Piechaczyk, Laure Isabelle et al. (2019). GRP94 rewires and buffers the FLT3-ITD signaling network and promotes survival of acute myeloid leukemic stem cells. (external link)
• Jebsen, Nina Louise; Apelseth, Torunn Oveland; Haugland, Hans Kristian et al. (2019). Enhanced T-lymphocyte infiltration in a desmoid tumor of the thoracic wall in a young woman treated with intratumoral injections of the oncolytic peptide LTX-315: A case report. (external link)
• Gjertsen, Bjørn Tore; Tislevoll, Benedicte Sjo; Fagerholt, Oda Helen Eck et al. (2019). Early response evaluation in AML using mass cytometry. (external link)
• Rahman, Mohummad Aminur; Navarro, Andrea Gras; Brekke, Jorunn et al. (2019). Bortezomib administered prior to temozolomide depletes MGMT, chemosensitizes glioblastoma with unmethylated MGMT promoter and prolongs animal survival. (external link)
• Forthun, Rakel Brendsdal; Hovland, Randi; Schuster, Cornelia et al. (2019). ctDNA detected by ddPCR reveals changes in tumour load in metastatic malignant melanoma treated with bevacizumab. (external link)
• Kreutzman, Anna; Yadav, Bhagwan; Brümmendorf, Tim H. et al. (2019). Immunological monitoring of newly diagnosed CML patients treated with bosutinib or imatinib first-line. (external link)
• Gullaksen, Stein-Erik; Bader, Lucius; Hellesøy, Monica et al. (2019). Titrating complex mass cytometry panels. (external link)
• Grønningsæter, Ida Sofie; Fredly, Hanne Kristin; Gjertsen, Bjørn Tore et al. (2019). Systemic Metabolomic Profiling of Acute Myeloid Leukemia Patients before and During Disease-Stabilizing Treatment Based on All-Trans Retinoic Acid, Valproic Acid, and Low-Dose Chemotherapy.. (external link)

2018

• Nepstad, Ina; Hatfield, Kimberley Joanne; Aasebø, Elise et al. (2018). Two acute myeloid leukemia patient subsets are identified based on the constitutive PI3K-Akt-mTOR signaling of their leukemic cells; a functional, proteomic and transcriptomic comparison. (external link)
• Gullaksen, Stein-Erik; Gjertsen, Bjørn Tore; Kirkeleit, Jorunn et al. (2018). Single cell signalling and immune profiles in chronic myeloid leukaemia. (external link)
• Kirkeleit, Jorunn; Riise, Trond; Bjørge, Tone et al. (2018). Maternal exposure to gasoline and exhaust increases the risk of childhood leukaemia in offspring - a prospective study in the Norwegian Mother and Child Cohort Study. (external link)
• Gjerde, Cecilie Gudveig; Mustafa, Kamal Babikeir Eln; Hellem, Sølve et al. (2018). Cell therapy induced regeneration of severely atrophied mandibular bone in a clinical trial.. (external link)
• Omsland, Maria; Pise-Masison, Cynthia A.; Fujikawa, Dai et al. (2018). Inhibition of tunneling nanotube (TNT) formation and Human T-cell leukemia virus type 1 (HTLV-1) transmission by cytarabine. (external link)
• Reikvam, Håkon; Skavland, Jørn; Gullaksen, Stein-Erik et al. (2018). Chronic Myeloid Leukemia Relapsing 25 Years after Allogenic Stem Cell Transplantation. (external link)
• Bischof, Katharina; Knappskog, Stian; Stefansson, Ingunn et al. (2018). High expression of the p53 isoform ? is associated with reduced progression-free survival in uterine serous carcinoma. (external link)
• Jørgensen, Katarina Mariann; Mosleth, Ellen Færgestad; Liland, Kristian Hovde et al. (2018). Gene expression response in peripheral blood cells of petroleum workers exposed to sub-ppm benzene levels. (external link)
• Kreitman, Robert J.; Dearden, Claire; Zinzani, Pier Luigi et al. (2018). Moxetumomab pasudotox in relapsed/refractory hairy cell leukemia. (external link)
• Brattås, Marte Karen; Lilleeng, Kyrre Flattun; Hovland, Randi et al. (2018). Philadelphia chromosome positive AML arising from JAK2-positive myelofibrosis. (external link)

2017

• Lowenberg, Bob; Pabst, Thomas; Maertens, Johan et al. (2017). Therapeutic value of clofarabine in younger and middle-aged (18-65 years) adults with newly diagnosed AML. (external link)
• Sopper, Sieghart; Mustjoki, Satu; White, Deborah et al. (2017). Reduced CD62L expression on T cells and increased soluble CD62L levels predict molecular response to tyrosine kinase inhibitor therapy in early chronic-phase chronic myelogenous leukemia. (external link)
• Sopper, Sieghart; Mustjoki, Satu; Gjertsen, Bjørn Tore et al. (2017). NK cell dynamics and association with molecular response in early chronic phase chronic myelogenous leukemia (CML-CP) patients treated with nilotinib. (external link)
• Laukkanen, S; Grönroos, T; Pölönen, P et al. (2017). In silico and preclinical drug screening identifies dasatinib as a targeted therapy for T-ALL. (external link)
• Andresen, Vibeke; Gjertsen, Bjørn Tore (2017). Drug Repurposing for the Treatment of Acute Myeloid Leukemia. (external link)
• Forthun, Rakel Brendsdal; Aasebø, Elise; Rasinger, Josef Daiel et al. (2017). Phosphoprotein DIGE profiles reflect blast differentiation, cytogenetic risk stratification, FLT3/NPM1 mutations and therapy response in acute myeloid leukaemia. (external link)
• Kotopoulis, Spiros; Stigen, Endre; Popa, Mihaela Lucia et al. (2017). Sonoporation with Acoustic Cluster Therapy (ACT®) induces transient tumour volume reduction in a subcutaneous xenograft model of pancreatic ductal adenocarcinoma. (external link)
• Karjalainen, Riikka; Popa, Mihaela Lucia; Liu, M et al. (2017). Stroma-derived factors stimulate JAK/STAT signaling in AML cells resulring in resistance to BCL2 inhibitor Venetoclax. (external link)
• Kontro, Mika; Kumar, Anil; Majumder, Muntasir Mamun et al. (2017). HOX gene expression predicts response to BCL-2 inhibition in acute myeloid leukemia. (external link)
• Sabir, Misbah; Hellesøy, Monica; Kivioja, Jarno et al. (2017). development of novel Highly Specific FLT3 Targeted Inhibitors for Combination or Sequential Therapy of Acute Myeloid Leukemia. (external link)
• Reikvam, Håkon; Hovland, Randi; Forthun, Rakel Brendsdal et al. (2017). Disease-stabilizing treatment based on all-trans retinoic acid and valproic acid in acute myeloid leukemia - identification of responders by gene expression profiling of pretreatment leukemic cells. (external link)
• Jebsen, Nina Louise; Scarlett, Samantha; Magnusdottir, Bergrun Tinna et al. (2017). Biomarker Panels and Contemporary Practice in Clinical Trials of Targeted Therapy. (external link)
• Gullaksen, Stein-Erik; Skavland, Jørn; Gavasso, Sonia et al. (2017). Single cell immune profiling by mass cytometry of newly diagnosed chronic phase chronic myeloid leukemia treated with nilotinib. (external link)
• Gjertsen, Bjørn Tore (2017). Proteomics and single cell immune and signaling profiling of myeloid leukemia. (external link)
• Forthun, Rakel Brendsdal; Sulen, Andre; Sjøholt, Gry et al. (2017). combination of interferon-alpha and valproic acid in acute myeloid leukemia cells in vitro and in vivo. (external link)
• Ayuda-Duran, Maria del Pilar; Zhang, B; Piechaczyck, L. et al. (2017). a precision medicin platform for acute myeloid leukemia to help unraveling the molecular addictions of FLT3-ITD-driven AML. (external link)
• Omsland, Maria; Bruserud, Øystein; Gjertsen, Bjørn Tore et al. (2017). Tunneling nanotube (TNT) formation is downregulated by cytarabine and NF-KB inhibition in acute myeloid leukemia (AML). (external link)
• Rajala, Hanna L.M.; Missiry, Mohamed El; Ruusila, Anniina et al. (2017). Tyrosine kinase inhibitor therapy-induced changes in humoral immunity in patients with chronic myeloid leukemia. (external link)
• Karjalainen, Riikka; Pemovska, Tea; Popa, Mihaela Lucia et al. (2017). JAK1/2 and BCL2 inhibitors synergize to counteract bone marrow stromal cell-induced protection of AML. (external link)

2016

• Thielen, Noortje; Richter, Johan; Baldauf, Matthias et al. (2016). Leukemic stem cell quantification in newly diagnosed patients with chronic myeloid leukemia predicts response to nilotinib therapy. (external link)
• Dimcevski, Georg Gjorgji; Kotopoulis, Spiros; Bjånes, Tormod Karlsen et al. (2016). A human clinical trial using ultrasound and microbubbles to enhance gemcitabine treatment of inoperable pancreatic cancer. (external link)
• Engen, Caroline Benedicte Nitter; Hajjar, Ehsan; Gjertsen, Bjørn Tore (2016). Development of personalized molecular therapy for acute myeloid leukemia. (external link)
• Kotopoulis, Spiros; Dimcevski, Georg Gjorgji; Cormack, Emmet Mc et al. (2016). Ultrasound- and microbubble-enhanced chemotherapy for treating pancreatic cancer: A phase I clinical trial. (external link)
• Sulen, Andre; Lygre, Stein Håkon Låstad; Hjelle, Sigrun Margrethe et al. (2016). Elevated monocyte phosphorylated p38 in nearby employees after a chemical explosion. (external link)
• Helland, Øystein; Popa, Mihaela Lucia; Bischof, Katharina et al. (2016). The HDACi panobinostat shows growth inhibition both in vitro and in a bioluminescent orthotopic surgical xenograft model of ovarian cancer. (external link)
• Sulen, Andre; Gullaksen, Stein-Erik; Bader, Lucius et al. (2016). Signaling effects of sodium hydrosulfide in healthy donor peripheral blood mononuclear cells. (external link)
• Sulen, Andre; Gjertsen, Bjørn Tore (2016). Leukocyte p38 and p53 proteins after environmental exposure; variation, associations and applicability. (external link)
• Leitch, Calum; Osdal, Tereza; Andresen, Vibeke et al. (2016). Hydroxyurea synergizes with valproic acid in wild-type p53 acute myeloid leukaemia. (external link)
• Andresen, Vibeke; Erikstein, Bjarte Skoe; Mukherjee, Herschel et al. (2016). Anti-proliferative activity of the NPM1 interacting natural product avrainvillamide in acute myeloid leukemia. (external link)
• Kotopoulis, Spiros; Dimcevski, Georg Gjorgji; McCormack, Emmet et al. (2016). Ultrasound- and microbubble-enhanced chemotherapy for treating pancreatic cancer: a phase I clinical trial. (external link)
• Gavasso, Sonia; Gullaksen, Stein-Erik; Skavland, Jørn et al. (2016). Single-cell proteomics: Potential implications for cancer diagnostics. (external link)
• Hjorth-Hansen, Henrik; Stentoft, Jesper; Richter, Johan et al. (2016). Safety and efficacy of the combination of pegylated interferon-α2b and dasatinib in newly diagnosed chronic-phase chronic myeloid leukemia patients. (external link)

2015

• Kotopoulis, Spiros; Popa, Mihaela Lucia; Safont, MJ et al. (2015). Sonoporation using Acoustic Cluster Therapy in combination With chemotherapy transiently reduces tumour volume.. (external link)
• Sandtorv, Alexander Harald; Leitch, Calum; Bedringaas, Siv Lise et al. (2015). 4-alkylated silver-N-heterocyclic carbene (NHC) complexes with cytotoxic effects in leukemia cells. (external link)
• Bruserud, Øystein; Reikvam, Håkon; Fredly, Hanne Kristin et al. (2015). Expression of the potential therapeutic target CXXC5 in primary acute myeloid leukemia cells - high expression is associated with adverse prognosis as well as altered intracellular signaling and transcriptional regulation. (external link)
• Hjorth-Hansen, Henrik; Stenke, Leif; Söderlund, Stina et al. (2015). Dasatinib induces fast and deep responses in newly diagnosed chronic myeloid leukaemia patients in chronic phase: Clinical results from a randomised phase-2 study (NordCML006). (external link)
• Kotopoulis, Spiros; Popa, Mihaela Lucia; Safont, MJ et al. (2015). Sonoporation using Acoustic Cluster Therapy in combination With chemotherapy transiently reduces tumour volume.. (external link)
• Myklebost, Ola; Lothe, Ragnhild A; Gjertsen, Bjørn Tore et al. (2015). Bør hver kreftpasient bli et eget forskningsprosjekt?. (external link)
• Landskron, Johannes; Helland, Øystein; Torgersen, Knut Martin et al. (2015). Activated regulatory and memory T-cells accumulate in malignant ascites from ovarian carcinoma patients. (external link)
• Gjertsen, Bjørn Tore; Schöffski, Patrick (2015). Discovery and development of the Polo-like kinase inhibitor volasertib in cancer therapy. (external link)
• Mukherjee, Herschel; Chan, Kok-Ping; Andresen, Vibeke et al. (2015). Interactions of the natural product (+)-avrainvillamide with nucleophosmin and exportin-1 mediate the cellular localization of nucleophosmin and its aml-associated mutants. (external link)

2014

• Gavasso, Sonia; Mosleth, Ellen Færgestad; Marøy, Tove Helene et al. (2014). Deficient phosphorylation of stat-1 in leukocytes identifies neutralizing antibodies in multiple sclerosis patients treated with interferon-beta. (external link)
• Helland, Øystein; Popa, Mihaela Lucia; Vintermyr, Olav Karsten et al. (2014). First in-mouse development and application of a surgically relevant xenograft model of ovarian carcinoma. (external link)
• Aasebø, Elise; Vaudel, Marc; Mjaavatten, Olav et al. (2014). Performance of super-SILAC based quantitative proteomics for comparison of different acute myeloid leukemia (AML) cell lines. (external link)
• Kotopoulis, Spiros; Dimcevski, Georg Gjorgji; Gjertsen, Bjørn Tore et al. (2014). Sonoporation: from the lab to human clinical trials. (external link)
• Rizzieri, David A.; Vey, Norbert; Thomas, Xavier et al. (2014). A phase II study of elacytarabine in combination with idarubicin and of human equilibrative nucleoside transporter 1 expression in patients with acute myeloid leukemia and persistent blasts after the first induction course. (external link)
• Kotopoulis, Spiros; Haugse, Ragnhild; Mujic, Maja et al. (2014). Evaluation of the effects of clinical diagnostic ultrasound in combination with ultrasound contrast agents on cell stress: Single cell analysis of intracellular phospho-signaling pathways in blood cancer cells and normal blood leukocytes. (external link)
• Kotopoulis, Spiros; Delalande, Anthony; Popa, Mihaela Lucia et al. (2014). Sonoporation-enhanced chemotherapy significantly reduces primary tumour burden in an orthotopic pancreatic cancer xenograft. (external link)
• Li, Ling; Osdal, Tereza; Ho, Yinway et al. (2014). SIRT1 activation by a c-MYC oncogenic network promotes the maintenance and drug resistance of human FLT3-ITD acute myeloid leukemia stem cells. (external link)
• Andresen, Vibeke; Omsland, Maria; Gjertsen, Bjørn Tore et al. (2014). Cell-to-Cell Communication in Acute Myeloid Leukemia by Tunneling Nanotubes. (external link)
• Kontro, M; Kuusanmäki, H; Eldfors, S et al. (2014). Novel activating STAT5B mutations as putative drivers of T-cell acute lymphoblastic leukemia. (external link)
• Engen, Caroline Benedicte Nitter; Wergeland, Line; Skavland, Jørn et al. (2014). Targeted Therapy of FLT3 in Treatment of AML-Current Status and Future Directions. (external link)
• Gjertsen, Bjørn Tore (2014). Mot en mer spesifikk kreftbehandling? :. (external link)
• Hampson, Peter; Wang, Keqing; Ersvær, Elisabeth et al. (2014). Up-regulation of anti-apoptotic genes confers resistance to the novel anti-leukemic compound PEP005 in primary AML cells. (external link)
• Landskron, Johannes; Helland, Øystein; Torgersen, Knut Martin et al. (2014). Activated regulatory and memory T-cells accumulate in malignant ascites from ovarian carcinoma patients. (external link)
• Haaland, Ingvild; Opsahl, Jill Anette; Berven, Frode et al. (2014). Molecular mechanisms of nutlin-3 involve acetylation of p53, histones and heat shock proteins in acute myeloid leukemia. (external link)

2013

• Herfindal, Lars; Myhren, Lene Elisabeth; Gjertsen, Bjørn Tore et al. (2013). Functional p53 is required for rapid restoration of daunorubicin-induced lesions of the spleen. (external link)
• Øye, Ola Kristoffer; Jørgensen, Katarina Mariann; Hjelle, Sigrun Margrethe et al. (2013). Gel2DE-A software tool for correlation analysis of 2D gel electrophoresis data. (external link)
• Gausdal, Gro; Wergeland, Anita; Skavland, Jørn et al. (2013). Cyclic AMP can promote APL progression and protect myeloid leukemia cells against anthracycline-induced apoptosis. (external link)
• Kloster, Martine Müller; Naderi, Elin Hallan; Haaland, Ingvild et al. (2013). cAMP signalling inhibits p53 acetylation and apoptosis via HDAC and SIRT deacetylases. (external link)
• Helland, Øystein; Bishof, Katharina; Popa, Mihaela Lucia et al. (2013). Histone deacetylase inhibisjon i kombinasjon med platinum i en klinisk relevant ortotopisk musemodel for ovarialcancer. (external link)
• Helland, Øystein; Popa, Mihaela Lucia; Gjertsen, Bjørn Tore et al. (2013). Panobinostat / carboplatin delay postsurgical relapse of ovarian carcinomas in an orthotopic mouse model. (external link)
• Fredly, Hanne Kristin; Gjertsen, Bjørn Tore; Bruserud, Øystein (2013). Histone deacetylase inhibition in the treatment of acute myeloid leukemia: the effects of valproic acid on leukemic cells, and the clinical and experimental evidence for combining valproic acid with other antileukemic agents. (external link)
• Bredholt, Therese; Ersvær, Elisabeth; Erikstein, Bjarte Skoe et al. (2013). Distinct single cell signal transduction signatures in leukocyte subsets stimulated with khat extract, amphetamine-like cathinone, cathine or norephedrine. (external link)
• Reikvam, Håkon; Kittang, Astrid Marta Olsnes; Melve, Guro Kristin et al. (2013). Targeted anti-leukemic therapy as disease-stabilizing treatment for acute myeloid leukemia relapse after allogeneic stem cell transplantation: will it be possible to combine these strategies with retransplantation or donor lymphocyte infusions?. (external link)
• Andresen, Vibeke; Wang, Xiang; Ghimire, Sakhila et al. (2013). Tunneling nanotube (TNT) formation is independent of p53 expression. (external link)
• McCormack, Emmet; Adams, Katherine J.; Hassan, Namir J. et al. (2013). Bi-specific TCR-anti CD3 redirected T-cell targeting of NY-ESO-1-and LAGE-1-positive tumors. (external link)
• Gjertsen, Bjørn Tore (2013). Phosphoprotein signaling in acute myeloid leukemia. (external link)
• Pemovska, Tea; Kontro, Mika; Yadav, Bhagwan et al. (2013). Individualized systems medicine strategy to tailor treatments for patients with chemorefractory acute myeloid leukemia. (external link)
• Reikvam, Håkon; Nepstad, Ina; Sulen, Andre et al. (2013). Increased antileukemic effects in human acute myeloid leukemia by combining HSP70 and HSP90 inhibitors. (external link)
• Fredly, Hanne Kristin; Ersvær, Elisabeth; Kittang, Astrid Marta Olsnes et al. (2013). The combination of valproic acid, all-trans retinoic acid and low-dose cytarabine as disease-stabilizing treatment in acute myeloid leukemia. (external link)
• Silden, Elisabeth; Hjelle, Sigrun Margrethe; Wergeland, Line et al. (2013). Expression of TP53 isoforms p53 beta or p53 gamma enhances chemosensitivity in TP53(null) cell lines. (external link)
• Mustjoki, Satu; Richter, Johan; Barbany, Gisela et al. (2013). Impact of malignant stem cell burden on therapy outcome in newly diagnosed chronic myeloid leukemia patients. (external link)
• Kotopoulis, Spiros; Delalande, Anthony; Popa, Mihaela et al. (2013). Ultrasound and microbubble enhanced therapy of orthotopic human pancreatic cancer in mice. (external link)
• McCormack, Emmet; Mujic, Maja; Osdal, Tereza et al. (2013). Multiplexed mAbs: a new strategy in preclinical time-domain imaging of acute myeloid leukemia. (external link)
• Mujic, Maja; Haugse, Ragnhild; Kotopoulis, Spiros et al. (2013). Ultrasound combined with microbubbles modulates signal transduction pathways in blood cells. (external link)
• Dimcevski, Georg Gjorgji; Kotopoulis, Spiros; Hoem, Dag et al. (2013). Ultrasound-assisted treatment of an inoperable pancreatic cancer. (external link)
• McCormack, Emmet; Silden, Elisabeth; West, Richard M. et al. (2013). Nitroreductase, a near-infrared reporter platform for in vivo time-domain optical imaging of metastatic cancer. (external link)
• Engen, Caroline Benedicte Nitter; Wergeland, Line; Gjertsen, Bjørn Tore (2013). Målrettet behandling av akutt myelogen leukemi - hemmere mot FLT3 og andre kinaser viser vei. (external link)

2012

• Mujic, Maja; Kotopoulis, Spiros; Delalande, Anthony et al. (2012). Flow cytometic characterization and sorting of ultrasound contrast agents. (external link)
• Ånensen, Nina; Hjelle, Sigrun Margrethe; Van, Belle Werner et al. (2012). Correlation analysis of p53 protein isoforms with NPM1/FLT3 mutations and therapy response in acute myeloid leukemia. (external link)
• Gullaksen, Stein-Erik Uriarte; Micoulet, Alexandre; Gjertsen, Bjørn Tore (2012). Deformation of acute myeloid leukaemia cells in micro-constriction array; a novel tool to study cell stress signalling. (external link)
• Tsykunova, Galina; Reikvam, Håkon; Ahmed, Aymen B et al. (2012). Targeting of polo-like kinases and their cross talk with Aurora kinases - possible therapeutic strategies in human acute myeloid leukemia?. (external link)
• McCormack, Emmet Martin; Haaland, Ingvild; Venås, Gurid et al. (2012). Synergistic induction of p53 mediated apoptosis by valproic acid and nutlin-3 in acute myeloid leukemia. (external link)
• Oveland, Eystein; Wergeland, Line; Hovland, Randi et al. (2012). Ectopic expression of Flt3 kinase inhibits proliferation and promotes cell death in different human cancer cell lines. (external link)
• Hjelle, Sigrun Margrethe; Sulen, Andre; Øye, Ola Kristoffer et al. (2012). Leukocyte p53 protein biosignature through standard-aligned two-dimensional immunoblotting. (external link)
• Reikvam, Håkon; Hatfield, Kimberley Joanne; Ersvær, Elisabeth et al. (2012). Expression profile of heat shock proteins in acute myeloid leukaemia patients reveals a distinct signature strongly associated with FLT3 mutation status - consequences and potentials for pharmacological intervention. (external link)
• Bjugn, Roger; Gjertsen, Bjørn Tore (2012). Humane celler og helseforskningsloven. (external link)
• Gjertsen, Bjørn Tore; Wiig, Helge (2012). Investigation of therapy resistance mechanisms in myeloid leukemia by protein profiling of bone marrow extracellular fluid. (external link)
• Hallenborg, Philip; Feddersen, Søren; Francoz, Sarah et al. (2012). Mdm2 controls CREB-dependent transactivation and initiation of adipocyte differentiation. (external link)
• Giles, Francis; Mahon, François-Xavier; Gjertsen, Bjørn Tore et al. (2012). Developmental Therapeutics Consortium report on study design effects on trial outcomes in chronic myeloid leukaemia. (external link)
• Fredly, Hanne Kristin; Reikvam, Håkon; Gjertsen, Bjørn Tore et al. (2012). Disease-stabilizing treatment with all-trans retinoic acid and valproic acid in acute myeloid leukemia: Serum hsp70 and hsp90 levels and serum cytokine profiles are determined by the disease, patient age, and anti-leukemic treatment. (external link)
• Forthun, Rakel Brendsdal; Sengupta, Tanima; Skjeldam, Hanne Kim et al. (2012). Cross-species functional genomic analysis identifies resistance genes of the histone deacetylase inhibitor valproic acid. (external link)
• Delalande, Anthony; Kotopoulis, Spiros; Pichon, Chantal et al. (2012). Microbubbles and cell interactions. (external link)
• Øye, Ola Kristoffer; Ulvang, Dag Magne; Jørgensen, Katarina Mariann et al. (2012). Volume visualization for exploration of population trends in two-dimensional gel electrophoresis protein data. (external link)
• Gavasso, Sonia; Gjertsen, Bjørn Tore; Anderssen, Endre et al. (2012). Immunogenic effects of recombinant interferon-beta therapy disrupt the JAK/STAT pathway in primary immune cells from patients with multiple sclerosis. (external link)

2011

• Fredly, Hanne Kristin; Ersvær, Elisabeth; Gjertsen, Bjørn Tore et al. (2011). Immunogenic apoptosis in human acute myeloid leukemia (AML): primary human AML cells expose calreticulin and release heat shock protein (HSP) 70 and HSP90 during apoptosis. (external link)
• Jørgensen, Katarina Mariann; Hjelle, Sigrun Margrethe; Øye, Ola Kristoffer et al. (2011). Untangling the intracellular signalling network in cancer - a strategy for data integration in acute myeloid leukemia. (external link)
• Gjertsen, Bjørn Tore (2011). Stratification of pediatric acute myeloid leukemia through cancer cell gene-expression profiling. (external link)
• Skavland, Jørn; Jørgensen, Katarina Mariann; Hadziavdic, Kenan et al. (2011). Specific cellular signal-transduction responses to in vivo combination therapy with ATRA, valproic acid and theophylline in acute myeloid leukemia. (external link)

2010

• Hatfield, Kimberley Joanne; Bedringaas, Siv Lise; Ryningen, Anita et al. (2010). Hypoxia increases HIF-1 alpha expression and constitutive cytokine release by primary human acute myeloid leukaemia cells. (external link)
• Gjerdrum, Christine; Tiron, Crina Elena; Høiby, Torill et al. (2010). Axl is an essential epithelial-to-mesenchymal transition-induced regulator of breast cancer metastasis and patient survival. (external link)
• McCormack, Emmet Martin; Skavland, Jørn; Mujic, Maja et al. (2010). Lentinan: hematopoietic, immunological, and efficacy studies in a syngeneic model of acute myeloid leukemia. (external link)
• Fredly, Hanne Kristin; Bjørnsen, Camilla I. Stapnes; Gjertsen, Bjørn Tore et al. (2010). Combination of the histone deacetylase inhibitor valproic acid with oral hydroxyurea or 6-mercaptopurin can be safe and effective in patients with advanced acute myeloid leukaemia - a report of five cases. (external link)
• Erikstein, Bjarte Skoe; McCormack, Emmet Martin; Tronstad, Karl Johan et al. (2010). Protein kinase A activators and the pan-PPAR agonist tetradecylthioacetic acid elicit synergistic anti-leukaemic effects in AML through CREB. (external link)
• Ersvær, Elisabeth; Liseth, Knut; Skavland, Jørn et al. (2010). Intensive chemotherapy for acute myeloid leukemia differentially affects circulating TC1, TH1, TH17 and TREG cells. (external link)
• Erikstein, Bjarte Skoe; Hagland, Hanne; Nikolaisen, Julie et al. (2010). Cellular stress induced by resazurin leads to autophagy and cell death via production of reactive oxygen species and mitochondrial impairment. (external link)
• Hjelle, Sigrun Margrethe; Forthun, Rakel Brendsdal; Haaland, Ingvild et al. (2010). Clinical proteomics of myeloid leukemia. (external link)
• Semaeva, Elvira; Tenstad, Olav; Skavland, Jørn et al. (2010). Access to the spleen microenvironment through lymph shows local cytokine production, increased cell flux, and altered signaling of immune cells during lipopolysaccharide-induced acute inflammation. (external link)

2009

• Olsnes, Astrid Marta; Ersvær, Elisabeth; Ryningen, Anita et al. (2009). The protein kinase C agonist PEP005 increases NF-kB expression, induces differentiation and increases constitutive chemokine release by primary acute myeloid leukaemia cells. (external link)
• Øyan, Anne Margrete; Ånensen, Nina; Bø, Trond Hellem et al. (2009). Genes of cell-cell interactions, chemotherapy detoxification and apoptosis are induced during chemotherapy of acute myeloid leukemia. (external link)
• Gjertsen, Bjørn Tore (2009). Er høyt hemoglobinnivå farlig?. (external link)
• Hatfield, Kimberley Joanne; Øyan, Anne Margrete; Ersvær, Elisabeth et al. (2009). Phase II study of subcutaneous alemtuzumab without dose escalation in patients with advanced-stage, relapsed chronic lymphocytic leukaemia. (external link)
• Christoffersen, Thoralf; Guren, Tormod K.; Spindler, Karen-Lise Garm et al. (2009). Cancer therapy targeted at cellular signal transduction mechanisms: strategies, clinical results, and unresolved issues. (external link)
• Reikvam, Håkon; Olsnes, Astrid Marta; Gjertsen, Bjørn Tore et al. (2009). Nuclear Factor-kappaB Signaling: A Contributor in Leukemogenesis and a Target for Pharmacological Intervention in Human Acute Myelogenous Leukemia. (external link)
• Stapnes, Camilla I; Gjertsen, Bjørn Tore; Reikvam, Håkon et al. (2009). Targeted therapy in acute myeloid leukaemia: current status and future directions. (external link)
• Hatfield, Kimberley Joanne; Øyan, Anne Margrete; Ersvær, Elisabeth et al. (2009). Primary human acute myeloid leukaemia cells increase the proliferation of microvascular endothelial cells through the release of soluble mediators. (external link)
• Lukandu, Ochiba Mohammed; Bredholt, Therese; Neppelberg, Evelyn et al. (2009). Early loss of mitochondrial inner transmembrane potential in khat-induced cell death of primary normal human oral cells. (external link)
• Hofmann, Matthias; McCormack, Emmet Martin; Mujic, Maja et al. (2009). Increased plasma colloid osmotic pressure facilitates the uptake of therapeutic macromolecules in a xenograft tumour model. (external link)
• Oveland, Eystein; Gjertsen, Bjørn Tore; Wergeland, Line et al. (2009). Ligand-induced Flt3-downregulation modulates cell death associated proteins and enhances chemosensitivity to idarubicin in THP-1 acute myeloid leukemia cells. (external link)
• Bredholt, Therese; Dimba, Elisabeth Anne Okumu; Hagland, Hanne et al. (2009). Camptothecin and khat (Catha edulis Forsk.) induced distinct cell death phenotypes involving modulation of c-FLIPL, Mcl-1, procaspase-8 and mitochondrial function in acute myeloid leukemia cell lines. (external link)
• Christoffersen, Thoralf; Gjertsen, Bjørn Tore; Engebråten, Olav et al. (2009). Signalhemmere. (external link)
• Ryningen, Anita; Stapnes, Camilla I; Lassalle, Philippe et al. (2009). A subset of patients with high-risk acute myelogenous leukemia shows improved peripheral blood cell counts when treated with the combination of valproic acid, theophylline and all-trans retinoic acid. (external link)

2008

• McCormack, Emmet Martin; Bruserud, Øystein; Gjertsen, Bjørn Tore (2008). Review: genetic models of acute myeloid leukaemia. (external link)
• Gjertsen, Bjørn Tore; McCormack, Emmet Martin (2008). Erythropoietin a safe bet in haemorrhagic shock?. (external link)
• Gausdal, Gro; Gjertsen, Bjørn Tore; McCormack, Emmet Martin et al. (2008). Abolition of stress-induced protein synthesis sensitizes leukemia cells to anthracycline-induced death. (external link)
• Gjertsen, Bjørn Tore; Lorens, James (2008). Comprehensive Analysis of Gene Function: RNA interference and Chemical Genomics. (external link)
• Bruserud, Øystein; Ersvær, Elisabeth; Olsnes, Astrid Marta et al. (2008). Anticancer Immunotherapy in Combination with Proapoptotic Therapy. (external link)
• Ryningen, Anita; Stapnes, Camilla I; Paulsen, Kristin et al. (2008). In vivo biological effects of ATRA in the treatment of AML. (external link)
• Hatfield, Kimberley Joanne; Hovland, Randi; Øyan, Anne Margrete et al. (2008). Release of angiopoietin-1 by primary human acute myelogenous leukemia cells is associated with mutations of nucleophosmin, increased by bone marrow stromal cells and possibly antagonized by high systemic angiopoietin-2 levels. (external link)
• Lukandu, Ochiba Mohammed; Costea, Daniela Elena; Dimba, Elisabeth Anne Okumu et al. (2008). Khat induces G1-phase arrest and increased expression of stress-sensitive p53 and p16 proteins in normal human oral keratinocytes and fibroblasts. (external link)
• Kirkeleit, Jorunn; Riise, Trond; Gjertsen, Bjørn Tore et al. (2008). Effects of benzene on human hematopoiesis. (external link)

2007

• Ånensen, Nina; Øyan, Anne Margrete; Huseby, Sjur et al. (2007). Early gene expression of acute myeloid leukemia in response to chemotherapy. (external link)
• Øyan, Anne Margrete; Ånensen, Nina; Bø, Trond Hellem et al. (2007). Early gene expression signature of chemotherapy treated acute myeloid leukemia in vivo. (external link)
• Øyan, Anne Margrete; Bø, Trond Hellem; Jonassen, Inge et al. (2007). Global gene expression in classification, pathogenetic understanding and identification of therapeutic targets in Acute Myeloid Leukemia. (external link)
• Irish, Jonathan C.; Ånensen, Nina; Hovland, Randi et al. (2007). Flt3 Y591 duplication and Bc1-2 overexpression are detected in acute myeloid leukemia cells with high levels of phosphorylated wild-type p53. (external link)
• Hagland, Hanne; Nikolaisen, Julie; Hodneland, Linn Iren et al. (2007). Targeting mitochondria in the treatment of human cancer: a coordinated attack against cancer cell energy metabolism and signalling. (external link)
• Ersvær, Elisabeth; Hampson, Peter; Hatfield, Kimberley Joanne et al. (2007). T cells remaining after intensive chemotherapy for acute myelogenous leukemia show a broad cytokine release profile including high levels of interferon-gamma that can be further increased by a novel protein kinase C agonist PEP005. (external link)
• Stapnes, Camilla I; Døskeland, Anne Paulus; Hatfield, Kimberley Joanne et al. (2007). The proteasome inhibitors bortezomib and PR-171 have antiproliferative and proapoptotic effects on primary human acute myeloid leukaemia cells. (external link)
• Stapnes, Camilla I; Ryningen, Anita; Hatfield, Kimberley Joanne et al. (2007). Functional characteristics and gene expression profiles of primary acute myeloid leukamia cells indentify patient subgroups that differ susceptibility to histone deactylase inhibitors. (external link)
• Huang, Tien-Sheng; Myklebust, Line Merethe; Kjærland, Endre et al. (2007). LEDGF/p75 has increased expression in blasts from chemotherapy-resistant human acute myelogenic leukemia patients and protects leukemia cells from apoptosis in vitro. (external link)
• Wergeland, Line; Sjøholt, Gry; Haaland, Ingvild et al. (2007). Pre-apoptotic response to therapeutic DNA damage involves protein modulation of Mcl-1, Hdm2 and Flt3 in acute myeloid leukemia cells. (external link)
• McCormack, Emmet Martin; Micklem, David Robert; Pindard, Lars Erik et al. (2007). In vivo optical Imaging of acute myeloid leukemia by green fluorescent protein: Time-domain autofluorescence decoupling, fluorophore quantification, and localization. (external link)
• Ersvær, Elisabeth; Zhang, Jian-Ying; McCormack, Emmet Martin et al. (2007). Cyclin B1 is commonly expressed in the cytoplasm of primary human acute myelogenous leukemia cells and serves as a leukemia-associated antigen associated with autoantibody response in a subset of patients. (external link)
• Bruserud, Øystein; Stapnes, Camilla I; Ersvær, Elisabeth et al. (2007). Histone deacetylase inhibitors in cancer treatment: a review of the clinical toxicity and the modulation of gene expression in cancer cells. (external link)
• Ersvær, Elisabeth; Hampson, Peter; Wendelbo, Øystein et al. (2007). Circulating T cells in patients with untreated acute myelogenous leukemia are heterogeneous and can be activated through the CD3/TCR complex. (external link)
• Gjertsen, Bjørn Tore; Bredholt, Therese; Ånensen, Nina et al. (2007). Bcl-2 antisense in the treatment of human malignancies: A delusion in targeted therapy. (external link)
• McCormack, Emmet Martin; Belankov, Alexandre; Mujic, Maja et al. (2007). Discrimination and Quantification of Spectrally Similar Near-Infrared Probes by Time-Domain (TD) Optical Imaging in AML models. (external link)
• Wergeland, Line; Oveland, Eystein; Sjøholt, Gry et al. (2007). Flt3 Mutations in Proximity to an Ubiquitin Dependent Endocytosis Motif Suspend Its Hdm2 Modulation. (external link)
• Mujic, Maja; McCormack, Emmet Martin; Ryningen, Anita et al. (2007). Development and evaluation of labeled antibodies as optical contrast reagents in acute myeloid leukemia (AML). (external link)
• Parlati, F; Aujay, M; Bedringaas, Siv Lise et al. (2007). Anti-Tumor Activity of Immunoproteasome Selective Inhibitors. (external link)
• Venaas, Gurid; McCormack, Emmet Martin; Haaland, Ingvild et al. (2007). In vivo optical imaging of p53 specific targeted therapy in Acute Myeloid Leukaemia. (external link)
• Silden, Elisabeth; McCormack, Emmet Martin; Micklem, David Robert et al. (2007). Development of a near infrared reporter system for in vivo imaging. (external link)
• Gjertsen, Bjørn Tore (2007). Early protein and gene modulation in response to induction chemotherapy of acute myeloid leukemia. (external link)
• Gjertsen, Bjørn Tore (2007). Early Protein and Gene Modulation in Response to Induction Chemotherapy of Acute Myeloid Leukemia. (external link)
• Ersvær, Elisabeth; Bruserud, Øystein; Gjertsen, Bjørn Tore (2007). Immunological aspects of acute myelogenous leukemia. (external link)
• Gausdal, Gro; Gjertsen, Bjørn Tore; Doskeland, Stein Ove (2007). New lessons from an “old” drug: A proteomic study of anthracycline-induced apoptosis in acute myelogenous leukemia. (external link)
• Wergeland, Line; Gjertsen, Bjørn Tore; Bruserud, Øystein (2007). Flt3 receptor tyrosine kinase in AML and its modulation of the p53/Hdm2/Bcl-2 pathway. (external link)
• Ersvær, Elisabeth; Skavland, Jørn; Ulvestad, Elling et al. (2007). Effects of interferon gamma on native human acute myelogenous leukaemia cells. (external link)
• Bruserud, Øystein; Ryningen, Anita; Olsnes, Astrid Marta et al. (2007). Subclassification of patients with acute myelogenous leukemia based on chemokine responsiveness and constitutive chemokine release by their leukemic cells. (external link)
• Petersen, Kjell; Øyan, Anne Margrete; Rostad, Kari et al. (2007). Comparison of nucleic acid targets prepared from total RNA or poly(A) RNA for DNA oligonucleotide microarray hybridization. (external link)

2006

• Øyan, Anne Margrete; Bø, Trond Hellem; Jonassen, Inge et al. (2006). cDNA microarray analysis of non-selected cases of acute myeloid leukemia demonstrates distinct clustering independent of cytogenetic aberrations and consistent with morphological signs of differentiation. (external link)
• Ånensen, Nina; Øyan, Anne Margrete; Bourdon, Jean-Christophe et al. (2006). A distinct p53 protein isoform signature reflects the onset of induction chemotherapy for acute myeloid leukemia. (external link)
• Belle, Werner Van; Ånensen, Nina; Haaland, Ingvild et al. (2006). Correlation analysis of two-dimensional gel electrophoretic protein patterns and biological variables. (external link)
• Ånensen, Nina; Skavland, Jørn; Stapnes, Camilla I et al. (2006). Acute myelogenous leukemia in a patient with Li-Fraumeni syndrome treated with valproic acid, theophyllamine and all-trans retinoic acid: a case report. (external link)
• Oveland, Eystein; Fladmark, Kari Espolin; Wergeland, Line et al. (2006). Proteomics approaches to elucidate oncogenic tyrosine kinase signaling in myeloid malignancies. (external link)
• Øyan, Anne Margrete; Ånensen, Nina; Bø, Trond Hellem et al. (2006). The early gene expression signature of acute myeloid leukemia (AML) blasts during in vivo chemotherapy. (external link)
• Bruserud, Øystein; Stapnes, Camilla I; Tronstad, Karl Johan et al. (2006). Protein lysine acetylation in normal and leukaemic haematopoiesis: HDACs as possible therapeutic targets in adult AML. (external link)
• Bruserud, Øystein; McCormack, Emmet Martin; Gjertsen, Bjørn Tore (2006). Immunotherapy in chronic lymphocytic leukemia. (external link)
• Øyan, Anne Margrete; Ånensen, Nina; Bø, Trond Hellem et al. (2006). The early gene expression signature of acute myeloid leukemia (AML) blasts during in vivo chemotherapy. (external link)
• Øyan, Anne Margrete; Bø, Trond Hellem; Jonassen, Inge et al. (2006). cDNA microarray analysis of non-selected cases of acute myeloid leukemia demonstrates distinct clustering independent of cytogenetic aberrations and consistent with morphological signs of differentiation. (external link)
• Stapnes, Camilla I; Ryningen, Anita; Gjertsen, Bjørn Tore et al. (2006). Treatment with valproic acid, all-trans retinoic acid (ATRA) and theophyllamine for 9 days caused a persistent increase in peripheral blood platelet counts for a patient with acute myelogenous leukemia. (external link)
• Ryningen, Anita; Ersvær, Elisabeth; Øyan, Anne Margrete et al. (2006). Stress-induced in vitro apoptosis of native human acute myelogenous leukemia (AML) cells shows a wide variation between patients and is associated with low BCL-2 : Bax ratio and low levels of heat shock protein 70 and 90. (external link)
• Ånensen, Nina; Gjertsen, Bjørn Tore (2006). p53 protein biosignatures in acute myeloid leukemia. (external link)
• Sjøholt, Gry; Bedringaas, Siv Lise; Døskeland, Anne Paulus et al. (2006). Proteomic strategies for individualizing therapy of acute myeloid leukemia (AML). (external link)
• Krakstad, Camilla; Herfindal, Lars; Gjertsen, Bjørn Tore et al. (2006). CaM-kinasell-dependent commitment to microcystin-induced apoptosis is coupled to cell budding, but not to shrinkage or chromatin hypercondensation. (external link)
• Sjøholt, Gry; Bedringaas, Siv Lise; Døskeland, Anne Paulus et al. (2006). Proteomic strategies for individualizing therapy of acute myeloid leukemia (AML). (external link)
• Ånensen, Nina; Haaland, Ingvild; Santos, Clive D et al. (2006). Proteomics of p53 in diagnostics and therapy of acute myeloid leukemia. (external link)
• Belle, Werner Van; Sjøholt, Gry; Ånensen, Nina et al. (2006). Adaptive contrast enhancement of two-dimensional electrophoretic protein gel images facilitates visualization, orientation and alignment. (external link)
• Bruserud, Øystein; Tronstad, Karl Johan; McCormack, Emmet Martin et al. (2006). Is targeted chemotherapy an alternative to immunotherapy in chronic lymphocytic leukemia?. (external link)

2005

• Dimba, Elisabeth Anne Okumu; Bredholt, Therese; Gjertsen, Bjørn Tore et al. (2005). Khat- and cathionine-induced apoptosis is modulated by Bcl-2 protein expression. (external link)
• Gjertsen, Bjørn Tore (2005). Individualizing therapy in acute myeloid leukemia through modulation of signaling networks. (external link)
• Hatfield, Kimberley Joanne; Olsnes, Astrid Marta; Gjertsen, Bjørn Tore et al. (2005). Antiangiogenic therapy in acute myelogenous leukemia: Targeting of vascular endothelial growth factor and interleukin 8 as possible antileukemic strategies. (external link)
• Bredholt, Therese; Dimba, Elisabeth Anne Okumu; Fossan, K.O. et al. (2005). Molecular mechanisms of apoptosis induced by khat extract and its alkaloids cathinone and cathine in acute myeloid leukemia. (external link)
• Øyan, Anne Margrete; Bø, Trond Hellem; Jonassen, Inge et al. (2005). CD34 expression in native human acute myelogenous leukemia blasts: Differences in CD34 membrane molecule expression are associated with different gene expression profiles. (external link)
• Gjertsen, Bjørn Tore (2005). Single cell profiling of potentiated phospho-protein networks in cancer cells. (external link)
• Gjertsen, Bjørn Tore (2005). The Role of Bcl-2 in Apoptosis Induced by khat (Catha Edulis) in Acute Myeloid Leukemia Cell Lines. (external link)
• Ryningen, Anita; Wergeland, Line; Glenjen, Nils et al. (2005). In vitro crosstalk between fibroblasts and native human acute myelogenous leukemia (AML) blasts via local cytokine networks results in increased proliferation and decreased apoptosis of AML cells as well as increased levels of proangiogenic Interleukin 8. (external link)
• McCormack, Emmet Martin; Bruserud, Øystein; Gjertsen, Bjørn Tore (2005). Animal models of acute myelogenous leukaemia - development, application and future perspectives. (external link)
• Bø, Trond Hellem; Stordrange, Laila; Øyan, Anne Margrete et al. (2005). Analysis of treatment response in acute myeloid leukemia patients using DNA microarrays. (external link)
• Sjøholt, Gry; Ånensen, Nina; Wergeland, Line et al. (2005). Proteomics in acute myelogenous leukaemia (AML): Methodological strategies-and identification of protein targets for novel antileukaemic therapy. (external link)
• Sjøholt, Gry; Ånensen, Nina; Wergeland, Line et al. (2005). Proteomics in acute myelogenous leukaemia (AML): methodological strategies and identification of protein targets for novel antileukaemic therapy. (external link)
• Dimba, Elisabeth Anne Okumu; Bredholt, Therese; Costea, Daniela-Elena et al. (2005). Mechanisms of apoptosis induction by khat alkaloids in leukaemia cells. (external link)

See a complete overview of publications in Cristin.