The overriding goal is to explain how information is physically stored and represented in the brain, and how these processes are disrupted, altered, or destroyed in disorders of cognition including memory loss. Our research focus is the molecular control of synaptic plasticity. We aim to uncover the logic of synaptic plasticity at the level of protein synthesis, protein functional properties, and the dynamics of protein interaction networks.

Specific research areas:

• Arc as a master regulator of long-term synaptic plasticity and cognition
• Translational control of synaptic plasticity
• Non-coding RNA regulation and function in synaptic plasticity

2016

• Jesper L.V. Maag; Debabrata Panja; Ida Sporild et al. (2016). Corrigendum to Dynamic expression of long noncoding RNAs and repeat elements in synaptic plasticity [Front. Neurosci. (2015), 9:351. doi: 10.3389/fnins.2015.00351]. (external link)
• SD Kuipers; Andrea Trentani; Sudarshan Patil et al. (2016). BDNF-induced LTP is associated with rapid Arc/Arg3.1-dependent enhancement in adult hippocampal neurogenesis. (external link)
• Clive R. Bramham; KB Jensen; CG Proud (2016). Tuning specific translation in cancer metastasis and synaptic memory: control at the MNK-eIF4E axis. (external link)
• Ognjen Bojovic; Clive R. Bramham; Arne Tjølsen (2016). Stimulation-induced expression of immediate early gene proteins in the dorsal horn is increased in neuropathy. (external link)
• Adrian M. Szum; Clive R. Bramham (2016). The localization and function of Arc in the neuronal cell nucleus. (external link)
• Sjoukje Kuipers; Andrea Trentani; Adrian Tiron et al. (2016). BDNF-induced LTP is associated with rapid Arc/Arg3.1-dependent enhancement in adult hippocampal neurogenesis. (external link)

2003

• Clive R. Evjen Bramham (2003). BDNF as a consolidation factor in adult synaptic plasicity. (external link)
• Clive R. Evjen Bramham (2003). BDNF as a consolidation factor in adult synaptic plasicity. (external link)
• Clive R. Evjen Bramham (2003). BDNF as a consolidation factor in adult synaptic plasisity. (external link)
• Clive R. Evjen Bramham (2003). BDNF-induced synaptic consolidation requires ongoing translation of the immediate early gene Arc. (external link)
• Patrick Ernfors; Clive R. Evjen Bramham (2003). The coupling of a TrkB tyrosine residue to LTP. (external link)
• Tambudzai Kanhema; Bjarte Håvik; Dagestad Grethe et al. (2003). BDNF, translation control and dendritic protein synthesis in adult synaptic plasticity. (external link)
• Clive R. Evjen Bramham (2003). BDNF as a consolidation factor in adult synaptic plasicity. (external link)
• Clive R. Evjen Bramham (2003). Understanding synaptic plasicity. (external link)
• Clive R. Evjen Bramham (2003). BDNF as a consolidation factor in adult synaptic plasicity. (external link)
• Clive R. Evjen Bramham (2003). På sporet av hukommelsen. (external link)
• Clive R. Evjen Bramham (2003). Neurotrophic factors and synaptic plasticity. (external link)
• Clive R. Evjen Bramham (2003). BDNF as a consolidation factor in adult synaptic plasicity. (external link)
• Clive R. Evjen Bramham (2003). Neurobiology of learning and plasticity. (external link)
• Clive R. Evjen Bramham (2003). På sporet av hukommelsen. (external link)
• Clive R. Evjen Bramham (2003). BDNF as a consolidation factor in adult synaptic plasticity. (external link)
• Clive R. Evjen Bramham (2003). BDNF as a consolidation factor in adult synaptic plasicity. (external link)
• Clive R. Evjen Bramham (2003). BDNF as a consolidation factor in adult synaptic plasisity. (external link)
• Clive R. Evjen Bramham (2003). Trophic factors and plasticity. (external link)

2021

• Anni Vedeler; Clive Raymond Evjen Bramham (2021). Editorial: Coordination of mRNA Transport and Translation With Vesicle and Organelle Trafficking and Dynamics. (external link)
• Erik Ingmar Hallin; Sigurbjörn Markusson; Lev Bottger et al. (2021). Crystal and solution structures reveal oligomerization of individual capsid homology domains of Drosophila Arc. (external link)
• Plinio C. Casarotto; Mykhailo Girych; Senem M. Fred et al. (2021). Antidepressant drugs act by directly binding to TRKB neurotrophin receptors. (external link)
• Erik Ingmar Hallin; Clive Raymond Evjen Bramham; Petri Kursula (2021). Structural properties and peptide ligand binding of the capsid homology domains of human Arc. (external link)
• Francisca Acuña-Hinrichsen; Adriana Covarrubias-Pinto; Yuta Ishizuka et al. (2021). Herpes Simplex Virus Type 1 Neuronal Infection Triggers the Disassembly of Key Structural Components of Dendritic Spines. (external link)

2023

• Martino Avallone; Joaquín Pardo; Tadiwos Feyissa Mergiya et al. (2023). Visualizing Arc protein dynamics and localization in the mammalian brain using AAV-mediated in situ gene labeling. (external link)
• Sudarshan Patil; Kleanthi Chalkiadaki; Tadiwos Feyissa Mergiya et al. (2023). eIF4E phosphorylation recruits β-catenin to mRNA cap and promotes Wnt pathway translation in dentate gyrus LTP maintenance. (external link)
• Jiaxing Song; Clive Raymond Evjen Bramham; Hongyu Zhang (2023). Regulation of AMPA Receptor Diffusion Trapping at the Synapses by Arc Protein. (external link)
• Lasse Neset; Clive Raymond Evjen Bramham; Petri Tapani Kursula (2023). Nanobody-aided structural study of the activity- regulated cytoskeleton-associated protein (Arc) using synchrotron radiation and cryo-EM. (external link)
• Aamra Mahboob; Francois Philippe Pauzin; Clive Raymond Evjen Bramham (2023). Effect of Arc N-lobe expression on synaptic efficacy in medial perforant path-evoked transmission in the rat dentate gyrus in vivo. (external link)
• Clive Raymond Evjen Bramham; Volkmar Lessmann; Anthony J. Hannan et al. (2023). Editorial: Synaptopathies: from bench to bedside. (external link)
• Tadiwos Feyissa Mergiya; Jens Edvard Trygstad Gundersen; Tambudzai Kanhema et al. (2023). Detection of Arc/Arg3.1 oligomers in rat brain: constitutive and synaptic activity-evoked dimer expression in vivo. (external link)
• Ingjald Pilskog; Kjetil Vikene; Clive Raymond Evjen Bramham et al. (2023). Den plastiske hjernen – fra molekyler til bevissthet. (external link)

2012

• Karin Wibrand; Pai Balagopal Sreenivasa; Taweeporn Siripornmongcolchai et al. (2012). MicroRNA regulation of the synaptic plasticity-related gene arc. (external link)
• Bjarte Håvik; Franziska A. Degenhardt; Stefan Johansson et al. (2012). DCLK1 variants are associated across schizophrenia and attention deficit/hyperactivity disorder. (external link)
• Clive R. Bramham; Ashraf Pakzad Fathpour (2012). Remodeling of the microRNA-induced silencing complex during LTP in the adult rat brain in vivo. (external link)
• Janne Grønli; Grethe Dagestad; Anne Marita Milde et al. (2012). Chronic mild stress abolishes a relationship between sleep architecture and translational control. (external link)
• Balagopal Pai; Clive R. Evjen Bramham (2012). miRNA-mediated regulation of translation in synaptic plasticity. (external link)
• Janne Grønli; Grethe Dagestad; Anne Marita Milde et al. (2012). Post-transcriptional effects and interactions between chronic mild stress and acute sleep deprivation: Regulation of translation factor and cytoplasmic polyadenylation element-binding protein phosphorylation. (external link)
• Shunit Gal-Ben-Ari; Justin W. Kenney; Hadile Ounalla-Saad et al. (2012). Consolidation and translation regulation. (external link)
• Magdalena Dziembowska; Jacek Milek; Aleksandra Janusz et al. (2012). Activity-dependent local translation of matrix metalloproteinase-9. (external link)
• Christel Marie Vieuille; Clive R. Bramham (2012). Modulation of the Ago2-Associated microRNA Induced Silencing Complex during Long-Term Potentiation in the Rat Dentate Gyrus in Vivo. (external link)
• Jonathan Soule; Maria Nordheim Alme; Craig Myrum et al. (2012). Balancing arc synthesis, mRNA decay, and proteasomal degradation : maximal protein expression triggered by rapid eye movement sleep-like bursts of muscarinic cholinergic receptor stimulation. (external link)

1992

• Clive R. Evjen Bramham (1992). In vivo studies on long-term potentiation (LTP) in the dentate gyrus : role of opioid and NMDA receptors, and modulation by behavioral state. (external link)

2006

• Janne Grønli; Clive R. Evjen Bramham; Robert Murison et al. (2006). Chronic mild stress inhibits BDNF protein expression and CREB activation in the dentate gyrus but not in the hippocampus proper. (external link)
• Sjoukje Kuipers; Andrea Trentani; Christel Westenbroek et al. (2006). Unique patterns of FOS, phospho-CREB and BrdU immunoreactivity in the female rat brain following chronic stress and citalopram treatment. (external link)
• Karin Wibrand; Elhoucine Messaoudi; Bjarte Håvik et al. (2006). Identification of genes co-upregulated with Arc during BDNF-induced long-term potentiation in adult rat dentate gyrus in vivo. (external link)
• Grethe Dagestad; Sjoukje Kuipers; Elhoucine Messaoudi et al. (2006). Chronic fluoxetine induces region-specific changes in translation factor eIF4E and eEF2 activity in the rat brain. (external link)
• Tambudzai Kanhema; Grethe Dagestad; Debabrata Panja et al. (2006). Dual regulation of translation initiation and peptide chain elongation during BDNF-induced LTP in vivo: evidence for compartment-specific translation control. (external link)
• Sjoukje Kuipers; Clive R. Evjen Bramham (2006). Brain-derived neurotrophic factor mechanisms and function in adult synaptic plasticity: New insights and implications for therapy. (external link)
• Mona Inger Breivik; Arne Tjølsen; Clive R. Evjen Bramham (2006). Genaktivering ved langtidspotensiering (LTP) i spinale smertesystem. (external link)
• Jonathan Soule; Elhoucine Messaoudi; Clive R. Evjen Bramham (2006). Brain-derived neurotrophic factor and control of synaptic consolidation in the adult brain. (external link)

2022

• Patrick Unneland Pagenhart; Clive Raymond Evjen Bramham; Francois Philippe Pauzin (2022). Analysis of mRNA poly(A) tail length in relation to long-term potentiation of synaptic transmission in the rat dentate gyrus in vivo. (external link)
• Yuta Ishizuka; Tadiwos Feyissa Mergiya; Rodolfo Da Silva Mazzarini Baldinotti et al. (2022). Correction to: Development and Validation of Arc Nanobodies: New Tools for Probing Arc Dynamics and Function (Neurochemical Research, (2022), 10.1007/s11064-022-03573-5). (external link)
• Agnieszka Grabowska; Hanna Sas-Nowosielska; Bartosz Wojtas et al. (2022). Activation-induced chromatin reorganization in neurons depends on HDAC1 activity. (external link)
• Yuta Ishizuka; Tadiwos Feyissa Mergiya; Rodolfo Da Silva Mazzarini Baldinotti et al. (2022). Development and Validation of Arc Nanobodies: New Tools for Probing Arc Dynamics and Function. (external link)
• Maria Steene Eriksen; Clive Raymond Evjen Bramham (2022). Molecular physiology of Arc/Arg3.1: The oligomeric state hypothesis of synaptic plasticity. (external link)
• Thomas Myhre Dale; Clive Raymond Evjen Bramham; Tambudzai Kanhema (2022). Study the mRNA which crisscross with Activity-Regulated Cytoskeleton-Associated Protein (Arc) in the nucleus of hippocampus tissue post HFS-LTP. (external link)
• Sigurbjörn Markusson; Erik Ingmar Hallin; Helene J. Bustad et al. (2022). High-affinity anti-Arc nanobodies provide tools for structural and functional studies. (external link)

2010

• Karin Wibrand; Debabrata Panja; Adrian Tiron et al. (2010). Differential regulation of mature and precursor microRNA expression by NMDA and metabotropic glutamate receptor activation during LTP in the adult dentate gyrus in vivo. (external link)
• Michael Bidinosti; Israeli Ran; Maria R. Sanchez-Carbente et al. (2010). Postnatal deamidation of 4E-BP2 in brain enhances its association with raptor and alters kinetics of excitatory synaptic transmission. (external link)
• Clive R. Evjen Bramham; Maria Nordheim Alme; Margarethe Bittins et al. (2010). The Arc of synaptic memory. (external link)
• Craig Myrum; Clive R. Evjen Bramham; Jonathan Soule (2010). Identification of Arc/Arg3.1 Binding Partners. (external link)

2017

• Andrea Rørvik Marti; Sudarshan Patil; Jelena Mrdalj et al. (2017). No escaping the rat race: simulated night shift work alters the time-of-day variation in BMAL1 translational activity in the prefrontal cortex. (external link)
• Graciano Leal; Diogo Comprido; Pasqualino de Luca et al. (2017). The RNA-Binding Protein hnRNP K Mediates the Effect of BDNF on Dendritic mRNA Metabolism and Regulates Synaptic NMDA Receptors in Hippocampal Neurons. (external link)
• Oleksii Nikolaienko; Sudarshan Patil; Maria Steene Eriksen et al. (2017). Arc protein: a flexible hub for synaptic plasticity and cognition. (external link)
• Aina Iren Aanes Bekken; Clive R. Bramham (2017). Activity-Regulated Cytoskeleton-associated (Arc) Protein: Interaction with Actin-Binding Proteins in the adult rat brain. (external link)
• Sverre Grødem; Clive R. Bramham; Sergei Baryshnikov (2017). Dynamic Analysis of Arc Protein Oligomerization by Förster Resonance Energy Transfer. (external link)
• Oleksii Nikolaienko; Maria Steene Eriksen; Sudarshan Patil et al. (2017). Stimulus-evoked ERK-dependent phosphorylation of activity-regulated cytoskeleton-associated protein (Arc) regulates its neuronal subcellular localization. (external link)
• Rajeevkumar Nair Raveendran; Sudarshan Patil; Adrian Tiron et al. (2017). Dynamic Arc SUMOylation and selective interaction with F-actin-binding protein Drebrin A in LTP consolidation in vivo. (external link)
• Jesper L.V. Maag; Dominik C. Kaczorowski; Debabrata Panja et al. (2017). Widespread promoter methylation of synaptic plasticity genes in long-term potentiation in the adult brain in vivo.. (external link)
• Craig Myrum; Jonathan Soule; Margarethe Bittins et al. (2017). Arc interacts with the integral endoplasmic reticulum protein, calnexin. (external link)
• Johanne Eriksen Rimstad; Clive R. Bramham; Sudarshan Patil (2017). Arc expression and protein-protein interactions in a mouse model of Alzheimer’s disease. Exercise- and novelty-induced changes in Arc, BDNF, and PS1 expression and Arc PS1 interaction in APP/PS1 and WT mice. (external link)
• Ida Ajvazi Herdlevær; Clive R. Bramham (2017). Dynamics of actin cytoskeleton in dendritic spines -interactions between Arc and Drebrin A. (external link)
• Agata Gozdz; Oleksii Nikolaienko; Malgorzata Urbanska et al. (2017). GSK3α and GSK3β Phosphorylate Arc and Regulate its Degradation. (external link)
• Craig Myrum; Oleksii Nikolaienko; Clive R. Bramham et al. (2017). Implication of the APP gene in intellectual abilities. (external link)

2007

• Bjarte Håvik; Håvard Røkke; Girstaute Dagyte et al. (2007). Synaptic activity-induced global gene expression patterns in the dentate gyrus of adult behaving rats: Induction of immunity-linked genes. (external link)
• Clive R. Evjen Bramham (2007). Control of synaptic consolidation in the dentate gyrus: mechanisms, functions, and therapeutic implications. (external link)
• Clive R. Evjen Bramham; DG Wells (2007). Dendritic mRNA: transport, translation and function. (external link)
• Elhoucine Messaoudi; Tambudzai Kanhema; Jonathan Soule et al. (2007). Sustained Arc/Arg3.1 synthesis controls long-term potentiation consolidation through regulation of local actin polymerization in the dentate gyrus In vivo. (external link)
• Maria Nordheim Alme; Karin Wibrand; Grethe Dagestad et al. (2007). Chronic fluoxetine treatment induces brain region-specific upregulation of genes associated with BDNF-induced long-term potentiation. (external link)
• Bjarte Håvik; Clive R. Evjen Bramham (2007). Additive viability-loss following hsp70/hsc70 double interference and Hsp90 inhibition in two breast cancer cell lines. (external link)

2015

• Craig Myrum; Anne Baumann; Helene J. Bustad et al. (2015). Arc is a flexible modular protein capable of reversible self-oligomerization. (external link)
• Malgorzata H. Hall; Adriana Magalska; Monika Malinowska et al. (2015). Localization and regulation of PML bodies in the adult mouse brain. (external link)
• Yifat Segev; Iliana Barrera; Hadile Ounallah-Saad et al. (2015). PKR inhibition rescues memory deficit and atf4 overexpression in apoe ε4 human replacement mice. (external link)
• Craig Myrum; Sudheer Giddaluru; Kaya Kvarme Jacobsen et al. (2015). Common variants in the ARC gene are not associated with cognitive abilities. (external link)
• Jesper L.V. Maag; Debabrata Panja; Ida Sporild et al. (2015). Dynamic expression of long noncoding RNAs and repeat elements in synaptic plasticity. (external link)
• Syed Ainul Abideen; Clive R. Bramham; Ashraf Fathpour Pakzad (2015). Expression of Argonaute 2 and associated proteins following LTP induction in the dentate gyrus in vivo: comparsion between lysates and fractionated synaptoneurosomes. (external link)
• Ognjen Bojovic; Debabrata Panja; Margarethe Bittins et al. (2015). Time course of immediate early gene protein expression in the spinal cord following conditioning stimulation of the sciatic nerve in rats. (external link)
• Ognjen Bojovic; Clive R. Bramham; Arne Tjølsen (2015). Chronic morphine treatment enhances sciatic nerve stimulation-induced immediate early gene expression in the rat dorsal horn. (external link)

2020

• Eli-Eelika Esvald; Jürgen Tuvikene; Alex Sirp et al. (2020). CREB family transcription factors are major mediators of BDNF transcriptional autoregulation in cortical neurons. (external link)
• Hongyu Zhang; Clive R. Bramham (2020). Bidirectional Dysregulation of AMPA Receptor-Mediated Synaptic Transmission and Plasticity in Brain Disorders. (external link)
• Andrea Rørvik Marti; Torhild Pedersen; Jonathan P. Wisor et al. (2020). Cognitive function and brain plasticity in a rat model of shift work: role of daily rhythms, sleep and glucocorticoids. (external link)
• Elham Taha; Sudarshan Patil; Iliana Barrera et al. (2020). eEF2/eEF2K Pathway in the Mature Dentate Gyrus Determines Neurogenesis Level and Cognition. (external link)
• Maria Steene Eriksen; Oleksii Nikolaienko; Erik Ingmar Hallin et al. (2020). Arc self‐association and formation of virus‐like capsids are mediated by an N‐terminal helical coil motif. (external link)
• Hongyu Zhang; Clive R. Bramham (2020). Arc/Arg3.1 function in long-term synaptic plasticity: Emerging mechanisms and unresolved issues. (external link)
• Jan Stefan Olofsson; Clive R. Bramham; Tambudzai Kanhema (2020). Investigation of Arc interaction with mRNA in the nucleus of SH-SY5Y Neuroblastoma cells. (external link)
• Helene Bustad Johannessen; Marte Innselset Flydal; Jorge Cuéllar et al. (2020). The solution structure of the human brain-protein arc studied by NMR. (external link)

2005

• Janne Grønli; Robert Murison; Tambudzai Kanhema et al. (2005). Chronic mild stress, an animal model of depression, affects the expression of BDNF and 5-HT levels over the sleep/wake cycle in hippocampus in rats. (external link)
• Clive R. Evjen Bramham (2005). Molecular mechanisms of synaptic consolidation during sleep: BDNF function and dendritic protein synthesis. (external link)
• Clive R. Evjen Bramham; El Houcine Messaoudi (2005). BDNF function in adult synaptic plasticity: the synaptic consolidation hypothesis. Prog Neurobiol. (external link)

2013

• Taweeporn Siripornmongcolchai; Clive R. Bramham; Karin Wibrand (2013). MicroRNA regulation in synaptic plasticity and expression of plasticity-associated genes during social defeat stress. (external link)
• Karin Wibrand; Kjetil Berge; Michael Messaoudi et al. (2013). Enhanced cognitive function and antidepressant-like effects after krill oil supplementation in rats. (external link)
• Lasse Vesta; Clive R. Bramham; Kai Ove Skaftnesmo (2013). Early life stress influences on stress handling in adulthood - development of depressive- and anxiety-like behavior in Wistar rats. (external link)
• Maria Steene Eriksen; Clive R. Bramham; Oleksii Nikolaienko (2013). In search of a binding site for extracellular signal-regulated kinase (ERK) to the synaptic plasticity-related protein Arc. (external link)
• Linda Hildegard Bergersen; Clive R. Bramham; Kenneth Hugdahl et al. (2013). The changing brain – Insights into the mechanisms of neural and behavioral adaptation to the environment. (external link)
• Kine Terese Rønnestad; Clive R. Bramham; Birgitte Berentsen (2013). The Role of miR-­‐326 in Basal Synaptic Transmission and Long-­‐Term Potentiation in the Rat Dentate Gyrus In Vivo. (external link)

2002

• Bjarte Håvik; Håvard Røkke; Svend Davanger et al. (2002). Effect of LTP induction in awake rats on the expression and dendritic trafficking of Arc and alpha-CaMKII mRNA: a real-time PCR analysis of synaptodendrosomes. (external link)
• Vibeke Steenslid; Elhoucine Messaoudi; Clive R. Evjen Bramham (2002). Effect of acute intrahippocampal BDNF infusion on synaptic efficacy at Schaffer collateral-CA1 synapses in vivo. (external link)
• Clive R. Evjen Bramham; Elhoucine Messaoudi; Kjetil Bårdsen (2002). Neurotrophins and synaptic plasticity in the adult hippocampus. (external link)
• Håvard Røkke; Bjarte Håvik; Kjetil Bårdsen et al. (2002). LTP-induced regulation of the immediate early genes arc and zif268 in the dentate gyrus of freely moving rats: effect of sleep-wakefulness state. (external link)
• Clive R. Evjen Bramham; Marit Eikemo (2002). Det gåtefulle minnet. (external link)
• Mary E. McCutchen; Clive R. Evjen Bramham; Lucas Pozzo-Miller (2002). Modulation of neuronal calcium signaling by neurotrophic factors. (external link)
• Bjarte Håvik; Håvard Røkke; Svend Davanger et al. (2002). Rapid dendritic trafficking and translation of pre-existing CaMKII mRNA during LTP in awake rats. (external link)
• Clive R. Evjen Bramham (2002). Making memories last: brain-derived neurotrophic factor (BDNF) as a trigger for synaptic consolidation. (external link)
• Elhoucine Messaoudi; Shui-Wang Ying; Tambudzai Kanhema et al. (2002). BDNF triggers transcription-dependent, late phase LTP in vivo. (external link)
• Clive R. Evjen Bramham (2002). The instructive role of BDNF in long-term potentiation. (external link)
• Elhoucine Messaoudi; Shui-Wang Ying; Tambudzai Kanhema et al. (2002). Brain-derived neurotrophic factor triggers transcription-dependent, late phase long-term potentiation in vivo. (external link)
• Shui-Wang Ying; Marie Futter; Kobi Rosenblum et al. (2002). Brain-derived neurotrophic factor induces long-term potentiation in intact adult hippocampus: requirement for ERK activation coupled to CREB and upregulation of Arc synthesis. (external link)
• W.J. Tyler; M Alonso; Clive R. Evjen Bramham et al. (2002). From acquisition to consolidation: on the role of brain-derived neurotrophic factor signaling in hippocampal-dependent learning. (external link)

2001

• Clive R. Evjen Bramham (2001). BDNF, LTP and neuroprotection. (external link)
• Clive R. Evjen Bramham (2001). BDNF and synaptic plasticity in the hippicampus in vivo. (external link)
• Clive R. Evjen Bramham (2001). BDNF and synaptic plasticity in the hippocampus in vivo. (external link)
• Tambudzai Kanhema; Shui-Wang Ying; Angus C. Nairn et al. (2001). BDNF-induced long-term potentiation in the dentate gyrus in vivo is associated with phosphorylation of elongation factor-2. (external link)
• Clive R. Evjen Bramham (2001). Brain-derived neurotrophophic factor (BDNF) and Long-Term synaptic plasticity. (external link)
• Clive R. Evjen Bramham (2001). BDNF and synaptic plasticity in the hippicampus in vivo. (external link)
• Clive R. Evjen Bramham (2001). BDNF and synaptic plasticity in the hippicampus in vivo. (external link)
• Clive R. Evjen Bramham (2001). BDNF and synaptic plasticity in the hippicampus in vivo. (external link)
• Elhoucine Messaoudi; Clive R. Evjen Bramham (2001). Characterization of BDNF-induced LTP in the dentate gyrus in vivo. (external link)
• Tambudzai Kanhema; Shui-Wang Ying; Angus C. Nairn et al. (2001). BDNF-induced long-term potentiation in the dentate gyrus in vivo is associated with phosphorylation of elongation factor-2. (external link)

2009

• Clive R. Evjen Bramham; Henriette Aksnes (2009). Time-lapse imaging of Arc/Arg3.1 protein degradation in hippocampal neurons using the novel photoconvertible fluorescent protein Dendra2. (external link)
• Peter Jedlicka; Stephan W. Schwarzacher; Raphael Winkels et al. (2009). Impairment of in vivo theta-burst long term potentiation and network excitability in the dentate gyrus of synaptopodin-deficient mice lacking the spine apparatus and the cisternal organelle. (external link)
• Clive R. Evjen Bramham; Debabrata Panja; Adrian Tiron et al. (2009). Arc/Arg3.1 synthesis and control of LTp consolidation in the adult dentate gyrus in vivo. (external link)
• Stephanie Le Hellard; Bjarte Håvik; Thomas Espeseth et al. (2009). Variants in doublecortin- and calmodulin kinase like 1, a gene up-regulated by BDNF, are Associated with memory and general cognitive abilities. (external link)
• Debabrata Panja; Girstaute Dagyte; Mivhael Bidinosti et al. (2009). Novel Translational Control in Arc-dependent Long Term Potentiation Consolidation in Vivo. (external link)
• Clive R. Evjen Bramham; Birgitte Berentsen (2009). microRNA-34a Function in Long-Term Potentiation in the Dentate Gyrus of the Anaesthetised Rat. (external link)
• Henriette Aksnes; Rajeevkumar Raveendran Nair; Clive R. Bramham (2009). Time-lapse imaging of Arc protein degradation and synthesis in hippocampal neurons. (external link)
• Sjoukje Kuipers; Adrian Tiron; Jonathan Soule et al. (2009). Selective survival and maturation of adult-born dentate granule cells expressing the immediate early gene Arc/Arg3.1. (external link)

2014

• Manja Schubert; Debabrata Panja; Mette Haugen et al. (2014). Paraneoplastic CDR2 and CDR2L antibodies affect Purkinje cell calcium homeostasis. (external link)
• Janne Grønli; Jonathan Soule; Clive R. Bramham (2014). Sleep and protein synthesis-dependent synaptic plasticity: impacts of sleep loss and stress. (external link)
• Debabrata Panja; Justin W. Kenney; Laura D'Andrea et al. (2014). Two-stage translational control of dentate gyrus LTP consolidation is mediated by sustained BDNF-TrkB signaling to MNK. (external link)
• Pai Balagopal Sreenivasa; Taweeporn Siripornmongcolchai; Birgitte Berentsen et al. (2014). NMDA receptor-dependent regulation of miRNA expression and association with Argonaute during LTP in vivo. (external link)
• Clive R. Bramham; Debabrata Panja (2014). BDNF regulation of synaptic structure, function, and plasticity. (external link)
• Sudip Debnath; Clive R. Bramham; Sudarshan Patil (2014). Arc protein-protein interaction in long-term potentiation in the rat dentate gyrus in vivo. (external link)
• Ida Sporild; Clive R. Bramham; Karin Wibrand (2014). Characterization of two predicted long non-coding RNAs in long-term synaptic plasticity in rat hippocampus. (external link)
• Debabrata Panja; Clive R. Bramham (2014). BDNF mechanisms in late LTP formation: A synthesis and breakdown. (external link)

1999

• Håvard Røkke; Clive R. Evjen Bramham (1999). LTP induction in the dentate gyrus of freely moving rats is modulated by dentate EEG spikes. (external link)
• Elhoucine Messaoudi; Clive R. Evjen Bramham (1999). NMDA receptor activation is not required for BDNF-induced LTP in the rat dentate gyrus in vivo. (external link)
• G Thomas; Karen Toska; Clive R. Evjen Bramham et al. (1999). Mitogen and stress activated protein kinase signaling pathways: emerging functions in the nervous system. (external link)
• Clive R. Evjen Bramham; Elhoucine Messaoudi; M. Webber et al. (1999). BDNF-induced LTP is associated with enhanced ZIF/268 protein expression in rat dantate gyrus in vivo. (external link)
• Gareth Thomas; Karen Toska; Clive R. Evjen Bramham et al. (1999). MAP and SAP kinase signaling pathways: emerging functions in the nervous system. (external link)

2008

• Clive R. Evjen Bramham (2008). Local protein synthesis, actin dynamics, and LTP consolidation. (external link)
• Janne Grønli; Grethe Dagestad; Anne Marita Milde et al. (2008). Sleep deprivation as an antidepressant treatment following chronic mild stress: effects on translation factor EIF4E and EEF2 activity. (external link)
• Jonathan Soule; Z Penke-Verdier; Tambudzai Kanhema et al. (2008). Object-place recognition learning triggers rapid induction of plasticity-related immediate early genes and synaptic proteins in the rat dentate gyrus. (external link)
• May Lillian Ofte; Clive R. Evjen Bramham (2008). Effect of Antidepressant Treatment on the Expression of LTP-associated MicroRNAs. (external link)
• Clive R. Evjen Bramham; PF Worley; MJ Moore et al. (2008). The immediate early gene arc/arg3.1: regulation, mechanisms, and function. (external link)
• Frøydis Haugan; Karin Wibrand; Atle Fiskå et al. (2008). Stability of long term facilitation and expression of zif268 and Arc in the spinal cord dorsal horn is modulated by conditioning stimulation within the physiological frequency range of primary afferent fibers. (external link)

2024

• Rodolfo Da Silva Mazzarini Baldinotti; Francois Philippe Pauzin; Hauk Fevang et al. (2024). A Nanobody-Based Proximity Ligation Assay Detects Constitutive and Stimulus-Regulated Native Arc/Arg3.1 Oligomers in Hippocampal Neuronal Dendrites. (external link)
• Jose Miguel Godoy Munoz; Lasse Neset; Sigurbjörn Markusson et al. (2024). Structural characterization of two nanobodies targeting the ligand-binding pocket of human Arc. (external link)
• Maria Letizia Potenza; Stefan Matthias Adriaan Blankvoort; Miguel Carvalho et al. (2024). Generation of an enhancer-driven gene expression viral tool specific to dentate granule cell-types through direct hippocampal injection. (external link)
• Anna Karisdotter Einarsen; Clive Raymond Evjen Bramham; Francois Philippe Pauzin (2024). The Role of eIF4E in Translation Initiation Dynamics During Long-term Synaptic Plasticity in The Mouse Dentate Gyrus In-vivo. (external link)
• Fereshteh Farajdokht; Craig Myrum; Clive Raymond Evjen Bramham et al. (2024). Editorial: Impact of sex and gender on neurocognitive aging and behavior. (external link)

2000

• Clive R. Evjen Bramham; M.A. Lynch; M. Plummer et al. (2000). Symposium: Neurotrophins and synaptic plasticity in the hippocampus. (external link)
• Håvard Røkke; Clive R. Evjen Bramham (2000). Pairing of low frequency perforant path stimulation and endogenous exitatory events in dentate gyrus of the freely behaving rat. (external link)
• Lars Jørgen Rygh; Kjetil Bårdsen; Clive R. Evjen Bramham (2000). In vivo monitoring of TrkB-Fc efficacy and time course using paired-pulse inhibition in the dentate gyrus. (external link)
• Elhoucine Messaoudi; S. Croll; Clive R. Evjen Bramham (2000). Characterization of BDNF-induced long-term potentiation in the rat dentate gyrus. (external link)
• K. Rosenblum; M. Futter; K. Voss et al. (2000). GFP-ERKII translocation in neurons: a marker for long-term synaptic plasticity. (external link)
• Håvard Røkke; M. Webber; S. Hunt et al. (2000). LTP induction in wakefulness and sleep-effect on expression patterns of immediate early genes. (external link)
• Gerald Valentine; Sumana Chakravarty; John Sarvey et al. (2000). Fragile X (fmr1) mRNA expression is differentially regulated in two adult models of activity-dependent gene expression. (external link)
• Shui-Wang Ying; K. Rosenblum; M. Futter et al. (2000). Activation of MAPK signaling pathway is required in BDNF-induced long-term potentation in the adult hippocampus in vivo. (external link)

1998

• Kjetil Bårdsen; El Houcine Messaoudi; Clive R. Evjen Bramham (1998). Effect of the BDNF-scavenger TrkB-IgF on LTP in the rat dentate gyrus in vivo. (external link)
• Clive R. Evjen Bramham (1998). Neurotrophin regulation of synaptic plasticity in the adult nervous system. (external link)
• Clive R. Evjen Bramham (1998). Phasic boosting of medial perforant path-evoked granule cell output time-locked to spontaneous dentate EEG spikes in awake rats. (external link)
• Elhoucine Messaoudi; Kjetil Bårdsen; Bolek Srebro et al. (1998). In vivo BDNF-induced long-lasting potentiation in the rat dentate gyrus. (external link)
• Clive R. Evjen Bramham; Kjetil Bårdsen; Elhoucine Messaoudi (1998). Endogenous neurotrophins and LTP in the dentate gyrus in vivo: effect of BDNF-scavenger Trk-IgG. (external link)
• Clive R. Evjen Bramham; S. Alhers; J. Sarvey (1998). Acute cold stress leading to elevated corticosterone neither enhances synaptic efficacy nor impairs tetanus-evoked LTP in the dentate gyrus of free moving rats. (external link)
• Elhoucine Messaoudi; Boleslaw Srebro; Clive R. Evjen Bramham (1998). Acute intrahippocampal infusion of BDNF induces lasting potentiation of synaptic transmission in the rat dentate gyrus. (external link)

2018

• Andrea Rørvik Marti; Silje Skrede; Jelena Mrdalj et al. (2018). Extending the photoperiod impacts circadian rhythmicity and gene expression in prefrontal cortex and retina- Impact of exposure to blue-enriched light.. (external link)
• Andrea Rørvik Marti; jorrit waslander; Silje Skrede et al. (2018). Extended photoperiod alters circadian rhythmicity and expression of neuroplasticity markers. The impact of blue-enriched light.. (external link)
• Erik Ingmar Hallin; Maria Steene Eriksen; Sergei Baryshnikov et al. (2018). Structure of monomeric full‐length ARC sheds light on molecular flexibility, protein interactions, and functional modalities. (external link)
• Janne Grønli; Andrea Rørvik Marti; jorrit waslander et al. (2018). Extended photoperiod alters sleep and expression of synaptic plasticity-associated genes. The impact of blue-enriched light.. (external link)
• Maria Steene Eriksen; Clive R. Bramham (2018). The immediate early protein Arc: an exploration of protein structure and regulation. (external link)

2025

• Sigrid Skaar; Clive Raymond Evjen Bramham; Hongyu Zhang (2025). Impact of an Interfering Peptide on Anxiety-Like Behavior, Spatial Memory, and Recognition Memory in a 5xFAD Mouse Model of Alzheimer´s Disease. (external link)
• Preeti Kute; Francois Philippe Pauzin; Kornel Labun et al. (2025). Transcriptome-wide mapping of small ribosomal subunits elucidates scanning mechanisms of translation initiation in the mammalian brain. (external link)
• Tobias Helliksen Kongsgård; Clive Raymond Evjen Bramham; Hongyu Zhang (2025). Effects of a novel synthetic peptide on anxiety-like behaviour and fear memory in a 5xFAD mouse model of Alzheimer's disease. (external link)
• Håvard Håvardsholm Nesbø; Clive Raymond Evjen Bramham; Hongyu Zhang (2025). Examining Pro- and Antidepressant Effects of Two Synthetic Peptides in C57BL/6 Mice Under Baseline Conditions and in a Corticosterone Induced Chronic Mild Stress Model. (external link)

2019

• Yuta Ishizuka; Clive R. Bramham (2019). A simple DMSO-based method for cryopreservation of primary hippocampal and cortical neurons. (external link)
• Birgitte Berentsen; Sudarshan Patil; Kine Terese Rønnestad et al. (2019). MicroRNA-34a acutely regulates synaptic efficacy in the adult dentate gyrus in vivo. (external link)

1996

• Clive R. Evjen Bramham; Teresa Southard; John M Sarvey et al. (1996). Unilateral LTP triggers bilateral increases in hippocampal neurotrophin and trk receptor mRNA expression in behaving rats: Evidence for interhemisp communication. (external link)
• Clive R. Evjen Bramham; John M Sarvey (1996). Endogenous Activation of µ and -1 Opioid Receptors Is Required for Long-Term Potentiation Induction in the Lateral Perforant Path: Dependence on GABAergic Inhibition. (external link)

1991

• M. A. Lynch; M. P. Clements; K. L. Voss et al. (1991). Is arachidonic acid a retrograde messenger in long-term potentiation?. (external link)
• Clive R. Evjen Bramham; N. W. Milgram; Boleslaw Srebro (1991). Activation of AP5-sensitive NMDA-receptors is required to induce LTP of synaptic transmission in the lateral perforant path. (external link)
• Clive R. Evjen Bramham; N. W. Milgram; Boleslaw Srebro (1991). Delta opioid receptor activation is required to induce LTP of synaptic transmission in the lateral perforant path in vivo. (external link)

2004

• M Gooney; El Houcine Messaoudi; F O Maher et al. (2004). BDNF-induced LTP in dentate gyrus is impaired with age: analysis of changes in cell signalling events. (external link)

2011

• Janne Grønli; Grethe Dagestad; Anne Marita Milde et al. (2011). Chronic mild stress and acute sleep deprivation: interactive and brain-region specific effects on regulation of translation factor and CPEB phosphorylation. (external link)
• Yurika Rajbhandari; Clive R. Evjen Bramham (2011). Regulation of micro-RNA induced silencing complex during long-term potentiation in the dentate gyrus In vivo. (external link)
• Caroline M Coppens; Taweeporn Siripornmongcolchai; Karin Wibrand et al. (2011). Social defeat during adolescence and adulthood differentially induce BDNF-regulated immediate early genes. (external link)
• Bjarte Håvik; Stephanie Le Hellard; Marcella Rietschel et al. (2011). The Complement Control-Related Genes CSMD1 and CSMD2 Associate to Schizophrenia. (external link)

See a complete overview of publications in Cristin.

Papers by topic

Arc protein structure, function, and regulation

Avallone. M., Pardo, J., Mergiya, T.F., Rajova, J. Räsänen, A., Davidsson, M., Åkerblom, M., Quintino, L., Kumar, D., Bramham, C.R., & Björklund, T. (2023) Visualizing Arc protein dynamics and localization in the mammalian brain using adeno-associated virus-mediated in situ gene labeling. Front. Mol. Neurosci. Vol 16, doi:10.3389/fnmol.2023.1140785.

Mergiya, T.F., Gundersen, J.E.T., Kanhema, T., Brighter, G., Ishizuka, Y., & Bramham, C.R. (2023) Detection of Arc/Arg3.1 oligomers in rat brain: constitutive and synaptic activity-evoked dimer expression in vivo. Front. Mol. Neurosci. Vol 16, doi: 10.3389/fnmol.2023.1142361

Eriksen M.S. and Bramham C.R. (2022) Molecular physiology of Arc/Arg3.1: The oligomeric state hypothesis of synaptic plasticity. Acta Physiologica, e13886. doi.org/10.1111/apha.13886

Ishizuka, Y., Mergiya, T.F. Baldinotti, R., Xu, J., Hallin, E.I., Markússon, S., Kursula, P., and Bramham, C.R. (2022). Development and Validation of Arc Nanobodies: New Tools for Probing Arc Dynamics and Function. Neurochem Res 47, 2656–2666 doi.org/10.1007/s11064-022-03573-5.

Markússon, S, Hallin, E.I., Bustad, H.J., Raasakka, A., Xu, J., Muruganandam, G., Loris, R., Martinez, A., Bramham, C.R. and Kursula, P. (2022). High-affinity anti-Arc nanobodies provide tools for structural and functional studies. PLoS ONE 17(6): e0269281. doi.org/10.1371/journal.pone.0269281

Hallin, E.I., Markússon, S., Böttger, L., Torda, A.E., Bramham, C.R., and Kursula, K. (2021) Crystal and solution structures reveal oligomerization of individual capsid homology domains of Drosophila Arc. PLoS One 16, e0251459. doi.org/10.1371/journal.pone.0251459

Hallin, E.I., Bramham, C.R., and Kursula, K. Structural properties and peptide ligand binding of the capsid homology domains of human Arc (2021) Biochem Biophys Res Commun 26, doi.org/10.1101/2020.12.17.423319 

Eriksen MS, Nikolaienko O, Hallin EI, Grødem S, Bustad HJ, Flydal MI, Merski I, Hosokawa T, Lascu D, Akerkar S, Cuéllar J, Chambers JJ, O’Connell R, Muruganandam G, Loris R, Touma C, Kanhema T, Hayashi Y, Stratton MM, Valpuesta JM, Kursula P, Martinez A and Bramham CR  (2020). Arc self-association and formation of virus-like capsids are mediated by an N-terminal helical coil motif. The FEBS Journal. https://doi.org/10.1111/febs.15618

Zhang, H. and Bramham, C.R. (2020) Arc function in long-term synaptic plasticity: emerging mechanisms and unresolved issues. Eur J Neurosci, doi.org/10.1111/ejn.14958

Hallin, EI, Eriksen, M., Baryshnikov, S., Nikolaienko, Grødem, S., Hosokawa, Y. Hayashi, Y., *Bramham, C.R. and *Kursula, P.  (2018) Structure of monomeric full-length ARC sheds light on molecular flexibility, protein interactions, and functional modalities. J. Neurochem. doi.org/10.1111/jnc.14556.  

Nikolaienko, O., Patil, S, Eriksen, M.S., and Bramham, C.R., (2018) Arc protein: a flexible hub for synaptic plasticity and cognition. Semin Cell Dev Biol, 77:33-42. dx.doi.org/10.1016/j.semcdb.2017.09.006

Nair, R.R., Patil S., Tiron, A, Kanhema, T., Panja, D., Schiro, L., Parobzak, K., Wilczynski, G., and Bramham, C.R. (2017) Dynamic Arc SUMOylation and selective interaction with F-actin binding protein drebrin A in LTP consolidation in vivo. Front Synaptic Neurosci. doi: 10.3389/fnsyn.2017.00008

Gozdz, A., Nikolaienko, O., Urbanska, M., Cymerman, I.A., Sitkiewicz, E., Dadlez, M., Bramham. C.R., and Jaworski, J (2017) GSK3α and GSK3β phosphorylate Arc and regulate its degradation. Front Mol Neurosci. http://doi: 10.3389/fnmol.2017.00192

Nikolaienko O, Eriksen MS, Patil S, Bito H, and Bramham CR (2017)  Stimulus-evoked ERK-dependent phosphorylation of activity-regulated cytoskeleton-associated protein (Arc) regulates its neuronal subcellular localization. Neuroscience 360:68–80. http://doi: 10.1016/j.neuroscience.2017.07.026.

Myrum, C., Soulé, J., Bittins, M., Cavagnini, K., Eriksen, M.S., Goff, K., Ziemek, S., Patil, S., Szum, A., Nair, R.R. and Bramham, C.R. (2017) Arc interacts with the integral ER protein, calnexin. Frontiers Cell Neurosci. doi.org/10.3389/fncel.2017.00294.

Kuipers, S., Trentani, A., Tiron, A, Mao, X., Kuhl, D., and Bramham, C.R.  (2016) BDNF-induced LTP is associated with rapid Arc-dependent enhancement in adult hippocampal neurogenesis. Scientific Reports, http://doi: 10.1038/srep21222.

Myrum,C., Baumann, A., Bustad, H.J., Flydal, M.I., Mariaule,V., Alvira, S., Cuéllar, J., Soulé, J., Valpuesta J.M., Márquez, J.A., *Martinez, A., and *Bramham,C.R. (2015) Arc is a flexible modular protein capable of reversible self-oligomerization. Biochem J. 468, 145-158. http://doi 10.1042/BJ20141446

Myrum C, Giddaluru S, Jacobsen K, Espeseth T, Nyberg L, Lundervold A J, Haavik J, Nilsson L, Reinvang I, Steen V M, Johansson S, Wibrand K, *Le Hellard S, and *Bramham C R. (2015) Common variants in the ARC gene are not associated with cognitive abilities. Brain and Behavior, doi: 10.1002/brb3.376.

Soule J, Alme MN, Myrum C, Schubert M, Kanhema T, Bramham CR (2012) Balancing Arc synthesis, mRNA decay, and proteasomal degradation: maximal protein expression triggered by REM sleep-like bursts of muscarinic cholinergic receptor stimulation. J Biological Chemistry, 287(26): 22354-66. 

Wibrand, K., Pai, B., Siripornmongcolchai, T, Bittins, M., Berentsen, B., Ofte, M.L,  Weigel, A., Skaftnesmo, K.O., and Bramham C.R.   (2012) MicroRNA regulation of the synaptic plasticity related gene Arc. PLoS ONE 7(7): e41688.

Bramham CR, Alme MN, Bittins M, Kuipers SD, Nair RR, Pai B, Panja D, Schubert M, Soule J, Tiron A, Wibrand K (2010) The Arc of synaptic memory. Exp Brain Res 200:125-140.

Kuipers SD, Tiron A, Soule J, Messaoudi E, Trentani A, Bramham CR (2009) Selective survival and maturation of adult-born dentate granule cells expressing the immediate early gene Arc/Arg3.1. PLoS ONE 4(3): e4885.

Bramham CR, Worley PF, Moore MJ, Guzowski JF (2008) The immediate early gene Arc/Arg.1: regulation, mechanisms, and function. J Neurosci. 27(39): 10445-10455.

Soule J, Penke-Verdier Z, Alme M, Kanhema T, Laroche S, Bramham CR (2008) Object-place recognition learning triggers rapid induction of plasticity-related immediate early genes and synaptic proteins  in the rat dentate gyrus. Neural Plasticity, Article ID 269097, 12 pages.    

Messaoudi,E., Kanhema,T., Soule,J., Tiron,A., Dagyte,G., da Silva,B., and Bramham,C.R.  (2007) Sustained Arc synthesis controls LTP consolidation through regulation of local actin polymerization in the dentate gyrus in vivo.  J. Neurosci. 27: 10445-10455.  

Ying SW, Futter M, Rosenblum K, Webber MJ, Hunt SP, Bliss TV, Bramham CR (2002) Brain-derived neurotrophic factor induces long-term potentiation in intact adult hippocampus: requirement for ERK activation coupled to CREB and upregulation of Arc synthesis. J Neurosci 22: 1532-1540.

 

BDNF

Cassarotto, P., Girych, M., Fred, S.M., Moliner, R., Enkavi, G., Biojone, C., Cannarozzo, C., Brunello, C.A, Steinzeig, A., Winkel, F., Patil, S., Vestring, S.,  Serchov, T., Laukkanen, L., Cardon, I., Antila, H., Rog, T., Bramham, C.R., Normann, C., Lauri, S.E., Vattulainen, I., and Castrén, E.,  (2021) Antidepressants act by directly binding to TRKB neurotrophin receptors. Cell 184:1-15. 10.1016/j.cell.2021.01.034

Esvald, E.-E., Tuvikene, J., Sirp, A., Patil, S., Bramham, C.R., & Timmusk, T. (2020) CREB family transcription factors are major mediators of BDNF transcriptional autoregulation in cortical neurons. J. Neurosci., 40(7):1405-1426. doi.org/10.1523/JNEUROSCI.0367-19.2019.

Panja, D and Bramham, C.R. (2017) BDNF function in long-term synaptic plasticity in the dentate gyrus in vivo:  methods for local drug delivery and biochemical analysis of translation. In: Neuromethods. Humana Press. doi.org/10.1007/7657_2017_7

Kuipers, S., Trentani, A., Tiron, A, Mao, X., Kuhl, D., and Bramham, C.R.  (2016) BDNF-induced LTP is associated with rapid Arc-dependent enhancement in adult hippocampal neurogenesis. Scientific Reports, doi: 10.1038/srep21222.

Panja, D., Kenney, J.W., D’Andrea, L., Zalfa, F., Vedeler, A., Wibrand, K., Fukunaga, R., Bagni, C., Proud, C.G., and Bramham, C.R. (2014). Two-stage translational control of dentate gyrus LTP consolidation is mediated by sustained BDNF-TrkB signaling to MNK. Cell Rep. 9, 1430–1445.

Panja, D., and Bramham, C. R. (2014). BDNF mechanisms in late LTP formation: a synthesis and breakdown. Neuropharmacology, 76: 664-676 . doi:10.1016/j.neuropharm.2013.06.024

Coppens, C. M., Siripornmongcolchai, T., Wibrand, K., Alme, M. N., Buwalda, B., de Boer, S. F., Koolhaas, J. M., and Bramham, C. R. (2011) Social defeat during adolescence and adulthood differentially induce BDNF-regulated immediate early genes. Front Behav. Neurosci. 5:72., Epub Nov 2.

Messaoudi,E., Kanhema,T., Soule,J., Tiron,A., Dagyte,G., da Silva,B., and Bramham,C.R.  (2007) Sustained Arc synthesis controls LTP consolidation through regulation of local actin polymerization in the dentate gyrus in vivo.  J. Neurosci. 27: 10445-10455.  

Alme MN, Wibrand K, Dagestad G, Bramham CR (2007) Chronic fluoxetine treatment induces brain region-specific upregulation of genes associated with BDNF-induced long-term potentiation. Neural Plast 2007: 26496. PMID: 18301726

Wibrand K, Messaoudi E, Havik B, Steenslid V, Løvlie R, Steen VM, and Bramham CR (2006) Identification of genes co-upregulated with Arc during BDNF-induced long-term potentiation in the adult rat dentate gyrus in vivo. Eur J Neurosci 23: 1501-1511.

Kanhema, T.,  Dagestad, G., Panja, D., Messaoudi, E., Haavik, B., Ying, S.W.,  Nairn, A.C., Sonenberg, N. and Bramham, C.R.  (2006) Dual regulation of translation initiation and peptide chain elongation during BDNF-induced LTP in vivo: evidence for compartment-specific translation control.  J Neurochem. 99:1328-1337.   

Bramham,C.R  and Messaoudi, E. (2005) BDNF function in adult synaptic plasticity: the synaptic consolidation hypothesis.  Prog. Neurobiol, 76: 99-125. 

Gooney, M., Messaoudi, E., Maher, F.O., *Bramham, C.R., and *Lynch, M.A. (2004) BDNF-induced LTP in dentate gyrus is impaired with age: analysis of changes in cell signalling events. Neurbiol Aging.  25: 1323-1331.

Ying SW, Futter M, Rosenblum K, Webber MJ, Hunt SP, Bliss TV, Bramham CR (2002) Brain-derived neurotrophic factor induces long-term potentiation in intact adult hippocampus: requirement for ERK activation coupled to CREB and upregulation of Arc synthesis. J Neurosci 22: 1532-1540.

Messaoudi E, Ying SW, Kanhema T, Croll SD, Bramham CR (2002) BDNF triggers transcription-dependent, late phase LTP in vivo. J Neurosci 22: 7453-7461.

Messaoudi, E., Bårdsen, K.,  Srebro, B., and C.R. Bramham (1998) Acute intrahippocampal infusion of brain-derived neurotrophic factor induces lasting potentiation of synaptic transmission in the rat dentate gyrus.  J. Neurophysiol. 79: 496-499.

 

Translational control and dendritic protein synthesis

Patil, S., Chalkiadaki, K., Mergiya, T.F, Krimbacher, K., Amorim, I.S., Akerkar, S., Gkogkas, C.G., and Bramham, C.R. (2023) eIF4E phosphorylation recruits β-catenin to mRNA cap and promotes Wnt pathway translation in dentate gyrus LTP maintenance. iScience, 26(5), 106649. doi.org/10.1016/j.isci.2023.106649

Chalkiadaki, K., Kouloulia, S., Bramham, C.R., and Gkogkas, C (2020) Regulation of protein synthesis by eIF4E in the brain. In The Oxford Handbook of Neuronal Protein Synthesis pp 1–22. 10.1093/oxfordhb/9780190686307.013.12

Taha E, Patil S, Barrera I, Proud CG, Bramham CR, Rosenblum K (2020) eEF2/eEF2K pathway in the mature dentate gyrus determines neurogenesis level and cognition. Current Biology 30:1–15. doi.org/10.1016/j.cub.2020.06.061.

Berentsen B, Patil S, Wibrand K, Goff KM, Pajak M, Simpson IT, and Bramham CR. (2020) microRNA-34a acutely regulates synaptic efficacy in the adult dentate gyrus in vivo. Molecular Neurobiology doi.org/10.1007/s12035-019-01816-1

Bramham, C.R., Jensen, K, and Proud, CG. (2016) Tuning specific translation in cancer metastasis and synaptic memory: control at the MNK-eIF4E axis.  Trends in Biochemistry, 41: 847-858. dx.doi.org/10.1016/j.tibs.2016.07.008.

Panja, D., Kenney, J.W., D’Andrea, L., Zalfa, F., Vedeler, A., Wibrand, K., Fukunaga, R., Bagni, C., Proud, C.G., and Bramham, C.R. (2014). Two-stage translational control of dentate gyrus LTP consolidation is mediated by sustained BDNF-TrkB signaling to MNK. Cell Rep. 9, 1430–1445.

Grønli, J., Soulé, J., and Bramham, C.R. (2014). Sleep and protein synthesis-dependent synaptic plasticity: impacts of sleep loss and stress. Front. Behav. Neurosci. 7, 1–18.

Grønli,J., Dagestad,G., Milde,A.M., Murison,R., and Bramham,C.R. (2012). Post-transcriptional effects and interactions between chronic mild stress and acute sleep deprivation: Regulation of translation factor and cytoplasmic polyadenylation element-binding protein phosphorylation. Behav. Brain Res. 235, 251-262.

Panja, D., Dagyte, G., Bidinosti, M.,. Wibrand, K.,  Kristiansen, A.M., Sonenberg, N., and Bramham, C.R.  (2009) Novel translational control in Arc-dependent long-term potentiation consolidation in vivo.  J. Biological Chemistry 284: 31498-31511.  

Bramham, C.R.  (2008) Local protein synthesis, actin dynamics, and LTP consolidation. Curr Opin Neurobiol. 18: 524-531.

Bramham C. R. and Wells D. G. (2007) Dendritic mRNA: transport, translation, and function. Nature Rev Neurosci, 8 (10):776 – 789.

Dagestad,G., Messaoudi,E., and Bramham,C.R. (2006). Chronic fluoxetine induces region specific changes in translation factor eIF4E and eEF2 activity in the rat brain.  Eur J Neurosci., 23: 2814-2818.

Kanhema, T.,  Dagestad, G., Panja, D., Messaoudi, E., Haavik, B., Ying, S.W.,  Nairn, A.C., Sonenberg, N. and Bramham, C.R.  (2006) Dual regulation of translation initiation and peptide chain elongation during BDNF-induced LTP in vivo: evidence for compartment-specific translation control.  J Neurochem. 99:1328-1337.   

Håvik, B., Røkke, H., Bårdsen, K., Davanger, S. and Bramham, C.R. (2003) High-frequency bursts trigger rapid delivery of pre-existing CaMKII mRNA to synapses: a mechanism in dendritic protein synthesis during long-term potentiation in adult awake rats.  Eur. J. Neurosci., 17: 2679-2689.

 

Gene expression and non-coding RNAs

Berentsen B, Patil S, Wibrand K, Goff KM, Pajak M, Simpson IT, and Bramham CR. (2020) microRNA-34a acutely regulates synaptic efficacy in the adult dentate gyrus in vivo. Molecular Neurobiology doi.org/10.1007/s12035-019-01816-1

Maag, J.L.V. Panja, D, Kaczorowski, D.C. Peters, T.J., Bramham, C.R., Wibrand, K.,    and Dinger, M.E.  (2017) Widespread promoter methylation of synaptic plasticity genes in long-term potentiation in the adult brain in vivo. BMC Genomics. 18 (2017) 250. doi:10.1186/s12864-017-3621-x.

Maag, J.L.V., Panja,D., Sporild, I, Patil, S., Kaczorowski, D.C., *Bramham, C.R., *Dinger, M., and *Wibrand, K. (2015) Dynamic expression of long noncoding RNAs and repeat elements in synaptic plasticity. Frontiers in Neuroscience.  9:351. doi:10.3389/fnins.2015.00351

Pai, B., Siripornmongcolchai, T., Berentsen, B., Pakzad, A., Vieuille, C., Pallesen, S., Pajak, M., Simpson, T.I., Armstrong, J.D., Wibrand, K., and Bramham, C.R. (2014). NMDA receptor-dependent regulation of miRNA expression and association with Argonaute during LTP in vivo. Front. Cell. Neurosci. 7, 1–15.

Wibrand, K., Pai, B., Siripornmongcolchai, T, Bittins, M., Berentsen, B., Ofte, M.L,  Weigel, A., Skaftnesmo, K.O., and Bramham C.R.   (2012) MicroRNA regulation of the synaptic plasticity related gene Arc. PLoS ONE 7(7): e41688. 

Wibrand, K., Panja, D., Tiron, A., Ofte, M.L., Skaftnesmo, K. Sohn-Lee, C., Pena, J., Tuschl, T. and Bramham, C.R. (2010) Differential regulation of mature and precursor microRNA expression by NMDAR and metabotropic glutamate receptor expression activation during LTP in the dentate gyrus in vivo. Eur J Neurosci 31: 636-645. 

Håvik, B., Røkke, H., Dagyte, G., Stavrum, A-K., *Bramham, C.R., and *Steen, V.M. (2007) Synaptic activity-induced global gene expression patterns in the dentate gyrus of adult behaving rats: induction of immunity-linked gene sets. (*Equal contribution).  Neuroscience, 148: 925-936.

Wibrand K, Messaoudi E, Havik B, Steenslid V, Løvlie R, Steen VM, and Bramham CR (2006) Identification of genes co-upregulated with Arc during BDNF-induced long-term potentiation in the adult rat dentate gyrus in vivo. Eur J Neurosci 23: 1501-1511.

Human Genetics

Myrum, C., Nikolaienko, O. Bramham, C.R. Haavik, J., and Zayats, T. Implication of the APP gene in intellectual abilities. (2017) J Alz Dis. 59(2):723-735. doi: 10.3233/JAD-170049.

Myrum C, Giddaluru S, Jacobsen K, Espeseth T, Nyberg L, Lundervold A J, Haavik J, Nilsson L, Reinvang I, Steen V M, Johansson S, Wibrand K, *Le Hellard S, and *Bramham C R. (2015) Common variants in the ARC gene are not associated with cognitive abilities. Brain and Behavior, doi: 10.1002/brb3.376.

Havik, B., Degenhardt, F. A., Johansson, S., Fernandes, C. P., Hinney, A., Scherag, A., Lybaek, H., Djurovic, S., Christoforou, A., Ersland, K. M., Giddaluru, S., O'Donovan, M. C., Owen, M. J., Craddock, N., Muhleisen, T. W., Mattheisen, M., Schimmelmann, B. G., Renner, T., Warnke, A., Herpertz-Dahlmann, B., Sinzig, J., Albayrak, O., Rietschel, M., Nothen, M. M., Bramham, C. R., Werge, T., Hebebrand, J., Haavik, J., Andreassen, O. A., Cichon, S., Steen, V. M., and Le Hellard S. (2012) DCLK1 Variants are associated across schizophrenia and attention deficit/hyperactivity disorder PLoS ONE 7, e35424

Le Hellard S, Havik B, Espeseth T, Breilid H, Lovlie R, Luciano M, Gow AJ, Harris SE, Starr JM, Wibrand K, Lundervold AJ, Porteous DJ, Bramham CR, Deary IJ, Reinvang I, Steen VM (2009) Variants in doublecortin- and calmodulin kinase like 1, a gene up-regulated by BDNF, are associated with memory and general cognitive abilities. PLoS One 4:e7534.

 

Publications in CRIStin database with links:

 

• Arc as a master regulator of long-term synaptic plasticity 
• Translational control of synaptic plasticity
• Non-coding RNA regulation and function in synaptic plasticity

Links to currently funded projects:t

The Impact of Cytoplasmic Polyadenylation on Local Translation in Neurons. EEA grant for Poland-Norway Research Cooperation. 2020-2024.

Mohn Research Center for Plasticity and Neural Circuit Dynamics in the Brain. Supported by the Trond Mohn Foundation, the University of Bergen (UiB) and the Norwegian University of Science and Technology (NTNU). 2021-2026.