Diabetes, obesity and nutrition

Hormones, diagnostics and breast cancer

Hormone Laboratory Research Group

Mohn Nutrition Research Laboratory www.uib.no/mohn-elab

Endocrinology and Medical Biochemistry

Academic article

• Lee, Oukseub; Bazzi, Latifa A.; Xu, Yanfei et al. (2024). A randomized Phase I pre-operative window trial of transdermal endoxifen in women planning mastectomy: Evaluation of dermal safety, intra-mammary drug distribution, and biologic effects. (external link)
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• Mellgren, Gunnar; Helland, Thomas; Jonsdottir, Kristin et al. (2024). Håvard Søiland. (external link)
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• Hagen, Ingrid Valheim; Helland, Anita; Bratlie, Marianne et al. (2023). Serum concentrations of amino acids and tryptophan metabolites are affected by consumption of a light breakfast: a clinical intervention study in adults with overweight or obesity. (external link)
• O'Keeffe, Maria; Oterhals, Åge; Vikøren, Linn Anja Slåke et al. (2023). Dietary fish intake increased the concentration of soluble ACE2 in rats. Can fish consumption reduce the risk of COVID-19 infection through interception of SARS-CoV-2 by soluble ACE2?. (external link)
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• Flølo, Tone Nygaard; Fosså, Alexander; Nedkvitne, Jonas Ingolf Petersson et al. (2023). Long-term impact of gastropexy on use of acid-reducing medication, second operations for gastroesophageal reflux and subjective reflux symptoms after sleeve gastrectomy. (external link)
• Laupsa-Borge, Johnny; Grytten, Elise; Bohov, Pavol et al. (2023). Sex-specific responses in glucose-insulin homeostasis and lipoprotein-lipid components after high-dose supplementation with marine n-3 PUFAs in abdominal obesity: a randomized double-blind crossover study. (external link)
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• Haugen, Christine; Lysne, Vegard; Haldorsen, Ingfrid S. et al. (2022). MRI adipose tissue segmentation and quantification in R (RAdipoSeg). (external link)
• Sommersten, Cathrine Horn; Laupsa-Borge, Johnny; Andersen, Amanda Iselin Olesen et al. (2022). Diets differing in carbohydrate cellularity and amount similarly reduced visceral fat in people with obesity - a randomized controlled trial (CARBFUNC). (external link)
• Helland, Anita; Bratlie, Marianne; Hagen, Ingrid Valheim et al. (2022). Consumption of a light meal affects serum concentrations of one-carbon metabolites and B-vitamins. A clinical intervention study. (external link)
• Haugstøyl, Martha Eimstad; Cornillet, Martin; Strand, Kristina et al. (2022). Distinct T cell subsets in adipose tissue are associated with obesity. (external link)
• Strand, Kristina; Stiglund, Natalie; Haugstøyl, Martha Eimstad et al. (2022). Subtype-specific surface proteins on adipose tissue macrophages and their association to obesity-induced insulin resistance. (external link)
• Nielsen, Hans Jørgen; Nedrebø, Bjørn Gunnar; Fosså, Alexander et al. (2022). Seven-year trajectories of body weight, quality of life and comorbidities following Roux-en-Y gastric bypass and sleeve gastrectomy. (external link)
• Madsen, Andre; Almås, Bjørg; Bruserud, Ingvild Særvold et al. (2022). Reference Curves for Pediatric Endocrinology: Leveraging Biomarker Z-Scores for Clinical Classifications. (external link)
• Jersin, Regine Åsen; Tallapragada, Divya Sri Priyanka; Madsen, Andre et al. (2021). Role of the Neutral Amino Acid Transporter Slc7a10 in Adipocyte Lipid Storage, Obesity and Insulin Resistance. (external link)
• Hanem, Liv Guro Engen; Salvesen, Øyvind; Madsen, Andre et al. (2021). Maternal PCOS status and metformin in pregnancy: Steroid hormones in 5–10 years old children from the PregMet randomized controlled study. (external link)
• Grytten, Elise; Laupsa-Borge, Johnny; Bohov, Pavol et al. (2021). Changes in lipoprotein particle subclasses, standard lipids, and apolipoproteins after supplementation with n-3 or n-6 PUFAs in abdominal obesity: A randomized double-blind crossover study. (external link)
• Chen, Yuanhuang; Marcath, Lauren A.; Eliassen, Finn Magnus et al. (2021). Effect of genetic variability in 20 pharmacogenes on concentrations of tamoxifen and its metabolites. (external link)
• Helland, Anita; Bratlie, Marianne; Hagen, Ingrid Valheim et al. (2021). Effect of high intake of cod or salmon on serum total neopterin concentration: a randomised clinical trial. (external link)
• Ueland, Grethe Åstrøm; Kellmann, Ralf; Jørstad, Melissa Davidsen et al. (2021). Bedtime Salivary Cortisol as a Screening Test for Cushing Syndrome in Children. (external link)
• Gissler, Mark Colin; Anto-Michel, Nathaly; Pennig, Jan et al. (2021). Genetic Deficiency of TRAF5 Promotes Adipose Tissue Inflammation and Aggravates Diet-Induced Obesity in Mice. (external link)
• Vikøren, Linn A.; Drotningsvik, Aslaug; Midttun, Øivind et al. (2021). Baked cod consumption delayed the development of kidney and liver dysfunction and affected plasma amino acid concentrations, but did not affect blood pressure, blood glucose or liver triacylglycerol concentrations in obese fa/fa Zucker rats.. (external link)
• DeCensi, Andrea; Johansson, Harriet; Helland, Thomas et al. (2021). Association of CYP2D6 genotype and tamoxifen metabolites with breast cancer recurrence in a low-dose trial. (external link)
• Sinnott-Armstrong, Nicholas A; Sousa, Isabel S.; Laber, Samantha et al. (2021). A regulatory variant at 3q21.1 confers an increased pleiotropic risk for hyperglycemia and altered bone mineral density. (external link)
• Doncheva, Atanaska Ivanova; Norheim, Frode Amador; Hjorth, Marit et al. (2021). Serglycin Is Involved in Adipose Tissue Inflammation in Obesity. (external link)
• Bertelsen, Bjørn-Erik; Viste, Kristin; Helland, Thomas et al. (2021). Simultaneous Quantification of Aromatase Inhibitors and Estrogens in Postmenopausal Breast Cancer Patients. (external link)
• Horn, Cathrine; Laupsa-Borge, Johnny; Andersen, Amanda et al. (2021). Meal patterns associated with energy intake in people with obesity. (external link)
• Dankel, Simon N; Grytten, Elise; Bjune, Jan-Inge et al. (2020). COL6A3 expression in adipose tissue cells is associated with levels of the homeobox transcription factor PRRX1. (external link)
• Peccatori, Fedro Alessandro; Codacci-Pisanelli, Giovanni; Mellgren, Gunnar et al. (2020). First-in-human pharmacokinetics of tamoxifen and its metabolites in the milk of a lactating mother: A case study. (external link)
• Helland, Thomas; Naume, Bjørn; Hustad, Steinar et al. (2020). Low Z-4OHtam concentrations are associated with adverse clinical outcome among early stage premenopausal breast cancer patients treated with adjuvant tamoxifen. (external link)
• Madsen, Andre; Oehme, Ninnie; Roelants, Mathieu et al. (2020). Testicular Ultrasound to Stratify Hormone References in a Cross-Sectional Norwegian Study of Male Puberty . (external link)
• Nilsen, Mona Synnøve; Åsen Jersin, Regine; Ulvik, Arve et al. (2020). 3-hydroxyisobutyrate, a strong marker of insulin resistance in type 2 diabetes and obesity that modulates white and brown adipocyte metabolism. (external link)
• Madsen, Andre; Bruserud, Ingvild Særvold; Bertelsen, Bjørn-Erik et al. (2020). Hormone references for ultrasound breast staging and endocrine profiling to detect female onset of puberty. (external link)
• Wang, Lifeng; Sinnott-Armstrong, Nicholas A; Wagschal, Alexandre et al. (2020). A MicroRNA Linking Human Positive Selection and Metabolic Disorders. (external link)
• Bratlie, Marianne; Hagen, Ingrid Valheim; Helland, Anita et al. (2020). Effects of high intake of cod or salmon on gut microbiota profile, faecal output and serum concentrations of lipids and bile acids in overweight adults: a randomised clinical trial. (external link)
• Bratlie, Marianne; Hagen, Ingrid Valheim; Helland, Anita et al. (2020). Five salmon dinners per week were not sufficient to prevent the reduction in serum vitamin D in autumn at 60° north latitude: A randomised trial. (external link)
• Bjune, Jan-Inge; Dyer, Laurence; Røsland, Gro Vatne et al. (2019). The homeobox factor Irx3 maintains adipogenic identity. (external link)
• Helland, Thomas; Hagen, Kari Britt; Haugstøyl, Martha Eimstad et al. (2019). Drug monitoring of tamoxifen metabolites predicts vaginal dryness and verifies a low discontinuation rate from the Norwegian Prescription Database. (external link)
• Drotningsvik, Aslaug; Midttun, Øivind; Vikøren, Linn Anja Slåke et al. (2019). Urine and plasma concentrations of amino acids and plasma vitamin status differ, and are differently affected by salmon intake, in obese Zucker fa/fa rats with impaired kidney function and in Long-Evans rats with healthy kidneys. (external link)
• Hagen, Ingrid Valheim; Helland, Anita; Bratlie, Marianne et al. (2019). TMAO, creatine and 1-methylhistidine in serum and urine are potential biomarkers of cod and salmon intake: a randomised clinical trial in adults with overweight or obesity. (external link)
• Gudbrandsen, Oddrun Anita; Dankel, Simon N; Skumsnes, Lillian et al. (2019). Short-term effects of Vertical sleeve gastrectomy and Roux-en-Y gastric bypass on glucose homeostasis. (external link)
• Svärd, Jessica; Røst, Therese Halvorsen; Sommervoll, Camilla Elise Nergård et al. (2019). Absence of the proteoglycan decorin reduces glucose tolerance in overfed male mice. (external link)
• Stiglund, Natalie; Strand, Kristina; Cornillet, Martin et al. (2019). Retained NK cell phenotype and functionality in non-alcoholic fatty liver disease. (external link)
• Dankel, Simon N; Røst, Therese Halvorsen; Kulyté, Agné et al. (2019). The Rho GTPase RND3 regulates adipocyte lipolysis. (external link)
• Hovland, Ida Heir; Leikanger, Ingrid Sande; Stokkeland, Oddbjørg et al. (2019). Effects of low doses of fish and milk proteins on glucose regulation and markers of insulin sensitivity in overweight adults: a randomised, double blind study. (external link)
• Johansson, Harriet; Aristarco, Valentina; Gandini, Sara et al. (2019). Prognostic impact of genetic variants of CYP19A1 and UGT2B17 in a randomized trial for endocrine-responsive postmenopausal breast cancer. (external link)
• Madsen, Andre; Oehme, Ninnie; Roelants, Mathieu et al. (2019). Testicular ultrasound to stratify hormone references in a cross-sectional Norwegian study of male puberty. (external link)
• Schmedes, Mette; Balderas, Claudia; Aadland, Eli Kristin et al. (2018). The effect of lean-seafood and non-seafood diets on fasting and postprandial serum metabolites and lipid species: Results from a randomized crossover intervention study in healthy adults. (external link)
• Ueland, Grethe Åstrøm; Methlie, Paal; Øksnes, Marianne et al. (2018). The short cosyntropin test revisited: new normal reference range using LC-MS/MS. (external link)
• Vildmyren, Iselin Thowsen; Cao, Huy John Vu; Haug, Lina Bowitz et al. (2018). Daily intake of protein from cod residual material lowers serum concentrations of nonesterified fatty acids in overweight healthy adults: A randomized double-blind pilot study. (external link)
• Schmedes, Mette; Brejnrod, Asker; Aadland, Eli Kristin et al. (2018). The effect of lean-seafood and non-seafood diets on fecal metabolites and gut microbiome: results from a randomized crossover intervention study. (external link)
• Kareem Eldin, Mohammed Adhmed Abdel Ghafar; Frøysa, Håvard G; Karlsen, Odd Andre et al. (2018). LC-MS/MS based profiling and dynamic modelling of the steroidogenesis pathway in adrenocarcinoma H295R cells. (external link)
• Vikøren, Linn Anja Slåke; Drotningsvik, Aslaug; Bergseth, Marthe Tønder et al. (2018). Intake of baked cod fillet resulted in lower serum cholesterol and higher long chain n-3 PUFA concentrations in serum and tissues in hypercholesterolemic obese Zucker fa/fa rats. (external link)
• Christensen, Monika; Fadnes, Dag Jone Stokke; Røst, Therese Halvorsen et al. (2018). Inflammatory markers, the tryptophan-kynurenine pathway, and Vitamin B status after bariatric surgery. (external link)
• Vikøren, Linn Anja Slåke; Drotningsvik, Aslaug; Mwakimonga, Angela Kipesile et al. (2018). Diets containing salmon fillet delay development of high blood pressure and hyperfusion damage in kidneys in obese Zucker fa/fa rats. (external link)
• Bozickovic, Olivera; Skartveit, Linn; Svendsen, Agnete et al. (2018). A novel SRC-2-dependent regulation of epithelial-mesenchymal transition in breast cancer cells. (external link)
• Bjune, Jan-Inge; Haugen, Christine; Gudbrandsen, Oddrun Anita et al. (2018). IRX5 regulates adipocyte amyloid precursor protein and mitochondrial respiration in obesity. (external link)
• Vikøren, Linn Anja Slåke; Drotningsvik, Aslaug; Mjøs, Svein Are et al. (2018). Salmon fillet intake led to higher serum triacylglycerol in obese zucker Fa/Fa rats but not in normolipidemic Long-Evans rats. (external link)
• Grytaas, Marianne Aardal; Strømsøy, Siri S.; Rørvik, Jarle et al. (2017). Clinical Characteristics and Long-Term Outcome of Primary Aldosteronism in a Norwegian Population. (external link)
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• Helland, Thomas; Henne, Nina; Bifulco, Ersilia et al. (2017). Serum concentrations of active tamoxifen metabolites predict long-term survival in adjuvantly treated breast cancer patients. (external link)
• Veum, Vivian Lohmann; Laupsa-Borge, Johnny; Eng, Øyvin Andre Solberg et al. (2017). Visceral adiposity and metabolic syndrome after very high-fat and low-fat isocaloric diets: A randomized controlled trial. (external link)
• Strand, Elin; Pedersen, Eva Ringdal; Svingen, Gard Frodahl Tveitevåg et al. (2017). Serum acylcarnitines and risk of cardiovascular death and acute myocardial infarction in patients with stable angina pectoris. (external link)
• Johansson, Bente Berg; Fjeld, Karianne; Solheim, Marie Holm et al. (2017). Nuclear import of glucokinase in pancreatic beta-cells is mediated by a nuclear localization signal and modulated by SUMOylation. (external link)
• Ejarque, Miriam; Borlaug, Marianne; Vilarrasa, Núria et al. (2017). Angiopoietin-like protein 8/betatrophin as a new determinant of type 2 diabetes remission after bariatric surgery. (external link)
• Helland, Anita; Bratlie, Marianne; Hagen, Ingrid Valheim et al. (2017). High intake of fatty fish, but not of lean fish, improved postprandial glucose regulation and increased the n-3 PUFA content in the leucocyte membrane in healthy overweight adults: A randomised trial. (external link)
• Rebnord, Eirik Wilberg; Strand, Elin; Midttun, Øivind et al. (2017). The kynurenine:tryptophan ratio as a predictor of incident type 2 diabetes mellitus in individuals with coronary artery disease. (external link)
• Vikøren, Linn Anja Slåke; Drotningsvik, Aslaug; Bergseth, Marthe Tønder et al. (2017). Effects of baked and raw salmon fillet on lipids and n-3 PUFAs in serum and tissues in Zucker fa/fa rats. (external link)
• Mauland, Karen Klepsland; Eng, Øyvin Andre Solberg; Ytre-Hauge, Sigmund et al. (2017). High visceral fat percentage is associated with poor outcome in endometrial cancer. (external link)
• Skrede, Silje; Gonzalez-Garcia, Ismael; Martins, Luis et al. (2017). Lack of ovarian secretions reverts the anabolic action of olanzapine in female rats. (external link)
• Braadland, Peder; Grytli, Helene Hartvedt; Ramberg, Håkon Andre et al. (2016). Low β2-adrenergic receptor level may promote development of castration resistant prostate cancer and altered steroid metabolism . (external link)
• Madsen, Andre Greger; Bjune, Jan Inge; Bjørkhaug, Lise et al. (2016). The cAMP-dependent protein kinase downregulates glucose-6-phosphatase expression through RORα and SRC-2 coactivator transcriptional activity. (external link)
• Flågeng, Marianne Hauglid; Larionov, Alexey; Geisler, Jürgen et al. (2016). Treatment with aromatase inhibitors stimulates the expression of epidermal growth factor receptor-1 and neuregulin 1 in ER positive/HER-2/neu non-amplified primary breast cancers. (external link)
• Johansson, Harriet; Gandini, Sara; Serrano, Davide et al. (2016). A pooled analysis of CYP2D6 genotype in breast cancer prevention trials of low-dose tamoxifen. (external link)
• Schmedes, Mette; Aadland, Eli Kristin; Sundekilde, Ulrik Kræmer et al. (2016). Lean-seafood intake decreases urinary markers of mitochondrial lipid and energy metabolism in healthy subjects: Metabolomics results from a randomized crossover intervention study. (external link)
• Aadland, Eli Kristin; Graff, Ingvild Eide; Lavigne, Charles et al. (2016). Lean seafood intake reduces postprandial c-peptid and lactate concentrations in healthy adults in a randomized controlled trial with a crossover design. (external link)
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• Hagen, Ingrid Valheim; Helland, Anita; Bratlie, Marianne et al. (2016). High intake of fatty fish, but not of lean fish, affects serum concentrations of TAG and HDL-cholesterol in healthy, normal-weight adults: A randomised trial. (external link)
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• Svingen, Gard Frodahl Tveitevåg; Schartum-Hansen, Hall; Ueland, Per Magne et al. (2015). Elevated plasma dimethylglycine is a risk marker of mortality in patients with coronary heart disease. (external link)
• Helland, Thomas; Gjerde, Jennifer; Dankel, Simon N et al. (2015). The active tamoxifen metabolite endoxifen (4OHNDtam) strongly down-regulates cytokeratin 6 (CK6) in MCF-7 breast cancer cells. (external link)
• Christensen, Monika; Fenne, Ingvild Sveinsgjerd; Nordbø, Yngve et al. (2015). Novel inflammatory biomarkers in primary hyperparathyroidism. (external link)
• Bozickovic, Olivera; Hoang, Tuyen; Fenne, Ingvild Sveinsgjerd et al. (2015). Cyclin C interacts with steroid receptor coactivator 2 and upregulates cell cycle genes in MCF-7 cells. (external link)
• Flågeng, Marianne Hauglid; Knappskog, Stian; Gjerde, Jennifer et al. (2015). Estrogens correlate with PELP1 expression in ER positive breast cancer. (external link)
• Claussnitzer, Melina; Dankel, Simon N; Kim, Kyoung-Han et al. (2015). FTO obesity variant circuitry and adipocyte browning in humans. (external link)
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• Falorni, Alberto; Bini, Vittorio; Betterle, Corrado et al. (2015). Determination of 21-hydroxylase autoantibodies: Inter-laboratory concordance in the Euradrenal International Serum Exchange Program. (external link)
• McCulloch, Laura J.; Rawling, Tom J.; Sjöholm, Kajsa et al. (2015). COL6A3 is regulated by leptin in human adipose tissue and reduced in obesity. (external link)
• Aadland, Eli Kristin; Lavigne, Charles; Graff, Ingvild Eide et al. (2015). Lean-seafood intake reduces cardiovascular lipid risk factors in healthy subjects: results from a randomized controlled trial with a crossover design. (external link)
• Madsen, Andre Greger; Bozickovic, Olivera; Bjune, Jan Inge et al. (2015). Metformin inhibits hepatocellular glucose, lipid and cholesterol biosynthetic pathways by transcriptionally suppressing steroid receptor coactivator 2 (SRC-2). (external link)
• Dankel, Simon E Nitter; Degerud, Eirik Magnus Meek; Borkowski, Kamil et al. (2014). Weight cycling promotes fat gain and altered clock gene expression in adipose tissue in C57BL/6J mice. (external link)
• Claussnitzer, Melina; Dankel, Simon E Nitter; Klocke, Bernward et al. (2014). Leveraging cross- species transcription factor binding site patterns: from diabetes risk loci to disease mechanisms. (external link)
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• Dankel, Simon E Nitter; Svärd, Jessica; Matthä, Simone et al. (2014). COL6A3 expression in adipocytes associates with insulin resistance and depends on PPARγ and adipocyte size. (external link)
• Christensen, Monika; Fenne, Ingvild Sveinsgjerd; Flågeng, Marianne Hauglid et al. (2014). Estradiol determines the effects of PTH on ERα-dependent transcription in MC3T3-E1 cells. (external link)
• Ussar, Siegfried; Lee, Kevin; Dankel, Simon N et al. (2014). ASC-1, PAT2, and P2RX5 are cell surface markers for white, beige, and brown adipocytes.. (external link)
• Flågeng, Marianne Hauglid; Knappskog, Stian; Haynes, Ben P. et al. (2013). Inverse regulation of EGFR/HER1 and HER2-4 in normal and malignant human breast tissue. (external link)
• Lien, Ernst Asbjørn; Søiland, Håvard; Lundgren, Steinar et al. (2013). Serum concentrations of tamoxifen and its metabolites increase with age during steady-state treatment. (external link)
• Methlie, Paal; Dankel, Simon E Nitter; Myhra, Tone Sæterdal et al. (2013). Changes in adipose glucocorticoid metabolism before and after bariatric surgery assessed by direct hormone measurements. (external link)
• Viste, Kristin; Grytaas, Marianne Aardal; Jørstad, Melissa et al. (2013). Efficacy of adrenal venous sampling is increased by point of care cortisol analysis. (external link)
• Christensen, Monika; Apalset, Ellen M; Nordbø, Yngve et al. (2013). 1,25-dihydroxyvitamin D and the vitamin D receptor gene polymorphism apa1 influence bone mineral density in primary hyperparathyroidism. (external link)
• Fenne, Ingvild Sveinsgjerd; Helland, Thomas; Flågeng, Marianne Hauglid et al. (2013). Downregulation of steroid receptor coactivator-2 modulates estrogen-responsive genes and stimulates proliferation of MCF-7 breast cancer cells. (external link)
• Våge, Villy; Nilsen, Roy Miodini; Berstad, Arnold et al. (2013). Predictors for remission of major components of the metabolic syndrome after biliopancreatic diversion with duodenal switch (BPDDS). (external link)
• Hoang, Tuyen; Fenne, Ingvild Sveinsgjerd; Madsen, Andre Greger et al. (2013). cAMP response element-binding protein interacts with and stimulates the proteasomal degradation of the nuclear receptor coactivator GRIP1. (external link)
• Rosendahl-Riise, Hanne; Nielsen, Hans Jørgen; Mellgren, Gunnar et al. (2013). Energy intake, nutritional status and weight reduction in patients one year after laparoscopic sleeve gastrectomy. (external link)
• Veum, Vivian Lohmann; Dankel, Simon E Nitter; Gjerde, Jennifer et al. (2012). The nuclear receptors NUR77, NURR1 and NOR1 in obesity and during fat loss. (external link)
• Moi, Line Leonore Haugan; Flågeng, Marianne Hauglid; Gjerde, Jennifer et al. (2012). Steroid receptor coactivators, HER-2 and HER-3 expression is stimulated by tamoxifen treatment in DMBA-induced breast cancer. (external link)
• Gjerde, Jennifer; Gandini, Sara; Guerrieri-Gonzaga, Aliana et al. (2012). Tissue distribution of 4-hydroxy-N-desmethyltamoxifen and tamoxifen-N-oxide. (external link)
• Christensen, Monika; Pedersen, Eva Kristine Ringdal; Nordbø, Yngve et al. (2012). Vitamin B6 status and interferon-γ-mediated immune activation in primary hyperparathyroidism. (external link)
• Serrano, Davide; Lazzeroni, Matteo; Zambon, Carlo–Federico et al. (2011). Efficacy of tamoxifen based on cytochrome P450 2D6, CYP2C19 and SULT1A1 genotype in the Italian Tamoxifen Prevention Trial. (external link)
• Christensen, Monika; Dankel, Simon E Nitter; Nordbø, Yngve et al. (2011). Primary hyperparathyroidism influences the expression of inflammatory and metabolic genes in adipose tissue. (external link)
• Liaset, Bjørn; Hao, Qin; Jørgensen, Henry et al. (2011). Nutritional regulation of bile acid metabolism is associated with improved pathological characteristics of the metabolic syndrome. (external link)
• Dankel, Simon E Nitter; Hoang, Tuyen; Flågeng, Marianne Hauglid et al. (2010). cAMP-mediated regulation of HNF-4 alpha depends on the level of coactivator PGC-1 alpha. (external link)
• Aumo, Linda; Rusten, Marte; Mellgren, Gunnar et al. (2010). Functional roles of protein kinase A (PKA) and exchange protein directly activated by 3',5'-cyclic adenosine 5'-monophosphate (cAMP) 2 (EPAC2) in cAMP-mediated actions in adrenocortical cells. (external link)
• Dankel, Simon E Nitter; Fadnes, Dag Jone Stokke; Stavrum, Anne-Kristin et al. (2010). Switch from stress response to homeobox transcription factors in adipose tissue after profound fat loss. (external link)
• Gjerde, Jennifer; Geisler, Jürgen; Lundgren, Steinar et al. (2010). Associations between tamoxifen, estrogens, and FSH serum levels during steady state tamoxifen treatment of postmenopausal women with breast cancer. (external link)
• Moi, Line Leonore Haugan; Flågeng, Marianne Hauglid; Gandini, Sara et al. (2010). Effect of low-dose tamoxifen on steroid receptor coactivator 3/amplified in breast cancer 1 in normal and malignant human breast tissue. (external link)
• Bratland, Eirik; Bredholt, Geir; Mellgren, Gunnar et al. (2009). The purification and application of biologically active recombinant steroid cytochrome P450 21-hydroxylase: The major autoantigen in autoimmune Addison's disease. (external link)
• Flageng, MH; Hauglid, Marianne; Moi, Line Leonore Haugan et al. (2009). Nuclear receptor co-activators and HER-2/neu are upregulated in breast cancer patients during neo-adjuvant treatment with aromatase inhibitors. (external link)
• Liaset, Bjørn; Madsen, Lise; Hao, Qin et al. (2009). Fish protein hydrolysate elevates plasma bile acids and reduces visceral adipose tissue mass in rats. (external link)
• Røst, Therese Halvorsen; Moi, Line Leonore Haugan; Berge, Kjetil et al. (2009). A pan-PPAR ligand induces hepatic fatty acid oxidation in PPAR alpha-/- mice possibly through PGC-1 mediated PPAR delta coactivation. (external link)
• Fenne, Ingvild Sveinsgjerd; Hoang, Tuyen; Hauglid, Marianne et al. (2008). Recruitment of coactivator glucocorticoid receptor interacting protein 1 to an estrogen receptor transcription complex is regulated by the 3',5'-cyclic adenosine 5'-monophosphate-dependent protein kinase. (external link)
• Gjerde, Jennifer Fernandez; Hauglid, Marianne; Hauglid, M et al. (2008). Effects of CYP2D6 and SULT1A1 genotypes including SULT1A1 gene copy number on tamoxifen metabolism. (external link)
• Gjerde, Jennifer; Geisler, Jurgen; Lundgren, Steinar et al. (2007). A study of association between estrogen and tamoxifen metabolism, cytochrome 2D6 and sulfotransferae 1A1 polymorphisms, and sulfotransferase 1A1 gene copy number during steady sate tamoxifen treatment. (external link)
• Kisanga, Elton Richard; Mellgren, Gunnar; Lien, Ernst Asbjørn (2005). Excretion of hydroxylated metabolites of tamoxifen in human bile and urine. (external link)
• Kisanga, Elton Richard; Moi, Line Leonore Haugan; Gjerde, Jennifer et al. (2005). Induction of hepatic drug-metabolising enzymes and tamoxifen metabolite profile in relation to administration route during low-dose treatment in nude rats. (external link)
• Gjerde, Jennifer Fernandez; Kisanga, Elton Richard; Hauglid, Marianne et al. (2005). Identification and quantification of tamoxifen and four metabolites in serum by liquid chromatography-tandem mass spectrometry. (external link)
• Hoang, Tuyen; Fenne, Ingvild Sveinsgjerd; Cook, Carol Ann et al. (2004). cAMP-dependent protein kinase regulates ubiquitin-proteasome-mediated degradation and subcellular localization of the nuclear receptor coactivator GRIP1. (external link)
• Bøe, Anette Susanne; Bredholt, Geir; Knappskog, Per et al. (2004). Autoantibodies against 21-hydroxylase and side-chain cleavage enzyme in autoimmune Addison's disease are mainly immunoglobulin G1. (external link)
• Æsøy, Reidun; Mellgren, Gunnar; Morohashi, Ken-Ichirou et al. (2002). Activation of cAMP-dependent protein kinase increases the protein level of steroidogenic factor-1. (external link)
• Lund, Johan; Jacob, Anne Lilybert J.; Aesöy, R. et al. (1998). Biochemical and functional analysis of nuclear receptors as targets in cAMP-dependent control of bovine CYP17. (external link)
• Lund, Johan; Jacob, Anne L.; Æsøy, Reidun et al. (1998). Biochemical and functional analysis of nuclear receptors as targets in cAMP-dependent control of bovine CYP17. (external link)
• Lund, Johan; Bakke, Marit; Mellgren, Gunnar et al. (1997). Transcriptional regulation of the bovine CYP17 gene by cAMP. (external link)
• Fladmark, Kari Espolin; Gjertsen, Bjørn Tore; Molven, Anders et al. (1997). Gap junctions and growth control in liver regeneration and in isolated rat hepatocytes. (external link)
• Mellgren, Gunnar; Bruland, T; Døskeland, A.P et al. (1997). Synergistic antiproliferative actions of cyclic adenosine 3',5'-monophosphate, interleukin-1beta, and activators of Ca%2%+/calmodulin-dependent protein kinase in primary hepatocytes. (external link)
• Flatmark, K.E.; Gjertsen, B.T.; Molven, Anders et al. (1997). Gap junctions and growth control in liver regeneration and in isolated rat hepatocytes. (external link)
• Houge, G; Robaye, B; Eikholm, TS et al. (1995). Fine mapping of 28S rRNA sites specifically cleaved in cells undergoing apoptosis. (external link)
• Mellgren, Gunnar; Vintermyr, Olav Karsten; Døskeland, SO (1995). Okadaic acid, cAMP, and selected nutrients inhibit hepatocyte proliferation at different stages in G%b: Modulation of the cAMP effect by phosphatase inhibitors and nutrients. (external link)
• Gjertsen, BT; Mellgren, Gunnar; Otten, A et al. (1995). Novel Rp-cAMPS analogs as tools for inhibition of type I cAMP-dependent protein kinase in cell culture. Basal cAMP-kinase activity modulates hepatocyte DNA replication and interleukin-1_b action. (external link)
• Brustugun, OT; Mellgren, Gunnar; Gjertsen, BT et al. (1995). Sensitive and rapid detection of _b-galactosidase expression in intact cells by microinjection of fluorescent substrate. (external link)
• Jensen, P. H.; Cressey, L.; Gjertsen, Bjørn Tore et al. (1994). Cleaved intracellular plasminogen activator inhibitor-2 is a marker of apoptosis present in human myeloid leukemia cells. (external link)
• Mellgren, Gunnar; Vintermyr, Olav Karsten; Bøe, Ragnar et al. (1993). Hepatocyte DNA replication is abolished by inhibitors selecting protein phosphatase 2A rather than phosphatase 1. (external link)

Poster

• Vinnes, Erik Wilhelm; Aakre, Kristin Moberg; Fernø, Johan et al. (2024). Long-term effect of bariatric surgery on circulating GDF15 concentrations. (external link)
• Jensen, Caroline; Mellgren, Gunnar; Dankel, Simon N et al. (2024). Quality and quantity of carbohydrates, fecal SCFAs and gastrointestinal symptoms - results from a RCT (CARBFUNC). (external link)
• Bjune, Mona Synnøve; Dyer, Laurence; McCann, Adrian et al. (2022). Altered hepatic HIBCH expression is associated with hepatic lipid accumulation and fatty liver. (external link)
• Nilsen, Mona Synnøve; Åsen Jersin, Regine; Madsen, Andre et al. (2019). Adipocyte amino acid metabolism in obesity-related metabolic diseases . (external link)
• Tallapragada, Divya Sri Priyanka; Laber, Samantha; Mellgren, Gunnar et al. (2019). Generation and validation of immortalized human paired subcutaneous and omental adipocyte models to study obesity. (external link)
• Lunde, Siri; Helland, Thomas; Jonassen, Janne et al. (2018). A prospective, longitudinal, breast cancer biobank (PBCB) in western Norway. (external link)
• Jersin, Regine; Madsen, Andre; Willems, Aron et al. (2018). Impaired D-serine uptake in adipocytes promotes oxidative stress and visceral obesity. (external link)
• Tallapragada, Divya Sri Priyanka; Mellgren, Gunnar; Dankel, Simon N (2018). Gene marker panel for omental and subcutaneous adipocytes in humans . (external link)
• Bjune, Jan-Inge; Haugen, Christine; Gudbrandsen, Oddrun Anita et al. (2018). Irx5 regulates body weight via amyloid precursor protein and mitochondrial respiration in adipocytes. (external link)
• Bjune, Jan-Inge; Haugen, Christine; Gudbrandsen, Oddrun Anita et al. (2018). Irx5 regulates body weight via amyloid precursor protein (App) and mitochondrial respiration in adipocytes. (external link)
• Bjørkhaug, Lise; Hornnes, Lorentze; Kaci, Alba et al. (2017). Functional analysis of various HNF4A variants identifies increased transactivation function of R85W causing the mutation specific phenotype of neonatal hyperinsulinism and Fanconi syndrome. (external link)
• Vildmyren, Iselin Thowsen; Cao, John; Karlsen, Ida Ulrikke et al. (2016). Effects of water soluble and water insoluble cod protein on lipid metabolism in overweight adults. (external link)
• Vildmyren, Iselin Thowsen; Cao, John; Karlsen, Ida Ulrikke et al. (2016). Effects of water soluble and water insoluble cod protein on lipid metabolism in overweight adults. (external link)
• Bergseth, Marthe; Drotningsvik, Aslaug; Vikøren, Linn Anja Slåke et al. (2016). Effects of intake of baked and raw fish on serum lipids and fatty acid composition in obese rats. (external link)
• Vikøren, Linn Anja Slåke; Drotningsvik, Aslaug; Vildmyren, Iselin Thowsen et al. (2016). Effects of salmon filet intake on blood pressure regulation. (external link)
• Madsen, Andre; Bozickovic, Olivera; Bjune, Jan-Inge et al. (2016). Repression of liver SRC-2 by metformin inhibits glucose, lipid and cholesterol biosynthesis. (external link)
• Bjune, Jan-Inge; Madsen, Andre; Bjørkhaug, Lise et al. (2016). PKA downregulates glucose-6phosphatase Expression through RORα and SRC2. (external link)
• Vikøren, Linn Anja Slåke; Drotningsvik, Aslaug; Mellgren, Gunnar et al. (2015). INTAKE OF FISH PROTEIN AND EFFECTS ON GLUCOSE REGULATION AND LIPID METABOLISM IN OBESE ZUCKER RATS. (external link)
• Fernø, Johan; Willems, Aron; Dankel, Simon N et al. (2014). SLC7A10, a novel adipocyte-enriched gene with a potential role in adipocyte differentiation. (external link)
• Flågeng, Marianne Hauglid; Bozickovic, Olivera; Skartveit, Linn et al. (2014). Steroid receptor coactivators during short-term estrogen deprivation. (external link)
• Veum, Vivian Lohmann; Laupsa-Borge, Johnny; Eng, Øyvin Solberg et al. (2014). A moderate energy-restricted very-high-fat diet reduces fat mass and improves metabolic health in abdominally obese middle-aged men. (external link)
• Pedersen, Eva Ringdal; Tuseth, Nora; Eussen, Simone et al. (2014). Associations of plasma kynurenines with risk of acute myocardial infarction in patients with stable angina pectoris. (external link)
• Schmedes, Mette; Yde, Christian Clement; Aadland, Eli Kristin et al. (2014). Metabolomic studies on the urinary response to a diet based on either lean seafood or other protein sources. (external link)
• Haugen, Christine; Dankel, Simon N; Kim, K. Han et al. (2014). Role of homeobox transcription factors IRX3 and IRX5 in mitochondrial development and activity in adipose tissue. (external link)
• Haugen, Christine; Dankel, Simon E Nitter; Kim, K. Han et al. (2013). Role of homeobox transcription factor IRX5 in obesity and metabolic health. (external link)
• Haugen, Christine; Dankel, Simon E Nitter; Kim, K. Han et al. (2013). Deficiency of Irx5 is associated with decreased fat mass in male CD1 mice. (external link)
• Aadland, Eli Kristin; Graff, Ingvild Eide; Liaset, Bjørn et al. (2013). A controlled randomized intervention study with lean seafood vs terrestrial animal proteins in healthy subjects: data on body mass and body composition. (external link)
• Christensen, Monika; Nordbø, Yngve; Varhaug, Jan Erik et al. (2013). Vitamin D levels in patients with primary hyperparathyroidism; a follow-up study after parathyroidectomy. (external link)
• Flågeng, Marianne Hauglid; Larionov, Alexey; Geisler, Jürgen et al. (2012). Inverse regulation of Neuregulin 1 and HER-3 during treatment with aromatase inhibitors of estrogen receptor-positive breast cancer. (external link)
• Christensen, Monika; Pedersen, Eva Kristine Ringdal; Nordbø, Yngve et al. (2012). Systemic Inflammation in Primary Hyperparathyroidism: Influences on Plasma Vitamin B6 Levels and Interferon-γ Mediated Immune Activation. (external link)
• Dankel, Simon E Nitter; Degerud, Eirik Magnus Meek; Fjære, Even et al. (2012). Candidate genes for fat regain after weight cycling in mice. (external link)
• Degerud, Eirik Magnus Meek; Dankel, Simon E Nitter; Fjære, Even et al. (2012). CDKN1A associates with fat regain after weight cycling in mice. (external link)
• Dankel, Simon E Nitter; Fadnes, Dag Jone Stokke; Gudbrandsen, Oddrun Anita et al. (2011). Prediction of obesity candidate genes by multiple gene expression analyses of adipose tissue. (external link)
• Veum, Vivian Lohmann; Dankel, Simon E Nitter; Gjerde, Jennifer et al. (2011). The nuclear receptors NURR77, NURR1 and NOR1 in obesity and during fat loss. (external link)
• Flågeng, Marianne Hauglid; Knappskog, Stian; Lønning, Per Eystein et al. (2011). The nuclear receptor coactivator PELP1/MNAR is positively correlated with estrogen levels in breast cancer patients. (external link)
• Fenne, Ingvild Sveinsgjerd; Flågeng, Marianne Hauglid; Helland, Thomas et al. (2011). Characterization of Global Gene Expression in Breast Cancer Cells after cAMP/PKA-mediated downregulation of Steroid Receptor Coactivator 2. (external link)
• Christensen, Monika; Dankel, Simon E Nitter; Nordbø, Yngve et al. (2011). Differential Expression of Inflammatory and Metabolic Genes in Adipose Tissue of Patients with Primary Huperparathyroidism. (external link)
• Hoang, Tuyen; Dankel, Simon E Nitter; Fadnes, Dag Jone Stokke et al. (2010). Gene Expression Profile of Nuclear Receptors and Coregulators in Adipose Tissues in Morbid Obesity and after Profound Fat Loss. (external link)
• Dankel, Simon E Nitter; Fadnes, Dag Jone Stokke; Gudbrandsen, Oddrun Anita et al. (2010). Low Omental Expression of Fat Loss-Associated Homeobox Transcription Factors in Morbid Obesity. (external link)
• Dankel, Simon E Nitter; Fadnes, Dag Jone Stokke; Stavrum, Anne-Kristin et al. (2010). From stress response to developmental processes in abdominal subcutaneous adipose tissue after bariatric surgery. (external link)
• Gjerde, Jennifer; Guerrieri-Gonzaga, Aliana; Bonanni, Bernardo et al. (2010). Distribution of tamoxifen and five metabolites into normal and malignant human breast cancer tissue during conventional and low dose treatment. (external link)
• Flågeng, Marianne Hauglid; Moi, Line Leonore Haugan; Gandini, Sara et al. (2010). Expression of Steroid Receptor Coactivators and HER-2/neu in normal and malignant breast tissue in controls and tamoxifen treated patients. (external link)
• Flågeng, Marianne Hauglid; Knappskog, Stian; Larionov, Alexey et al. (2010). Epidermal growth factor receptors (ErbB/HER) and the ligand Neuregulin 1 (NRG1) increase in breast tumors during short time treatment with aromatase inhibitors. (external link)
• Christensen, Monika; Fenne, Ingvild Sveinsgjerd; Flågeng, Marianne Hauglid et al. (2009). PTH inhibits ligand-dependent activation of estrogen receptor alfa in MC3T3 Osteoblasts. (external link)
• Christensen, Monika; Fenne, Ingvild Sveinsgjerd; Flågeng, Marianne Hauglid et al. (2009). PTH inhibits ligand-dependent activation of estrogen receptor alfa in MC3T3 osteoblasts. (external link)
• Flågeng, Marianne Hauglid; Moi, Line Leonore Haugan; Dixon, J. Michael et al. (2009). HER-2/neu and nuclear receptor coactivators are upregulated in breast cancer tumors during estrogen deprivation. (external link)
• Gjerde, Jennifer; Geisler, Jürgen; Lundgren, Steinar et al. (2009). Relations between FSH, SHBG and tamoxifen metabolism during steady state tamoxifen treatment. (external link)
• Fenne, Ingvild Sveinsgjerd; Flågeng, Marianne Hauglid; Hoang, Tuyen et al. (2009). Role of the cAMP-PKA Signaling Pathway in the Regulation of ERalpha-dependent transcription by Steroid Receptor Coactivators in Breast Cancer Cells. (external link)
• Hoang, Tuyen; Fenne, Ingvild Sveinsgjerd; Bergsvåg, Mari et al. (2009). The Role of PKA and CREB in regulation of the Steroid Receptor Coactivator GRIP1/SRC-2. (external link)
• Dankel, Simon E Nitter; Hoang, Tuyen; Sagen, Jørn V. et al. (2008). cAMP Regulates Nuclear Receptor Coactivator GRIP1–Mediated Coactivation of HNF-4alpha in HepG2 Cells. (external link)
• Bergsvåg, Mari; Fenne, Ingvild Sveinsgjerd; Hoang, Tuyen et al. (2008). SEARCH FOR UBIQUITINATION SITES AND UBIQUTIN-RELATED PHOSPHORYLATION SITES IN THE STEROID RECEPTOR COACTIVATOR GRIP1. (external link)
• Hauglid, Marianne; Moi, Line Leonore Haugan; Dixon, Michael et al. (2008). Changes in mRNA expression levels of steroid receptor coactivators correlate with treatment response to aromatase inhibition in human breast cancer. (external link)
• Dankel, Simon E Nitter; Hoang, Tuyen; Sagen, Jørn V. et al. (2008). cAMP/PKA Exerts Differential Effects on GRIP1- and PGC-1α-Mediated HNF-4α Transcriptional Activity in HepG2 and COS-1 Cells. (external link)
• Mellgren, Gunnar; Hoang, Tuyen; Sagen, Jørn V. et al. (2007). Regulation of HNF-4alpha transcriptional activity by the coactivators GRIP1 and PGC-1alpha. (external link)
• Gjerde, Jennifer Fernandez; Hauglid, Marianne; Breilid, Harald et al. (2007). Effect of CYP2D6 and SULT1A1 Genotypes on the serum concentration of 4-OHtamoxifen and 4-OH-N-Demethyltamoxifen during steady state treatment of breast cancer patients. (external link)
• Gjerde, Jennifer; Geisler, Jurgen; Lundgren, Steinar et al. (2007). A study of association between estrogen and tamoxifen metabolism, cytochrome 2D6 and sulfotransferae 1A1 polymorphisms, and sulfotransferase 1A1 gene copy number during steady sate tamoxifen treatment. (external link)
• Hoang, Tuyen; Fenne, Ingvild Sveinsgjerd; Johannessen, Mona et al. (2006). ROLES OF cAMP RESPONSE ELEMENT BINDING PROTEIN (CREB) IN REGULATION OF GLUCOCORTICOID RECEPTOR INTERACTING PROTEIN 1 (GRIP1). (external link)
• Fenne, Ingvild Sveinsgjerd; Hoang, Tuyen; Mellgren, Gunnar (2006). Endocrine regulation of the nuclear receptor coactivator GRIP1 through the cAMP-signalling pathway. (external link)
• Moi, Line Leonore Haugan; Kisanga, Elton Richard; Gjerde, Jennifer et al. (2005). Effects of low-dose tamoxifen treatment on expression of drug-metabolising enzymes in rat liver in relation to administration route. (external link)
• Røst, Therese Halvorsen; Mellgren, Gunnar; Berge, Rolf Kristian (2005). A pan-PPAR ligand induces differential coactivation of PPARs by SRCs and PGC-1. (external link)
• Ladstein, Sigve; Hildrestrand, Gunn A.; Halvorsen, Harald K. et al. (2005). Molecular cloning and characterization of estrogen receptors in Atlantic salmon (Salmo salar). (external link)
• Gjerde, Jennifer; Hauglid, M; Breilid, H et al. (2005). Relationship between CYP2D6 and SULT1A1 genotype and serum concentration of tamoxifen and its metabolites during steady state treatment in breast cancer patients. (external link)
• Fenne, Ingvild Sveinsgjerd; Hoang, Tuyen; Mellgren, Gunnar (2005). Hormonal regulation of the intranuclear localization of the nuclear hormone receptor coactivator GRIP1. (external link)
• Hoang, Tuyen; Fenne, Ingvild Sveinsgjerd; Lien, Ernst Asbjørn et al. (2005). CHARACTERIZATION OF THE MOLECULAR MECHANISMS BY WHICH THE LEVEL OF NUCLEAR HORMONE RECEPTOR COACTIVATOR GRIP1 IS REGULATED. (external link)
• Gjerde, Jennifer Fernandez; Hauglid, Marianne; Breilid, Harald et al. (2005). Relationship between CYP2D6 and SULT1A1 genotypes and serum concentrations of tamoxifen and its metabolites during steady state treatment in breast cancer patients. (external link)
• Moi, Line Leonore Haugan; Kisanga, Elton Richard; Gjerde, Jennifer et al. (2004). Tamoxifen metabolism and induction of hepatic drug-metabolizing enzymes in nude rats. (external link)
• Røst, Therese Halvorsen ; Gudbrandsen, Oddrun Anita; Tronstad, Karl Johan et al. (2004). PPAR-delta activation in relation to reduction of adipose tissue. (external link)
• Haugan, Line; Mellgren, Gunnar (2004). Tamoxifen metabolism and induction of hepatic drug metabolising enzymes in nude rats. (external link)

Academic lecture

• Flølo, Tone Nygaard; Fosså, Alexander; Waage, Jo Erling Riise et al. (2023). Long-term impact of gastropexy on use of acid-reducing medication, second operations for gastroesophageal reflux and subjective reflux symptoms after sleeve gastrectomy . (external link)
• Bjune, Jan-Inge; Laber, Samantha; Dyer, Laurence et al. (2021). Epigenetic control of adipogenesis by Irx3. (external link)
• Bjune, Mona Synnøve; Dyer, Laurence; Blüher, Matthias et al. (2021). Altered hepatic HIBCH expression is associated with hepatic lipid accumulation and fatty liver. (external link)
• Nilsen, Mona Synnøve; Åsen Jersin, Regine; McCann, Adrian et al. (2019). Circulating 3-hydroxyisobutyrate (3-HIB) as a clinical marker of prediabetes and T2D in patients with obesity. (external link)
• Nilsen, Mona Synnøve; Åsen Jersin, Regine; Madsen, Andre et al. (2018). Amino acid metabolism in adipocytes. (external link)
• Aadland, Eli Kristin; Lavigne, Charles; Graff, Ingvild Eide et al. (2015). Lean seafood intake reduces cardiovascular risk factors in healthy subjects. (external link)
• Mellgren, Gunnar (2012). Homeobox transcription factors IRX3 and 5 in obesity. (external link)
• Mellgren, Gunnar (2012). Novel transcription factors in obesity. (external link)
• Dankel, Simon E Nitter; Fadnes, Dag Jone Stokke; Christoforou, Andrea et al. (2012). Integrative genomics links homeobox transcription factors to intra-abdominal obesity. (external link)
• Dankel, Simon E Nitter; Degerud, Eirik Magnus Meek; Fjære, Even et al. (2012). Weight cycling affects adipose tissue genes involved in circadian rhythm and lipid metabolism. (external link)
• Hagen, Ingrid Valheim; Helland, Anita; Bratlie, Marianne et al. (2012). Effects of a high fish intake on lipid and bile acid levels in serum and feces from overweight and obese adults. (external link)
• Helland, Anita; Bratlie, Marianne; Hagen, Ingrid Valheim et al. (2012). Effect of a high fish intake on glucose tolerance and GLP-1 levels in overweight and obese adults. (external link)
• Bratlie, Marianne; Hagen, Ingrid Valheim; Helland, Anita et al. (2012). Effects of a high fish intake on leukocyte membrane fatty acid composition and leukocyte function ex vivo in overweight and obese adults. (external link)
• Mellgren, Gunnar (2010). Oppregulering av østrogen-receptor koaktivatorer og HER-2/neu under endokrin behandling av brystkreft. (external link)
• Mellgren, Gunnar (2010). Presentasjon av strategisk satsing innen ernæring og overvekt. (external link)
• Mellgren, Gunnar (2009). Hva kan vi lære av sykelig fedme? Fedme og genekspresjon. (external link)
• Mellgren, Gunnar; Dankel, Simon E Nitter (2009). Bariatric surgery dramatically alters global gene expression in adipose tissue. (external link)
• Mellgren, Gunnar (2009). Adipogen – en studie av fettvev til pasienter som har gjennomgått overvektskirurgi. (external link)
• Mellgren, Gunnar (2008). Nuclear Receptor Coactivators. (external link)
• Mellgren, Gunnar (2008). Marine macronutrients, metabolic homeostasis and obesity. (external link)
• Mellgren, Gunnar (2007). Role of cAMP in Regulation of the Nuclear Receptor Coactivator GRIP1. (external link)
• Mellgren, Gunnar (2006). NUCLEAR RECEPTORS IN ENDOCRINE FUNCTION AND DISEASE. (external link)
• Røst, Therese Halvorsen; Mellgren, Gunnar; Berge, Rolf Kristian (2005). A pan-PPAR ligand induces differential coactivation of PPARs by SRCs and PGC-1. (external link)
• Mellgren, Gunnar (2005). Regulering av steroidhormonreseptorer ved protein-protein interaksjon. (external link)
• Mellgren, Gunnar (2005). Endocrine regulation of a nuclear receptor coactivator. (external link)
• Bratland, E; Bredholt, G; Knappskog, Per et al. (2005). Cellular immunity to 21-hydroxylase in patients with autoimmune Addison's disease. (external link)
• Røst, Therese Halvorsen; Mellgren, Gunnar; Berge, Rolf Kristian (2004). Tetradecylthioacetic acid induces ligand dependent coactivation of PPARs by PGC-1 and SRC coactivators. (external link)
• Mellgren, Gunnar (2004). Hormonal regulation of nuclear receptor coactivator GRIP1. (external link)
• Mellgren, Gunnar (2004). Intracellulære hormonreseptorer - betydning av nye koregulator proteiner. (external link)
• Mellgren, Gunnar (2004). Prisforedrag - Novo Nordisk pris for fremragende forskning i endokrinologi. (external link)
• Mellgren, Gunnar (2004). Hormonal regulation of the Glucocorticoid receptor interacting protein 1 (GRIP1). (external link)
• Mellgren, Gunnar (2004). Nuclear Receptor Interacting Proteins as Molecular Targets in Breast Carcinoma. (external link)
• Mellgren, Gunnar (2004). cAMP-depentent protein kinase regulates ubiquitin-proteasome mediated degradation of the nuclear receptor coactivator GRIP1. (external link)
• Brustugun, Odd Terje; Fladmark, Kari Espolin; Mellgren, Gunnar et al. (1998). Ultrarapid apoptosis induction in a variety of cell types injected with phosphatase inhibitors is mediated through Ca2 /calmodulin dependent protei kinase activity. (external link)

Academic literature review

• Eliassen, Finn; Blåfjelldal, Vibeke Iren Jensen; Helland, Thomas et al. (2023). Importance of endocrine treatment adherence and persistence in breast cancer survivorship: a systematic review. (external link)
• Bjune, Jan-Inge; Strømland, Pouda Panahandeh; Jersin, Regine Åsen et al. (2022). Metabolic and Epigenetic Regulation by Estrogen in Adipocytes. (external link)
• Helland, Thomas; Alsomairy, Sarah; Lin, Chenchia et al. (2021). Generating a precision endoxifen prediction algorithm to advance personalized tamoxifen treatment in patients with breast cancer. (external link)
• Fernø, Johan; Strand, Kristina; Mellgren, Gunnar et al. (2019). Natural killer cells as sensors of adipose tissue stress. (external link)
• Dankel, Simon E Nitter; Staalesen, Vidar; Bjørndal, Bodil et al. (2011). Tissue-specific effects of bariatric surgery including mitochondrial function. (external link)
• Lund, Johan; Børud, Bente; Mellgren, Gunnar et al. (2002). Differential regulation of SF-1-cofactor interactions. (external link)

Article in business/trade/industry journal

• Søiland, Håvard; Janssen, Emiel; Helland, Thomas et al. (2022). Liquid biopsies and patient-reported outcome measures for integrative monitoring of patients with early-stage breast cancer: a study protocol for the longitudinal observational Prospective Breast Cancer Biobanking (PBCB) study. (external link)

Abstract

• De Censi, Andrea; Johansson, Harriet Ann; Helland, Thomas et al. (2020). Relationship between CYP2D6 genotype, tamoxifen metabolites, and adverse events, tumor biomarkers and breast cancer recurrence in a low-dose phase III trial in noninvasive disease. (external link)
• Gjerde, Jennifer; Geisler, Jürgen; Lundgren, Steinar et al. (2010). Effects of CYP2C19 genotype on tamoxifen and estrogen metabolism. (external link)
• Dankel, Simon E Nitter; Fadnes, Dag Jone Stokke; Stavrum, Anne-Kristin et al. (2010). From stress response to developmental processes in abdominal subcutaneous adipose tissue after bariatric surgery. (external link)
• Hoang, Tuyen; Dankel, Simon E Nitter; Fadnes, Dag Jone Stokke et al. (2010). Gene Expression Profile of Nuclear Receptors and Coregulators in Adipose Tissues in Morbid Obesity and after Profound Fat Loss. (external link)
• Gjerde, Jennifer Fernandez; Hauglid, Marianne; Breilid, Harald et al. (2007). Effect of CYP2D6 and SULT1A1 genotypes on the serum concentration of 4-hydroxytamoxifen and 4-hydroxy-N-demethyltamoxifen during steady state treatment of breast cancer patients. (external link)
• Gjerde, Jennifer Fernandez; Geisler, Jurgen; Lundgren, Steinar et al. (2007). A study of associations between estrogen and tamoxifen metabolism, cytochrome 2D6 and sulfotransferase 1A1 polymorphisms, and sulfotransferase 1A1 gene copy number during steady state tamoxifen treatment. (external link)
• Gjerde, Jennifer Fernandez; Hauglid, Marianne; Breilid, Harald et al. (2005). Relationship between CYP2D6 and SULT1A1 genotypes and serum concentrations of tamoxifen and its metabolites during steady state treatment in breast cancer patients. (external link)

Academic chapter/article/Conference paper

• Mosleth, Ellen Færgestad; McLeod, Anette; Rud, Ida et al. (2020). Analysis of Megavariate Data in Functional Omics. (external link)
• Gjerde, Jennifer; Moi, Line Leonore Haugan; Mellgren, Gunnar et al. (2012). Tamoxifen metabolism and biological activity. (external link)
• Moi, Line Leonore Haugan; Flågeng, Marianne Hauglid; Fenne, Ingvild Sveinsgjerd et al. (2011). Steroid Receptor Coactivators and Their Expression, Regulation and Functional Role in Endocrine Responsive and Resistant Breast Cancer. (external link)
• Moi, Line Leonore Haugan; Flågeng, Marianne Hauglid; Dankel, Simon E Nitter et al. (2011). Steroid Receptor Coactivators and Endocrine Treatment in Breast Cancer. (external link)
• Brustugun, Odd Terje; Mellgren, Gunnar; Gjertsen, Bjørn Tore et al. (1996). Sensitive and rapid detection of B-galactosidase expression in intact cells by microinjection of fluorecent substrate. (external link)

Doctoral dissertation

• Helland, Thomas; Mellgren, Gunnar (2019). Tamoxifen in the treatment of luminal breast cancer. Implications of active metabolites on gene expression, side effects and clinical outcome. (external link)
• Ueland, Grethe Åstrøm; Husebye, Eystein Sverre; Methlie, Paal et al. (2019). Improved diagnostic workup of hyper- and hypocortisolism. (external link)
• Vikøren, Linn Anja Slåke; Gudbrandsen, Oddrun Anita; Dierkes, Jutta et al. (2018). Salmon and cod fillet consumption and effects on metabolic risk factors. Intervention studies in humans and rats with overweight and obesity. (external link)
• Jacobsen, Rhian Gaenor; Lewis, Aurelia Eva; Mellgren, Gunnar (2017). Nuclear phosphoinositide 3-kinase signalling in adipogenesis and the role of DNA topoisomerase IIα as a potential nuclear polyphosphoinositide-binding protein. (external link)
• Bozickovic, Olivera; Mellgren, Gunnar (2015). Regulation and function of steroid receptor coactivator 2 in hepatoma and breast cancer cells. (external link)
• Moi, Line Leonore Haugan; Mellgren, Gunnar (2012). Endocrine treatment of breast cancer: Tamoxifen metabolism, steroid receptor coactivators and growth factor receptors. (external link)
• Hoang, Tuyen; Mellgren, Gunnar; Lien, Ernst Asbjørn (2007). Nuclear Receptor Coregulators- Role of Protein-Protein Interactions and cAMP/PKA Signaling. (external link)
• Mellgren, Gunnar (1996). Hepatocyte growth inhibition by cAMP-dependent protein kinase and other signaling pathways. (external link)

Lecture

• Dankel, Simon N; Tallapragada, Divya Sri Priyanka; Armstrong, Nasa-Sinnott et al. (2019). Integrative Genomics Links Homeobox Transcription Factors to Risk of Visceral Adiposity . (external link)

Textbook

• Mellgren, Gunnar; Angelsen, Anders; Eikesdal, Hans Petter et al. (2016). MEDIKAMENTELL KREFTBEHANDLING - CYTOSTATIKABOKEN Kapittel 19 - Hormoner og antihormoner . (external link)

Popular scientific article

• Moi, Line Leonore Haugan; Flågeng, Marianne Hauglid; Mellgren, Gunnar (2013). Steroid reseptor koaktivatorer, HER-2 og hormonbehandling ved brystkreft. (external link)

Masters thesis

• Stokkeland, Oddbjørg; Gudbrandsen, Oddrun Anita; Mellgren, Gunnar (2013). Effects of Fish Protein and Peptides on Inflammatory Markers and Subjective Joint Pain in Overweight and Obese Adults. (external link)
• Hovland, Ida; Gudbrandsen, Oddrun Anita; Mellgren, Gunnar (2013). Effects of Fish Protein and Peptides on Glucose Tolerance and Leptin:Adiponectin Ratio in Overweight and Obese Adults. (external link)
• Waage, Kaia; Gudbrandsen, Oddrun Anita; Mellgren, Gunnar (2013). Effects of Fish Protein and Peptides on Ex Vivo Leukocyte Function and Leukocyte Membrane Fatty Acid Composition in Overweight and Obese Adults. (external link)
• Helland, Anita; Gudbrandsen, Oddrun Anita; Mellgren, Gunnar (2012). Effects of a high fish intake on glucose tolerance and GLP-1 levels in overweight and obese adults. (external link)
• Hagen, Ingrid Valheim; Gudbrandsen, Oddrun Anita; Mellgren, Gunnar (2012). Effects of a high fish intake on lipid and bile acid levels in serum and feces from overweight and obese adults. (external link)
• Bratlie, Marianne; Gudbrandsen, Oddrun Anita; Mellgren, Gunnar (2012). Effects of a high fish intake on leukocyte membrane fatty acid composition and leukocyte function ex vivo in overweight and obese adults. (external link)
• Gjessing, Hanne Rosendahl; Gudbrandsen, Oddrun Anita; Mellgren, Gunnar (2010). Impact of Laparoscopic Sleeve Gastrectomy on Body Mass Index, Nutritional Status and Co-morbidity.. (external link)
• Mellgren, Gunnar; Veum, Vivian (2009). Fractionation of human adipose tissue using collagenase: gene expression analysis of nuclear receptors (NR) 4A. (external link)
• Mellgren, Gunnar (2008). Nazanin Saemi: Expression and purification of nuclear receptor coactivator GRIP1 deletion mutants. (external link)
• Mellgren, Gunnar; Saemi, Nazanin; Hoang, Tuyen (2007). Expression and purification of Nuclear Receptor Coactivator GRIP1 deletion mutants. (external link)
• Sagen, Jørn V.; Mellgren, Gunnar; Dankel, Simon (2006). Role of cAMP/PKA in Regulation of GRIP1- and PGC1alpha-Mediated Coactivation of Nuclear Receptor HNF4Alpha. (external link)

Popular scientific lecture

• Mellgren, Gunnar (2009). Hva skal til for å lykkes i forskning?. (external link)

Compendium

• Mellgren, Gunnar (2004). Endokrinologi. Kompendium for studenter i biokjemi II. (external link)

Thesis at a second degree level

• Røst, Therese Halvorsen; Berge, Rolf Kristian; Mellgren, Gunnar (2003). 3-Thia Fatty Acids Inhibit MCF-7 Breast Cancer Cell Proliferation and Induce Ligand Dependent Coactivation of PPARs by p160 Coactivators. (external link)

See a complete overview of publications in Cristin.

Selected publications:

Mellgren, G., Gjertsen, B.T, Otten, A., Maronde, E., Genieser, H-G., Jasdorff, B., Vintermyr, O.K., McKnight, G.S., and Døskeland, S.O. (1995) Novel Rp-cAMPS analogs as tools for inhibition of cAMP-kinase in cell culture. Basal cAMP-kinase activity modulates interleukin-1b action. J. Biol. Chem., 270:20599-20607.

Fladmark, K.E, Brustugun, O.T, Mellgren, G, Krakstad, C, Bøe, R., Vintermyr, O.K., Schulman, H., and Døskeland, S.O. (2002) Ca²⁺/calmodulin dependent protein kinase II is required for microcystin-induced apoptosis. J. Biol. Chem., 277:2804-2811.

Børud, B., Hoang, T., Bakke, M, Jacob, A., Lund, J, and Mellgren, G (2002). The nuclear coactivators p/CIP and TIF2 differentially regulate PKA-dependent transcriptional activity of Steroidogenic factor-1. Mol. Endocrinol., 16:757-773.

Børud, B., Mellgren, G., Lund, J. and Bakke, M. (2003) Cloning and Characterization of a Novel Zinc-finger Protein that Modulates the Transcriptional Activity of Nuclear Receptors. Mol. Endocrinol., 17:2303-2319 

Hoang, T., Fenne, I., Cook, C., Børud, B., Bakke, M., Lien, E.A and Mellgren, G (2004) cAMP-dependent Protein Kinase Regulates Ubiquitin-proteasome mediated Degradation and Subcellular Localization of the Nuclear Receptor Coactivator GRIP1. J. Biol. Chem., 279:49120-49130.

Gjerde, J., Hauglid, M., Breilid, H., Lundgren, S., Varhaug, J.E., Kisanga, E.R., Mellgren, G., Steen, V.M., and Lien, E.A. (2007). Effects of CYP2D6 and SULT1A1 genotypes including SULT1A1 gene copy number on tamoxifen metabolism. Ann Oncol., 19:56-61.

Fenne, I.S., Hoang, T., Hauglid, M, Sagen, JV, Lien, E.A., and Mellgren, G. (2008). Recruitment of coactivator GRIP1 to an estrogen receptor transcription complex is regulated by cAMP-dependent protein kinase. Endocrinology, 149:4336-45.

Moi, L.H.L., Hauglid, M., Gandini, S, Aliana, G.G., Bonanni, B., Lazzeroni, M., Gjerde, J, Lien, E.A., Decensi, A, and Mellgren G. (2010) Effects of low dose tamoxifen on Steroid Receptor Coactivator 1/Amplified in Breast Cancer 1 in normal an malignant breast tissue. Clin. Cancer Res., 16:2176-86

Dankel SE, Fadnes D, Stavrum AK, Stansberg C, Holdhus R, Hoang T, Veum V, Christensen B, Vaage V, Sagen JV, Steen VM, Mellgren G (2010) Switch from stress response to homeobox transcription factors in adipose tissue after profound fat loss. PLoS ONE, 9;5(6):e11033

Monika H.E. Christensen, Eva K.R. Pedersen, Yngve Nordbø, Jan Erik Varhaug, Øyvind Midttun, Per M. Ueland, Ottar K. Nygaard, Gunnar Mellgren, Ernst A. Lien (2012) Vitamin B6 Status and Interferon-γ Mediated Immune Activation in Primary Hyperparathyroidism. J Intern Medicine. Jul 3. doi: 10.1111/j.1365-2796.2012.02570.x

Hoang, T. Fenne, I,  Johannessen, M, Lien, E.A., Moens, U and Mellgren, G. (2013) cAMP Response Element Binding Protein (CREB) Interacts with the nuclear receptor coactivator GRIP1 and mediates its degradation. Endocrinology,Apr;154(4):1513-27. doi: 10.1210/en.2012-2049. Epub 2013 Mar 5.

Claussnitzer M, Dankel SN, Klocke B, Grallert H, Glunk V, Berulava T, Lee H, Oskolkov N, Fadista J, Ehlers K, Wahl S, Hoffmann C, Qian K, Rönn T, Riess H, Müller-Nurasyid M, Bretschneider N, Schroeder T, Skurk T, Horsthemke B; DIAGRAM+Consortium, Spieler D, Klingenspor M, Seifert M, Kern MJ, Mejhert N, Dahlman I, Hansson O, Hauck SM, Blüher M, Arner P, Groop L, Illig T, Suhre K, Hsu YH, Mellgren G, Hauner H, Laumen H. Leveraging cross-species transcription factor binding site patterns: from diabetes risk loci to disease mechanisms. Cell. 2014 Jan 16;156(1-2):343-58

Ussar S, Lee KY, Dankel SN, Boucher J, Haering MF, Kleinridders A, Thomou T, Xue R, Macotela Y, Cypess AM, Tseng YH, Mellgren G, Kahn CR. ASC-1, PAT2, and P2RX5 are cell surface markers for white, beige, and brown adipocytes. Science Translational Medicine, 2014, 6(247);247ra103. 

Aadland EK, Lavigne C, Graff IE, Eng Ø, Paquette M, Holthe A, Mellgren G, Jacques H, Liaset B. Lean-seafood intake reduces cardiovascular lipid risk factors in healthy subjects: results from a randomized controlled trial with a crossover design. Am J Clin Nutr. 2015 Sep;102(3):582-92. 

Melina Claussnitzer, Simon Nitter Dankel, Gerald Quon, Kyoung-Han Kim, Wouter Meuleman, Christine Haugen, Viktoria Glunk, Isabel Sousa, Jacqueline L. Beaudry, Vijitha Puviindran, Nezar A. Abdennur, Jannel Liu, Per-Arne Svensson, Yi-Hsiang Hsu, Daniel J. Drucker, Gunnar Mellgren, Chi-Chung Hui, Hans Hauner, Manolis Kellis. FTO Obesity Variant Circuitry and Adipocyte Browning in Humans. New Engl. J. Medicine, 2015 Sep 3;373(10):895-907

Vivian L. Veum, Johnny Laupsa-Borge, Øyvin Eng, Espen Rostrup, Terje H. Larsen, Jan Erik Nordrehaug, Ottar Nygård, Jørn V. Sagen, Oddrun A. Gudbrandsen, Simon N. Dankel, Gunnar Mellgren. Visceral adiposity and metabolic syndrome after very-high-fat and low-fat isocaloric diets: a randomized controlled trial (FATFUNC). Am J Clin Nutr. 2017 Jan;105(1):85-99

Serum concentrations of active tamoxifen metabolites predict long-term survival in adjuvantly treated breast cancer patients. Helland T, Henne N, Bifulco E, Naume B, Borgen E, Kristensen VN, Kvaløy JT, Lash TL, Alnæs GIG, van Schaik RH, Janssen EAM, Hustad S, Lien EA, ‡Mellgren G, ‡Søiland H. Breast Cancer Res. 2017 Nov 28;19(1):125. doi: 10.1186/s13058-017-0916-4. 

IRX5 regulates adipocyte amyloid precursor protein and mitochondrial respiration in obesity. Bjune JI, Haugen C, Gudbrandsen O, Nordbø OP, Nielsen HJ, Våge V, Njølstad PR, Sagen JV, Dankel SN, Mellgren G. Int J Obes (Lond). 2019 Nov;43(11):2151-2162

The homeobox factor Irx3 maintains adipogenic identity. Bjune JI, Dyer L, Røsland GV, Tronstad KJ, Njølstad PR, Sagen JV, Dankel SN, Mellgren G. Metabolism. 2019 Nov 18;103:154014. doi: 10.1016/j.metabol.2019.154014.

Testicular ultrasound to stratify hormone references in a cross-sectional Norwegian study of male puberty. Madsen A, Oehme NB, Roelants M, Bruserud IS, Eide GE, Viste K, Bjerknes R, Almås B, Rosendahl K, Sagen JV, Mellgren G, Juliusson PB. J Clin Endocrinol Metab. 2019 Oct 26. pii: dgz094. doi: 10.1210/clinem/dgz094.

3-Hydroxyisobutyrate, A Strong Marker of Insulin Resistance in Type 2 Diabetes and Obesity That Modulates White and Brown Adipocyte Metabolism. Nilsen MS, Jersin RÅ, Ulvik A, Madsen A, McCann A, Svensson P-A, Svensson M-E, Nedrebø B-G, Gudbrandsen OA, Tell GS, Kahn CR,Ueland PM, Mellgren G, and Dankel SN. Diabetes 2020; 69:1–14 https://doi.org/10.2337/db19-1174.

https://www.uib.no/en/rg/hormonelaboratory

Mohn Nutrition Research Laboratory funded by Trond Mohn stiftelse www.uib.no/mohn-elab

https://www.uib.no/diabetes/en

Spesialist i indremedisin, hormonsykdommer og medisinsk biokjemi