TargetRNA

TargetRNA is a MSCA doctoral training network. In total, 16 doctoral candidates will work together across different disciplines to jointly advance the field of RNA-ligand design. 

In recent years it became increasingly evident that RNAs constitute promising macromolecular drug targets for small molecule drugs. By targeting upstream RNA, current undruggable protein-mediated pathways could be effectively modulated thereby opening for innovative therapies that my redefine the treatment strategies for a range of conditions. However, to advance this field of research, a new generation of scientists that can further develop and ultimately master the challenging process of drug design applied to RNA molecules is needed. Therefore, the TargetRNA network aims to educate and nurture the next generation of scientists with cutting-edge interdisciplinary skills in the discovery and biological characterization of RNA modulators and thus generate fundamental knowledge on what drives affinity and specificity of small molecules binding to RNA. 

Here, we will focus on developing antimicrobial tool compounds to selectively reshape the human gut microbiome by targeting RNA, an area with vast implications for medicine. Training through research activities, spanning from computational and medicinal chemistry over structural and molecular biology to microbiology and in vivo models, will be supplemented by an innovative training program in specific and transferable skills for interdisciplinary drug discovery strategies to target RNA, including FAIR data principles, open science practices as well as responsible development and sustainable implementation of new innovations. 

To achieve the ambitious research and training goals, the TargetRNA network unites leading scientists from 13 academic partners (8 beneficiaries, 5 associated) and 4 industry partners (1 beneficiaries, 3 associated) based in 9 countries.