The overriding goal is to explain how information is physically stored and represented in the brain, and how these processes are disrupted, altered, or destroyed in disorders of cognition including memory loss. Our research focus is the molecular control of synaptic plasticity. We aim to uncover the logic of synaptic plasticity at the level of protein synthesis, protein functional properties, and the dynamics of protein interaction networks.

Specific research areas:

• Arc as a master regulator of long-term synaptic plasticity and cognition
• Translational control of synaptic plasticity
• Non-coding RNA regulation and function in synaptic plasticity

Papers by topic

Arc protein structure, function, and regulation

Avallone. M., Pardo, J., Mergiya, T.F., Rajova, J. Räsänen, A., Davidsson, M., Åkerblom, M., Quintino, L., Kumar, D., Bramham, C.R., & Björklund, T. (2023) Visualizing Arc protein dynamics and localization in the mammalian brain using adeno-associated virus-mediated in situ gene labeling. Front. Mol. Neurosci. Vol 16, doi:10.3389/fnmol.2023.1140785.

Mergiya, T.F., Gundersen, J.E.T., Kanhema, T., Brighter, G., Ishizuka, Y., & Bramham, C.R. (2023) Detection of Arc/Arg3.1 oligomers in rat brain: constitutive and synaptic activity-evoked dimer expression in vivo. Front. Mol. Neurosci. Vol 16, doi: 10.3389/fnmol.2023.1142361

Eriksen M.S. and Bramham C.R. (2022) Molecular physiology of Arc/Arg3.1: The oligomeric state hypothesis of synaptic plasticity. Acta Physiologica, e13886. doi.org/10.1111/apha.13886

Ishizuka, Y., Mergiya, T.F. Baldinotti, R., Xu, J., Hallin, E.I., Markússon, S., Kursula, P., and Bramham, C.R. (2022). Development and Validation of Arc Nanobodies: New Tools for Probing Arc Dynamics and Function. Neurochem Res 47, 2656–2666 doi.org/10.1007/s11064-022-03573-5.

Markússon, S, Hallin, E.I., Bustad, H.J., Raasakka, A., Xu, J., Muruganandam, G., Loris, R., Martinez, A., Bramham, C.R. and Kursula, P. (2022). High-affinity anti-Arc nanobodies provide tools for structural and functional studies. PLoS ONE 17(6): e0269281. doi.org/10.1371/journal.pone.0269281

Hallin, E.I., Markússon, S., Böttger, L., Torda, A.E., Bramham, C.R., and Kursula, K. (2021) Crystal and solution structures reveal oligomerization of individual capsid homology domains of Drosophila Arc. PLoS One 16, e0251459. doi.org/10.1371/journal.pone.0251459

Hallin, E.I., Bramham, C.R., and Kursula, K. Structural properties and peptide ligand binding of the capsid homology domains of human Arc (2021) Biochem Biophys Res Commun 26, doi.org/10.1101/2020.12.17.423319 

Eriksen MS, Nikolaienko O, Hallin EI, Grødem S, Bustad HJ, Flydal MI, Merski I, Hosokawa T, Lascu D, Akerkar S, Cuéllar J, Chambers JJ, O’Connell R, Muruganandam G, Loris R, Touma C, Kanhema T, Hayashi Y, Stratton MM, Valpuesta JM, Kursula P, Martinez A and Bramham CR  (2020). Arc self-association and formation of virus-like capsids are mediated by an N-terminal helical coil motif. The FEBS Journal. https://doi.org/10.1111/febs.15618

Zhang, H. and Bramham, C.R. (2020) Arc function in long-term synaptic plasticity: emerging mechanisms and unresolved issues. Eur J Neurosci, doi.org/10.1111/ejn.14958

Hallin, EI, Eriksen, M., Baryshnikov, S., Nikolaienko, Grødem, S., Hosokawa, Y. Hayashi, Y., *Bramham, C.R. and *Kursula, P.  (2018) Structure of monomeric full-length ARC sheds light on molecular flexibility, protein interactions, and functional modalities. J. Neurochem. doi.org/10.1111/jnc.14556.  

Nikolaienko, O., Patil, S, Eriksen, M.S., and Bramham, C.R., (2018) Arc protein: a flexible hub for synaptic plasticity and cognition. Semin Cell Dev Biol, 77:33-42. dx.doi.org/10.1016/j.semcdb.2017.09.006

Nair, R.R., Patil S., Tiron, A, Kanhema, T., Panja, D., Schiro, L., Parobzak, K., Wilczynski, G., and Bramham, C.R. (2017) Dynamic Arc SUMOylation and selective interaction with F-actin binding protein drebrin A in LTP consolidation in vivo. Front Synaptic Neurosci. doi: 10.3389/fnsyn.2017.00008

Gozdz, A., Nikolaienko, O., Urbanska, M., Cymerman, I.A., Sitkiewicz, E., Dadlez, M., Bramham. C.R., and Jaworski, J (2017) GSK3α and GSK3β phosphorylate Arc and regulate its degradation. Front Mol Neurosci. http://doi: 10.3389/fnmol.2017.00192

Nikolaienko O, Eriksen MS, Patil S, Bito H, and Bramham CR (2017)  Stimulus-evoked ERK-dependent phosphorylation of activity-regulated cytoskeleton-associated protein (Arc) regulates its neuronal subcellular localization. Neuroscience 360:68–80. http://doi: 10.1016/j.neuroscience.2017.07.026.

Myrum, C., Soulé, J., Bittins, M., Cavagnini, K., Eriksen, M.S., Goff, K., Ziemek, S., Patil, S., Szum, A., Nair, R.R. and Bramham, C.R. (2017) Arc interacts with the integral ER protein, calnexin. Frontiers Cell Neurosci. doi.org/10.3389/fncel.2017.00294.

Kuipers, S., Trentani, A., Tiron, A, Mao, X., Kuhl, D., and Bramham, C.R.  (2016) BDNF-induced LTP is associated with rapid Arc-dependent enhancement in adult hippocampal neurogenesis. Scientific Reports, http://doi: 10.1038/srep21222.

Myrum,C., Baumann, A., Bustad, H.J., Flydal, M.I., Mariaule,V., Alvira, S., Cuéllar, J., Soulé, J., Valpuesta J.M., Márquez, J.A., *Martinez, A., and *Bramham,C.R. (2015) Arc is a flexible modular protein capable of reversible self-oligomerization. Biochem J. 468, 145-158. http://doi 10.1042/BJ20141446

Myrum C, Giddaluru S, Jacobsen K, Espeseth T, Nyberg L, Lundervold A J, Haavik J, Nilsson L, Reinvang I, Steen V M, Johansson S, Wibrand K, *Le Hellard S, and *Bramham C R. (2015) Common variants in the ARC gene are not associated with cognitive abilities. Brain and Behavior, doi: 10.1002/brb3.376.

Soule J, Alme MN, Myrum C, Schubert M, Kanhema T, Bramham CR (2012) Balancing Arc synthesis, mRNA decay, and proteasomal degradation: maximal protein expression triggered by REM sleep-like bursts of muscarinic cholinergic receptor stimulation. J Biological Chemistry, 287(26): 22354-66. 

Wibrand, K., Pai, B., Siripornmongcolchai, T, Bittins, M., Berentsen, B., Ofte, M.L,  Weigel, A., Skaftnesmo, K.O., and Bramham C.R.   (2012) MicroRNA regulation of the synaptic plasticity related gene Arc. PLoS ONE 7(7): e41688.

Bramham CR, Alme MN, Bittins M, Kuipers SD, Nair RR, Pai B, Panja D, Schubert M, Soule J, Tiron A, Wibrand K (2010) The Arc of synaptic memory. Exp Brain Res 200:125-140.

Kuipers SD, Tiron A, Soule J, Messaoudi E, Trentani A, Bramham CR (2009) Selective survival and maturation of adult-born dentate granule cells expressing the immediate early gene Arc/Arg3.1. PLoS ONE 4(3): e4885.

Bramham CR, Worley PF, Moore MJ, Guzowski JF (2008) The immediate early gene Arc/Arg.1: regulation, mechanisms, and function. J Neurosci. 27(39): 10445-10455.

Soule J, Penke-Verdier Z, Alme M, Kanhema T, Laroche S, Bramham CR (2008) Object-place recognition learning triggers rapid induction of plasticity-related immediate early genes and synaptic proteins  in the rat dentate gyrus. Neural Plasticity, Article ID 269097, 12 pages.    

Messaoudi,E., Kanhema,T., Soule,J., Tiron,A., Dagyte,G., da Silva,B., and Bramham,C.R.  (2007) Sustained Arc synthesis controls LTP consolidation through regulation of local actin polymerization in the dentate gyrus in vivo.  J. Neurosci. 27: 10445-10455.  

Ying SW, Futter M, Rosenblum K, Webber MJ, Hunt SP, Bliss TV, Bramham CR (2002) Brain-derived neurotrophic factor induces long-term potentiation in intact adult hippocampus: requirement for ERK activation coupled to CREB and upregulation of Arc synthesis. J Neurosci 22: 1532-1540.

 

BDNF

Cassarotto, P., Girych, M., Fred, S.M., Moliner, R., Enkavi, G., Biojone, C., Cannarozzo, C., Brunello, C.A, Steinzeig, A., Winkel, F., Patil, S., Vestring, S.,  Serchov, T., Laukkanen, L., Cardon, I., Antila, H., Rog, T., Bramham, C.R., Normann, C., Lauri, S.E., Vattulainen, I., and Castrén, E.,  (2021) Antidepressants act by directly binding to TRKB neurotrophin receptors. Cell 184:1-15. 10.1016/j.cell.2021.01.034

Esvald, E.-E., Tuvikene, J., Sirp, A., Patil, S., Bramham, C.R., & Timmusk, T. (2020) CREB family transcription factors are major mediators of BDNF transcriptional autoregulation in cortical neurons. J. Neurosci., 40(7):1405-1426. doi.org/10.1523/JNEUROSCI.0367-19.2019.

Panja, D and Bramham, C.R. (2017) BDNF function in long-term synaptic plasticity in the dentate gyrus in vivo:  methods for local drug delivery and biochemical analysis of translation. In: Neuromethods. Humana Press. doi.org/10.1007/7657_2017_7

Kuipers, S., Trentani, A., Tiron, A, Mao, X., Kuhl, D., and Bramham, C.R.  (2016) BDNF-induced LTP is associated with rapid Arc-dependent enhancement in adult hippocampal neurogenesis. Scientific Reports, doi: 10.1038/srep21222.

Panja, D., Kenney, J.W., D’Andrea, L., Zalfa, F., Vedeler, A., Wibrand, K., Fukunaga, R., Bagni, C., Proud, C.G., and Bramham, C.R. (2014). Two-stage translational control of dentate gyrus LTP consolidation is mediated by sustained BDNF-TrkB signaling to MNK. Cell Rep. 9, 1430–1445.

Panja, D., and Bramham, C. R. (2014). BDNF mechanisms in late LTP formation: a synthesis and breakdown. Neuropharmacology, 76: 664-676 . doi:10.1016/j.neuropharm.2013.06.024

Coppens, C. M., Siripornmongcolchai, T., Wibrand, K., Alme, M. N., Buwalda, B., de Boer, S. F., Koolhaas, J. M., and Bramham, C. R. (2011) Social defeat during adolescence and adulthood differentially induce BDNF-regulated immediate early genes. Front Behav. Neurosci. 5:72., Epub Nov 2.

Messaoudi,E., Kanhema,T., Soule,J., Tiron,A., Dagyte,G., da Silva,B., and Bramham,C.R.  (2007) Sustained Arc synthesis controls LTP consolidation through regulation of local actin polymerization in the dentate gyrus in vivo.  J. Neurosci. 27: 10445-10455.  

Alme MN, Wibrand K, Dagestad G, Bramham CR (2007) Chronic fluoxetine treatment induces brain region-specific upregulation of genes associated with BDNF-induced long-term potentiation. Neural Plast 2007: 26496. PMID: 18301726

Wibrand K, Messaoudi E, Havik B, Steenslid V, Løvlie R, Steen VM, and Bramham CR (2006) Identification of genes co-upregulated with Arc during BDNF-induced long-term potentiation in the adult rat dentate gyrus in vivo. Eur J Neurosci 23: 1501-1511.

Kanhema, T.,  Dagestad, G., Panja, D., Messaoudi, E., Haavik, B., Ying, S.W.,  Nairn, A.C., Sonenberg, N. and Bramham, C.R.  (2006) Dual regulation of translation initiation and peptide chain elongation during BDNF-induced LTP in vivo: evidence for compartment-specific translation control.  J Neurochem. 99:1328-1337.   

Bramham,C.R  and Messaoudi, E. (2005) BDNF function in adult synaptic plasticity: the synaptic consolidation hypothesis.  Prog. Neurobiol, 76: 99-125. 

Gooney, M., Messaoudi, E., Maher, F.O., *Bramham, C.R., and *Lynch, M.A. (2004) BDNF-induced LTP in dentate gyrus is impaired with age: analysis of changes in cell signalling events. Neurbiol Aging.  25: 1323-1331.

Ying SW, Futter M, Rosenblum K, Webber MJ, Hunt SP, Bliss TV, Bramham CR (2002) Brain-derived neurotrophic factor induces long-term potentiation in intact adult hippocampus: requirement for ERK activation coupled to CREB and upregulation of Arc synthesis. J Neurosci 22: 1532-1540.

Messaoudi E, Ying SW, Kanhema T, Croll SD, Bramham CR (2002) BDNF triggers transcription-dependent, late phase LTP in vivo. J Neurosci 22: 7453-7461.

Messaoudi, E., Bårdsen, K.,  Srebro, B., and C.R. Bramham (1998) Acute intrahippocampal infusion of brain-derived neurotrophic factor induces lasting potentiation of synaptic transmission in the rat dentate gyrus.  J. Neurophysiol. 79: 496-499.

 

Translational control and dendritic protein synthesis

Patil, S., Chalkiadaki, K., Mergiya, T.F, Krimbacher, K., Amorim, I.S., Akerkar, S., Gkogkas, C.G., and Bramham, C.R. (2023) eIF4E phosphorylation recruits β-catenin to mRNA cap and promotes Wnt pathway translation in dentate gyrus LTP maintenance. iScience, 26(5), 106649. doi.org/10.1016/j.isci.2023.106649

Chalkiadaki, K., Kouloulia, S., Bramham, C.R., and Gkogkas, C (2020) Regulation of protein synthesis by eIF4E in the brain. In The Oxford Handbook of Neuronal Protein Synthesis pp 1–22. 10.1093/oxfordhb/9780190686307.013.12

Taha E, Patil S, Barrera I, Proud CG, Bramham CR, Rosenblum K (2020) eEF2/eEF2K pathway in the mature dentate gyrus determines neurogenesis level and cognition. Current Biology 30:1–15. doi.org/10.1016/j.cub.2020.06.061.

Berentsen B, Patil S, Wibrand K, Goff KM, Pajak M, Simpson IT, and Bramham CR. (2020) microRNA-34a acutely regulates synaptic efficacy in the adult dentate gyrus in vivo. Molecular Neurobiology doi.org/10.1007/s12035-019-01816-1

Bramham, C.R., Jensen, K, and Proud, CG. (2016) Tuning specific translation in cancer metastasis and synaptic memory: control at the MNK-eIF4E axis.  Trends in Biochemistry, 41: 847-858. dx.doi.org/10.1016/j.tibs.2016.07.008.

Panja, D., Kenney, J.W., D’Andrea, L., Zalfa, F., Vedeler, A., Wibrand, K., Fukunaga, R., Bagni, C., Proud, C.G., and Bramham, C.R. (2014). Two-stage translational control of dentate gyrus LTP consolidation is mediated by sustained BDNF-TrkB signaling to MNK. Cell Rep. 9, 1430–1445.

Grønli, J., Soulé, J., and Bramham, C.R. (2014). Sleep and protein synthesis-dependent synaptic plasticity: impacts of sleep loss and stress. Front. Behav. Neurosci. 7, 1–18.

Grønli,J., Dagestad,G., Milde,A.M., Murison,R., and Bramham,C.R. (2012). Post-transcriptional effects and interactions between chronic mild stress and acute sleep deprivation: Regulation of translation factor and cytoplasmic polyadenylation element-binding protein phosphorylation. Behav. Brain Res. 235, 251-262.

Panja, D., Dagyte, G., Bidinosti, M.,. Wibrand, K.,  Kristiansen, A.M., Sonenberg, N., and Bramham, C.R.  (2009) Novel translational control in Arc-dependent long-term potentiation consolidation in vivo.  J. Biological Chemistry 284: 31498-31511.  

Bramham, C.R.  (2008) Local protein synthesis, actin dynamics, and LTP consolidation. Curr Opin Neurobiol. 18: 524-531.

Bramham C. R. and Wells D. G. (2007) Dendritic mRNA: transport, translation, and function. Nature Rev Neurosci, 8 (10):776 – 789.

Dagestad,G., Messaoudi,E., and Bramham,C.R. (2006). Chronic fluoxetine induces region specific changes in translation factor eIF4E and eEF2 activity in the rat brain.  Eur J Neurosci., 23: 2814-2818.

Kanhema, T.,  Dagestad, G., Panja, D., Messaoudi, E., Haavik, B., Ying, S.W.,  Nairn, A.C., Sonenberg, N. and Bramham, C.R.  (2006) Dual regulation of translation initiation and peptide chain elongation during BDNF-induced LTP in vivo: evidence for compartment-specific translation control.  J Neurochem. 99:1328-1337.   

Håvik, B., Røkke, H., Bårdsen, K., Davanger, S. and Bramham, C.R. (2003) High-frequency bursts trigger rapid delivery of pre-existing CaMKII mRNA to synapses: a mechanism in dendritic protein synthesis during long-term potentiation in adult awake rats.  Eur. J. Neurosci., 17: 2679-2689.

 

Gene expression and non-coding RNAs

Berentsen B, Patil S, Wibrand K, Goff KM, Pajak M, Simpson IT, and Bramham CR. (2020) microRNA-34a acutely regulates synaptic efficacy in the adult dentate gyrus in vivo. Molecular Neurobiology doi.org/10.1007/s12035-019-01816-1

Maag, J.L.V. Panja, D, Kaczorowski, D.C. Peters, T.J., Bramham, C.R., Wibrand, K.,    and Dinger, M.E.  (2017) Widespread promoter methylation of synaptic plasticity genes in long-term potentiation in the adult brain in vivo. BMC Genomics. 18 (2017) 250. doi:10.1186/s12864-017-3621-x.

Maag, J.L.V., Panja,D., Sporild, I, Patil, S., Kaczorowski, D.C., *Bramham, C.R., *Dinger, M., and *Wibrand, K. (2015) Dynamic expression of long noncoding RNAs and repeat elements in synaptic plasticity. Frontiers in Neuroscience.  9:351. doi:10.3389/fnins.2015.00351

Pai, B., Siripornmongcolchai, T., Berentsen, B., Pakzad, A., Vieuille, C., Pallesen, S., Pajak, M., Simpson, T.I., Armstrong, J.D., Wibrand, K., and Bramham, C.R. (2014). NMDA receptor-dependent regulation of miRNA expression and association with Argonaute during LTP in vivo. Front. Cell. Neurosci. 7, 1–15.

Wibrand, K., Pai, B., Siripornmongcolchai, T, Bittins, M., Berentsen, B., Ofte, M.L,  Weigel, A., Skaftnesmo, K.O., and Bramham C.R.   (2012) MicroRNA regulation of the synaptic plasticity related gene Arc. PLoS ONE 7(7): e41688. 

Wibrand, K., Panja, D., Tiron, A., Ofte, M.L., Skaftnesmo, K. Sohn-Lee, C., Pena, J., Tuschl, T. and Bramham, C.R. (2010) Differential regulation of mature and precursor microRNA expression by NMDAR and metabotropic glutamate receptor expression activation during LTP in the dentate gyrus in vivo. Eur J Neurosci 31: 636-645. 

Håvik, B., Røkke, H., Dagyte, G., Stavrum, A-K., *Bramham, C.R., and *Steen, V.M. (2007) Synaptic activity-induced global gene expression patterns in the dentate gyrus of adult behaving rats: induction of immunity-linked gene sets. (*Equal contribution).  Neuroscience, 148: 925-936.

Wibrand K, Messaoudi E, Havik B, Steenslid V, Løvlie R, Steen VM, and Bramham CR (2006) Identification of genes co-upregulated with Arc during BDNF-induced long-term potentiation in the adult rat dentate gyrus in vivo. Eur J Neurosci 23: 1501-1511.

 

Human Genetics

Myrum, C., Nikolaienko, O. Bramham, C.R. Haavik, J., and Zayats, T. Implication of the APP gene in intellectual abilities. (2017) J Alz Dis. 59(2):723-735. doi: 10.3233/JAD-170049.

Myrum C, Giddaluru S, Jacobsen K, Espeseth T, Nyberg L, Lundervold A J, Haavik J, Nilsson L, Reinvang I, Steen V M, Johansson S, Wibrand K, *Le Hellard S, and *Bramham C R. (2015) Common variants in the ARC gene are not associated with cognitive abilities. Brain and Behavior, doi: 10.1002/brb3.376.

Havik, B., Degenhardt, F. A., Johansson, S., Fernandes, C. P., Hinney, A., Scherag, A., Lybaek, H., Djurovic, S., Christoforou, A., Ersland, K. M., Giddaluru, S., O'Donovan, M. C., Owen, M. J., Craddock, N., Muhleisen, T. W., Mattheisen, M., Schimmelmann, B. G., Renner, T., Warnke, A., Herpertz-Dahlmann, B., Sinzig, J., Albayrak, O., Rietschel, M., Nothen, M. M., Bramham, C. R., Werge, T., Hebebrand, J., Haavik, J., Andreassen, O. A., Cichon, S., Steen, V. M., and Le Hellard S. (2012) DCLK1 Variants are associated across schizophrenia and attention deficit/hyperactivity disorder PLoS ONE 7, e35424

Le Hellard S, Havik B, Espeseth T, Breilid H, Lovlie R, Luciano M, Gow AJ, Harris SE, Starr JM, Wibrand K, Lundervold AJ, Porteous DJ, Bramham CR, Deary IJ, Reinvang I, Steen VM (2009) Variants in doublecortin- and calmodulin kinase like 1, a gene up-regulated by BDNF, are associated with memory and general cognitive abilities. PLoS One 4:e7534.

 

Publications in CRIStin database with links:

 

2024

• Potenza, Maria Letizia; Blankvoort, Stefan Matthias Adriaan; Carvalho, Miguel et al. (2024). Generation of an enhancer-driven gene expression viral tool specific to dentate granule cell-types through direct hippocampal injection. (external link)
• Godoy Munoz, Jose Miguel; Neset, Lasse; Markusson, Sigurbjörn et al. (2024). Structural characterization of two nanobodies targeting the ligand-binding pocket of human Arc. (external link)

2023

• Bramham, Clive Raymond Evjen; Lessmann, Volkmar; Hannan, Anthony J. et al. (2023). Editorial: Synaptopathies: from bench to bedside. (external link)
• Avallone, Martino; Pardo, Joaquín; Mergiya, Tadiwos Feyissa et al. (2023). Visualizing Arc protein dynamics and localization in the mammalian brain using AAV-mediated in situ gene labeling. (external link)
• Song, Jiaxing; Bramham, Clive Raymond Evjen; Zhang, Hongyu (2023). Regulation of AMPA Receptor Diffusion Trapping at the Synapses by Arc Protein. (external link)
• Mergiya, Tadiwos Feyissa; Gundersen, Jens Edvard Trygstad; Kanhema, Tambudzai et al. (2023). Detection of Arc/Arg3.1 oligomers in rat brain: constitutive and synaptic activity-evoked dimer expression in vivo. (external link)
• Neset, Lasse; Bramham, Clive Raymond Evjen; Kursula, Petri Tapani (2023). Nanobody-aided structural study of the activity- regulated cytoskeleton-associated protein (Arc) using synchrotron radiation and cryo-EM. (external link)
• Mahboob, Aamra; Pauzin, Francois Philippe; Bramham, Clive Raymond Evjen (2023). Effect of Arc N-lobe expression on synaptic efficacy in medial perforant path-evoked transmission in the rat dentate gyrus in vivo. (external link)
• Patil, Sudarshan; Chalkiadaki, Kleanthi; Mergiya, Tadiwos Feyissa et al. (2023). eIF4E phosphorylation recruits β-catenin to mRNA cap and promotes Wnt pathway translation in dentate gyrus LTP maintenance. (external link)
• Pilskog, Ingjald; Vikene, Kjetil; Bramham, Clive Raymond Evjen et al. (2023). Den plastiske hjernen – fra molekyler til bevissthet. (external link)

2022

• Eriksen, Maria Steene; Bramham, Clive Raymond Evjen (2022). Molecular physiology of Arc/Arg3.1: The oligomeric state hypothesis of synaptic plasticity. (external link)
• Markusson, Sigurbjörn; Hallin, Erik Ingmar; Bustad, Helene J. et al. (2022). High-affinity anti-Arc nanobodies provide tools for structural and functional studies. (external link)
• Dale, Thomas Myhre; Bramham, Clive Raymond Evjen; Kanhema, Tambudzai (2022). Study the mRNA which crisscross with Activity-Regulated Cytoskeleton-Associated Protein (Arc) in the nucleus of hippocampus tissue post HFS-LTP. (external link)
• Ishizuka, Yuta; Mergiya, Tadiwos Feyissa; Baldinotti, Rodolfo Da Silva Mazzarini et al. (2022). Correction to: Development and Validation of Arc Nanobodies: New Tools for Probing Arc Dynamics and Function (Neurochemical Research, (2022), 10.1007/s11064-022-03573-5). (external link)
• Ishizuka, Yuta; Mergiya, Tadiwos Feyissa; Baldinotti, Rodolfo Da Silva Mazzarini et al. (2022). Development and Validation of Arc Nanobodies: New Tools for Probing Arc Dynamics and Function. (external link)
• Pagenhart, Patrick Unneland; Bramham, Clive Raymond Evjen; Pauzin, Francois Philippe (2022). Analysis of mRNA poly(A) tail length in relation to long-term potentiation of synaptic transmission in the rat dentate gyrus in vivo. (external link)
• Grabowska, Agnieszka; Sas-Nowosielska, Hanna; Wojtas, Bartosz et al. (2022). Activation-induced chromatin reorganization in neurons depends on HDAC1 activity. (external link)

2021

• Casarotto, Plinio C.; Girych, Mykhailo; Fred, Senem M. et al. (2021). Antidepressant drugs act by directly binding to TRKB neurotrophin receptors. (external link)
• Vedeler, Anni; Bramham, Clive Raymond Evjen (2021). Editorial: Coordination of mRNA Transport and Translation With Vesicle and Organelle Trafficking and Dynamics. (external link)
• Hallin, Erik Ingmar; Markusson, Sigurbjörn; Bottger, Lev et al. (2021). Crystal and solution structures reveal oligomerization of individual capsid homology domains of Drosophila Arc. (external link)
• Acuña-Hinrichsen, Francisca; Covarrubias-Pinto, Adriana; Ishizuka, Yuta et al. (2021). Herpes Simplex Virus Type 1 Neuronal Infection Triggers the Disassembly of Key Structural Components of Dendritic Spines. (external link)
• Hallin, Erik Ingmar; Bramham, Clive Raymond Evjen; Kursula, Petri (2021). Structural properties and peptide ligand binding of the capsid homology domains of human Arc. (external link)

2020

• Zhang, Hongyu; Bramham, Clive R. (2020). Bidirectional Dysregulation of AMPA Receptor-Mediated Synaptic Transmission and Plasticity in Brain Disorders. (external link)
• Zhang, Hongyu; Bramham, Clive R. (2020). Arc/Arg3.1 function in long-term synaptic plasticity: Emerging mechanisms and unresolved issues. (external link)
• Marti, Andrea Rørvik; Pedersen, Torhild; Wisor, Jonathan P. et al. (2020). Cognitive function and brain plasticity in a rat model of shift work: role of daily rhythms, sleep and glucocorticoids. (external link)
• Taha, Elham; Patil, Sudarshan; Barrera, Iliana et al. (2020). eEF2/eEF2K Pathway in the Mature Dentate Gyrus Determines Neurogenesis Level and Cognition. (external link)
• Eriksen, Maria Steene; Nikolaienko, Oleksii; Hallin, Erik Ingmar et al. (2020). Arc self‐association and formation of virus‐like capsids are mediated by an N‐terminal helical coil motif. (external link)
• Johannessen, Helene Bustad; Flydal, Marte Innselset; Cuéllar, Jorge et al. (2020). The solution structure of the human brain-protein arc studied by NMR. (external link)
• Olofsson, Jan Stefan; Bramham, Clive R.; Kanhema, Tambudzai (2020). Investigation of Arc interaction with mRNA in the nucleus of SH-SY5Y Neuroblastoma cells. (external link)
• Esvald, Eli-Eelika; Tuvikene, Jürgen; Sirp, Alex et al. (2020). CREB family transcription factors are major mediators of BDNF transcriptional autoregulation in cortical neurons. (external link)

2019

• Berentsen, Birgitte; Patil, Sudarshan; Rønnestad, Kine Terese et al. (2019). MicroRNA-34a acutely regulates synaptic efficacy in the adult dentate gyrus in vivo. (external link)
• Ishizuka, Yuta; Bramham, Clive R. (2019). A simple DMSO-based method for cryopreservation of primary hippocampal and cortical neurons. (external link)

2018

• Eriksen, Maria Steene; Bramham, Clive R. (2018). The immediate early protein Arc: an exploration of protein structure and regulation. (external link)
• Hallin, Erik Ingmar; Eriksen, Maria Steene; Baryshnikov, Sergei et al. (2018). Structure of monomeric full‐length ARC sheds light on molecular flexibility, protein interactions, and functional modalities. (external link)
• Marti, Andrea Rørvik; Skrede, Silje; Mrdalj, Jelena et al. (2018). Extending the photoperiod impacts circadian rhythmicity and gene expression in prefrontal cortex and retina- Impact of exposure to blue-enriched light. . (external link)
• Marti, Andrea Rørvik; waslander, jorrit; Skrede, Silje et al. (2018). Extended photoperiod alters circadian rhythmicity and expression of neuroplasticity markers. The impact of blue-enriched light.. (external link)
• Grønli, Janne; Marti, Andrea Rørvik; waslander, jorrit et al. (2018). Extended photoperiod alters sleep and expression of synaptic plasticity-associated genes. The impact of blue-enriched light.. (external link)

2017

• Marti, Andrea Rørvik; Patil, Sudarshan; Mrdalj, Jelena et al. (2017). No escaping the rat race: simulated night shift work alters the time-of-day variation in BMAL1 translational activity in the prefrontal cortex. (external link)
• Nikolaienko, Oleksii; Patil, Sudarshan; Eriksen, Maria Steene et al. (2017). Arc protein: a flexible hub for synaptic plasticity and cognition. (external link)
• Leal, Graciano; Comprido, Diogo; de Luca, Pasqualino et al. (2017). The RNA-Binding Protein hnRNP K Mediates the Effect of BDNF on Dendritic mRNA Metabolism and Regulates Synaptic NMDA Receptors in Hippocampal Neurons. (external link)
• Bekken, Aina Iren Aanes; Bramham, Clive R. (2017). Activity-Regulated Cytoskeleton-associated (Arc) Protein: Interaction with Actin-Binding Proteins in the adult rat brain. (external link)
• Herdlevær, Ida Ajvazi; Bramham, Clive R. (2017). Dynamics of actin cytoskeleton in dendritic spines -interactions between Arc and Drebrin A. (external link)
• Maag, Jesper L.V.; Kaczorowski, Dominik C.; Panja, Debabrata et al. (2017). Widespread promoter methylation of synaptic plasticity genes in long-term potentiation in the adult brain in vivo.. (external link)
• Rimstad, Johanne Eriksen; Bramham, Clive R.; Patil, Sudarshan (2017). Arc expression and protein-protein interactions in a mouse model of Alzheimer’s disease: Exercise- and novelty-induced changes in Arc, BDNF, and PS1 expression and Arc PS1 interaction in APP/PS1 and WT mice. (external link)
• Grødem, Sverre; Bramham, Clive R.; Baryshnikov, Sergei (2017). Dynamic Analysis of Arc Protein Oligomerization by Förster Resonance Energy Transfer. (external link)
• Gozdz, Agata; Nikolaienko, Oleksii; Urbanska, Malgorzata et al. (2017). GSK3α and GSK3β Phosphorylate Arc and Regulate its Degradation. (external link)
• Nair Raveendran, Rajeevkumar; Patil, Sudarshan; Tiron, Adrian et al. (2017). Dynamic Arc SUMOylation and selective interaction with F-actin-binding protein Drebrin A in LTP consolidation in vivo. (external link)
• Nikolaienko, Oleksii; Eriksen, Maria Steene; Patil, Sudarshan et al. (2017). Stimulus-evoked ERK-dependent phosphorylation of activity-regulated cytoskeleton-associated protein (Arc) regulates its neuronal subcellular localization. (external link)
• Myrum, Craig; Nikolaienko, Oleksii; Bramham, Clive R. et al. (2017). Implication of the APP gene in intellectual abilities. (external link)
• Myrum, Craig; Soule, Jonathan; Bittins, Margarethe et al. (2017). Arc interacts with the integral endoplasmic reticulum protein, calnexin. (external link)

2016

• Kuipers, SD; Trentani, Andrea; Patil, Sudarshan et al. (2016). BDNF-induced LTP is associated with rapid Arc/Arg3.1-dependent enhancement in adult hippocampal neurogenesis. (external link)
• Maag, Jesper L.V.; Panja, Debabrata; Sporild, Ida et al. (2016). Corrigendum to Dynamic expression of long noncoding RNAs and repeat elements in synaptic plasticity [Front. Neurosci. (2015), 9:351. doi: 10.3389/fnins.2015.00351]. (external link)
• Bojovic, Ognjen; Bramham, Clive R.; Tjølsen, Arne (2016). Stimulation-induced expression of immediate early gene proteins in the dorsal horn is increased in neuropathy. (external link)
• Kuipers, Sjoukje; Trentani, Andrea; Tiron, Adrian et al. (2016). BDNF-induced LTP is associated with rapid Arc/Arg3.1-dependent enhancement in adult hippocampal neurogenesis. (external link)
• Szum, Adrian M.; Bramham, Clive R. (2016). The localization and function of Arc in the neuronal cell nucleus. (external link)
• Bramham, Clive R.; Jensen, KB; Proud, CG (2016). Tuning specific translation in cancer metastasis and synaptic memory: control at the MNK-eIF4E axis. (external link)

2015

• Hall, Malgorzata H.; Magalska, Adriana; Malinowska, Monika et al. (2015). Localization and regulation of PML bodies in the adult mouse brain. (external link)
• Myrum, Craig; Baumann, Anne; Bustad, Helene J. et al. (2015). Arc is a flexible modular protein capable of reversible self-oligomerization. (external link)
• Segev, Yifat; Barrera, Iliana; Ounallah-Saad, Hadile et al. (2015). PKR inhibition rescues memory deficit and atf4 overexpression in apoe ε4 human replacement mice. (external link)
• Bojovic, Ognjen; Bramham, Clive R.; Tjølsen, Arne (2015). Chronic morphine treatment enhances sciatic nerve stimulation-induced immediate early gene expression in the rat dorsal horn. (external link)
• Abideen, Syed Ainul; Bramham, Clive R.; Pakzad, Ashraf Fathpour (2015). Expression of Argonaute 2 and associated proteins following LTP induction in the dentate gyrus in vivo: comparsion between lysates and fractionated synaptoneurosomes. (external link)
• Myrum, Craig; Giddaluru, Sudheer; Jacobsen, Kaya Kvarme et al. (2015). Common variants in the ARC gene are not associated with cognitive abilities. (external link)
• Bojovic, Ognjen; Panja, Debabrata; Bittins, Margarethe et al. (2015). Time course of immediate early gene protein expression in the spinal cord following conditioning stimulation of the sciatic nerve in rats. (external link)
• Maag, Jesper L.V.; Panja, Debabrata; Sporild, Ida et al. (2015). Dynamic expression of long noncoding RNAs and repeat elements in synaptic plasticity. (external link)

2014

• Debnath, Sudip; Bramham, Clive R.; Patil, Sudarshan (2014). Arc protein-protein interaction in long-term potentiation in the rat dentate gyrus in vivo. (external link)
• Sporild, Ida; Bramham, Clive R.; Wibrand, Karin (2014). Characterization of two predicted long non-coding RNAs in long-term synaptic plasticity in rat hippocampus. (external link)
• Grønli, Janne; Soule, Jonathan; Bramham, Clive R. (2014). Sleep and protein synthesis-dependent synaptic plasticity: impacts of sleep loss and stress. (external link)
• Bramham, Clive R.; Panja, Debabrata (2014). BDNF regulation of synaptic structure, function, and plasticity. (external link)
• Panja, Debabrata; Bramham, Clive R. (2014). BDNF mechanisms in late LTP formation: A synthesis and breakdown. (external link)
• Sreenivasa, Pai Balagopal; Siripornmongcolchai, Taweeporn; Berentsen, Birgitte et al. (2014). NMDA receptor-dependent regulation of miRNA expression and association with Argonaute during LTP in vivo. (external link)
• Schubert, Manja; Panja, Debabrata; Haugen, Mette et al. (2014). Paraneoplastic CDR2 and CDR2L antibodies affect Purkinje cell calcium homeostasis. (external link)
• Panja, Debabrata; Kenney, Justin W.; D'Andrea, Laura et al. (2014). Two-stage translational control of dentate gyrus LTP consolidation is mediated by sustained BDNF-TrkB signaling to MNK. (external link)

2013

• Vesta, Lasse; Bramham, Clive R.; Skaftnesmo, Kai Ove (2013). Early life stress influences on stress handling in adulthood - development of depressive- and anxiety-like behavior in Wistar rats. (external link)
• Eriksen, Maria Steene; Bramham, Clive R.; Nikolaienko, Oleksii (2013). In search of a binding site for extracellular signal-regulated kinase (ERK) to the synaptic plasticity-related protein Arc. (external link)
• Rønnestad, Kine Terese; Bramham, Clive R.; Berentsen, Birgitte (2013). The Role of miR-­‐326 in Basal Synaptic Transmission and Long-­‐Term Potentiation in the Rat Dentate Gyrus In Vivo. (external link)
• Wibrand, Karin; Berge, Kjetil; Messaoudi, Michael et al. (2013). Enhanced cognitive function and antidepressant-like effects after krill oil supplementation in rats. (external link)
• Bergersen, Linda Hildegard; Bramham, Clive R.; Hugdahl, Kenneth et al. (2013). The changing brain – Insights into the mechanisms of neural and behavioral adaptation to the environment. (external link)
• Siripornmongcolchai, Taweeporn; Bramham, Clive R.; Wibrand, Karin (2013). MicroRNA regulation in synaptic plasticity and expression of plasticity-associated genes during social defeat stress. (external link)

2012

• Håvik, Bjarte; Degenhardt, Franziska A.; Johansson, Stefan et al. (2012). DCLK1 variants are associated across schizophrenia and attention deficit/hyperactivity disorder. (external link)
• Pai, Balagopal; Bramham, Clive R. Evjen (2012). miRNA-mediated regulation of translation in synaptic plasticity. (external link)
• Soule, Jonathan; Alme, Maria Nordheim; Myrum, Craig et al. (2012). Balancing arc synthesis, mRNA decay, and proteasomal degradation : maximal protein expression triggered by rapid eye movement sleep-like bursts of muscarinic cholinergic receptor stimulation. (external link)
• Gal-Ben-Ari, Shunit; Kenney, Justin W.; Ounalla-Saad, Hadile et al. (2012). Consolidation and translation regulation. (external link)
• Wibrand, Karin; Sreenivasa, Pai Balagopal; Siripornmongcolchai, Taweeporn et al. (2012). MicroRNA regulation of the synaptic plasticity-related gene arc. (external link)
• Vieuille, Christel Marie; Bramham, Clive R. (2012). Modulation of the Ago2-Associated microRNA Induced Silencing Complex during Long-Term Potentiation in the Rat Dentate Gyrus in Vivo. (external link)
• Grønli, Janne; Dagestad, Grethe; Milde, Anne Marita et al. (2012). Post-transcriptional effects and interactions between chronic mild stress and acute sleep deprivation: Regulation of translation factor and cytoplasmic polyadenylation element-binding protein phosphorylation. (external link)
• Bramham, Clive R.; Fathpour, Ashraf Pakzad (2012). Remodeling of the microRNA-induced silencing complex during LTP in the adult rat brain in vivo. (external link)
• Grønli, Janne; Dagestad, Grethe; Milde, Anne Marita et al. (2012). Chronic mild stress abolishes a relationship between sleep architecture and translational control. (external link)
• Dziembowska, Magdalena; Milek, Jacek; Janusz, Aleksandra et al. (2012). Activity-dependent local translation of matrix metalloproteinase-9. (external link)

2011

• Grønli, Janne; Dagestad, Grethe; Milde, Anne Marita et al. (2011). Chronic mild stress and acute sleep deprivation: interactive and brain-region specific effects on regulation of translation factor and CPEB phosphorylation. (external link)
• Rajbhandari, Yurika; Bramham, Clive R. Evjen (2011). Regulation of micro-RNA induced silencing complex during long-term potentiation in the dentate gyrus In vivo. (external link)
• Coppens, Caroline M; Siripornmongcolchai, Taweeporn; Wibrand, Karin et al. (2011). Social defeat during adolescence and adulthood differentially induce BDNF-regulated immediate early genes. (external link)
• Håvik, Bjarte; Le Hellard, Stephanie; Rietschel, Marcella et al. (2011). The Complement Control-Related Genes CSMD1 and CSMD2 Associate to Schizophrenia. (external link)

2010

• Bramham, Clive R. Evjen; Alme, Maria Nordheim; Bittins, Margarethe et al. (2010). The Arc of synaptic memory. (external link)
• Wibrand, Karin; Panja, Debabrata; Tiron, Adrian et al. (2010). Differential regulation of mature and precursor microRNA expression by NMDA and metabotropic glutamate receptor activation during LTP in the adult dentate gyrus in vivo. (external link)
• Bidinosti, Michael; Ran, Israeli; Sanchez-Carbente, Maria R. et al. (2010). Postnatal deamidation of 4E-BP2 in brain enhances its association with raptor and alters kinetics of excitatory synaptic transmission. (external link)
• Myrum, Craig; Bramham, Clive R. Evjen; Soule, Jonathan (2010). Identification of Arc/Arg3.1 Binding Partners. (external link)

2009

• Aksnes, Henriette; Nair, Rajeevkumar Raveendran; Bramham, Clive R. (2009). Time-lapse imaging of Arc protein degradation and synthesis in hippocampal neurons. (external link)
• Bramham, Clive R. Evjen; Panja, Debabrata; Tiron, Adrian et al. (2009). Arc/Arg3.1 synthesis and control of LTp consolidation in the adult dentate gyrus in vivo. (external link)
• Kuipers, Sjoukje; Tiron, Adrian; Soule, Jonathan et al. (2009). Selective survival and maturation of adult-born dentate granule cells expressing the immediate early gene Arc/Arg3.1. (external link)
• Jedlicka, Peter; Schwarzacher, Stephan W.; Winkels, Raphael et al. (2009). Impairment of in vivo theta-burst long term potentiation and network excitability in the dentate gyrus of synaptopodin-deficient mice lacking the spine apparatus and the cisternal organelle. (external link)
• Le Hellard, Stephanie; Håvik, Bjarte; Espeseth, Thomas et al. (2009). Variants in doublecortin- and calmodulin kinase like 1, a gene up-regulated by BDNF, are Associated with memory and general cognitive abilities. (external link)
• Panja, Debabrata; Dagyte, Girstaute; Bidinosti, Mivhael et al. (2009). Novel Translational Control in Arc-dependent Long Term Potentiation Consolidation in Vivo. (external link)
• Bramham, Clive R. Evjen; Aksnes, Henriette (2009). Time-lapse imaging of Arc/Arg3.1 protein degradation in hippocampal neurons using the novel photoconvertible fluorescent protein Dendra2. (external link)
• Bramham, Clive R. Evjen; Berentsen, Birgitte (2009). microRNA-34a Function in Long-Term Potentiation in the Dentate Gyrus of the Anaesthetised Rat. (external link)

2008

• Grønli, Janne; Dagestad, Grethe; Milde, Anne Marita et al. (2008). Sleep deprivation as an antidepressant treatment following chronic mild stress: effects on translation factor EIF4E and EEF2 activity. (external link)
• Haugan, Frøydis; Wibrand, Karin; Fiskå, Atle et al. (2008). Stability of long term facilitation and expression of zif268 and Arc in the spinal cord dorsal horn is modulated by conditioning stimulation within the physiological frequency range of primary afferent fibers. (external link)
• Ofte, May Lillian; Bramham, Clive R. Evjen (2008). Effect of Antidepressant Treatment on the Expression of LTP-associated MicroRNAs. (external link)
• Bramham, Clive R. Evjen (2008). Local protein synthesis, actin dynamics, and LTP consolidation. (external link)
• Soule, Jonathan; Penke-Verdier, Z; Kanhema, Tambudzai et al. (2008). Object-place recognition learning triggers rapid induction of plasticity-related immediate early genes and synaptic proteins in the rat dentate gyrus. (external link)
• Bramham, Clive R. Evjen; Worley, PF; Moore, MJ et al. (2008). The immediate early gene arc/arg3.1: regulation, mechanisms, and function. (external link)

2007

• Bramham, Clive R. Evjen (2007). Control of synaptic consolidation in the dentate gyrus: mechanisms, functions, and therapeutic implications. (external link)
• Bramham, Clive R. Evjen; Wells, DG (2007). Dendritic mRNA: transport, translation and function. (external link)
• Messaoudi, Elhoucine; Kanhema, Tambudzai; Soule, Jonathan et al. (2007). Sustained Arc/Arg3.1 synthesis controls long-term potentiation consolidation through regulation of local actin polymerization in the dentate gyrus In vivo. (external link)
• Håvik, Bjarte; Røkke, Håvard; Dagyte, Girstaute et al. (2007). Synaptic activity-induced global gene expression patterns in the dentate gyrus of adult behaving rats: Induction of immunity-linked genes. (external link)
• Håvik, Bjarte; Bramham, Clive R. Evjen (2007). Additive viability-loss following hsp70/hsc70 double interference and Hsp90 inhibition in two breast cancer cell lines. (external link)
• Alme, Maria Nordheim; Wibrand, Karin; Dagestad, Grethe et al. (2007). Chronic fluoxetine treatment induces brain region-specific upregulation of genes associated with BDNF-induced long-term potentiation. (external link)

2006

• Grønli, Janne; Bramham, Clive R. Evjen; Murison, Robert et al. (2006). Chronic mild stress inhibits BDNF protein expression and CREB activation in the dentate gyrus but not in the hippocampus proper. (external link)
• Kuipers, Sjoukje; Bramham, Clive R. Evjen (2006). Brain-derived neurotrophic factor mechanisms and function in adult synaptic plasticity: New insights and implications for therapy. (external link)
• Breivik, Mona Inger; Tjølsen, Arne; Bramham, Clive R. Evjen (2006). Genaktivering ved langtidspotensiering (LTP) i spinale smertesystem. (external link)
• Soule, Jonathan; Messaoudi, Elhoucine; Bramham, Clive R. Evjen (2006). Brain-derived neurotrophic factor and control of synaptic consolidation in the adult brain. (external link)
• Dagestad, Grethe; Kuipers, Sjoukje; Messaoudi, Elhoucine et al. (2006). Chronic fluoxetine induces region-specific changes in translation factor eIF4E and eEF2 activity in the rat brain. (external link)
• Kanhema, Tambudzai; Dagestad, Grethe; Panja, Debabrata et al. (2006). Dual regulation of translation initiation and peptide chain elongation during BDNF-induced LTP in vivo: evidence for compartment-specific translation control. (external link)
• Kuipers, Sjoukje; Trentani, Andrea; Westenbroek, Christel et al. (2006). Unique patterns of FOS, phospho-CREB and BrdU immunoreactivity in the female rat brain following chronic stress and citalopram treatment. (external link)
• Wibrand, Karin; Messaoudi, Elhoucine; Håvik, Bjarte et al. (2006). Identification of genes co-upregulated with Arc during BDNF-induced long-term potentiation in adult rat dentate gyrus in vivo. (external link)

2005

• Grønli, Janne; Murison, Robert; Kanhema, Tambudzai et al. (2005). Chronic mild stress, an animal model of depression, affects the expression of BDNF and 5-HT levels over the sleep/wake cycle in hippocampus in rats. (external link)
• Bramham, Clive R. Evjen (2005). Molecular mechanisms of synaptic consolidation during sleep: BDNF function and dendritic protein synthesis. (external link)
• Bramham, Clive R. Evjen; Messaoudi, El Houcine (2005). BDNF function in adult synaptic plasticity: the synaptic consolidation hypothesis. Prog Neurobiol. (external link)

2004

• Gooney, M; Messaoudi, El Houcine; Maher, F O et al. (2004). BDNF-induced LTP in dentate gyrus is impaired with age: analysis of changes in cell signalling events. (external link)

2003

• Bramham, Clive R. Evjen (2003). På sporet av hukommelsen. (external link)
• Bramham, Clive R. Evjen (2003). Trophic factors and plasticity. (external link)
• Bramham, Clive R. Evjen (2003). På sporet av hukommelsen. (external link)
• Ernfors, Patrick; Bramham, Clive R. Evjen (2003). The coupling of a TrkB tyrosine residue to LTP. (external link)
• Bramham, Clive R. Evjen (2003). Neurobiology of learning and plasticity. (external link)
• Bramham, Clive R. Evjen (2003). BDNF as a consolidation factor in adult synaptic plasicity. (external link)
• Bramham, Clive R. Evjen (2003). BDNF as a consolidation factor in adult synaptic plasicity. (external link)
• Bramham, Clive R. Evjen (2003). BDNF as a consolidation factor in adult synaptic plasisity. (external link)
• Bramham, Clive R. Evjen (2003). Understanding synaptic plasicity. (external link)
• Bramham, Clive R. Evjen (2003). Neurotrophic factors and synaptic plasticity. (external link)
• Bramham, Clive R. Evjen (2003). BDNF as a consolidation factor in adult synaptic plasisity. (external link)
• Bramham, Clive R. Evjen (2003). BDNF as a consolidation factor in adult synaptic plasicity. (external link)
• Bramham, Clive R. Evjen (2003). BDNF as a consolidation factor in adult synaptic plasicity. (external link)
• Bramham, Clive R. Evjen (2003). BDNF as a consolidation factor in adult synaptic plasticity. (external link)
• Bramham, Clive R. Evjen (2003). BDNF as a consolidation factor in adult synaptic plasicity. (external link)
• Bramham, Clive R. Evjen (2003). BDNF as a consolidation factor in adult synaptic plasicity. (external link)
• Bramham, Clive R. Evjen (2003). BDNF-induced synaptic consolidation requires ongoing translation of the immediate early gene Arc. (external link)
• Kanhema, Tambudzai; Håvik, Bjarte; Grethe, Dagestad et al. (2003). BDNF, translation control and dendritic protein synthesis in adult synaptic plasticity. (external link)

2002

• Bramham, Clive R. Evjen; Messaoudi, Elhoucine; Bårdsen, Kjetil (2002). Neurotrophins and synaptic plasticity in the adult hippocampus. (external link)
• Bramham, Clive R. Evjen (2002). Making memories last: brain-derived neurotrophic factor (BDNF) as a trigger for synaptic consolidation. (external link)
• Ying, Shui-Wang; Futter, Marie; Rosenblum, Kobi et al. (2002). Brain-derived neurotrophic factor induces long-term potentiation in intact adult hippocampus: requirement for ERK activation coupled to CREB and upregulation of Arc synthesis. (external link)
• Messaoudi, Elhoucine; Ying, Shui-Wang; Kanhema, Tambudzai et al. (2002). Brain-derived neurotrophic factor triggers transcription-dependent, late phase long-term potentiation in vivo. (external link)
• Tyler, W.J.; Alonso, M; Bramham, Clive R. Evjen et al. (2002). From acquisition to consolidation: on the role of brain-derived neurotrophic factor signaling in hippocampal-dependent learning. (external link)
• McCutchen, Mary E.; Bramham, Clive R. Evjen; Pozzo-Miller, Lucas (2002). Modulation of neuronal calcium signaling by neurotrophic factors. (external link)
• Bramham, Clive R. Evjen (2002). The instructive role of BDNF in long-term potentiation. (external link)
• Bramham, Clive R. Evjen; Eikemo, Marit (2002). Det gåtefulle minnet. (external link)
• Steenslid, Vibeke; Messaoudi, Elhoucine; Bramham, Clive R. Evjen (2002). Effect of acute intrahippocampal BDNF infusion on synaptic efficacy at Schaffer collateral-CA1 synapses in vivo. (external link)
• Messaoudi, Elhoucine; Ying, Shui-Wang; Kanhema, Tambudzai et al. (2002). BDNF triggers transcription-dependent, late phase LTP in vivo. (external link)
• Røkke, Håvard; Håvik, Bjarte; Bårdsen, Kjetil et al. (2002). LTP-induced regulation of the immediate early genes arc and zif268 in the dentate gyrus of freely moving rats: effect of sleep-wakefulness state. (external link)
• Håvik, Bjarte; Røkke, Håvard; Davanger, Svend et al. (2002). Effect of LTP induction in awake rats on the expression and dendritic trafficking of Arc and alpha-CaMKII mRNA: a real-time PCR analysis of synaptodendrosomes. (external link)
• Håvik, Bjarte; Røkke, Håvard; Davanger, Svend et al. (2002). Rapid dendritic trafficking and translation of pre-existing CaMKII mRNA during LTP in awake rats. (external link)

2001

• Bramham, Clive R. Evjen (2001). BDNF and synaptic plasticity in the hippicampus in vivo. (external link)
• Bramham, Clive R. Evjen (2001). BDNF and synaptic plasticity in the hippicampus in vivo. (external link)
• Bramham, Clive R. Evjen (2001). BDNF and synaptic plasticity in the hippicampus in vivo. (external link)
• Bramham, Clive R. Evjen (2001). BDNF and synaptic plasticity in the hippicampus in vivo. (external link)
• Bramham, Clive R. Evjen (2001). BDNF, LTP and neuroprotection. (external link)
• Bramham, Clive R. Evjen (2001). BDNF and synaptic plasticity in the hippocampus in vivo. (external link)
• Bramham, Clive R. Evjen (2001). Brain-derived neurotrophophic factor (BDNF) and Long-Term synaptic plasticity. (external link)
• Kanhema, Tambudzai; Ying, Shui-Wang; Nairn, Angus C. et al. (2001). BDNF-induced long-term potentiation in the dentate gyrus in vivo is associated with phosphorylation of elongation factor-2. (external link)
• Kanhema, Tambudzai; Ying, Shui-Wang; Nairn, Angus C. et al. (2001). BDNF-induced long-term potentiation in the dentate gyrus in vivo is associated with phosphorylation of elongation factor-2. (external link)
• Messaoudi, Elhoucine; Bramham, Clive R. Evjen (2001). Characterization of BDNF-induced LTP in the dentate gyrus in vivo. (external link)

2000

• Valentine, Gerald; Chakravarty, Sumana; Sarvey, John et al. (2000). Fragile X (fmr1) mRNA expression is differentially regulated in two adult models of activity-dependent gene expression. (external link)
• Røkke, Håvard; Webber, M.; Hunt, S. et al. (2000). LTP induction in wakefulness and sleep-effect on expression patterns of immediate early genes. (external link)
• Ying, Shui-Wang; Rosenblum, K.; Futter, M. et al. (2000). Activation of MAPK signaling pathway is required in BDNF-induced long-term potentation in the adult hippocampus in vivo. (external link)
• Rosenblum, K.; Futter, M.; Voss, K. et al. (2000). GFP-ERKII translocation in neurons: a marker for long-term synaptic plasticity. (external link)
• Bramham, Clive R. Evjen; Lynch, M.A.; Plummer, M. et al. (2000). Symposium: Neurotrophins and synaptic plasticity in the hippocampus. (external link)
• Røkke, Håvard; Bramham, Clive R. Evjen (2000). Pairing of low frequency perforant path stimulation and endogenous exitatory events in dentate gyrus of the freely behaving rat. (external link)
• Messaoudi, Elhoucine; Croll, S.; Bramham, Clive R. Evjen (2000). Characterization of BDNF-induced long-term potentiation in the rat dentate gyrus. (external link)
• Rygh, Lars Jørgen; Bårdsen, Kjetil; Bramham, Clive R. Evjen (2000). In vivo monitoring of TrkB-Fc efficacy and time course using paired-pulse inhibition in the dentate gyrus. (external link)

1999

• Thomas, Gareth; Toska, Karen; Bramham, Clive R. Evjen et al. (1999). MAP and SAP kinase signaling pathways: emerging functions in the nervous system. (external link)
• Thomas, G; Toska, Karen; Bramham, Clive R. Evjen et al. (1999). Mitogen and stress activated protein kinase signaling pathways: emerging functions in the nervous system. (external link)
• Messaoudi, Elhoucine; Bramham, Clive R. Evjen (1999). NMDA receptor activation is not required for BDNF-induced LTP in the rat dentate gyrus in vivo. (external link)
• Røkke, Håvard; Bramham, Clive R. Evjen (1999). LTP induction in the dentate gyrus of freely moving rats is modulated by dentate EEG spikes. (external link)
• Bramham, Clive R. Evjen; Messaoudi, Elhoucine; Webber, M. et al. (1999). BDNF-induced LTP is associated with enhanced ZIF/268 protein expression in rat dantate gyrus in vivo. (external link)

1998

• Bramham, Clive R. Evjen (1998). Neurotrophin regulation of synaptic plasticity in the adult nervous system. (external link)
• Bramham, Clive R. Evjen; Alhers, S.; Sarvey, J. (1998). Acute cold stress leading to elevated corticosterone neither enhances synaptic efficacy nor impairs tetanus-evoked LTP in the dentate gyrus of free moving rats. (external link)
• Messaoudi, Elhoucine; Srebro, Boleslaw; Bramham, Clive R. Evjen (1998). Acute intrahippocampal infusion of BDNF induces lasting potentiation of synaptic transmission in the rat dentate gyrus. (external link)
• Bramham, Clive R. Evjen (1998). Phasic boosting of medial perforant path-evoked granule cell output time-locked to spontaneous dentate EEG spikes in awake rats. (external link)
• Bramham, Clive R. Evjen; Bårdsen, Kjetil; Messaoudi, Elhoucine (1998). Endogenous neurotrophins and LTP in the dentate gyrus in vivo: effect of BDNF-scavenger Trk-IgG. (external link)
• Bårdsen, Kjetil; Messaoudi, El Houcine; Bramham, Clive R. Evjen (1998). Effect of the BDNF-scavenger TrkB-IgF on LTP in the rat dentate gyrus in vivo. (external link)
• Messaoudi, Elhoucine; Bårdsen, Kjetil; Srebro, Bolek et al. (1998). In vivo BDNF-induced long-lasting potentiation in the rat dentate gyrus. (external link)

1996

• Bramham, Clive R. Evjen; Southard, Teresa; Sarvey, John M et al. (1996). Unilateral LTP triggers bilateral increases in hippocampal neurotrophin and trk receptor mRNA expression in behaving rats: Evidence for interhemisp communication. (external link)
• Bramham, Clive R. Evjen; Sarvey, John M (1996). Endogenous Activation of µ and -1 Opioid Receptors Is Required for Long-Term Potentiation Induction in the Lateral Perforant Path: Dependence on GABAergic Inhibition. (external link)

1992

• Bramham, Clive R. Evjen (1992). In vivo studies on long-term potentiation (LTP) in the dentate gyrus : role of opioid and NMDA receptors, and modulation by behavioral state. (external link)

1991

• Lynch, M. A.; Clements, M. P.; Voss, K. L. et al. (1991). Is arachidonic acid a retrograde messenger in long-term potentiation?. (external link)
• Bramham, Clive R. Evjen; Milgram, N. W.; Srebro, Boleslaw (1991). Delta opioid receptor activation is required to induce LTP of synaptic transmission in the lateral perforant path in vivo. (external link)
• Bramham, Clive R. Evjen; Milgram, N. W.; Srebro, Boleslaw (1991). Activation of AP5-sensitive NMDA-receptors is required to induce LTP of synaptic transmission in the lateral perforant path. (external link)

See a complete overview of publications in Cristin.

• Arc as a master regulator of long-term synaptic plasticity 
• Translational control of synaptic plasticity
• Non-coding RNA regulation and function in synaptic plasticity

Links to currently funded projects:t

The Impact of Cytoplasmic Polyadenylation on Local Translation in Neurons. EEA grant for Poland-Norway Research Cooperation. 2020-2024.

Mohn Research Center for Plasticity and Neural Circuit Dynamics in the Brain. Supported by the Trond Mohn Foundation, the University of Bergen (UiB) and the Norwegian University of Science and Technology (NTNU). 2021-2026.