Odd André Karlsen

Position

Professor

Belonging

Department of Biological Sciences (BIO)

Research groups

Research

My research interests concern the molecular mechanisms and mode of actions underlying the toxicity of environmental pollutants, and how this may manifest across biological organizations and produce higher level effects (organism, population). My research focuses mainly on marine organisms, and central topics within my current research activities include endocrine disruption, nuclear receptors, biomarkers, bioassays, microplastics, integrative genomics/toxicogenomics, chemicals of emerging concern, and cocktail effects.

I am currently leading the University of Bergen’s network for marine plastic pollution (Plastics Network). This network embraces cross-disciplinary research concerning plastic and microplastic pollution in our oceans, encompassing the investigation of the presence, distribution, and effects of plastic pollution, as well as its societal, legal, and health implications.

Teaching

Responsible for BIO216 Toxicology (course evaluation)

Supervisor in BIO299 Research practise in biology/molecular biology

Lecturer in BIO208 Environmental impact of aquaculture

Lecturer in BIO316 Selected topics in environmental toxicology

Scientific coordinator for the Environmental Toxicology master program at the Department of Biological Sciences

Publications
Lecture
Academic article
Academic lecture
Poster
Report
Doctoral dissertation
Feature article
Abstract
Academic literature review
Thesis at a second degree level

See a complete overview of publications in Cristin.

Projects

2023-2027; Whales and polar bear in a petri dish: decoding marine mammal toxicology through in vitro and in silico approaches – Marma-detox (RCN), WP-leader

2023-2027; Reproductive toxicity and generational effects of a contaminant mixture in fish (ToxiGen)(RCN), Partner

2021-2025;  Effects of antifouling copper coating in aquaculture – implications for fish health, performance and sustainability of production (CAPS)(RCN 325849), WP-leader

2020-2024; Distribution, fate and effects of microplastics in the appendicularian zooplankton Oikopleura dioica (UiB), PI

2021; dCod Pollution Sensing Kit (RCN 323092), Partner

2020-2023; Joint evaluation and mitigation of emerging contaminant risks (INTPART)(RCN (309476), WP-leader

2020-2022; Cellular responses to contaminant exposure in marine mammals from the Arctic (The FRAM-centre), Partner    

2020; 8th Norwegian Environmental Toxicology Symposium (NETS) – Ocean Health in the Anthropocene (RCN 311098), PI

2018-2021; Produced water fractionation and advanced chemical and toxicological characterization using sensitive life stages of marine fish species (PW-EXPOSED)(RCN 280511), WP-leader

2016-2021; dCod 1.0 – decoding the systems toxicology of Atlantic cod (Gadus morhua)(RCN(248840), WP-leader

2015-2019; iCod 2.0 - integrative environmental genomics of Atlantic cod (Gadus morhua)(RCN 244564), PI

2015-2019; Network for improving research based higher education in basic and applied microbiology( EURASIA, PEA-LT-2016/10095), Partner

2015-2016; In vitro fish: New 3D models for nutritional and toxicological research RCN (244507), Partner

2009-2013; iCod – integrative envionmental genomics of cod (Gadus morhua)(RCN (92441) , PI

Utdanning

 2005; Philosophiae Doctor (PhD) i molekylærbiologi. Tittel på avhandling: ”Molecular analyses of copper responding proteins in Methylococcus capsulatus (Bath)”. Molekylærbiologisk institutt, Universitetet i Bergen, Norge

2001; Candidatus scientiarum i molekylærbiologi. Tittel på hovedfagsoppgave: ”The proteome of Methylococcus capsulatus (Bath); An initial study by two-dimensional gel electrophoresis”. Molekylærbiologisk institutt, Universitetet i Bergen, Norge

1998; 35 vektall fra programmet "Høyskolekandidat i bioteknologi". Høyskolen i Hedmark, Hamar, Norge

Nylige forskningsartikler

Yadetie F, Brun NR, Giebichenstein J, Dmoch K, Hylland K, Borgå K, Karlsen OA, Goksøyr A. Transcriptome responses in copepods Calanus finmarchicus, Calanus glacialis and Calanus hyperboreus exposed to phenanthrene and benzo[a]pyrene. Mar Genomics. 2022 Aug 12;65:100981. doi: 10.1016/j.margen.2022.100981

Søderstrøm S, Lille-Langøy R, Yadetie F, Rauch M, Milinski A, Dejaegere A, Stote RH, Goksøyr A, Karlsen OA*. Agonistic and potentiating effects of perfluoroalkyl substances (PFAS) on the Atlantic cod (Gadus morhua) peroxisome proliferator-activated receptors (Ppars). Environ Int. 2022 May;163:107203. doi: 10.1016/j.envint.2022.107203.

Strobel A, Lille-Langøy R, Segner H, Burkhardt-Holm P, Goksøyr A, Karlsen OA. Xenobiotic metabolism and its physiological consequences in high-Antarctic Notothenioid fishes. Polar Biol. 2022;45(2):345-358. doi: 10.1007/s00300-021-02992-4

Dale K, Yadetie F, Horvli T, Zhang X, Frøysa HG, Karlsen OA, Goksøyr A. Single PFAS and PFAS mixtures affect nuclear receptor- and oxidative stress-related pathways in precision-cut liver slices of Atlantic cod (Gadus morhua). Sci Total Environ. 2022 Mar 25;814:152732. doi: 10.1016/j.scitotenv.2021.152732.

Lille-Langøy R, Jørgensen KB, Goksøyr A, Pampanin DM, Sydnes MO, Karlsen OA*. Substituted Two- to Five-Ring Polycyclic Aromatic Compounds Are Potent Agonists of Atlantic Cod (Gadus morhua) Aryl Hydrocarbon Receptors Ahr1a and Ahr2a. Environ Sci Technol. 2021 Nov 16;55(22):15123-15135. doi: 10.1021/acs.est.1c02946

Aranguren-Abadía L, Yadetie F, Donald CE, Sørhus E, Myklatun LE, Zhang X, Lie KK, Perrichon P, Nakken CL, Durif C, Shema S, Browman HI, Skiftesvik AB, Goksøyr A, Meier S, Karlsen OA*. Photo-enhanced toxicity of crude oil on early developmental stages of Atlantic cod (Gadus morhua). Sci Total Environ. 2022 Feb 10;807(Pt 1):150697. doi: 10.1016/j.scitotenv.2021.150697.

Goksøyr SØ, Goldstone J, Lille-Langøy R, Lock EJ, Olsvik PA, Goksøyr A, Karlsen OA*. Polycyclic aromatic hydrocarbons modulate the activity of Atlantic cod (Gadus morhua) vitamin D receptor paralogs in vitro. Aquat Toxicol. 2021 Jul 16;238:105914. doi: 10.1016/j.aquatox.2021.105914

Goksøyr SØ, Sørensen H, Grøsvik BE, Pampanin DM, Goksøyr A, Karlsen OA*. Toxicity assessment of urban marine sediments from Western Norway using a battery of stress-activated receptors and cell-based bioassays from fish. Environ Toxicol Pharmacol. 2021 Oct;87:103704. doi: 10.1016/j.etap.2021.103704.

Yadetie F, Brun NR, Vieweg I, Nahrgang J, Karlsen OA, Goksøyr A. Transcriptome responses in polar cod (Boreogadus saida) liver slice culture exposed to benzo[a]pyrene and ethynylestradiol: insights into anti-estrogenic effects. Toxicol In Vitro. 2021 Sep;75:105193. doi: 10.1016/j.tiv.2021.105193.

Eide M, Zhang X, Karlsen OA, Goldstone JV, Stegeman J, Jonassen I, Goksøyr A. The chemical defensome of five model teleost fish. Sci Rep. 2021 May 18;11(1):10546. doi: 10.1038/s41598-021-89948-0