I hold a PhD from the University of Bergen on molecular alterations suggesting new treatment strategies in uterine carcinomas. I am currently a researcher in the Bergen Gynecological Cancer Research Group, working on gynecological cancer. My main focus is to characterize targetable molecular alterations driving aggressive uterine carcinoma. Currently, I am working on a study comparing radiomic features from whole tumor segmented magnetic resonance imaging (MRI) scans to genomic profiles. This radiogenomic approach will detect novel prognosticators for disease outcome and may reveal new treatment strategies in cervical cancer.

Academic article

• Mari Kyllesø Halle; Erlend Hodneland; Kari Strøno Wagner-Larsen et al. (2024). Radiomic profiles improve prognostication and reveal targets for therapy in cervical cancer. (external link)
• Hege Fredriksen Berg; Zhenlin Ju; Madeleine Myrvold et al. (2020). Development of prediction models for lymph node metastasis in endometrioid endometrial carcinoma. (external link)
• David Erik Forsse; Hege Fredriksen Berg; Olivera Bozickovic et al. (2020). Maintained survival outcome after reducing lymphadenectomy rates and optimizing adjuvant treatment in endometrial cancer. (external link)
• Magdalene A Earp; Linda E. Kelemen; Anthony M. Magliocco et al. (2014). Genome-wide association study of subtype-specific epithelial ovarian cancer risk alleles using pooled DNA. (external link)
• Stefania Bellone; Kyungjo Jeong; Mari Kyllesø Halle et al. (2024). Integrated mutational landscape analysis of poorly differentiated high-grade neuroendocrine carcinoma of the uterine cervix. (external link)
• Elin Strand; Ingvild Løberg Tangen; Kristine Eldevik Fasmer et al. (2019). Blood metabolites associate with prognosis in endometrial cancer. (external link)
• Hilde Renate Haugen Engerud; Ingvild Løberg Tangen; Ansgar Berg et al. (2014). High level of HSF1 associates with aggressive endometrial carcinoma and suggests potential for HSP90 inhibitors. (external link)
• Mari Kyllesø Halle; Aishwarya Sundaresan; Jianqing Zhang et al. (2021). Genomic alterations associated with mutational signatures, DNA damage repair and chromatin remodeling pathways in cervical carcinoma.. (external link)
• Hilde Renate Engerud; Hege Fredriksen Berg; Madeleine Myrvold et al. (2020). High degree of heterogeneity of PD-L1 and PD-1 from primary to metastatic endometrial cancer. (external link)
• Kari Strøno Wagner-Larsen; Njål Gjærde Lura; Øyvind Salvesen et al. (2022). Interobserver agreement and prognostic impact for MRI–based 2018 FIGO staging parameters in uterine cervical cancer. (external link)
• Henrica Maria Johanna Werner; Jone Trovik; Mari Kyllesø Halle et al. (2014). Stathmin Protein Level, a Potential Peredictive Marker for Taxane Treatment Response in Endometrial Cancer. (external link)
• Hui Shen; BL Fridley; HL Song et al. (2013). Epigenetic analysis leads to identification of HNF1B as a subtype-specific susceptibility gene for ovarian cancer. (external link)
• Ingvild Løberg Tangen; Henrica Maria Johanna Werner; Anna Berg et al. (2014). Loss of progesterone receptor links to high proliferation and increases from primary to metastatic endometrial cancer lesions. (external link)
• Mari Kyllesø Halle; Marte Sødal; David Erik Forsse et al. (2021). A 10-gene prognostic signature points to LIMCH1 and HLA-DQB1 as important players in aggressive cervical cancer disease. (external link)
• Mari Kyllesø Halle; Camilla Krakstad; Hilde Renate Haugen Engerud et al. (2014). Molecular profiling in fresh tissue with high tumor cell content promotes enrichment for aggressive adenocarcinomas in cervix. (external link)
• Erling Andre Høivik; Erlend Hodneland; Julie Andrea Dybvik et al. (2021). A radiogenomics application for prognostic profiling of endometrial cancer. (external link)
• Kari Strøno Wagner-Larsen; Erlend Hodneland; Kristine Eldevik Fasmer et al. (2023). MRI-based radiomic signatures for pretreatment prognostication in cervical cancer. (external link)
• Ingvild Løberg Tangen; Jennifer Taylor Venereis; Mari Kyllesø Halle et al. (2017). Expression of glucocorticoid receptor is associated with aggressive primary endometrial cancer and increases from primary to metastatic lesions. (external link)
• Agnes Jørgensen Eide; Mari Kyllesø Halle; Njål Lura et al. (2023). Visceral fat percentage for prediction of outcome in uterine cervical cancer. (external link)
• Elisabeth Wik; Jone Trovik; Kanthida Kusonmano et al. (2014). Endometrial Carcinoma Recurrence Score (ECARS) validates to identify aggressive disease and associates with markers of epithelial-mesenchymal transition and PI3K alterations. (external link)
• Anna Berg; Kristine Eldevik Fasmer; Karen Klepsland Mauland et al. (2016). Tissue and imaging biomarkers for hypoxia predict poor outcome in endometrial cancer. (external link)
• Mari Kyllesø Halle; Akinyemi I Ojesina; Hilde Renate Engerud et al. (2017). Clinicopathologic and molecular markers in cervical carcinoma: a prospective cohort study. (external link)
• Fiona J. Ruiz; Aishwarya Sundaresan; Jin Zhang et al. (2021). Genomic characterization and therapeutic targeting of HPV undetected cervical carcinomas. (external link)
• Erlend Hodneland; Sathiesh Kumar Kaliyugarasan; Kari Strøno Wagner-Larsen et al. (2022). Fully Automatic Whole-Volume Tumor Segmentation in Cervical Cancer. (external link)
• Kanthida Kusonmano; Mari Kyllesø Halle; Elisabeth Wik et al. (2018). Identification of highly connected and differentially expressed gene subnetworks in metastasizing endometrial cancer. (external link)
• William J. Gibson; Erling Andre Høivik; Mari Kyllesø Halle et al. (2016). The genomic landscape and evolution of endometrial carcinoma progression and abdominopelvic metastasis. (external link)
• David Erik Forsse; Ingvild Løberg Tangen; Kristine Eldevik Fasmer et al. (2019). Blood steroid levels predict survival in endometrial cancer and reflect tumor estrogen signaling. (external link)
• Ingvild Løberg Tangen; Therese Bredholt Onyango; Reidun Kristin Kopperud et al. (2016). Androgen receptor as potential therapeutic target in metastatic endometrial cancer. (external link)
• Camilla Krakstad; Ingvild Løberg Tangen; Erling Andre Høivik et al. (2015). ATAD2 overexpression links to enrichment of B-MYBtranslational signatures and development of aggressive endometrial carcinoma. (external link)
• Mari Kyllesø Halle; Ingvild Løberg Tangen; Hege Fredriksen Berg et al. (2017). HER2 expression patterns in paired primary and metastatic endometrial cancer lesions. (external link)
• Akinyemi Ojesina; Lee Lichtenstein; Samuel S. Freeman et al. (2014). Landscape of genomic alterations in cervical carcinomas. (external link)
• Liv Beathe Gansmo; Merete Pauline Bjørnslett; Mari Kyllesø Halle et al. (2017). MDM2 promoter polymorphism del1518 (rs3730485) and its impact on endometrial and ovarian cancer risk. (external link)
• Bridget Charbonneau; MS Block; WR Bamlet et al. (2014). Risk of ovarian cancer and the NF-kB pathway: Genetic association with IL1A and TNFSF10. (external link)
• Nigar Sofiyeva; Camilla Krakstad; Mari Kyllesø Halle et al. (2022). APOBEC3A/B deletion polymorphism and endometrial cancer risk. (external link)
• Hege Fredriksen Berg; Jone Trovik; Marta Espevold Hjelmeland et al. (2025). Pragmatic preoperative molecular classification of endometrial cancers; Replacing POLE sequencing with hormone receptor staining. (external link)
• Ingvild Løberg Tangen; Camilla Krakstad; Mari Kyllesø Halle et al. (2014). Switch in FOXA1 status associates with endometrial cancer progression. (external link)
• Marit Louise Ulvang; Oda Vik Fløtre; Hege Fredriksen Berg et al. (2025). Co-expression of tissue factor, TROP2, and NECTIN4 in primary and matched metastatic cervical cancer lesions. (external link)
• Njål Gjærde Lura; Kari Strøno Wagner-Larsen; David Erik Forsse et al. (2022). What MRI-based tumor size measurement is best for predicting long-term survival in uterine cervical cancer?. (external link)
• Karen Klepsland Mauland; Elisabeth Wik; Erling Andre Høivik et al. (2016). Aneuploidy related transcriptional changes in endometrial cancer link low expression of chromosome 15q genes to poor survival. (external link)
• Vikram Rao Bollineni; Sigmund Ytre-Hauge; Ankush Gulati et al. (2018). The prognostic value of preoperative FDG-PET/CT metabolic parameters in cervical cancer patients. (external link)
• Anna Berg; Ankush Gulati; Sigmund Ytre-Hauge et al. (2017). Preoperative imaging markers and PDZ-binding kinase tissue expression predict low-risk disease in endometrial hyperplasias and low grade cancers. (external link)
• Jennifer Permuth-Wey; K Lawrenson; HC Shen et al. (2013). Identification and molecular characterization of a new ovarian cancer susceptibility locus at 17q21.31. (external link)
• Paul D.P. Pharoah; Mari Kyllesø Halle; Camilla Krakstad et al. (2013). GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer. (external link)
• Njål Lura; Kari Strøno Wagner-Larsen; Stian Torkildson Ryste et al. (2025). Tumor ADC value predicts outcome and yields refined prognostication in uterine cervical cancer. (external link)
• Siv Mjøs; Henrica Maria Johanna Werner; Even Birkeland et al. (2017). PIK3CA exon9 mutations associate with reduced survival, and are highly concordant between matching primary tumors and metastases in endometrial cancer. (external link)
• Ankur Chakravarthy; Ian Reddin; Stephen Henderson et al. (2022). Integrated analysis of cervical squamous cell carcinoma cohorts from three continents reveals conserved subtypes of prognostic significance. (external link)
• Camilla Krakstad; Hege Fredriksen Berg; Kristina Yvonne Kathe Lindemann et al. (2024). Frequency of ERBB2-Low Expression in Endometrial Cancer. (external link)
• Jirong Long; Wei Zheng; Yong-Bing Xiang et al. (2012). Genome-wide association study identifies a possible susceptibility locus for endometrial cancer. (external link)
• Ryan J. Delahanty; Yong-Bing Xiang; Amanda Spurdle et al. (2013). Polymorphisms in inflammation pathway genes and endometrial cancer risk. (external link)
• Hanna Helgeland; Simen Rød Sandve; Jacob Torgersen et al. (2014). The evolution and functional divergence of the beta-carotene oxygenase gene family in teleost fish-Exemplified by Atlantic salmon. (external link)
• Camilla Krakstad; Even Birkeland; Danila Seidel et al. (2012). High-throughput mutation profiling of primary and metastatic endometrial cancers identifies KRAS, FGFR2 and PIK3CA to be frequently mutated. (external link)
• Hege Fredriksen Berg; Hilde Renate Engerud; Madeleine Myrvold et al. (2022). Mismatch repair markers in preoperative and operative endometrial cancer samples; expression concordance and prognostic value. (external link)
• Stig E. Bojesen; Karen A Pooley; Sharon E Johnatty et al. (2013). Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer. (external link)
• Frederik Holst; Henrica Maria Johanna Werner; Siv Mjøs et al. (2019). PIK3CA amplification associates with aggressive phenotype but not markers of AKT-mTOR signaling in endometrial carcinoma. (external link)
• Erling Andre Høivik; Kanthida Kusonmano; Mari Kyllesø Halle et al. (2014). Hypomethylation of the CTCFL/BORIS promoter and aberrant expression during endometrial cancer progression suggests a role as an Epi-driver gene. (external link)
• Erlend Hodneland; Erling Andersen; Kari Strøno Wagner-Larsen et al. (2024). Impact of MRI radiomic feature normalization for prognostic modelling in uterine endometrial and cervical cancers. (external link)
• Mari Kyllesø Halle; Ane Cecilie Dæhli Munk; Birgit Øvstebø Engesæter et al. (2021). A gene signature identifying CIN3 regression and cervical cancer survival. (external link)
• Anna Berg; Erling Andre Høivik; Siv Mjøs et al. (2015). Molecular profiling of endometrial carcinoma precursor, primary and metastatic lesions suggests different targets for treatment in obese compared to non-obese patients. (external link)
• Ji-Yeon Yang; Henrica Maria Johanna Werner; Jie Li et al. (2016). Integrative protein-based prognostic model for early-stage endometrioid endometrial cancer. (external link)
• Mari Kyllesø Halle; Olivera Bozickovic; David Erik Forsse et al. (2024). Clinicopathological and radiological stratification within FIGO 2018 stages improves risk-prediction in cervical cancer. (external link)
• Madeleine Charlotte van der Berg; Hege Fredriksen Berg; Tomasz Stokowy et al. (2024). Expression patterns of mismatch repair proteins in cervical cancer uncover independent prognostic value of MSH-2. (external link)
• Irene Tveiterås Øvestad; Birgit Øvstebø Engesæter; Mari Kyllesø Halle et al. (2021). High-Grade Cervical Intraepithelial Neoplasia (CIN) Associates with Increased Proliferation and Attenuated Immune Signaling. (external link)
• Hilde Eide Lien; Hege Fredriksen Berg; Mari Kyllesø Halle et al. (2023). Single-cell profiling of low-stage endometrial cancers identifies low epithelial vimentin expression as a marker of recurrent disease. (external link)
• Kari Strøno Wagner-Larsen; Njål Lura; Ankush Gulati et al. (2025). MRI delta radiomics during chemoradiotherapy for prognostication in locally advanced cervical cancer. (external link)
• Reham Helwa; Liv Beathe Gansmo; Merete Pauline Bjørnslett et al. (2021). Impact of MDM2 promoter SNP55 (rs2870820) on risk of endometrial and ovarian cancer. (external link)
• Liv Beathe Gansmo; Merete Pauline Bjørnslett; Mari Kyllesø Halle et al. (2016). The MDM4 SNP34091 (rs4245739) C-allele is associated with increased risk of ovarian—but not endometrial cancer. (external link)

Doctoral thesis (PhD)

• Mari Kyllesø Halle; Helga Salvesen; Camilla Krakstad (2017). Molecular alterations suggesting new treatment strategies in uterine carcinomas. (external link)

Journal corrigendum

• Hilde Eide Lien; Hege Fredriksen Berg; Mari Kyllesø Halle et al. (2023). Corrigendum to “Single-cell profiling of low-stage endometrial cancers identifies low epithelial vimentin expression as a marker of recurrent disease” [EBioMedicine 92 (2023) 104595] (eBioMedicine (2023) 92, (S2352396423001603), (10.1016/j.ebiom.2023.104595)). (external link)

Letter to the editor

• Mari Kyllesø Halle; Henrica Maria Johanna Werner; Camilla Krakstad et al. (2012). Stratification based on high tumour cell content in fresh frozen tissue promotes selection of aggressive endometrial carcinomas. (external link)

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