Diabetes, obesity and nutrition

Hormones, diagnostics and breast cancer

Hormone Laboratory Research Group

Mohn Nutrition Research Laboratory www.uib.no/mohn-elab

Endocrinology and Medical Biochemistry

Academic article

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• Nicholas A Sinnott-Armstrong; Isabel S. Sousa; Samantha Laber et al. (2021). A regulatory variant at 3q21.1 confers an increased pleiotropic risk for hyperglycemia and altered bone mineral density. (external link)
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• Thomas Helland; Bjørn Naume; Steinar Hustad et al. (2020). Low Z-4OHtam concentrations are associated with adverse clinical outcome among early stage premenopausal breast cancer patients treated with adjuvant tamoxifen. (external link)
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• Linn Anja Slåke Vikøren; Aslaug Drotningsvik; Angela Kipesile Mwakimonga et al. (2018). Diets containing salmon fillet delay development of high blood pressure and hyperfusion damage in kidneys in obese Zucker fa/fa rats. (external link)
• Ingrid Valheim Hagen; Anita Helland; Marianne Bratlie et al. (2023). Serum concentrations of amino acids and tryptophan metabolites are affected by consumption of a light breakfast: a clinical intervention study in adults with overweight or obesity. (external link)
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• Ingrid Valheim Hagen; Anita Helland; Marianne Bratlie et al. (2019). TMAO, creatine and 1-methylhistidine in serum and urine are potential biomarkers of cod and salmon intake: a randomised clinical trial in adults with overweight or obesity. (external link)
• Tuyen Hoang; Ingvild Sveinsgjerd Fenne; Andre Greger Madsen et al. (2013). cAMP response element-binding protein interacts with and stimulates the proteasomal degradation of the nuclear receptor coactivator GRIP1. (external link)
• Jennifer Fernandez Gjerde; Marianne Hauglid; M Hauglid et al. (2008). Effects of CYP2D6 and SULT1A1 genotypes including SULT1A1 gene copy number on tamoxifen metabolism. (external link)
• Regine Åsen Jersin; Divya Sri Priyanka Tallapragada; Andre Madsen et al. (2021). Role of the Neutral Amino Acid Transporter Slc7a10 in Adipocyte Lipid Storage, Obesity and Insulin Resistance. (external link)
• Simon N Dankel; Therese Halvorsen Røst; Agné Kulyté et al. (2019). The Rho GTPase RND3 regulates adipocyte lipolysis. (external link)
• Linn Anja Slåke Vikøren; Aslaug Drotningsvik; Svein Are Mjøs et al. (2018). Salmon fillet intake led to higher serum triacylglycerol in obese zucker Fa/Fa rats but not in normolipidemic Long-Evans rats. (external link)
• Yuanhuang Chen; Lauren A. Marcath; Finn Magnus Eliassen et al. (2021). Effect of genetic variability in 20 pharmacogenes on concentrations of tamoxifen and its metabolites. (external link)
• Mark Colin Gissler; Nathaly Anto-Michel; Jan Pennig et al. (2021). Genetic Deficiency of TRAF5 Promotes Adipose Tissue Inflammation and Aggravates Diet-Induced Obesity in Mice. (external link)
• Anita Helland; Marianne Bratlie; Ingrid Valheim Hagen et al. (2022). Consumption of a light meal affects serum concentrations of one-carbon metabolites and B-vitamins. A clinical intervention study. (external link)
• Ingrid Valheim Hagen; Anita Helland; Marianne Bratlie et al. (2016). High intake of fatty fish, but not of lean fish, affects serum concentrations of TAG and HDL-cholesterol in healthy, normal-weight adults: A randomised trial. (external link)
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• Linn Anja Slåke Vikøren; Aslaug Drotningsvik; Marthe Tønder Bergseth et al. (2017). Effects of baked and raw salmon fillet on lipids and n-3 PUFAs in serum and tissues in Zucker fa/fa rats. (external link)
• Bente Berg Johansson; Karianne Fjeld; Marie Holm Solheim et al. (2017). Nuclear import of glucokinase in pancreatic beta-cells is mediated by a nuclear localization signal and modulated by SUMOylation. (external link)
• Anna M. Mc Laughlin; Thomas Helland; Fenja Klima et al. (2024). Nonlinear Mixed-Effects Model of Z-Endoxifen Concentrations in Tamoxifen-Treated Patients from the CEPAM Cohort. (external link)
• Fedro Alessandro Peccatori; Giovanni Codacci-Pisanelli; Gunnar Mellgren et al. (2020). First-in-human pharmacokinetics of tamoxifen and its metabolites in the milk of a lactating mother: A case study. (external link)
• Martha Eimstad Haugstøyl; Martin Cornillet; Kristina Strand et al. (2022). Distinct T cell subsets in adipose tissue are associated with obesity. (external link)
• Kristin Viste; Marianne Aardal Grytaas; Melissa Jørstad et al. (2013). Efficacy of adrenal venous sampling is increased by point of care cortisol analysis. (external link)
• Mette Schmedes; Claudia Balderas; Eli Kristin Aadland et al. (2018). The effect of lean-seafood and non-seafood diets on fasting and postprandial serum metabolites and lipid species: Results from a randomized crossover intervention study in healthy adults. (external link)
• Harriet Johansson; Sara Gandini; Davide Serrano et al. (2016). A pooled analysis of CYP2D6 genotype in breast cancer prevention trials of low-dose tamoxifen. (external link)
• Indu Dhar; Gard Frodahl Tveitevåg Svingen; Eva Ringdal Pedersen et al. (2022). Physical activity and risk of all-cause mortality in patients with stable angina pectoris: Effect modification by β-blocker treatment. (external link)
• Seema A. Khan; Xinlei Mi; Yanfei Xu et al. (2023). Presurgical Oral Tamoxifen vs Transdermal 4-Hydroxytamoxifen in Women with Ductal Carcinoma in Situ: A Randomized Clinical Trial. (external link)
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• Grethe Åstrøm Ueland; Paal Methlie; Marianne Øksnes et al. (2018). The short cosyntropin test revisited: new normal reference range using LC-MS/MS. (external link)
• Ida Heir Hovland; Ingrid Sande Leikanger; Oddbjørg Stokkeland et al. (2019). Effects of low doses of fish and milk proteins on glucose regulation and markers of insulin sensitivity in overweight adults: a randomised, double blind study. (external link)
• Astri Jeanette Meen; Atanaska Ivanova Doncheva; Yvonne Böttcher et al. (2023). Obesity Is Associated with Distorted Proteoglycan Expression in Adipose Tissue. (external link)
• Mona Synnøve Bjune; Laurence Dyer; Johnny Laupsa-Borge et al. (2023). Metabolic role of the hepatic valine/3-hydroxyisobutyrate (3-HIB) pathway in fatty liver disease. (external link)
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• Eva Ringdal Pedersen; Nora Tuseth; Simone Eussen et al. (2015). Associations of plasma kynurenines with risk of acute myocardial infarction in patients with stable angina pectoris. (external link)
• Monika Christensen; Ellen M Apalset; Yngve Nordbø et al. (2013). 1,25-dihydroxyvitamin D and the vitamin D receptor gene polymorphism apa1 influence bone mineral density in primary hyperparathyroidism. (external link)
• Aslaug Drotningsvik; Øivind Midttun; Linn Anja Slåke Vikøren et al. (2019). Urine and plasma concentrations of amino acids and plasma vitamin status differ, and are differently affected by salmon intake, in obese Zucker fa/fa rats with impaired kidney function and in Long-Evans rats with healthy kidneys. (external link)
• Vivian Lohmann Veum; Johnny Laupsa-Borge; Øyvin Andre Solberg Eng et al. (2017). Visceral adiposity and metabolic syndrome after very high-fat and low-fat isocaloric diets: A randomized controlled trial. (external link)
• Andre Greger Madsen; Jan Inge Bjune; Lise Bjørkhaug et al. (2016). The cAMP-dependent protein kinase downregulates glucose-6-phosphatase expression through RORα and SRC-2 coactivator transcriptional activity. (external link)
• Ernst Asbjørn Lien; Håvard Søiland; Steinar Lundgren et al. (2013). Serum concentrations of tamoxifen and its metabolites increase with age during steady-state treatment. (external link)
• Bjørn Liaset; Lise Madsen; Qin Hao et al. (2009). Fish protein hydrolysate elevates plasma bile acids and reduces visceral adipose tissue mass in rats. (external link)
• Monika Christensen; Eva Kristine Ringdal Pedersen; Yngve Nordbø et al. (2012). Vitamin B6 status and interferon-γ-mediated immune activation in primary hyperparathyroidism. (external link)
• Thomas Helland; Nina Henne; Ersilia Bifulco et al. (2017). Serum concentrations of active tamoxifen metabolites predict long-term survival in adjuvantly treated breast cancer patients. (external link)
• Silje Skrede; Ismael Gonzalez-Garcia; Luis Martins et al. (2017). Lack of ovarian secretions reverts the anabolic action of olanzapine in female rats. (external link)
• Eirik Bratland; Geir Bredholt; Gunnar Mellgren et al. (2009). The purification and application of biologically active recombinant steroid cytochrome P450 21-hydroxylase: The major autoantigen in autoimmune Addison's disease. (external link)
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• Jan-Inge Bjune; Laurence Dyer; Gro Vatne Røsland et al. (2019). The homeobox factor Irx3 maintains adipogenic identity. (external link)
• Andrea DeCensi; Harriet Johansson; Thomas Helland et al. (2021). Association of CYP2D6 genotype and tamoxifen metabolites with breast cancer recurrence in a low-dose trial. (external link)
• Alena M. Bubeck; Paul Urbain; Cathrine Horn et al. (2023). High-fat diet impact on intestinal cholesterol conversion by the microbiota and serum cholesterol levels. (external link)
• Jessica Svärd; Therese Halvorsen Røst; Camilla Elise Nergård Sommervoll et al. (2019). Absence of the proteoglycan decorin reduces glucose tolerance in overfed male mice. (external link)
• Rhian Gaenor Jacobsen; Fatemeh Mazloumi Gavgani; Gunnar Mellgren et al. (2016). DNA Topoisomerase IIα contributes to the early steps of adipogenesis in 3T3-L1 cells. (external link)
• Jaspreet Kaur; Sung Yun Jung; Marie Austdal et al. (2024). Quantitative proteomics reveals serum proteome alterations during metastatic disease progression in breast cancer patients. (external link)
• Paal Methlie; Simon E Nitter Dankel; Tone Sæterdal Myhra et al. (2013). Changes in adipose glucocorticoid metabolism before and after bariatric surgery assessed by direct hormone measurements. (external link)
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• Harriet Johansson; Valentina Aristarco; Sara Gandini et al. (2019). Prognostic impact of genetic variants of CYP19A1 and UGT2B17 in a randomized trial for endocrine-responsive postmenopausal breast cancer. (external link)
• Linn A. Vikøren; Aslaug Drotningsvik; Øivind Midttun et al. (2021). Baked cod consumption delayed the development of kidney and liver dysfunction and affected plasma amino acid concentrations, but did not affect blood pressure, blood glucose or liver triacylglycerol concentrations in obese fa/fa Zucker rats.. (external link)
• Simon N Dankel; Elise Grytten; Jan-Inge Bjune et al. (2020). COL6A3 expression in adipose tissue cells is associated with levels of the homeobox transcription factor PRRX1. (external link)
• Andre Madsen; Ninnie Oehme; Mathieu Roelants et al. (2020). Testicular Ultrasound to Stratify Hormone References in a Cross-Sectional Norwegian Study of Male Puberty. (external link)
• Cathrine Horn; Johnny Laupsa-Borge; Amanda Andersen et al. (2021). Meal patterns associated with energy intake in people with obesity. (external link)
• Anette Susanne Bøe; Geir Bredholt; Per Knappskog et al. (2004). Autoantibodies against 21-hydroxylase and side-chain cleavage enzyme in autoimmune Addison's disease are mainly immunoglobulin G1. (external link)
• Elton Richard Kisanga; Gunnar Mellgren; Ernst Asbjørn Lien (2005). Excretion of hydroxylated metabolites of tamoxifen in human bile and urine. (external link)
• Tuyen Hoang; Ingvild Sveinsgjerd Fenne; Carol Ann Cook et al. (2004). cAMP-dependent protein kinase regulates ubiquitin-proteasome-mediated degradation and subcellular localization of the nuclear receptor coactivator GRIP1. (external link)
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• Oukseub Lee; Latifa A. Bazzi; Yanfei Xu et al. (2024). A randomized Phase I pre-operative window trial of transdermal endoxifen in women planning mastectomy: Evaluation of dermal safety, intra-mammary drug distribution, and biologic effects. (external link)
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• Elton Richard Kisanga; Line Leonore Haugan Moi; Jennifer Gjerde et al. (2005). Induction of hepatic drug-metabolising enzymes and tamoxifen metabolite profile in relation to administration route during low-dose treatment in nude rats. (external link)
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• Anita Helland; Marianne Bratlie; Ingrid Valheim Hagen et al. (2017). High intake of fatty fish, but not of lean fish, improved postprandial glucose regulation and increased the n-3 PUFA content in the leucocyte membrane in healthy overweight adults: A randomised trial. (external link)
• Cathrine Horn Sommersten; Johnny Laupsa-Borge; Amanda Iselin Olesen Andersen et al. (2022). Diets differing in carbohydrate cellularity and amount similarly reduced visceral fat in people with obesity - a randomized controlled trial (CARBFUNC). (external link)
• Linn Anja Slåke Vikøren; Aslaug Drotningsvik; Marthe Tønder Bergseth et al. (2018). Intake of baked cod fillet resulted in lower serum cholesterol and higher long chain n-3 PUFA concentrations in serum and tissues in hypercholesterolemic obese Zucker fa/fa rats. (external link)
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• Karen Klepsland Mauland; Øyvin Andre Solberg Eng; Sigmund Ytre-Hauge et al. (2017). High visceral fat percentage is associated with poor outcome in endometrial cancer. (external link)
• Harriet Johansson; Aliana Guerrieri-Gonzaga; Sara Gandini et al. (2024). Alternative dosing regimen of exemestane in a randomized presurgical trial: the role of obesity in biomarker modulation. (external link)
• Christine Haugen; Vegard Lysne; Ingfrid S. Haldorsen et al. (2022). MRI adipose tissue segmentation and quantification in R (RAdipoSeg). (external link)
• Simon E Nitter Dankel; Tuyen Hoang; Marianne Hauglid Flågeng et al. (2010). cAMP-mediated regulation of HNF-4 alpha depends on the level of coactivator PGC-1 alpha. (external link)
• Johnny Laupsa-Borge; Elise Grytten; Pavol Bohov et al. (2023). Sex-specific responses in glucose-insulin homeostasis and lipoprotein-lipid components after high-dose supplementation with marine n-3 PUFAs in abdominal obesity: a randomized double-blind crossover study. (external link)
• Grethe Åstrøm Ueland; Ralf Kellmann; Melissa Davidsen Jørstad et al. (2021). Bedtime Salivary Cortisol as a Screening Test for Cushing Syndrome in Children. (external link)
• Gunnar Mellgren; Olav Karsten Vintermyr; Ragnar Bøe et al. (1993). Hepatocyte DNA replication is abolished by inhibitors selecting protein phosphatase 2A rather than phosphatase 1. (external link)
• Andre Madsen; Ingvild Særvold Bruserud; Bjørn-Erik Bertelsen et al. (2020). Hormone references for ultrasound breast staging and endocrine profiling to detect female onset of puberty. (external link)
• Monika Christensen; Dag Jone Stokke Fadnes; Therese Halvorsen Røst et al. (2018). Inflammatory markers, the tryptophan-kynurenine pathway, and Vitamin B status after bariatric surgery. (external link)
• Therese Halvorsen Røst; Line Leonore Haugan Moi; Kjetil Berge et al. (2009). A pan-PPAR ligand induces hepatic fatty acid oxidation in PPAR alpha-/- mice possibly through PGC-1 mediated PPAR delta coactivation. (external link)
• Peder Braadland; Helene Hartvedt Grytli; Håkon Andre Ramberg et al. (2016). Low β2-adrenergic receptor level may promote development of castration resistant prostate cancer and altered steroid metabolism. (external link)
• Line Leonore Haugan Moi; Marianne Hauglid Flågeng; Jennifer Gjerde et al. (2012). Steroid receptor coactivators, HER-2 and HER-3 expression is stimulated by tamoxifen treatment in DMBA-induced breast cancer. (external link)
• Jennifer Gjerde; Sara Gandini; Aliana Guerrieri-Gonzaga et al. (2012). Tissue distribution of 4-hydroxy-N-desmethyltamoxifen and tamoxifen-N-oxide. (external link)
• Oddrun Anita Gudbrandsen; Simon N Dankel; Lillian Skumsnes et al. (2019). Short-term effects of Vertical sleeve gastrectomy and Roux-en-Y gastric bypass on glucose homeostasis. (external link)
• Ingvild Sveinsgjerd Fenne; Thomas Helland; Marianne Hauglid Flågeng et al. (2013). Downregulation of steroid receptor coactivator-2 modulates estrogen-responsive genes and stimulates proliferation of MCF-7 breast cancer cells. (external link)
• Thomas Helland; Kari Britt Hagen; Martha Eimstad Haugstøyl et al. (2019). Drug monitoring of tamoxifen metabolites predicts vaginal dryness and verifies a low discontinuation rate from the Norwegian Prescription Database. (external link)
• Cathrine Horn; Eirin Semb Gjerde; Johnny Laupsa-Borge et al. (2023). Relationship between Ketones, Ghrelin, and, Appetite on Isocaloric Diets with Varying Carbohydrate Quality and Amount: Results from a Randomized Controlled Trial in People with Obesity (CARBFUNC). (external link)
• Lifeng Wang; Nicholas A Sinnott-Armstrong; Alexandre Wagschal et al. (2020). A MicroRNA Linking Human Positive Selection and Metabolic Disorders. (external link)
• Marianne Bratlie; Ingrid Valheim Hagen; Anita Helland et al. (2020). Effects of high intake of cod or salmon on gut microbiota profile, faecal output and serum concentrations of lipids and bile acids in overweight adults: a randomised clinical trial. (external link)
• K.E. Flatmark; B.T. Gjertsen; Anders Molven et al. (1997). Gap junctions and growth control in liver regeneration and in isolated rat hepatocytes. (external link)
• Johan Lund; Anne L. Jacob; Reidun Æsøy et al. (1998). Biochemical and functional analysis of nuclear receptors as targets in cAMP-dependent control of bovine CYP17. (external link)
• G Houge; B Robaye; TS Eikholm et al. (1995). Fine mapping of 28S rRNA sites specifically cleaved in cells undergoing apoptosis. (external link)
• Gunnar Mellgren; Olav Karsten Vintermyr; SO Døskeland (1995). Okadaic acid, cAMP, and selected nutrients inhibit hepatocyte proliferation at different stages in G%b: Modulation of the cAMP effect by phosphatase inhibitors and nutrients. (external link)
• Linda Aumo; Marte Rusten; Gunnar Mellgren et al. (2010). Functional roles of protein kinase A (PKA) and exchange protein directly activated by 3',5'-cyclic adenosine 5'-monophosphate (cAMP) 2 (EPAC2) in cAMP-mediated actions in adrenocortical cells. (external link)
• Monika Christensen; Ingvild Sveinsgjerd Fenne; Yngve Nordbø et al. (2015). Novel inflammatory biomarkers in primary hyperparathyroidism. (external link)
• Reidun Æsøy; Gunnar Mellgren; Ken-Ichirou Morohashi et al. (2002). Activation of cAMP-dependent protein kinase increases the protein level of steroidogenic factor-1. (external link)
• Ryoko Higa; Shirin Pourteymour; Pratibha Shrikant Kolan et al. (2025). Hepatic lipid metabolism is altered in Ubiad1+/- mice of both sexes. (external link)
• Line Leonore Haugan Moi; Marianne Hauglid Flågeng; Sara Gandini et al. (2010). Effect of low-dose tamoxifen on steroid receptor coactivator 3/amplified in breast cancer 1 in normal and malignant human breast tissue. (external link)

Conference lecture

• Gunnar Mellgren (2004). Hormonal regulation of the Glucocorticoid receptor interacting protein 1 (GRIP1). (external link)
• Gunnar Mellgren (2004). Prisforedrag - Novo Nordisk pris for fremragende forskning i endokrinologi. (external link)
• Jan-Inge Bjune; Samantha Laber; Laurence Dyer et al. (2021). Epigenetic control of adipogenesis by Irx3. (external link)
• Tone Nygaard Flølo; Alexander Fosså; Jo Erling Riise Waage et al. (2023). Long-term impact of gastropexy on use of acid-reducing medication, second operations for gastroesophageal reflux and subjective reflux symptoms after sleeve gastrectomy. (external link)
• Odd Terje Brustugun; Kari Espolin Fladmark; Gunnar Mellgren et al. (1998). Ultrarapid apoptosis induction in a variety of cell types injected with phosphatase inhibitors is mediated through Ca2 /calmodulin dependent protei kinase activity. (external link)
• Therese Halvorsen Røst; Gunnar Mellgren; Rolf Kristian Berge (2004). Tetradecylthioacetic acid induces ligand dependent coactivation of PPARs by PGC-1 and SRC coactivators. (external link)
• Ingrid Valheim Hagen; Anita Helland; Marianne Bratlie et al. (2012). Effects of a high fish intake on lipid and bile acid levels in serum and feces from overweight and obese adults. (external link)
• Marianne Bratlie; Ingrid Valheim Hagen; Anita Helland et al. (2012). Effects of a high fish intake on leukocyte membrane fatty acid composition and leukocyte function ex vivo in overweight and obese adults. (external link)
• Gunnar Mellgren (2006). NUCLEAR RECEPTORS IN ENDOCRINE FUNCTION AND DISEASE. (external link)
• Anita Helland; Marianne Bratlie; Ingrid Valheim Hagen et al. (2012). Effect of a high fish intake on glucose tolerance and GLP-1 levels in overweight and obese adults. (external link)
• Therese Halvorsen Røst; Gunnar Mellgren; Rolf Kristian Berge (2005). A pan-PPAR ligand induces differential coactivation of PPARs by SRCs and PGC-1. (external link)
• Gunnar Mellgren (2007). Role of cAMP in Regulation of the Nuclear Receptor Coactivator GRIP1. (external link)
• Gunnar Mellgren (2009). Hva kan vi lære av sykelig fedme? Fedme og genekspresjon. (external link)
• Gunnar Mellgren (2008). Nuclear Receptor Coactivators. (external link)
• Gunnar Mellgren (2008). Marine macronutrients, metabolic homeostasis and obesity. (external link)
• Mona Synnøve Bjune; Laurence Dyer; Matthias Blüher et al. (2021). Altered hepatic HIBCH expression is associated with hepatic lipid accumulation and fatty liver. (external link)
• Mona Synnøve Nilsen; Regine Åsen Jersin; Andre Madsen et al. (2018). Amino acid metabolism in adipocytes. (external link)
• Eli Kristin Aadland; Charles Lavigne; Ingvild Eide Graff et al. (2015). Lean seafood intake reduces cardiovascular risk factors in healthy subjects. (external link)
• E Bratland; G Bredholt; Per Knappskog et al. (2005). Cellular immunity to 21-hydroxylase in patients with autoimmune Addison's disease. (external link)
• Mona Synnøve Nilsen; Regine Åsen Jersin; Adrian McCann et al. (2019). Circulating 3-hydroxyisobutyrate (3-HIB) as a clinical marker of prediabetes and T2D in patients with obesity. (external link)
• Gunnar Mellgren (2005). Regulering av steroidhormonreseptorer ved protein-protein interaksjon. (external link)
• Gunnar Mellgren (2004). Nuclear Receptor Interacting Proteins as Molecular Targets in Breast Carcinoma. (external link)
• Gunnar Mellgren (2004). Intracellulære hormonreseptorer - betydning av nye koregulator proteiner. (external link)
• Gunnar Mellgren (2005). Endocrine regulation of a nuclear receptor coactivator. (external link)
• Gunnar Mellgren (2004). Hormonal regulation of nuclear receptor coactivator GRIP1. (external link)
• Gunnar Mellgren (2004). cAMP-depentent protein kinase regulates ubiquitin-proteasome mediated degradation of the nuclear receptor coactivator GRIP1. (external link)
• Gunnar Mellgren (2010). Oppregulering av østrogen-receptor koaktivatorer og HER-2/neu under endokrin behandling av brystkreft. (external link)
• Gunnar Mellgren (2010). Presentasjon av strategisk satsing innen ernæring og overvekt. (external link)
• Gunnar Mellgren; Simon E Nitter Dankel (2009). Bariatric surgery dramatically alters global gene expression in adipose tissue. (external link)
• Gunnar Mellgren (2009). Adipogen – en studie av fettvev til pasienter som har gjennomgått overvektskirurgi. (external link)
• Gunnar Mellgren (2012). Novel transcription factors in obesity. (external link)
• Gunnar Mellgren (2012). Homeobox transcription factors IRX3 and 5 in obesity. (external link)
• Simon E Nitter Dankel; Eirik Magnus Meek Degerud; Even Fjære et al. (2012). Weight cycling affects adipose tissue genes involved in circadian rhythm and lipid metabolism. (external link)
• Simon E Nitter Dankel; Dag Jone Stokke Fadnes; Andrea Christoforou et al. (2012). Integrative genomics links homeobox transcription factors to intra-abdominal obesity. (external link)

Conference poster

• Simon E Nitter Dankel; Tuyen Hoang; Jørn V. Sagen et al. (2008). cAMP/PKA Exerts Differential Effects on GRIP1- and PGC-1α-Mediated HNF-4α Transcriptional Activity in HepG2 and COS-1 Cells. (external link)
• Simon E Nitter Dankel; Tuyen Hoang; Jørn V. Sagen et al. (2008). cAMP Regulates Nuclear Receptor Coactivator GRIP1–Mediated Coactivation of HNF-4alpha in HepG2 Cells. (external link)
• Marianne Hauglid Flågeng; Stian Knappskog; Alexey Larionov et al. (2010). Epidermal growth factor receptors (ErbB/HER) and the ligand Neuregulin 1 (NRG1) increase in breast tumors during short time treatment with aromatase inhibitors. (external link)
• Linn Anja Slåke Vikøren; Aslaug Drotningsvik; Gunnar Mellgren et al. (2015). INTAKE OF FISH PROTEIN AND EFFECTS ON GLUCOSE REGULATION AND LIPID METABOLISM IN OBESE ZUCKER RATS. (external link)
• Marianne Hauglid Flågeng; Line Leonore Haugan Moi; Sara Gandini et al. (2010). Expression of Steroid Receptor Coactivators and HER-2/neu in normal and malignant breast tissue in controls and tamoxifen treated patients. (external link)
• Monika Christensen; Yngve Nordbø; Jan Erik Varhaug et al. (2013). Vitamin D levels in patients with primary hyperparathyroidism; a follow-up study after parathyroidectomy. (external link)
• Siri Lunde; Thomas Helland; Janne Jonassen et al. (2018). A prospective, longitudinal, breast cancer biobank (PBCB) in western Norway. (external link)
• Jennifer Gjerde; Aliana Guerrieri-Gonzaga; Bernardo Bonanni et al. (2010). Distribution of tamoxifen and five metabolites into normal and malignant human breast cancer tissue during conventional and low dose treatment. (external link)
• Erik Wilhelm Vinnes; Kristin Moberg Aakre; Johan Fernø et al. (2024). Long-term effect of bariatric surgery on circulating GDF15 concentrations. (external link)
• Vivian Lohmann Veum; Simon E Nitter Dankel; Jennifer Gjerde et al. (2011). The nuclear receptors NURR77, NURR1 and NOR1 in obesity and during fat loss. (external link)
• Lise Bjørkhaug; Lorentze Hornnes; Alba Kaci et al. (2017). Functional analysis of various HNF4A variants identifies increased transactivation function of R85W causing the mutation specific phenotype of neonatal hyperinsulinism and Fanconi syndrome. (external link)
• Mari Bergsvåg; Ingvild Sveinsgjerd Fenne; Tuyen Hoang et al. (2008). SEARCH FOR UBIQUITINATION SITES AND UBIQUTIN-RELATED PHOSPHORYLATION SITES IN THE STEROID RECEPTOR COACTIVATOR GRIP1. (external link)
• Jennifer Fernandez Gjerde; Marianne Hauglid; Harald Breilid et al. (2007). Effect of CYP2D6 and SULT1A1 Genotypes on the serum concentration of 4-OHtamoxifen and 4-OH-N-Demethyltamoxifen during steady state treatment of breast cancer patients. (external link)
• Marianne Hauglid; Line Leonore Haugan Moi; Michael Dixon et al. (2008). Changes in mRNA expression levels of steroid receptor coactivators correlate with treatment response to aromatase inhibition in human breast cancer. (external link)
• Marianne Hauglid Flågeng; Stian Knappskog; Per Eystein Lønning et al. (2011). The nuclear receptor coactivator PELP1/MNAR is positively correlated with estrogen levels in breast cancer patients. (external link)
• Eva Ringdal Pedersen; Nora Tuseth; Simone Eussen et al. (2014). Associations of plasma kynurenines with risk of acute myocardial infarction in patients with stable angina pectoris. (external link)
• Gunnar Mellgren; Tuyen Hoang; Jørn V. Sagen et al. (2007). Regulation of HNF-4alpha transcriptional activity by the coactivators GRIP1 and PGC-1alpha. (external link)
• Jennifer Gjerde; M Hauglid; H Breilid et al. (2005). Relationship between CYP2D6 and SULT1A1 genotype and serum concentration of tamoxifen and its metabolites during steady state treatment in breast cancer patients. (external link)
• Monika Christensen; Eva Kristine Ringdal Pedersen; Yngve Nordbø et al. (2012). Systemic Inflammation in Primary Hyperparathyroidism: Influences on Plasma Vitamin B6 Levels and Interferon-γ Mediated Immune Activation. (external link)
• Marianne Hauglid Flågeng; Alexey Larionov; Jürgen Geisler et al. (2012). Inverse regulation of Neuregulin 1 and HER-3 during treatment with aromatase inhibitors of estrogen receptor-positive breast cancer. (external link)
• Christine Haugen; Simon E Nitter Dankel; K. Han Kim et al. (2013). Deficiency of Irx5 is associated with decreased fat mass in male CD1 mice. (external link)
• Marianne Hauglid Flågeng; Line Leonore Haugan Moi; J. Michael Dixon et al. (2009). HER-2/neu and nuclear receptor coactivators are upregulated in breast cancer tumors during estrogen deprivation. (external link)
• Jennifer Gjerde; Jürgen Geisler; Steinar Lundgren et al. (2009). Relations between FSH, SHBG and tamoxifen metabolism during steady state tamoxifen treatment. (external link)
• Christine Haugen; Simon E Nitter Dankel; K. Han Kim et al. (2013). Role of homeobox transcription factor IRX5 in obesity and metabolic health. (external link)
• Therese Halvorsen Røst; Oddrun Anita Gudbrandsen; Karl Johan Tronstad et al. (2004). PPAR-delta activation in relation to reduction of adipose tissue. (external link)
• Sigve Ladstein; Gunn A. Hildrestrand; Harald K. Halvorsen et al. (2005). Molecular cloning and characterization of estrogen receptors in Atlantic salmon (Salmo salar). (external link)
• Ingvild Sveinsgjerd Fenne; Tuyen Hoang; Gunnar Mellgren (2005). Hormonal regulation of the intranuclear localization of the nuclear hormone receptor coactivator GRIP1. (external link)
• Line Haugan; Gunnar Mellgren (2004). Tamoxifen metabolism and induction of hepatic drug metabolising enzymes in nude rats. (external link)
• Divya Sri Priyanka Tallapragada; Samantha Laber; Gunnar Mellgren et al. (2019). Generation and validation of immortalized human paired subcutaneous and omental adipocyte models to study obesity. (external link)
• Therese Halvorsen Røst; Gunnar Mellgren; Rolf Kristian Berge (2005). A pan-PPAR ligand induces differential coactivation of PPARs by SRCs and PGC-1. (external link)
• Christine Haugen; Simon N Dankel; K. Han Kim et al. (2014). Role of homeobox transcription factors IRX3 and IRX5 in mitochondrial development and activity in adipose tissue. (external link)
• Divya Sri Priyanka Tallapragada; Gunnar Mellgren; Simon N Dankel (2018). Gene marker panel for omental and subcutaneous adipocytes in humans. (external link)
• Simon E Nitter Dankel; Dag Jone Stokke Fadnes; Oddrun Anita Gudbrandsen et al. (2011). Prediction of obesity candidate genes by multiple gene expression analyses of adipose tissue. (external link)
• Tuyen Hoang; Ingvild Sveinsgjerd Fenne; Mona Johannessen et al. (2006). ROLES OF cAMP RESPONSE ELEMENT BINDING PROTEIN (CREB) IN REGULATION OF GLUCOCORTICOID RECEPTOR INTERACTING PROTEIN 1 (GRIP1). (external link)
• Marianne Hauglid Flågeng; Olivera Bozickovic; Linn Skartveit et al. (2014). Steroid receptor coactivators during short-term estrogen deprivation. (external link)
• Regine Jersin; Andre Madsen; Aron Willems et al. (2018). Impaired D-serine uptake in adipocytes promotes oxidative stress and visceral obesity. (external link)
• Ingvild Sveinsgjerd Fenne; Tuyen Hoang; Gunnar Mellgren (2006). Endocrine regulation of the nuclear receptor coactivator GRIP1 through the cAMP-signalling pathway. (external link)
• Tuyen Hoang; Ingvild Sveinsgjerd Fenne; Mari Bergsvåg et al. (2009). The Role of PKA and CREB in regulation of the Steroid Receptor Coactivator GRIP1/SRC-2. (external link)
• Vivian Lohmann Veum; Johnny Laupsa-Borge; Øyvin Solberg Eng et al. (2014). A moderate energy-restricted very-high-fat diet reduces fat mass and improves metabolic health in abdominally obese middle-aged men. (external link)
• Ingvild Sveinsgjerd Fenne; Marianne Hauglid Flågeng; Tuyen Hoang et al. (2009). Role of the cAMP-PKA Signaling Pathway in the Regulation of ERalpha-dependent transcription by Steroid Receptor Coactivators in Breast Cancer Cells. (external link)
• Line Leonore Haugan Moi; Elton Richard Kisanga; Jennifer Gjerde et al. (2004). Tamoxifen metabolism and induction of hepatic drug-metabolizing enzymes in nude rats. (external link)
• Mona Synnøve Nilsen; Regine Åsen Jersin; Andre Madsen et al. (2019). Adipocyte amino acid metabolism in obesity-related metabolic diseases. (external link)
• Marthe Bergseth; Aslaug Drotningsvik; Linn Anja Slåke Vikøren et al. (2016). Effects of intake of baked and raw fish on serum lipids and fatty acid composition in obese rats. (external link)
• Linn Anja Slåke Vikøren; Aslaug Drotningsvik; Iselin Thowsen Vildmyren et al. (2016). Effects of salmon filet intake on blood pressure regulation. (external link)
• Jennifer Gjerde; Jurgen Geisler; Steinar Lundgren et al. (2007). A study of association between estrogen and tamoxifen metabolism, cytochrome 2D6 and sulfotransferae 1A1 polymorphisms, and sulfotransferase 1A1 gene copy number during steady sate tamoxifen treatment. (external link)
• Jennifer Fernandez Gjerde; Marianne Hauglid; Harald Breilid et al. (2005). Relationship between CYP2D6 and SULT1A1 genotypes and serum concentrations of tamoxifen and its metabolites during steady state treatment in breast cancer patients. (external link)
• Line Leonore Haugan Moi; Elton Richard Kisanga; Jennifer Gjerde et al. (2005). Effects of low-dose tamoxifen treatment on expression of drug-metabolising enzymes in rat liver in relation to administration route. (external link)
• Tuyen Hoang; Ingvild Sveinsgjerd Fenne; Ernst Asbjørn Lien et al. (2005). CHARACTERIZATION OF THE MOLECULAR MECHANISMS BY WHICH THE LEVEL OF NUCLEAR HORMONE RECEPTOR COACTIVATOR GRIP1 IS REGULATED. (external link)
• Iselin Thowsen Vildmyren; John Cao; Ida Ulrikke Karlsen et al. (2016). Effects of water soluble and water insoluble cod protein on lipid metabolism in overweight adults. (external link)
• Eli Kristin Aadland; Ingvild Eide Graff; Bjørn Liaset et al. (2013). A controlled randomized intervention study with lean seafood vs terrestrial animal proteins in healthy subjects: data on body mass and body composition. (external link)
• Tuyen Hoang; Simon E Nitter Dankel; Dag Jone Stokke Fadnes et al. (2010). Gene Expression Profile of Nuclear Receptors and Coregulators in Adipose Tissues in Morbid Obesity and after Profound Fat Loss. (external link)
• Simon E Nitter Dankel; Dag Jone Stokke Fadnes; Anne-Kristin Stavrum et al. (2010). From stress response to developmental processes in abdominal subcutaneous adipose tissue after bariatric surgery. (external link)
• Ingvild Sveinsgjerd Fenne; Marianne Hauglid Flågeng; Thomas Helland et al. (2011). Characterization of Global Gene Expression in Breast Cancer Cells after cAMP/PKA-mediated downregulation of Steroid Receptor Coactivator 2. (external link)
• Mette Schmedes; Christian Clement Yde; Eli Kristin Aadland et al. (2014). Metabolomic studies on the urinary response to a diet based on either lean seafood or other protein sources. (external link)
• Simon E Nitter Dankel; Dag Jone Stokke Fadnes; Oddrun Anita Gudbrandsen et al. (2010). Low Omental Expression of Fat Loss-Associated Homeobox Transcription Factors in Morbid Obesity. (external link)
• Monika Christensen; Ingvild Sveinsgjerd Fenne; Marianne Hauglid Flågeng et al. (2009). PTH inhibits ligand-dependent activation of estrogen receptor alfa in MC3T3 osteoblasts. (external link)
• Johan Fernø; Aron Willems; Simon N Dankel et al. (2014). SLC7A10, a novel adipocyte-enriched gene with a potential role in adipocyte differentiation. (external link)
• Mona Synnøve Bjune; Laurence Dyer; Adrian McCann et al. (2022). Altered hepatic HIBCH expression is associated with hepatic lipid accumulation and fatty liver. (external link)
• Jan-Inge Bjune; Christine Haugen; Oddrun Anita Gudbrandsen et al. (2018). Irx5 regulates body weight via amyloid precursor protein and mitochondrial respiration in adipocytes. (external link)
• Jan-Inge Bjune; Andre Madsen; Lise Bjørkhaug et al. (2016). PKA downregulates glucose-6phosphatase Expression through RORα and SRC2. (external link)
• Caroline Jensen; Gunnar Mellgren; Simon N Dankel et al. (2024). Quality and quantity of carbohydrates, fecal SCFAs and gastrointestinal symptoms - results from a RCT (CARBFUNC). (external link)
• Jan-Inge Bjune; Christine Haugen; Oddrun Anita Gudbrandsen et al. (2018). Irx5 regulates body weight via amyloid precursor protein (App) and mitochondrial respiration in adipocytes. (external link)
• Andre Madsen; Olivera Bozickovic; Jan-Inge Bjune et al. (2016). Repression of liver SRC-2 by metformin inhibits glucose, lipid and cholesterol biosynthesis. (external link)
• Iselin Thowsen Vildmyren; John Cao; Ida Ulrikke Karlsen et al. (2016). Effects of water soluble and water insoluble cod protein on lipid metabolism in overweight adults. (external link)
• Monika Christensen; Ingvild Sveinsgjerd Fenne; Marianne Hauglid Flågeng et al. (2009). PTH inhibits ligand-dependent activation of estrogen receptor alfa in MC3T3 Osteoblasts. (external link)
• Monika Christensen; Simon E Nitter Dankel; Yngve Nordbø et al. (2011). Differential Expression of Inflammatory and Metabolic Genes in Adipose Tissue of Patients with Primary Huperparathyroidism. (external link)
• Eirik Magnus Meek Degerud; Simon E Nitter Dankel; Even Fjære et al. (2012). CDKN1A associates with fat regain after weight cycling in mice. (external link)
• Simon E Nitter Dankel; Eirik Magnus Meek Degerud; Even Fjære et al. (2012). Candidate genes for fat regain after weight cycling in mice. (external link)

Academic book chapter

• Ellen Færgestad Mosleth; Anette McLeod; Ida Rud et al. (2020). Analysis of Megavariate Data in Functional Omics. (external link)
• Odd Terje Brustugun; Gunnar Mellgren; Bjørn Tore Gjertsen et al. (1996). Sensitive and rapid detection of B-galactosidase expression in intact cells by microinjection of fluorecent substrate. (external link)
• Line Leonore Haugan Moi; Marianne Hauglid Flågeng; Simon E Nitter Dankel et al. (2011). Steroid Receptor Coactivators and Endocrine Treatment in Breast Cancer. (external link)
• Jennifer Gjerde; Line Leonore Haugan Moi; Gunnar Mellgren et al. (2012). Tamoxifen metabolism and biological activity. (external link)
• Line Leonore Haugan Moi; Marianne Hauglid Flågeng; Ingvild Sveinsgjerd Fenne et al. (2011). Steroid Receptor Coactivators and Their Expression, Regulation and Functional Role in Endocrine Responsive and Resistant Breast Cancer. (external link)

Conference abstract

• Tuyen Hoang; Simon E Nitter Dankel; Dag Jone Stokke Fadnes et al. (2010). Gene Expression Profile of Nuclear Receptors and Coregulators in Adipose Tissues in Morbid Obesity and after Profound Fat Loss. (external link)
• Jennifer Fernandez Gjerde; Marianne Hauglid; Harald Breilid et al. (2007). Effect of CYP2D6 and SULT1A1 genotypes on the serum concentration of 4-hydroxytamoxifen and 4-hydroxy-N-demethyltamoxifen during steady state treatment of breast cancer patients. (external link)
• Jennifer Fernandez Gjerde; Jurgen Geisler; Steinar Lundgren et al. (2007). A study of associations between estrogen and tamoxifen metabolism, cytochrome 2D6 and sulfotransferase 1A1 polymorphisms, and sulfotransferase 1A1 gene copy number during steady state tamoxifen treatment. (external link)
• Simon E Nitter Dankel; Dag Jone Stokke Fadnes; Anne-Kristin Stavrum et al. (2010). From stress response to developmental processes in abdominal subcutaneous adipose tissue after bariatric surgery. (external link)
• Jennifer Gjerde; Jürgen Geisler; Steinar Lundgren et al. (2010). Effects of CYP2C19 genotype on tamoxifen and estrogen metabolism. (external link)
• Jennifer Fernandez Gjerde; Marianne Hauglid; Harald Breilid et al. (2005). Relationship between CYP2D6 and SULT1A1 genotypes and serum concentrations of tamoxifen and its metabolites during steady state treatment in breast cancer patients. (external link)
• Andrea De Censi; Harriet Ann Johansson; Thomas Helland et al. (2020). Relationship between CYP2D6 genotype, tamoxifen metabolites, and adverse events, tumor biomarkers and breast cancer recurrence in a low-dose phase III trial in noninvasive disease. (external link)

Master’s thesis

• Oddbjørg Stokkeland; Oddrun Anita Gudbrandsen; Gunnar Mellgren (2013). Effects of Fish Protein and Peptides on Inflammatory Markers and Subjective Joint Pain in Overweight and Obese Adults. (external link)
• Marianne Bratlie; Oddrun Anita Gudbrandsen; Gunnar Mellgren (2012). Effects of a high fish intake on leukocyte membrane fatty acid composition and leukocyte function ex vivo in overweight and obese adults. (external link)
• Hanne Rosendahl Gjessing; Oddrun Anita Gudbrandsen; Gunnar Mellgren (2010). Impact of Laparoscopic Sleeve Gastrectomy on Body Mass Index, Nutritional Status and Co-morbidity.. (external link)
• Kaia Waage; Oddrun Anita Gudbrandsen; Gunnar Mellgren (2013). Effects of Fish Protein and Peptides on Ex Vivo Leukocyte Function and Leukocyte Membrane Fatty Acid Composition in Overweight and Obese Adults. (external link)
• Ida Hovland; Oddrun Anita Gudbrandsen; Gunnar Mellgren (2013). Effects of Fish Protein and Peptides on Glucose Tolerance and Leptin:Adiponectin Ratio in Overweight and Obese Adults. (external link)
• Anita Helland; Oddrun Anita Gudbrandsen; Gunnar Mellgren (2012). Effects of a high fish intake on glucose tolerance and GLP-1 levels in overweight and obese adults. (external link)
• Ingrid Valheim Hagen; Oddrun Anita Gudbrandsen; Gunnar Mellgren (2012). Effects of a high fish intake on lipid and bile acid levels in serum and feces from overweight and obese adults. (external link)
• Gunnar Mellgren; Vivian Veum (2009). Fractionation of human adipose tissue using collagenase: gene expression analysis of nuclear receptors (NR) 4A. (external link)
• Jørn V. Sagen; Gunnar Mellgren; Simon Dankel (2006). Role of cAMP/PKA in Regulation of GRIP1- and PGC1alpha-Mediated Coactivation of Nuclear Receptor HNF4Alpha. (external link)
• Gunnar Mellgren (2008). Nazanin Saemi: Expression and purification of nuclear receptor coactivator GRIP1 deletion mutants. (external link)
• Gunnar Mellgren; Nazanin Saemi; Tuyen Hoang (2007). Expression and purification of Nuclear Receptor Coactivator GRIP1 deletion mutants. (external link)
• Therese Halvorsen Røst; Rolf Kristian Berge; Gunnar Mellgren (2003). 3-Thia Fatty Acids Inhibit MCF-7 Breast Cancer Cell Proliferation and Induce Ligand Dependent Coactivation of PPARs by p160 Coactivators. (external link)

Doctoral thesis (PhD)

• Linn Anja Slåke Vikøren; Oddrun Anita Gudbrandsen; Jutta Dierkes et al. (2018). Salmon and cod fillet consumption and effects on metabolic risk factors. Intervention studies in humans and rats with overweight and obesity. (external link)
• Olivera Bozickovic; Gunnar Mellgren (2015). Regulation and function of steroid receptor coactivator 2 in hepatoma and breast cancer cells. (external link)
• Gunnar Mellgren (1996). Hepatocyte growth inhibition by cAMP-dependent protein kinase and other signaling pathways. (external link)
• Grethe Åstrøm Ueland; Eystein Sverre Husebye; Paal Methlie et al. (2019). Improved diagnostic workup of hyper- and hypocortisolism. (external link)
• Thomas Helland; Gunnar Mellgren (2019). Tamoxifen in the treatment of luminal breast cancer. Implications of active metabolites on gene expression, side effects and clinical outcome. (external link)
• Rhian Gaenor Jacobsen; Aurelia Eva Lewis; Gunnar Mellgren (2017). Nuclear phosphoinositide 3-kinase signalling in adipogenesis and the role of DNA topoisomerase IIα as a potential nuclear polyphosphoinositide-binding protein. (external link)
• Tuyen Hoang; Gunnar Mellgren; Ernst Asbjørn Lien (2007). Nuclear Receptor Coregulators Role of Protein-Protein Interactions and cAMP/PKA Signaling. (external link)
• Line Leonore Haugan Moi; Gunnar Mellgren (2012). Endocrine treatment of breast cancer: Tamoxifen metabolism, steroid receptor coactivators and growth factor receptors. (external link)

Popular science article

• Line Leonore Haugan Moi; Marianne Hauglid Flågeng; Gunnar Mellgren (2013). Steroid reseptor koaktivatorer, HER-2 og hormonbehandling ved brystkreft. (external link)

Textbook

• Gunnar Mellgren; Anders Angelsen; Hans Petter Eikesdal et al. (2016). MEDIKAMENTELL KREFTBEHANDLING - CYTOSTATIKABOKEN Kapittel 19 - Hormoner og antihormoner. (external link)

Academic literature review

• Thomas Helland; Sarah Alsomairy; Chenchia Lin et al. (2021). Generating a precision endoxifen prediction algorithm to advance personalized tamoxifen treatment in patients with breast cancer. (external link)
• Simon E Nitter Dankel; Vidar Staalesen; Bodil Bjørndal et al. (2011). Tissue-specific effects of bariatric surgery including mitochondrial function. (external link)
• Johan Fernø; Kristina Strand; Gunnar Mellgren et al. (2019). Natural killer cells as sensors of adipose tissue stress. (external link)
• Finn Eliassen; Vibeke Iren Jensen Blåfjelldal; Thomas Helland et al. (2023). Importance of endocrine treatment adherence and persistence in breast cancer survivorship: a systematic review. (external link)
• Jan-Inge Bjune; Pouda Panahandeh Strømland; Regine Åsen Jersin et al. (2022). Metabolic and Epigenetic Regulation by Estrogen in Adipocytes. (external link)
• Johan Lund; Bente Børud; Gunnar Mellgren et al. (2002). Differential regulation of SF-1-cofactor interactions. (external link)

Working paper

• Gunnar Mellgren (2004). Endokrinologi. Kompendium for studenter i biokjemi II. (external link)

Letter to the editor

• Gunnar Mellgren; Thomas Helland; Kristin Jonsdottir et al. (2024). Håvard Søiland. (external link)

Professional article

• Håvard Søiland; Emiel Janssen; Thomas Helland et al. (2022). Liquid biopsies and patient-reported outcome measures for integrative monitoring of patients with early-stage breast cancer: a study protocol for the longitudinal observational Prospective Breast Cancer Biobanking (PBCB) study. (external link)

Lecture

• Gunnar Mellgren (2009). Hva skal til for å lykkes i forskning?. (external link)
• Simon N Dankel; Divya Sri Priyanka Tallapragada; Nasa-Sinnott Armstrong et al. (2019). Integrative Genomics Links Homeobox Transcription Factors to Risk of Visceral Adiposity. (external link)

See a complete overview of publications in NVA.

Selected publications:

Mellgren, G., Gjertsen, B.T, Otten, A., Maronde, E., Genieser, H-G., Jasdorff, B., Vintermyr, O.K., McKnight, G.S., and Døskeland, S.O. (1995) Novel Rp-cAMPS analogs as tools for inhibition of cAMP-kinase in cell culture. Basal cAMP-kinase activity modulates interleukin-1b action. J. Biol. Chem., 270:20599-20607.

Fladmark, K.E, Brustugun, O.T, Mellgren, G, Krakstad, C, Bøe, R., Vintermyr, O.K., Schulman, H., and Døskeland, S.O. (2002) Ca²⁺/calmodulin dependent protein kinase II is required for microcystin-induced apoptosis. J. Biol. Chem., 277:2804-2811.

Børud, B., Hoang, T., Bakke, M, Jacob, A., Lund, J, and Mellgren, G (2002). The nuclear coactivators p/CIP and TIF2 differentially regulate PKA-dependent transcriptional activity of Steroidogenic factor-1. Mol. Endocrinol., 16:757-773.

Børud, B., Mellgren, G., Lund, J. and Bakke, M. (2003) Cloning and Characterization of a Novel Zinc-finger Protein that Modulates the Transcriptional Activity of Nuclear Receptors. Mol. Endocrinol., 17:2303-2319 

Hoang, T., Fenne, I., Cook, C., Børud, B., Bakke, M., Lien, E.A and Mellgren, G (2004) cAMP-dependent Protein Kinase Regulates Ubiquitin-proteasome mediated Degradation and Subcellular Localization of the Nuclear Receptor Coactivator GRIP1. J. Biol. Chem., 279:49120-49130.

Gjerde, J., Hauglid, M., Breilid, H., Lundgren, S., Varhaug, J.E., Kisanga, E.R., Mellgren, G., Steen, V.M., and Lien, E.A. (2007). Effects of CYP2D6 and SULT1A1 genotypes including SULT1A1 gene copy number on tamoxifen metabolism. Ann Oncol., 19:56-61.

Fenne, I.S., Hoang, T., Hauglid, M, Sagen, JV, Lien, E.A., and Mellgren, G. (2008). Recruitment of coactivator GRIP1 to an estrogen receptor transcription complex is regulated by cAMP-dependent protein kinase. Endocrinology, 149:4336-45.

Moi, L.H.L., Hauglid, M., Gandini, S, Aliana, G.G., Bonanni, B., Lazzeroni, M., Gjerde, J, Lien, E.A., Decensi, A, and Mellgren G. (2010) Effects of low dose tamoxifen on Steroid Receptor Coactivator 1/Amplified in Breast Cancer 1 in normal an malignant breast tissue. Clin. Cancer Res., 16:2176-86

Dankel SE, Fadnes D, Stavrum AK, Stansberg C, Holdhus R, Hoang T, Veum V, Christensen B, Vaage V, Sagen JV, Steen VM, Mellgren G (2010) Switch from stress response to homeobox transcription factors in adipose tissue after profound fat loss. PLoS ONE, 9;5(6):e11033

Monika H.E. Christensen, Eva K.R. Pedersen, Yngve Nordbø, Jan Erik Varhaug, Øyvind Midttun, Per M. Ueland, Ottar K. Nygaard, Gunnar Mellgren, Ernst A. Lien (2012) Vitamin B6 Status and Interferon-γ Mediated Immune Activation in Primary Hyperparathyroidism. J Intern Medicine. Jul 3. doi: 10.1111/j.1365-2796.2012.02570.x

Hoang, T. Fenne, I,  Johannessen, M, Lien, E.A., Moens, U and Mellgren, G. (2013) cAMP Response Element Binding Protein (CREB) Interacts with the nuclear receptor coactivator GRIP1 and mediates its degradation. Endocrinology,Apr;154(4):1513-27. doi: 10.1210/en.2012-2049. Epub 2013 Mar 5.

Claussnitzer M, Dankel SN, Klocke B, Grallert H, Glunk V, Berulava T, Lee H, Oskolkov N, Fadista J, Ehlers K, Wahl S, Hoffmann C, Qian K, Rönn T, Riess H, Müller-Nurasyid M, Bretschneider N, Schroeder T, Skurk T, Horsthemke B; DIAGRAM+Consortium, Spieler D, Klingenspor M, Seifert M, Kern MJ, Mejhert N, Dahlman I, Hansson O, Hauck SM, Blüher M, Arner P, Groop L, Illig T, Suhre K, Hsu YH, Mellgren G, Hauner H, Laumen H. Leveraging cross-species transcription factor binding site patterns: from diabetes risk loci to disease mechanisms. Cell. 2014 Jan 16;156(1-2):343-58

Ussar S, Lee KY, Dankel SN, Boucher J, Haering MF, Kleinridders A, Thomou T, Xue R, Macotela Y, Cypess AM, Tseng YH, Mellgren G, Kahn CR. ASC-1, PAT2, and P2RX5 are cell surface markers for white, beige, and brown adipocytes. Science Translational Medicine, 2014, 6(247);247ra103. 

Aadland EK, Lavigne C, Graff IE, Eng Ø, Paquette M, Holthe A, Mellgren G, Jacques H, Liaset B. Lean-seafood intake reduces cardiovascular lipid risk factors in healthy subjects: results from a randomized controlled trial with a crossover design. Am J Clin Nutr. 2015 Sep;102(3):582-92. 

Melina Claussnitzer, Simon Nitter Dankel, Gerald Quon, Kyoung-Han Kim, Wouter Meuleman, Christine Haugen, Viktoria Glunk, Isabel Sousa, Jacqueline L. Beaudry, Vijitha Puviindran, Nezar A. Abdennur, Jannel Liu, Per-Arne Svensson, Yi-Hsiang Hsu, Daniel J. Drucker, Gunnar Mellgren, Chi-Chung Hui, Hans Hauner, Manolis Kellis. FTO Obesity Variant Circuitry and Adipocyte Browning in Humans. New Engl. J. Medicine, 2015 Sep 3;373(10):895-907

Vivian L. Veum, Johnny Laupsa-Borge, Øyvin Eng, Espen Rostrup, Terje H. Larsen, Jan Erik Nordrehaug, Ottar Nygård, Jørn V. Sagen, Oddrun A. Gudbrandsen, Simon N. Dankel, Gunnar Mellgren. Visceral adiposity and metabolic syndrome after very-high-fat and low-fat isocaloric diets: a randomized controlled trial (FATFUNC). Am J Clin Nutr. 2017 Jan;105(1):85-99

Serum concentrations of active tamoxifen metabolites predict long-term survival in adjuvantly treated breast cancer patients. Helland T, Henne N, Bifulco E, Naume B, Borgen E, Kristensen VN, Kvaløy JT, Lash TL, Alnæs GIG, van Schaik RH, Janssen EAM, Hustad S, Lien EA, ‡Mellgren G, ‡Søiland H. Breast Cancer Res. 2017 Nov 28;19(1):125. doi: 10.1186/s13058-017-0916-4. 

IRX5 regulates adipocyte amyloid precursor protein and mitochondrial respiration in obesity. Bjune JI, Haugen C, Gudbrandsen O, Nordbø OP, Nielsen HJ, Våge V, Njølstad PR, Sagen JV, Dankel SN, Mellgren G. Int J Obes (Lond). 2019 Nov;43(11):2151-2162

The homeobox factor Irx3 maintains adipogenic identity. Bjune JI, Dyer L, Røsland GV, Tronstad KJ, Njølstad PR, Sagen JV, Dankel SN, Mellgren G. Metabolism. 2019 Nov 18;103:154014. doi: 10.1016/j.metabol.2019.154014.

Testicular ultrasound to stratify hormone references in a cross-sectional Norwegian study of male puberty. Madsen A, Oehme NB, Roelants M, Bruserud IS, Eide GE, Viste K, Bjerknes R, Almås B, Rosendahl K, Sagen JV, Mellgren G, Juliusson PB. J Clin Endocrinol Metab. 2019 Oct 26. pii: dgz094. doi: 10.1210/clinem/dgz094.

3-Hydroxyisobutyrate, A Strong Marker of Insulin Resistance in Type 2 Diabetes and Obesity That Modulates White and Brown Adipocyte Metabolism. Nilsen MS, Jersin RÅ, Ulvik A, Madsen A, McCann A, Svensson P-A, Svensson M-E, Nedrebø B-G, Gudbrandsen OA, Tell GS, Kahn CR,Ueland PM, Mellgren G, and Dankel SN. Diabetes 2020; 69:1–14 https://doi.org/10.2337/db19-1174.

https://www.uib.no/en/rg/hormonelaboratory

Mohn Nutrition Research Laboratory funded by Trond Mohn stiftelse www.uib.no/mohn-elab

https://www.uib.no/diabetes/en