Spiros Kotopoulis
Position
Guest researcher
Affiliation
Publications
Academic article
- Tæraneh Jouleh; Ingrid Kvåle Nordaas; Spiros Kotopoulis et al. (2026). Assessment of Gallbladder Function in Patients with Type 2 Diabetes Using Three-Dimensional Ultrasound. (external link)
- Christiane Helgestad Gjerde; Katrin Kleinmanns; Anika Langer et al. (2026). A 3D ovarian cancer metastasis model using a decellularised peritoneal matrix to study therapy response. (external link)
- Tæraneh Jouleh; Spiros Kotopoulis; Georg Dimcevski et al. (2025). Comparison of two- and three-dimensional ultrasound for volume estimation of the meal-stimulated gallbladder. (external link)
- Melina Mühlenpfordt; Emma Bøe Olsen; Spiros Kotopoulis et al. (2023). Real-Time Intravital Imaging of Acoustic Cluster Therapy–Induced Vascular Effects in the Murine Brain. (external link)
- Annemieke van Wamel; Melina Mühlenpfordt; Rune Hansen et al. (2022). Ultrafast Microscopy Imaging of Acoustic Cluster Therapy Bubbles: Activation and Oscillation. (external link)
- Charl Smalberger; Malavika Nathan; David M. Rubin et al. (2022). Experimental setup for the ultrasonic fractionation of flowing whole blood in a capillary. (external link)
- Spiros Kotopoulis; Christina Lam; Ragnhild Haugse et al. (2022). Formulation and characterisation of drug-loaded antibubbles for image-guided and ultrasound-triggered drug delivery. (external link)
- Spiros Kotopoulis; Mihaela-Lucia Popa; Mireia Mayoral Safont et al. (2022). SonoVue® vs. Sonazoid™ vs. Optison™: Which Bubble Is Best for Low-Intensity Sonoporation of Pancreatic Ductal Adenocarcinoma?. (external link)
- Charissa Poon; Melina Mühlenpfordt; Marieke Olsman et al. (2022). Real-time intravital multiphoton microscopy to visualize focused ultrasound and microbubble treatments to increase blood-brain barrier permeability. (external link)
- Marieke Olsman; Melina Mühlenpfordt; Emma Bøe Olsen et al. (2021). Acoustic Cluster Therapy (ACT®) increases blood-brain barrier permeability and enhances accumulation of core-crosslinked polymeric micelles. (external link)
- Christopher W. Schultz; Gorka Ruiz de Garibay; Anika Langer et al. (2021). Selecting the optimal parameters for sonoporation of pancreatic cancer in a pre-clinical model. (external link)
- Øystein Solberg Eikrem; Spiros Kotopoulis; Mihaela-Lucia Popa et al. (2021). Ultrasound and Microbubbles Enhance Uptake of Doxorubicin in Murine Kidneys. (external link)
- Tormod Karlsen Bjånes; Spiros Kotopoulis; Elsa Thodesen Murvold et al. (2020). Ultrasound‐ and microbubble‐assisted gemcitabine delivery to pancreatic cancer cells. (external link)
- Tormod Karlsen Bjånes; Lars Petter Jordheim; Jan Schjøtt et al. (2020). Intracellular cytidine deaminase regulates gemcitabine metabolism in pancreatic cancer cell lines. (external link)
- Jason Castle; Spiros Kotopoulis; Flemming Forsberg (2020). Sonoporation for augmenting chemotherapy of pancreatic ductal adenocarcinoma. (external link)
- Nigel Bush; Andrew Healey; Anant Shah et al. (2020). Theranostic attributes of acoustic cluster therapy and its use for enhancing the effectiveness of liposomal doxorubicin treatment of human triple negative breast cancer in mice. (external link)
- Ragnhild Haugse; Anika Langer; Elisa Thodesen Murvold et al. (2020). Low-Intensity Sonoporation-Induced Intracellular Signalling of Pancreatic Cancer Cells, Fibroblasts and Endothelial Cells. (external link)
- Ragnhild Haugse; Anika Langer; Stein-Erik Gullaksen et al. (2019). Intracellular signaling in key pathways is induced by treatment with ultrasound and microbubbles in a leukemia cell line, but not in healthy peripheral blood mononuclear cells. (external link)
- Nigel Bush; Andrew Healey; Anant Shah et al. (2019). Acoustic Cluster Therapy displays theranostic capability in enhancing the effectiveness of liposomal doxorubicin treatment of human triple negative breast cancer in mice. (external link)
- Spiros Kotopoulis; Endre Stigen; Mihaela Lucia Popa et al. (2017). Sonoporation with Acoustic Cluster Therapy (ACT®) induces transient tumour volume reduction in a subcutaneous xenograft model of pancreatic ductal adenocarcinoma. (external link)
- Kathinka Retz; Spiros Kotopoulis; Torvid Kiserud et al. (2017). Measured acoustic intensities for clinical diagnostic ultrasound transducers and correlation with thermal index. (external link)
- Asta Kathinka H Retz; Spiros Kotopoulis; Torvid Kiserud et al. (2016). Measured acoustic intensities for clinical diagnostic ultrasound transducers and correlation with thermal index. (external link)
- Georg Gjorgji Dimcevski; Spiros Kotopoulis; Tormod Karlsen Bjånes et al. (2016). A human clinical trial using ultrasound and microbubbles to enhance gemcitabine treatment of inoperable pancreatic cancer. (external link)
- Spiros Kotopoulis; Georg Gjorgji Dimcevski; Emmet Mc Cormack et al. (2016). Ultrasound- and microbubble-enhanced chemotherapy for treating pancreatic cancer: A phase I clinical trial. (external link)
- Kristoffer Johansen; Spiros Kotopoulis; Albert T. Poortinga et al. (2016). Harmonic antibubbles. (external link)
- Torstein Yddal; Odd Helge Gilja; Sandy Cochran et al. (2016). Glass-windowed ultrasound transducers. (external link)
- Spiros Kotopoulis; Georg Gjorgji Dimcevski; Emmet McCormack et al. (2016). Ultrasound- and microbubble-enhanced chemotherapy for treating pancreatic cancer: a phase I clinical trial. (external link)
- Torstein Yddal; Sandy Cochran; Odd Helge Gilja et al. (2015). Open source, high throughput, ultrasound treatment chamber. (external link)
- Kristoffer Johansen; Spiros Kotopoulis; Michiel Postema (2015). Ultrasonically driven antibubbles encapsulated by Newtonian fluids for active leakage detection. (external link)
- Spiros Kotopoulis; Kristoffer Johansen; Odd Helge Gilja et al. (2015). Acoustically active antibubbles. (external link)
- Kristoffer Johansen; Spiros Kotopoulis; Albert T. Poortinga et al. (2015). Nonlinear echoes from encapsulated antibubbles. (external link)
- Kristoffer Johansen; Torstein Yddal; Spiros Kotopoulis et al. (2014). Acoustic filtering of particles in a flow regime. (external link)
- Spiros Kotopoulis; Georg Gjorgji Dimcevski; Bjørn Tore Gjertsen et al. (2014). Sonoporation: from the lab to human clinical trials. (external link)
- Spiros Kotopoulis; Ragnhild Haugse; Maja Mujic et al. (2014). Evaluation of the effects of clinical diagnostic ultrasound in combination with ultrasound contrast agents on cell stress: Single cell analysis of intracellular phospho-signaling pathways in blood cancer cells and normal blood leukocytes. (external link)
- Torstein Yddal; Spiros Kotopoulis; Odd Helge Gilja et al. (2014). Transparent glass-windowed ultrasound transducers. (external link)
- Spiros Kotopoulis; Anthony Delalande; Mihaela Lucia Popa et al. (2014). Sonoporation-enhanced chemotherapy significantly reduces primary tumour burden in an orthotopic pancreatic cancer xenograft. (external link)
- Spiros Kotopoulis; Sabrina Daniela Eder; Martin Møller Greve et al. (2013). Lab-on-a-chip device for fabrication of therapeutic microbubbles on demand. (external link)
- Spiros Kotopoulis; Georg Gjorgji Dimcevski; Odd Helge Gilja et al. (2013). Treatment of human pancreatic cancer using combined ultrasound, microbubbles, and gemcitabine: a clinical case study. (external link)
- Ivan Viola; Åsmund Birkeland; Veronika Šoltészová et al. (2013). High-quality 3D visualization of in-situ ultrasonography. (external link)
- Spiros Kotopoulis; Anthony Delalande; Chantal Pichon et al. (2012). Real-time sonoporation through HeLa cells. (external link)
- Spiros Kotopoulis; Han Wang; Sandy Cochran et al. (2012). High-frequency transducer for MR-guided FUS. (external link)
- Anthony Delalande; Spiros Kotopoulis; Tijs Rovers et al. (2011). Sonoporation at a low mechanical index. (external link)
- Bjoern Gerold; Spiros Kotopoulis; Craig McDougall et al. (2011). Laser-nucleated acoustic cavitation in focused ultrasound. (external link)
- Anthony Delalande; Ayache Bouakaz; Gilles Renault et al. (2011). Ultrasound and microbubbles assisted gene delivery in Achilles tendons: long lasting gene expression and restoration of fibromodulin KO phenotype. (external link)
- Anthony Delalande; Spiros Kotopoulis; Chantal Pichon et al. (2011). Sonoporation at a low MI. (external link)
- Spiros Kotopoulis; Han Wang; Sandy Cochran et al. (2011). Lithium niobate transducers for MRI-guided ultrasonic microsurgery. (external link)
- Spiros Kotopoulis; Michiel Postema (2010). Microfoam formation in a capillary. (external link)
- Spiros Kotopoulis; Han Wang; Sandy Cochran et al. (2010). Lithium niobate ultrasound transducers for high-resolution focused ultrasound surgery. (external link)
- Spiros Kotopoulis; Antje Schommartz; Michiel Postema (2009). Sonic cracking of blue-green algae. (external link)
- Spiros Kotopoulis; Antje Schommartz; Michiel Postema (2008). Safety radius for algae eradication at 200 kHz - 2.5 MHz. (external link)
Academic book chapter
- Ingrid Kvåle Nordaas; Tæraneh Jouleh; Audun Magerøy trelsgård et al. (2021). Sonoporation in pancreatic cancer (PDAC). (external link)
- Spiros Kotopoulis; Han Wang; Torstein Yddal et al. (2015). Novel multipurpose, low cost, modular, ultrasound transducers. (external link)
- Kristoffer Johansen; Spiros Kotopoulis; Michiel Postema (2015). Active leakage detection by searching for antibubbles. (external link)
- Kristoffer Johansen; Spiros Kotopoulis; Michiel Postema (2015). Ultrasonically driven antibubbles encapsulated by Newtonian fluids for active leakage detection. (external link)
- Kristoffer Johansen; Spiros Kotopoulis; Michiel Postema (2015). Introduction to antibubbles. (external link)
- Karoline Kjellsdotter Søvig; Spiros Kotopoulis; Kim Nylund et al. (2015). Volume estimation of the Gallbladder - 2D vs 3D Ultrasound. (external link)
- Spiros Kotopoulis; Mihaela Lucia Popa; MJ Safont et al. (2015). Sonoporation using Acoustic Cluster Therapy in combination With chemotherapy transiently reduces tumour volume.. (external link)
- Kristoffer Johansen; Spiros Kotopoulis; Albert T. Poortinga et al. (2015). Antibubbles. (external link)
- Spiros Kotopoulis; Kristoffer Johansen; Albert Poortinga et al. (2014). Acoustically active antibubbles for ultrasound imaging and targeted drug delivery. (external link)
- Spiros Kotopoulis; Michiel Postema (2013). Using ultrasound to separate oil, gas, and water. (external link)
- Spiros Kotopoulis; Anthony Delalande; Mihaela Popa et al. (2013). Ultrasound and microbubble enhanced therapy of orthotopic human pancreatic cancer in mice. (external link)
- Maja Mujic; Ragnhild Haugse; Spiros Kotopoulis et al. (2013). Ultrasound combined with microbubbles modulates signal transduction pathways in blood cells. (external link)
- Georg Gjorgji Dimcevski; Spiros Kotopoulis; Dag Hoem et al. (2013). Ultrasound-assisted treatment of an inoperable pancreatic cancer. (external link)
- Spiros Kotopoulis; Ragnhild Haugse; Michiel Postema (2013). Sonoporation: the hurdles that need to be surpassed. (external link)
- Spiros Kotopoulis; Anthony Delalande; Chantal Pichon et al. (2012). Biological and medical applications of low-intensity ultrasound. (external link)
- Bjoern Gerold; Spiros Kotopoulis; Sandy Cochran et al. (2012). Hybrid laser-ultrasound cavitation for cloud evolution studies. (external link)
- Michiel Postema; Spiros Kotopoulis; Klaus-Vitold Jenderka (2012). Basic Principles: Basic physical principles of medical ultrasound. (external link)
- Maja Mujic; Spiros Kotopoulis; Anthony Delalande et al. (2012). Flow cytometic characterization and sorting of ultrasound contrast agents. (external link)
- Anthony Delalande; Spiros Kotopoulis; Patrick Midoux et al. (2012). Ultrasound and microbubble-assisted gene delivery: insights for intracellular mechanism. (external link)
- Spiros Kotopoulis; Anthony Delalande; Chantal Pichon et al. (2012). Nonlinear microbubble behaviour for enhanced drug uptake. (external link)
- Spiros Kotopoulis; Anthony Delalande; Chantal Pichon et al. (2012). Real-time sonoporation through HeLa cells. (external link)
- Spiros Kotopoulis; Anthony Delalande; Chantal Pichon et al. (2012). Sonoporation: using ultrasound for targeted drug delivery. (external link)
- Anthony Delalande; Spiros Kotopoulis; Chantal Pichon et al. (2012). Microbubbles and cell interactions. (external link)
- Michiel Postema; Spiros Kotopoulis; Anthony Delalande et al. (2011). Ultrasound-guided delivery and sonoporation. (external link)
- Spiros Kotopoulis; Anthony Delalande; Chantal Pichon et al. (2011). On cells and sound. (external link)
- Spiros Kotopoulis; Michiel Postema (2011). Biomedical ultrasonics, cavitation, and sonoporation. (external link)
- Spiros Kotopoulis; Michiel Postema; Sandy Cochran (2011). Ultrasound transducers made with lithium niobate for HF HIFU. (external link)
- Anthony Delalande; Spiros Kotopoulis; Patrick Midoux et al. (2011). Cell-microbubble interaction and intracellular fate of plasmid DNA and microbubbles during the sonoporation process. (external link)
- Anthony Delalande; Spiros Kotopoulis; Chantal Pichon et al. (2011). Cancer cell sonoporation at low acoustic amplitudes. (external link)
- Anthony Delalande; Patrick Midoux; Chantal Pichon et al. (2011). Investigations of microbubble-cell interactions during the sonoporation process. (external link)
- Spiros Kotopoulis; Michiel Postema (2010). Forming morphing microfoam. (external link)
Academic literature review
Conference abstract
- James Posey; Priscilla Machado; John R. Eisenbrey et al. (2023). Sonoporation for disrupting the pancreatic cancer microenvironment to enhance chemotherapy delivery and improve outcomes.. (external link)
- Georg Gjorgji Dimcevski; Spiros Kotopoulis; Tormod Karlsen Bjånes et al. (2016). Ultrasound and microbubble enhanced treatment of inoperable pancreatic adeonocarcinoma. (external link)
- Spiros Kotopoulis; Georg Gjorgji Dimcevski; Dag Hoem et al. (2015). Ultrasound sonoporation in pancreatic adenocarcinoma. (external link)
- Spiros Kotopoulis; Michiel Postema (2013). High-speed photography of encapsulated microbubbles. (external link)
- Spiros Kotopoulis; Michiel Postema (2011). Therapeutic ultrasound and sonoporation. (external link)
Conference lecture
- Nils Kristian Skjaervold; Spiros Kotopoulis; Sverre Løvskar et al. (2023). Oxycate - utvikling av en trådløs engangs cerebral oksygenmonitor for prehospital bruk. (external link)
- Melina Mühlenpfordt; Emma Bøe Olsen; Spiros Kotopoulis et al. (2022). Real-time intravital imaging of the vascular effects induced by Acoustic Cluster Therapy (ACT®) in a murine brain. (external link)
- Melina Mühlenpfordt; Marieke Olsman; Emma Bøe Olsen et al. (2021). Acoustic Cluster Therapy (ACT®) enhances extravasation and parenchymal accumulation of core-crosslinked polymeric micelles in the brain. (external link)
- Spiros Kotopoulis; Mihaela Lucia Popa; MJ Safont et al. (2015). Sonoporation using Acoustic Cluster Therapy in combination With chemotherapy transiently reduces tumour volume.. (external link)
Conference poster
- Tæraneh Jouleh; Spiros Kotopoulis; Georg Dimcevski et al. (2024). Gallbladder Volumes Estimated by 2D Versus 3D Ultrasound. (external link)
- Melina Mühlenpfordt; Marieke Olsman; Emma Bøe Olsen et al. (2022). Acoustic Cluster Therapy (ACT®) increases blood-brain barrier permeability and enhances accumulation of core-crosslinked polymeric micelles. (external link)
- Tormod Karlsen Bjånes; Lars Petter Jordheim; Jan Schjøtt et al. (2019). Intracellular cytidine deaminase and gemcitabine metabolism in three pancreatic cancer cell lines. (external link)
- Tormod Karlsen Bjånes; Jan Schjøtt; Spiros Kotopoulis et al. (2019). Sonoporation and gemcitabine delivery in pancreatic cancer cell lines. (external link)
- Tormod Karlsen Bjånes; Lars Petter Jordheim; Jan Schjøtt et al. (2019). role of intracellular cytidine deaminase activity for gemcitabine metabolism in pancreatic cancer cell lines. (external link)
- Ragnhild Haugse; Anika Langer; Silje Maria Sundøy et al. (2019). Molecular mechanisms of sonoporation in pancreatic ductal adenocarcinoma (PDAC). (external link)
- Tormod Karlsen Bjånes; Lars Petter Jordheim; Jan Schjøtt et al. (2019). Intracellular cytidine deaminase and gemcitabine metabolism in three pancreatic cancer cell lines. (external link)
- Tormod Karlsen Bjånes; Elisa Ulvøen Thodesen; Jan Schjøtt et al. (2019). Sonoporation and gemcitabine delivery in pancreatic cell lines. (external link)
- Elisa Ulvøen Thodesen; Tormod Karlsen Bjånes; Ragnhild Haugse et al. (2019). in vitro optimisation of sonoporation conditions in pancreatic cancer. (external link)
- Nigel Bush; Andrew Healey; Anant Shah et al. (2019). Acoustic Cluster Therapy displays theranostic capability in enhancing the effectiveness of liposomal doxorubicin treatment of human triple negative breast cancer in mice. (external link)
- Karoline Kjellsdotter Søvig; Spiros Kotopoulis; Kim Nylund et al. (2015). Volume estimation of the Gallbladder - 2D vs 3D Ultrasound. (external link)