Jeg har en PhD fra Universitetet i Bergen (2017) der jeg undersøkte molekylære endringer i uterine svulster. Jeg er for tiden forsker i Bergen Gynekologiske Krefforskningsgruppe der mitt hovedfokus er å karakterisere kreftdrivere som man kan målrette behandling mot - med fokus på de mest aggressive uterine svulstene. jeg ser på genomiske, molekylære, radiologiske, og kliniskpatologiske drivere i disse kreftsvulstene og prøver å finne gode biomarkører for forbedret diagnostikk og prediksjon av behandlingsrespons. 

Vitenskapelig artikkel

• Mari Kyllesø Halle; Erlend Hodneland; Kari Strøno Wagner-Larsen et al. (2024). Radiomic profiles improve prognostication and reveal targets for therapy in cervical cancer. (ekstern lenke)
• Hege Fredriksen Berg; Zhenlin Ju; Madeleine Myrvold et al. (2020). Development of prediction models for lymph node metastasis in endometrioid endometrial carcinoma. (ekstern lenke)
• David Erik Forsse; Hege Fredriksen Berg; Olivera Bozickovic et al. (2020). Maintained survival outcome after reducing lymphadenectomy rates and optimizing adjuvant treatment in endometrial cancer. (ekstern lenke)
• Magdalene A Earp; Linda E. Kelemen; Anthony M. Magliocco et al. (2014). Genome-wide association study of subtype-specific epithelial ovarian cancer risk alleles using pooled DNA. (ekstern lenke)
• Stefania Bellone; Kyungjo Jeong; Mari Kyllesø Halle et al. (2024). Integrated mutational landscape analysis of poorly differentiated high-grade neuroendocrine carcinoma of the uterine cervix. (ekstern lenke)
• Elin Strand; Ingvild Løberg Tangen; Kristine Eldevik Fasmer et al. (2019). Blood metabolites associate with prognosis in endometrial cancer. (ekstern lenke)
• Hilde Renate Haugen Engerud; Ingvild Løberg Tangen; Ansgar Berg et al. (2014). High level of HSF1 associates with aggressive endometrial carcinoma and suggests potential for HSP90 inhibitors. (ekstern lenke)
• Mari Kyllesø Halle; Aishwarya Sundaresan; Jianqing Zhang et al. (2021). Genomic alterations associated with mutational signatures, DNA damage repair and chromatin remodeling pathways in cervical carcinoma.. (ekstern lenke)
• Hilde Renate Engerud; Hege Fredriksen Berg; Madeleine Myrvold et al. (2020). High degree of heterogeneity of PD-L1 and PD-1 from primary to metastatic endometrial cancer. (ekstern lenke)
• Kari Strøno Wagner-Larsen; Njål Gjærde Lura; Øyvind Salvesen et al. (2022). Interobserver agreement and prognostic impact for MRI–based 2018 FIGO staging parameters in uterine cervical cancer. (ekstern lenke)
• Henrica Maria Johanna Werner; Jone Trovik; Mari Kyllesø Halle et al. (2014). Stathmin Protein Level, a Potential Peredictive Marker for Taxane Treatment Response in Endometrial Cancer. (ekstern lenke)
• Hui Shen; BL Fridley; HL Song et al. (2013). Epigenetic analysis leads to identification of HNF1B as a subtype-specific susceptibility gene for ovarian cancer. (ekstern lenke)
• Ingvild Løberg Tangen; Henrica Maria Johanna Werner; Anna Berg et al. (2014). Loss of progesterone receptor links to high proliferation and increases from primary to metastatic endometrial cancer lesions. (ekstern lenke)
• Mari Kyllesø Halle; Marte Sødal; David Erik Forsse et al. (2021). A 10-gene prognostic signature points to LIMCH1 and HLA-DQB1 as important players in aggressive cervical cancer disease. (ekstern lenke)
• Mari Kyllesø Halle; Camilla Krakstad; Hilde Renate Haugen Engerud et al. (2014). Molecular profiling in fresh tissue with high tumor cell content promotes enrichment for aggressive adenocarcinomas in cervix. (ekstern lenke)
• Erling Andre Høivik; Erlend Hodneland; Julie Andrea Dybvik et al. (2021). A radiogenomics application for prognostic profiling of endometrial cancer. (ekstern lenke)
• Kari Strøno Wagner-Larsen; Erlend Hodneland; Kristine Eldevik Fasmer et al. (2023). MRI-based radiomic signatures for pretreatment prognostication in cervical cancer. (ekstern lenke)
• Ingvild Løberg Tangen; Jennifer Taylor Venereis; Mari Kyllesø Halle et al. (2017). Expression of glucocorticoid receptor is associated with aggressive primary endometrial cancer and increases from primary to metastatic lesions. (ekstern lenke)
• Agnes Jørgensen Eide; Mari Kyllesø Halle; Njål Lura et al. (2023). Visceral fat percentage for prediction of outcome in uterine cervical cancer. (ekstern lenke)
• Elisabeth Wik; Jone Trovik; Kanthida Kusonmano et al. (2014). Endometrial Carcinoma Recurrence Score (ECARS) validates to identify aggressive disease and associates with markers of epithelial-mesenchymal transition and PI3K alterations. (ekstern lenke)
• Anna Berg; Kristine Eldevik Fasmer; Karen Klepsland Mauland et al. (2016). Tissue and imaging biomarkers for hypoxia predict poor outcome in endometrial cancer. (ekstern lenke)
• Mari Kyllesø Halle; Akinyemi I Ojesina; Hilde Renate Engerud et al. (2017). Clinicopathologic and molecular markers in cervical carcinoma: a prospective cohort study. (ekstern lenke)
• Fiona J. Ruiz; Aishwarya Sundaresan; Jin Zhang et al. (2021). Genomic characterization and therapeutic targeting of HPV undetected cervical carcinomas. (ekstern lenke)
• Erlend Hodneland; Sathiesh Kumar Kaliyugarasan; Kari Strøno Wagner-Larsen et al. (2022). Fully Automatic Whole-Volume Tumor Segmentation in Cervical Cancer. (ekstern lenke)
• Kanthida Kusonmano; Mari Kyllesø Halle; Elisabeth Wik et al. (2018). Identification of highly connected and differentially expressed gene subnetworks in metastasizing endometrial cancer. (ekstern lenke)
• William J. Gibson; Erling Andre Høivik; Mari Kyllesø Halle et al. (2016). The genomic landscape and evolution of endometrial carcinoma progression and abdominopelvic metastasis. (ekstern lenke)
• David Erik Forsse; Ingvild Løberg Tangen; Kristine Eldevik Fasmer et al. (2019). Blood steroid levels predict survival in endometrial cancer and reflect tumor estrogen signaling. (ekstern lenke)
• Ingvild Løberg Tangen; Therese Bredholt Onyango; Reidun Kristin Kopperud et al. (2016). Androgen receptor as potential therapeutic target in metastatic endometrial cancer. (ekstern lenke)
• Camilla Krakstad; Ingvild Løberg Tangen; Erling Andre Høivik et al. (2015). ATAD2 overexpression links to enrichment of B-MYBtranslational signatures and development of aggressive endometrial carcinoma. (ekstern lenke)
• Mari Kyllesø Halle; Ingvild Løberg Tangen; Hege Fredriksen Berg et al. (2017). HER2 expression patterns in paired primary and metastatic endometrial cancer lesions. (ekstern lenke)
• Akinyemi Ojesina; Lee Lichtenstein; Samuel S. Freeman et al. (2014). Landscape of genomic alterations in cervical carcinomas. (ekstern lenke)
• Liv Beathe Gansmo; Merete Pauline Bjørnslett; Mari Kyllesø Halle et al. (2017). MDM2 promoter polymorphism del1518 (rs3730485) and its impact on endometrial and ovarian cancer risk. (ekstern lenke)
• Bridget Charbonneau; MS Block; WR Bamlet et al. (2014). Risk of ovarian cancer and the NF-kB pathway: Genetic association with IL1A and TNFSF10. (ekstern lenke)
• Nigar Sofiyeva; Camilla Krakstad; Mari Kyllesø Halle et al. (2022). APOBEC3A/B deletion polymorphism and endometrial cancer risk. (ekstern lenke)
• Hege Fredriksen Berg; Jone Trovik; Marta Espevold Hjelmeland et al. (2025). Pragmatic preoperative molecular classification of endometrial cancers; Replacing POLE sequencing with hormone receptor staining. (ekstern lenke)
• Ingvild Løberg Tangen; Camilla Krakstad; Mari Kyllesø Halle et al. (2014). Switch in FOXA1 status associates with endometrial cancer progression. (ekstern lenke)
• Marit Louise Ulvang; Oda Vik Fløtre; Hege Fredriksen Berg et al. (2025). Co-expression of tissue factor, TROP2, and NECTIN4 in primary and matched metastatic cervical cancer lesions. (ekstern lenke)
• Njål Gjærde Lura; Kari Strøno Wagner-Larsen; David Erik Forsse et al. (2022). What MRI-based tumor size measurement is best for predicting long-term survival in uterine cervical cancer?. (ekstern lenke)
• Karen Klepsland Mauland; Elisabeth Wik; Erling Andre Høivik et al. (2016). Aneuploidy related transcriptional changes in endometrial cancer link low expression of chromosome 15q genes to poor survival. (ekstern lenke)
• Vikram Rao Bollineni; Sigmund Ytre-Hauge; Ankush Gulati et al. (2018). The prognostic value of preoperative FDG-PET/CT metabolic parameters in cervical cancer patients. (ekstern lenke)
• Anna Berg; Ankush Gulati; Sigmund Ytre-Hauge et al. (2017). Preoperative imaging markers and PDZ-binding kinase tissue expression predict low-risk disease in endometrial hyperplasias and low grade cancers. (ekstern lenke)
• Jennifer Permuth-Wey; K Lawrenson; HC Shen et al. (2013). Identification and molecular characterization of a new ovarian cancer susceptibility locus at 17q21.31. (ekstern lenke)
• Paul D.P. Pharoah; Mari Kyllesø Halle; Camilla Krakstad et al. (2013). GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer. (ekstern lenke)
• Njål Lura; Kari Strøno Wagner-Larsen; Stian Torkildson Ryste et al. (2025). Tumor ADC value predicts outcome and yields refined prognostication in uterine cervical cancer. (ekstern lenke)
• Siv Mjøs; Henrica Maria Johanna Werner; Even Birkeland et al. (2017). PIK3CA exon9 mutations associate with reduced survival, and are highly concordant between matching primary tumors and metastases in endometrial cancer. (ekstern lenke)
• Ankur Chakravarthy; Ian Reddin; Stephen Henderson et al. (2022). Integrated analysis of cervical squamous cell carcinoma cohorts from three continents reveals conserved subtypes of prognostic significance. (ekstern lenke)
• Camilla Krakstad; Hege Fredriksen Berg; Kristina Yvonne Kathe Lindemann et al. (2024). Frequency of ERBB2-Low Expression in Endometrial Cancer. (ekstern lenke)
• Jirong Long; Wei Zheng; Yong-Bing Xiang et al. (2012). Genome-wide association study identifies a possible susceptibility locus for endometrial cancer. (ekstern lenke)
• Ryan J. Delahanty; Yong-Bing Xiang; Amanda Spurdle et al. (2013). Polymorphisms in inflammation pathway genes and endometrial cancer risk. (ekstern lenke)
• Hanna Helgeland; Simen Rød Sandve; Jacob Torgersen et al. (2014). The evolution and functional divergence of the beta-carotene oxygenase gene family in teleost fish-Exemplified by Atlantic salmon. (ekstern lenke)
• Camilla Krakstad; Even Birkeland; Danila Seidel et al. (2012). High-throughput mutation profiling of primary and metastatic endometrial cancers identifies KRAS, FGFR2 and PIK3CA to be frequently mutated. (ekstern lenke)
• Hege Fredriksen Berg; Hilde Renate Engerud; Madeleine Myrvold et al. (2022). Mismatch repair markers in preoperative and operative endometrial cancer samples; expression concordance and prognostic value. (ekstern lenke)
• Stig E. Bojesen; Karen A Pooley; Sharon E Johnatty et al. (2013). Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer. (ekstern lenke)
• Frederik Holst; Henrica Maria Johanna Werner; Siv Mjøs et al. (2019). PIK3CA amplification associates with aggressive phenotype but not markers of AKT-mTOR signaling in endometrial carcinoma. (ekstern lenke)
• Erling Andre Høivik; Kanthida Kusonmano; Mari Kyllesø Halle et al. (2014). Hypomethylation of the CTCFL/BORIS promoter and aberrant expression during endometrial cancer progression suggests a role as an Epi-driver gene. (ekstern lenke)
• Erlend Hodneland; Erling Andersen; Kari Strøno Wagner-Larsen et al. (2024). Impact of MRI radiomic feature normalization for prognostic modelling in uterine endometrial and cervical cancers. (ekstern lenke)
• Mari Kyllesø Halle; Ane Cecilie Dæhli Munk; Birgit Øvstebø Engesæter et al. (2021). A gene signature identifying CIN3 regression and cervical cancer survival. (ekstern lenke)
• Anna Berg; Erling Andre Høivik; Siv Mjøs et al. (2015). Molecular profiling of endometrial carcinoma precursor, primary and metastatic lesions suggests different targets for treatment in obese compared to non-obese patients. (ekstern lenke)
• Ji-Yeon Yang; Henrica Maria Johanna Werner; Jie Li et al. (2016). Integrative protein-based prognostic model for early-stage endometrioid endometrial cancer. (ekstern lenke)
• Mari Kyllesø Halle; Olivera Bozickovic; David Erik Forsse et al. (2024). Clinicopathological and radiological stratification within FIGO 2018 stages improves risk-prediction in cervical cancer. (ekstern lenke)
• Madeleine Charlotte van der Berg; Hege Fredriksen Berg; Tomasz Stokowy et al. (2024). Expression patterns of mismatch repair proteins in cervical cancer uncover independent prognostic value of MSH-2. (ekstern lenke)
• Irene Tveiterås Øvestad; Birgit Øvstebø Engesæter; Mari Kyllesø Halle et al. (2021). High-Grade Cervical Intraepithelial Neoplasia (CIN) Associates with Increased Proliferation and Attenuated Immune Signaling. (ekstern lenke)
• Hilde Eide Lien; Hege Fredriksen Berg; Mari Kyllesø Halle et al. (2023). Single-cell profiling of low-stage endometrial cancers identifies low epithelial vimentin expression as a marker of recurrent disease. (ekstern lenke)
• Kari Strøno Wagner-Larsen; Njål Lura; Ankush Gulati et al. (2025). MRI delta radiomics during chemoradiotherapy for prognostication in locally advanced cervical cancer. (ekstern lenke)
• Reham Helwa; Liv Beathe Gansmo; Merete Pauline Bjørnslett et al. (2021). Impact of MDM2 promoter SNP55 (rs2870820) on risk of endometrial and ovarian cancer. (ekstern lenke)
• Liv Beathe Gansmo; Merete Pauline Bjørnslett; Mari Kyllesø Halle et al. (2016). The MDM4 SNP34091 (rs4245739) C-allele is associated with increased risk of ovarian—but not endometrial cancer. (ekstern lenke)

Doktorgradsavhandling

• Mari Kyllesø Halle; Helga Salvesen; Camilla Krakstad (2017). Molecular alterations suggesting new treatment strategies in uterine carcinomas. (ekstern lenke)

Rettelse i tidsskrift

• Hilde Eide Lien; Hege Fredriksen Berg; Mari Kyllesø Halle et al. (2023). Corrigendum to “Single-cell profiling of low-stage endometrial cancers identifies low epithelial vimentin expression as a marker of recurrent disease” [EBioMedicine 92 (2023) 104595] (eBioMedicine (2023) 92, (S2352396423001603), (10.1016/j.ebiom.2023.104595)). (ekstern lenke)

Leserbrev

• Mari Kyllesø Halle; Henrica Maria Johanna Werner; Camilla Krakstad et al. (2012). Stratification based on high tumour cell content in fresh frozen tissue promotes selection of aggressive endometrial carcinomas. (ekstern lenke)

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