The aim of my research in analytical chemistry is to maximize the information that can be gained from analytical instrumentation by application of chemometrics.

The activities to achieve this goal can be divided into the following categories:

• Extraction of information from spectra and chromatograms for the purpose of quantification and identification. This includes techniques such as noise reduction, spectral matching and deconvolution of overlapping signals 
• Prediction of chromatographic retention, and retention based methods for identification 
• Optimization and standardization of chromatographic conditions by means of response surface methodology 

In addition, I also develop Matlab based software for chromatography and mass spectrometry used in our teaching and research, and maintain databases of chromatographic and mass spectrometric data of fatty acid methyl esters.

 

Courses

I teach the subjects KJEM/FARM-250 (Analytical Chemistry), KJEM350 (Quantitative Organic Analysis), and EMQAL AM15.

Master’s projects

Master’s projects in chemometrics or analytical chemistry are offered to students in the master’s programs in chemistry and medical technology.

Several of the master's projects are carried out in external laboratories, typically at Haukeland University Hospital or the Institute of Marine Research.

 

 

Academic article

• Rimmen, Eira V.; Mjøs, Svein Are; Søfteland, Eirik et al. (2024). Intake of herring oil, but not of anchovy oil, resulted in a lower serum cholesterol concentration in male Zucker Diabetic Sprague Dawley rats. (external link)
• Nakken, Charlotte L.; Berntssen, Marc HG; Meier, Sonnich et al. (2024). Exposure of Polycyclic Aromatic Hydrocarbons (PAHs) and Crude Oil to Atlantic Haddock (Melanogrammus aeglefinus): A Unique Snapshot of the Mercapturic Acid Pathway. (external link)
• Chhaganlal, Milan Narendra; Mjøs, Svein Are; Underhaug, Jarl (2023). Evaluation of NMR predictors for accuracy and ability to reveal trends in ¹H NMR spectra of fatty acids. (external link)
• Zeng, Yingxu; Deng, Baichuan; Kang, Zixin et al. (2023). Tissue accumulation of polystyrene microplastics causes oxidative stress, hepatopancreatic injury and metabolome alterations in Litopenaeus vannamei. (external link)
• Laroche, Olivier; Meier, Sonnich; Mjøs, Svein Are et al. (2022). Suspension-feeding benthic species’ physiological and microbiome response to salmon farming and associated environmental changes. (external link)
• Laroche, Olivier; Meier, Sonnich; Mjøs, Svein A. et al. (2021). Effects of fish farm activities on the sponge Weberella bursa, and its associated microbiota. (external link)
• Drotningsvik, Aslaug; Oterhals, Åge; Mjøs, Svein Are et al. (2020). Effects of intact and hydrolysed blue whiting proteins on blood pressure and markers of kidney function in obese Zucker fa/fa rats. (external link)
• Lin, Chenchen; Sengee, Amarjargal; Mjøs, Svein Are (2020). Minor compounds and potential interferents in gas chromatographic analyses of human serum fatty acids. (external link)
• Hovland, Ida Heir; Leikanger, Ingrid Sande; Stokkeland, Oddbjørg et al. (2019). Effects of low doses of fish and milk proteins on glucose regulation and markers of insulin sensitivity in overweight adults: a randomised, double blind study. (external link)
• Drotningsvik, Aslaug; Vikøren, Linn Anja Slåke; Mjøs, Svein Are et al. (2018). Water-soluble fish protein intake led to lower serum and liver cholesterol concentrations in obese zucker fa/fa rats. (external link)
• Vikøren, Linn Anja Slåke; Drotningsvik, Aslaug; Mjøs, Svein Are et al. (2018). Salmon fillet intake led to higher serum triacylglycerol in obese zucker Fa/Fa rats but not in normolipidemic Long-Evans rats. (external link)
• Waktola, Habtewold Deti; Mjøs, Svein Are (2018). Chromatographic efficiency of polar capillary columns applied for the analysis of fatty acid methyl esters by gas chromatography. (external link)
• Steinrücken, Pia; Prestegard, Siv Kristin; de Vree, Jeroen Hendrik et al. (2018). Comparing EPA production and fatty acid profiles of three Phaeodactylum tricornutum strains under western Norwegian climate conditions. (external link)
• Vikøren, Linn Anja Slåke; Drotningsvik, Aslaug; Bergseth, Marthe Tønder et al. (2018). Intake of baked cod fillet resulted in lower serum cholesterol and higher long chain n-3 PUFA concentrations in serum and tissues in hypercholesterolemic obese Zucker fa/fa rats. (external link)
• Steinrücken, Pia; Mjøs, Svein Are; Prestegard, Siv Kristin et al. (2018). Enhancing EPA Content in an Arctic Diatom: A Factorial Design Study to Evaluate Interactive Effects of Growth Factors. (external link)
• Steinrücken, Pia; Erga, Svein Rune; Mjøs, Svein Are et al. (2017). Bioprospecting North Atlantic microalgae with fast growth and high polyunsaturated fatty acid (PUFA) content for microalgae-based technologies. (external link)
• Hvidsten, Ina; Mjøs, Svein Are; Bødtker, Gunhild et al. (2017). Lipids of Dietzia sp. A14101. Part II: A study of the dynamics of the release of surface active compounds by Dietzia sp. A14101 into the medium. (external link)
• Vikøren, Linn Anja Slåke; Drotningsvik, Aslaug; Bergseth, Marthe Tønder et al. (2017). Effects of baked and raw salmon fillet on lipids and n-3 PUFAs in serum and tissues in Zucker fa/fa rats. (external link)
• Helland, Anita; Bratlie, Marianne; Hagen, Ingrid Valheim et al. (2017). High intake of fatty fish, but not of lean fish, improved postprandial glucose regulation and increased the n-3 PUFA content in the leucocyte membrane in healthy overweight adults: A randomised trial. (external link)
• Hvidsten, Ina; Mjøs, Svein Are; Holmelid, Bjarte et al. (2017). Lipids of Dietzia sp. A14101. Part I: A study of the production dynamics of surface-active compounds. (external link)
• Sørensen, Lisbet; Meier, Sonnich; Mjøs, Svein Are (2016). Application of gas chromatography/tandem mass spectrometry to determine a wide range of petrogenic alkylated polycyclic aromatic hydrocarbons in biotic samples. (external link)
• Zeng, Yingxu; Mjøs, Svein Are; Araujo, Pedro et al. (2016). An LC–MS-based lipidomics approach for studying the impact of dietary eicosapentaenoic acid on modulating methylmercury toxicity in mice. (external link)
• Prestegard, Siv Kristin; Erga, Svein Rune; Steinrücken, Pia et al. (2016). Specific metabolites in a Phaeodactylum tricornutum strain isolated from Western Norwegian fjord water. (external link)
• Lin, Chenchen; Andersen, John Roger; Våge, Villy et al. (2016). Intensive lifestyle intervention provides rapid reduction of serum fatty acid levels in women with severe obesity without lowering omega-3 to unhealthy levels. (external link)
• Drotningsvik, Aslaug; Mjøs, Svein Are; Pampanin, Daniela Maria et al. (2016). Dietary fish protein hydrolysates containing bioactive motifs affect serum and adipose tissue fatty acid compositions, serum lipids, postprandial glucose regulation and growth in obese Zucker fa/fa rats.. (external link)
• Rajalahti, Tarja; Lin, Chenchen; Mjøs, Svein Are et al. (2016). Changes in serum fatty acid and lipoprotein subclass concentrations from prepuberty to adulthood and during aging. (external link)
• Araujo, Pedro; Zhu, Han; Breivik, Joar Fjørtoft et al. (2016). Plackett-Burman design and fragmentation studies to assist the 1 comparison of techniques used to extract phospholipids prior to regiospecific characterization by liquid chromatography mass spectrometry. (external link)
• Zeng, Yingxu; Mjøs, Svein Are; David, Fabrice et al. (2016). Extension of least squares spectral resolution algorithm to high-resolution lipidomics data. (external link)
• Zeng, Yingxu; Du, Zhen-yu; Mjøs, Svein Are et al. (2016). Methylmercury Increases and Eicosapentaenoic Acid Decreases the Relative Amounts of Arachidonic Acid-Containing Phospholipids in Mouse Brain. (external link)
• Lin, Chenchen; Rajalahti, Tarja; Mjøs, Svein Are et al. (2016). Predictive associations between serum fatty acids and lipoproteins in healthy non-obese Norwegians: implications for cardiovascular health. (external link)
• Rajalahti, Tarja; Lin, Chenchen; Mjøs, Svein Are et al. (2016). Serum fatty acid and lipoprotein subclass concentrations and their associations in prepubertal healthy Norwegian children. (external link)
• Mjøs, Svein Are; Waktola, Habtewold D. (2015). Optimizing the relationship between chromatographic efficiency and retention times in temperature-programmed gas chromatography. (external link)
• Hvidsten, Ina; Mjøs, Svein Are; Bødtker, Gunhild et al. (2015). Data on pigments and long-chain fatty compounds identified in Dietzia sp. A14101 grown on simple and complex hydrocarbons. (external link)
• Giskeødegård, Guro F.; Hansen, Ailin Falkmo; Bertilsson, Helena et al. (2015). Metabolic markers in blood can separate prostate cancer from benign prostatic hyperplasia. (external link)
• Hvidsten, Ina; Mjøs, Svein Are; Bødtker, Gunhild et al. (2015). Fatty acids in bacterium Dietzia sp grown on simple and complex hydrocarbons determined as FAME by GC-MS. (external link)
• Lin, Chenchen; Våge, Villy; Mjøs, Svein Are et al. (2015). Changes in Serum Fatty Acid Levels During the First Year After Bariatric Surgery. (external link)
• Apablaza, Patricia; Brevik, Øyvind Jakobsen; Mjøs, Svein Are et al. (2015). Variable Number of Tandem Repeats (VNTR) analysis of Flavobacterium psychrophilum from salmonids in Chile and Norway. (external link)
• Drotningsvik, Aslaug; Mjøs, Svein Are; Høgøy, Ingmar Johan et al. (2014). A low dietary intake of cod protein is sufficient to increase growth, improve serum and tissue fatty acid compositions, and lower serum postprandial glucose and fasting non-esterified fatty acid concentrations in obese Zucker fa/fa rats. (external link)
• Gudbrandsen, Oddrun Anita; Kodama, Yosuke; Mjøs, Svein Are et al. (2014). Effects of duodenal switch alone or in combination with sleeve gastrectomy on body weight and lipid metabolism in rats. (external link)
• Lin, Chenchen; Wasta, Ziar Miran; Mjøs, Svein Are (2014). Evaluation of the retention pattern on ionic liquid columns for gas chromatographic analyses of fatty acid methyl esters. (external link)
• Chhaganlal, Milan; Skartland, Liv Kjersti; Mjøs, Svein Are (2014). Transfer of retention patterns in gas chromatography by means of response surface methodology. (external link)
• Bekhit, Michael Yemane; Grung, Bjørn; Mjøs, Svein Are (2014). Determination of Omega-3 Fatty Acids in Fish Oil Supplements Using Vibrational Spectroscopy and Chemometric Methods . (external link)
• Samuelsen, Tor Andreas; Mjøs, Svein Are; Oterhals, Åge (2014). Influence of type of raw material on fishmeal physicochemical properties, the extrusion process, starch gelatinization and physical quality of fish feed. (external link)
• Samuelsen, Tor Andreas; Mjøs, Svein Are; Oterhals, Åge (2013). Impact of variability in fishmeal physicochemical properties on the extrusion process, starch gelatinization and pellet durability and hardness. (external link)
• Kousoulaki, Katerina; Rønnestad, Ivar; Olsen, Hanne Jorun et al. (2013). Krill hydrolysate free amino acids responsible for feed intake stimulation in Atlantic salmon (Salmo salar). (external link)
• Zeng, Yingxu; Mjøs, Svein Are; Meier, Sonnich et al. (2013). Least squares spectral resolution of liquid chromatography-mass spectrometry data of glycerophospholipids. (external link)
• Wasta, Ziar Miran; Mjøs, Svein Are (2013). A database of chromatographic properties and mass spectra of fatty acid methyl esters from omega-3 products. (external link)
• Kousoulaki, Katerina; Olsen, Hanne Jorun; Albrektsen, Sissel et al. (2012). High growth rates in Atlantic salmon (Salmo salar L.) fed 7.5% fish meal in the diet. Micro-, ultra- and nano-filtration of stickwater and effects of different fractions and compounds on pellet quality and fish performance. (external link)
• Xiao, Liping; Mjøs, Svein Are; Haugsgjerd, Bjørn Ole (2012). Efficiencies of three common lipid extraction methods evaluated by calculating mass balances of the fatty acids. (external link)
• Sciotto, Caterina; Mjøs, Svein Are (2012). Trans isomers of EPA and DHA in Omega-3 products on the European market. (external link)
• Skartland, Liv Kjersti; Mjøs, Svein Are; Grung, Bjørn (2011). Experimental designs for modeling retention patterns and separation efficiency in analysis of fatty acid methyl esters by gas chromatography-mass spectrometry. (external link)
• Mjøs, Svein Are; Haugsgjerd, Bjørn Ole (2011). Trans Fatty Acid Analyses in Samples of Marine Origin: The Risk of False Positives. (external link)
• Zhang, Liangxiao; Mjøs, Svein Are; Meier, Sonnich et al. (2010). The vector of calibration ratios: A simple transfer method for mass spectra. (external link)
• Mjøs, Svein Are; Grung, Bjørn (2009). A Rank annihilation approach to reducing the scan-effect in gas chromatography-mass spectrometry data. (external link)
• Mjøs, Svein Are (2008). Retention behavior of trans isomers of eicosapentaenoic and docosahexaenoic acid methyl esters on a polyethylene glycol stationary phase. (external link)
• Boitsov, Stepan; Mjøs, Svein Are; Meier, Sonnich (2007). Identification of estrogen-like alkylphenols in produced water from offshore oil installations. (external link)
• Mjøs, Svein Are; Meier, Sonnich; Boitsov, Stepan (2006). Alkylphenol retention indices. (external link)
• Mjøs, Svein Are; Meier, Sonnich; Grahl-Nielsen, Otto (2006). Geometrical isomerisation of double bonds in acid catalysed preparation of fatty acid methyl esters. (external link)
• Mjøs, Svein Are; Solvang, Marianne (2006). Patterns in volatile components over heated fish powders. (external link)
• Mjøs, Svein Are; Solvang, Marianne (2006). Geometrical isomerisation of EPA and DHA at high temperatures. (external link)
• Meier, Sonnich; Mjøs, Svein Are; Joensen, Horaldur et al. (2006). Validation of a one-step extraction/methylation method for determination of fatty acids and cholesterol in marine tissues. (external link)
• Mjøs, Svein Are (2006). Prediction of equivalent chain lengths from two-dimensional fatty acid retention indices. (external link)
• Mjøs, Svein Are (2005). Properties of trans isomers of eicosapentaenoic acid and eicosahexaenoic acid methyl esters on cyanopropyl stationary phases. (external link)
• Mjøs, Svein Are (2004). Two-dimensional fatty acid retention indices. (external link)
• Mjøs, Svein Are (2004). Quantification of linolenic acid isomers by gas chromatography-mass spectrometry and deconvolution of overlapping chromatographic peaks. (external link)
• Mjøs, Svein Are (2004). The prediction of fatty acid structure from selected ions in electron impact mass spectra of fatty acid methyl esters. (external link)
• Mjøs, Svein Are (2003). Spectral transformations for deconvolution methods applied on gas chromatography–mass spectrometry data. (external link)
• Mjøs, Svein Are; Pettersen, Jan (2003). Determination of trans double bonds in polyunsaturated fatty acid methyl esters from their electron impact mass spectra. (external link)
• Mjøs, Svein Are; Pettersen, jan (2003). A rapid method for the analysis of hydrogenated fats by GC with IR detection. (external link)
• Mjøs, Svein Are (2003). Identification of fatty acids in gas chromatography by application of different temperature and pressure programs on a single capillary column. (external link)

Doctoral dissertation

• Steinrücken, Pia; Erga, Svein Rune; Prestegard, Siv Kristin et al. (2018). High-value fatty acids from microalgae. Bioprospecting and outdoor cultivation at northern latitudes. (external link)
• Zeng, Yingxu; Mjøs, Svein Are (2015). Application of liquid chromatographymass spectrometry and chemometrics in the automated characterization of molecular lipid species. (external link)
• Samuelsen, Tor Andreas; Oterhals, Åge; Mjøs, Svein Are (2015). Fishmeal physicochemical properties – Impact on the fish feed extrusion process, phase transitions and physical pellet quality. (external link)
• Mjøs, Svein Are (2006). Interpretation of chromatographic and mass spectrometric data from analyses of fatty acid methyl esters – Application of multivariate methods. (external link)

See a complete overview of publications in Cristin.

Selected publications:

M.N. Chhaganlal, J. Underhaug, S.A. Mjøs*, Evaluation of NMR predictors for accuracy and ability to reveal trends in 1H NMR spectra of fatty acids, MAGNETIC RESONANCE IN CHEMISTRY 61 (2023) 318-332. DOI: 10.1002/mrc.5336

C.C. Lin, A. Sengee, S.A. Mjøs*, Minor compounds and potential interferents in gas chromatographic analyses of human serum fatty acids. JOURNAL OF CHROMATOGRAPHY B 1138 (2020) 121963. DOI: 10.1016/j.jchromb.2019.121963

H.D. Waktola, S.A. Mjøs*, Chromatographic efficiency of polar capillary columns applied for the analysis of fatty acid methyl esters by gas chromatography, JOURNAL OF SEPARATION SCIENCE 41 (2018) 1582-1592. DOI: 10.1002/jssc.201700908

Y. Zeng, S.A. Mjøs*, F.P.A. David, A.W. Schmid, Extension of least squares spectral resolution algorithm to high-resolution lipidomics data. ANALYTICA CHIMICA ACTA 914 (2016) 35-46. DOI: 10.1016/j.aca.2016.02.002

S.A. Mjøs*, H.D. Waktola, Optimizing the relationship between chromatographic efficiency and retention times in temperature-programmed gas chromatography. JOURNAL OF SEPARATION SCIENCE 38 (2015) 3014-3027. DOI: 10.1002/jssc.201500364

M. Chhaganlal, L.K. Skartland, S.A. Mjøs*, Transfer  of retention patterns in gas chromatography by means of response surface  methodology, JOURNAL OF CHROMATOGRAPHY A 1332 (2014) 64-72. DOI: 10.1016/j.chroma.2014.01.039

Z. Wasta, S.A. Mjøs*, A database of chromatographic properties and mass spectra of fatty acid methyl esters from omega-3 products. JOURNAL OF CHROMATOGRAPHY A 1299 (2013) 94-102. DOI: 10.1016/j.chroma.2013.05.056

Y. Zeng, S.A. Mjøs*, S. Meier, C. Lin, R. Vadla, Least squares spectral resolution of liquid chromatography-mass  spectrometry data of glycerophospholipids. JOURNAL OF CHROMATOGRAPHY A  1280 (2013) 23-34. DOI: 10.1016/j.chroma.2012.12.070

C. Sciotto, S.A. Mjøs*, Trans isomers of EPA and DHA in omega-3 products on the European market. LIPIDS 47 (2012) 659-667. DOI: 10.1007/s11745-012-3672-3

L.K. Skartland, S.A. Mjøs*, B. Grung, Experimental designs for modeling retention patterns and separation efficiency in analysis of fatty acid methyl esters by gas chromatography-mass spectrometry. JOURNAL OF CHROMATOGRAPHY A 1218 (2011) 6823-6831. DOI: 10.1016/j.chroma.2011.07.077

S.A. Mjøs*, B. Grung, A Rank annihilation approach to reducing the scan-effect in gas chromatography-mass spectrometry data. ANALYTICA CHIMICA ACTA 640 (2009) 33-39. DOI: 10.1016/j.aca.2009.03.011

S. Meier*, S.A. Mjøs, H. Joensen, O. Grahl-Nielsen, Validation of a one-step extraction/methylation method for determination of fatty acids and cholesterol in marine tissues. JOURNAL OF CHROMATOGRAPHY A 1104 (2006) 291-298. DOI: 10.1016/j.chroma.2005.11.045

S.A. Mjøs, S. Meier, S. Boitsov*, Alkylphenol retention indices. JOURNAL OF CHROMATOGRAPHY A 1123 (2006) 98-105. DOI: 10.1016/j.chroma.2006.05.002

S.A. Mjøs*, O. Grahl-Nielsen, Prediction of gas chromatographic retention of polyunsaturated fatty acid methyl esters. JOURNAL OF CHROMATOGRAPHY A 1110 (2006) 171-180. DOI: 10.1016/j.chroma.2006.01.092

S.A. Mjøs*, The prediction of fatty acid structure from selected ions in electron impact mass spectra of fatty acid methyl esters. EUROPEAN JOURNAL OF LIPID SCIENCE AND TECHNOLOGY 106 (2004) 550-560. DOI: 10.1002/ejlt.200401013

S.A. Mjøs*, Two-dimensional fatty acid retention indices. JOURNAL OF CHROMATOGRAPHY A 1061 (2004) 201-209. DOI: 10.1016/j.chroma.2004.11.025

S.A. Mjøs*, Identification of fatty acids in gas  chromatography by application of different temperature and pressure programs  on a single capillary column. JOURNAL OF CHROMATOGRAPHY A 1015 (2003)  151-161. DOI: 10.1016/S0021-9673(03)01240-8

S.A. Mjøs*, Spectral transformations for deconvolution methods applied on gas chromatography-mass spectrometry data. ANALYTICA CHIMICA ACTA 488 (2003) 231-241. DOI: 10.1016/S0003-2670(03)00679-2

S.A. Mjøs*, J. Pettersen, A rapid method for the analysis of hydrogenated  fats by GC with IR detection. JOURNAL OF THE AMERICAN OIL CHEMISTS  SOCIETY 80 (2003) 839-846. DOI: 10.1007/s11746-003-0783-0

All publications in Christin: