Gruppen min bruker verktøy fra matematikk, statistikk, og informatikk til å forstå spørsmål i biologi og medisin. Man kan leser mer om arbeidet vårt hos nettsiden https://stochasticbiology.w.uib.no/ !

STAT200, STAT202

Vitenskapelig artikkel

• Renz, Jessica; Dauda, Kazeem Adesina; Aga, Olav Nicolay Larsson et al. (2025). Evolutionary accumulation modeling in AMR: machine learning to infer and predict evolutionary dynamics of multi-drug resistance. (ekstern lenke)
• Glastad, Robert Clay; Johnston, Iain (2025). Convergent pathways of reductive mitochondrial evolution characterized with hypercubic inference. (ekstern lenke)
• Sirota, Sarah Brooke; Bender, Rose Grace; Dominguez, Regina-Mae Villanueva et al. (2025). Global burden of lower respiratory infections and aetiologies, 1990–2023: a systematic analysis for the Global Burden of Disease Study 2023. (ekstern lenke)
• Dauda, Kazeem Adesina; Aga, Olav Nicolay Larsson; Johnston, Iain George (2025). Clustering Large-Scale Biomedical Data to Model Dynamic Accumulation Processes in Disease Progression and Anti-Microbial Resistance Evolution. (ekstern lenke)
• Kumar, Rajneesh; Johnston, Iain (2025). Estimating physical conditions supporting gradients of ATP concentration in the eukaryotic cell. (ekstern lenke)
• Diaz-Uriarte, Ramon; Johnston, Iain (2025). A Picture Guide to Cancer Progression and Evolutionary Accumulation Models: Systematic Critique, Plausible Interpretations, and Alternative Uses. (ekstern lenke)
• Dombi, Eszter; Marinaki, Tony; Spingardi, Paolo et al. (2024). Nucleoside supplements as treatments for mitochondrial DNA depletion syndrome. (ekstern lenke)
• Johnston, Iain; Diaz-Uriarte, Ramon (2024). A hypercubic Mk model framework for capturing reversibility in disease, cancer, and evolutionary accumulation modelling. (ekstern lenke)
• Garschall, Kathrin; Carreras, Eudald Pascual; Pascual, Belen Garcia et al. (2024). The cellular basis of feeding-dependent body size plasticity in sea anemones. (ekstern lenke)
• Aga, Olav Nicolay Larsson; Brun, Morten; Dauda, Kazeem Adesina et al. (2024). HyperTraPS-CT: Inference and prediction for accumulation pathways with flexible data and model structures. (ekstern lenke)
• Pascual, Belen Garcia; Salbu, Lars Moberg; Renz, Jessica et al. (2024). Comparing Structure and Dynamics of Transition Graphs by the Symmetric Difference Metric Over an Edge-Filtration. (ekstern lenke)
• Giannakis, Konstantinos; Richards, Luke; Dauda, Kazeem Adesina et al. (2024). Connecting Species-Specific Extents of Genome Reduction in Mitochondria and Plastids. (ekstern lenke)
• Kumar, Rajneesh; Johnston, Iain (2024). ATP dependence of decision-making capacity in a fine-grained model of gene regulatory networks. (ekstern lenke)
• Johnston, Iain (2024). The Nitroplast and Its Relatives Support a Universal Model of Features Predicting Gene Retention in Endosymbiont and Organelle Genomes. (ekstern lenke)
• Giannakis, Konstantinos; Richards, Luke; Johnston, Iain (2024). Ecological Predictors of Organelle Genome Evolution: Phylogenetic Correlations with Taxonomically Broad, Sparse, Unsystematized Data. (ekstern lenke)
• Pascual, Belen Garcia; Nordbotten, Jan Martin; Johnston, Iain (2023). Cellular and environmental dynamics influence species-specific extents of organelle gene retention. (ekstern lenke)
• Glastad, Robert Clay; Johnston, Iain (2023). Mitochondrial network structure controls cell-to-cell mtDNA variability generated by cell divisions. (ekstern lenke)
• Bjune, Mona Synnøve; Dyer, Laurence; Laupsa-Borge, Johnny et al. (2023). Metabolic role of the hepatic valine/3-hydroxyisobutyrate (3-HIB) pathway in fatty liver disease. (ekstern lenke)
• Broz, Amanda K.; Sloan, Daniel B.; Johnston, Iain (2023). Stochastic organelle genome segregation through Arabidopsis development and reproduction. (ekstern lenke)
• Stevens, Katie; Johnston, Iain; Luna, Estrella (2023). Data science approaches provide a roadmap to understanding the role of abscisic acid in defence. (ekstern lenke)
• Giannakis, Konstantinos; Broz, Amanda K.; Sloan, Daniel B. et al. (2023). Avoiding misleading estimates using mtDNA heteroplasmy statistics to study bottleneck size and selection. (ekstern lenke)
• Erickson, Jennifer Lee; Prautsch, Jennifer; Reynvoet, Frisine et al. (2023). Stromule Geometry Allows Optimal Spatial Regulation of Organelle Interactions in the Quasi-2D Cytoplasm. (ekstern lenke)
• Johnston, Iain; Slater, Mark; Cazier, Jean-Baptiste (2022). Interdisciplinary and Transferable Concepts in Bioinformatics Education: Observations and Approaches From a UK MSc Course. (ekstern lenke)
• Giannakis, Konstantinos; Arrowsmith, Samuel J.; Richards, Luke et al. (2022). Evolutionary inference across eukaryotes identifies universal features shaping organelle gene retention. (ekstern lenke)
• Radzvilavicius, Arunas; Johnston, Iain (2022). Organelle bottlenecks facilitate evolvability by traversing heteroplasmic fitness valleys. (ekstern lenke)
• Kerr, Ryan; Jabbari, Sara; Blair, Jessica et al. (2022). Dynamic Boolean modelling reveals the influence of energy supply on bacterial efflux pump expression. (ekstern lenke)
• Broz, Amanda K.; Keene, Alexandra; Gyorfy, Matheus Fernandes et al. (2022). Sorting of mitochondrial and plastid heteroplasmy in Arabidopsis is extremely rapid and depends on MSH1 activity. (ekstern lenke)
• Johnston, Iain George (2022). Optimal strategies in the Fighting Fantasy gaming system: influencing stochastic dynamics by gambling with limited resource. (ekstern lenke)
• Johnston, Iain; Dingle, Kamaludin; Greenbury, Sam et al. (2022). Symmetry and simplicity spontaneously emerge from the algorithmic nature of evolution. (ekstern lenke)
• Ziegler, Clare; Kulawska, Aleksandra; Kourmouli, Angeliki et al. (2022). Quantification and uncertainty of root growth stimulation by elevated CO<inf>2</inf> in a mature temperate deciduous forest. (ekstern lenke)
• Chustecki, Joanna M.; Etherington, Ross D; Gibbs, Daniel J. et al. (2022). Altered collective mitochondrial dynamics in the Arabidopsis msh1 mutant compromising organelle DNA maintenance. (ekstern lenke)
• Giannakis, Konstantinos; Chustecki, Joanna M.; Johnston, Iain George (2022). Exchange on dynamic encounter networks allows plant mitochondria to collect complete sets of mitochondrial DNA products despite their incomplete genomes. (ekstern lenke)
• Moen, Marcus Theodor; Johnston, Iain George (2022). HyperHMM: efficient inference of evolutionary and progressive dynamics on hypercubic transition graphs. (ekstern lenke)
• Edwards, David; Røyrvik, Ellen Christine; Chustecki, Joanne et al. (2021). Avoiding organelle mutational meltdown across eukaryotes with or without a germline bottleneck. (ekstern lenke)
• Pantic, Boris; Ives, Daniel; Mennuni, Mara et al. (2021). 2-Deoxy-D-glucose couples mitochondrial DNA replication with mitochondrial fitness and promotes the selection of wild-type over mutant mitochondrial DNA. (ekstern lenke)
• Radzvilavicius, Arunas; Layh, Sean; Hall, Matthew D. et al. (2021). Sexually antagonistic evolution of mitochondrial and nuclear linkage. (ekstern lenke)
• Peach, Robert; Greenbury, Sam; Johnston, Iain George et al. (2021). Understanding learner behaviour in online courses with Bayesian modelling and time series characterisation. (ekstern lenke)
• Chustecki, Joanna M.; Gibbs, Daniel J.; Bassel, George W. et al. (2021). Network analysis of Arabidopsis mitochondrial dynamics reveals a resolved tradeoff between physical distribution and social connectivity. (ekstern lenke)
• Johnston, Iain George; Røyrvik, Ellen Christine (2020). Data-Driven Inference Reveals Distinct and Conserved Dynamic Pathways of Tool Use Emergence across Animal Taxa. (ekstern lenke)
• Athanasiou, Angelos-Theodoros; Nussbaumer, T; Kummer, Stefan et al. (2020). S100A4 mRNA-protein relationship uncovered by measurement noise reduction. (ekstern lenke)
• Lechuga-Vieco, Ana Victoria; Latorre-Pellicer, Ana; Johnston, Iain et al. (2020). Cell identity and nucleo-mitochondrial genetic context modulate OXPHOS performance and determine somatic heteroplasmy dynamics. (ekstern lenke)
• Duran-Nebreda, Salva; Johnston, Iain George; Bassel, George (2020). Efficient vasculature investment in tissues can be determined without global information. (ekstern lenke)
• Røyrvik, Ellen Christine; Johnston, Iain (2020). MtDNA sequence features associated with 'selfish genomes' predict tissue-specific segregation and reversion. (ekstern lenke)
• Aryaman, Juvid; Bowles, Charlotte; Jones, Nick et al. (2019). Mitochondrial network state scales mtDNA genetic dynamics. (ekstern lenke)
• Johnston, Iain George; Burgstaller, Joerg (2019). Evolving mtDNA populations within cells. (ekstern lenke)
• Johnston, Iain George (2019). Varied mechanisms and models for the varying mitochondrial bottleneck. (ekstern lenke)
• Johnston, Iain (2019). Tension and resolution: dynamic, evolving populations of organelle genomes within plant cells. (ekstern lenke)
• Johnston, Iain George; Hoffmann, Till; Greenbury, Sam et al. (2019). Precision identification of high-risk phenotypes and progression pathways in severe malaria without requiring longitudinal data. (ekstern lenke)
• Ziegler, Clare; Dyson, Rosemary; Johnston, Iain George (2019). Model selection and parameter estimation for root architecture models using likelihood-free inference. (ekstern lenke)
• Johnston, Iain George (2019). Regulation of Mother-to-Offspring Transmission of mtDNA Heteroplasmy. (ekstern lenke)
• Kerr, Ryan; Jabbari, Sara; Johnston, Iain (2019). Intracellular Energy Variability Modulates Cellular Decision-Making Capacity. (ekstern lenke)
• Hoitzing, Hanne; Gammage, Payam; Haute, Lindsey van et al. (2019). Energetic costs of cellular and therapeutic control of stochastic mitochondrial DNA populations. (ekstern lenke)
• Greenbury, Sam; Barahona, Mauricio; Johnston, Iain (2019). HyperTraPS: Inferring probabilistic patterns of trait acquisition in evolutionary and disease progression pathways. (ekstern lenke)
• Johnston, Iain; Bassel, George (2018). Identification of a bet-hedging network motif generating noise in hormone concentrations and germination propensity in Arabidopsis. (ekstern lenke)

Vitenskapelig oversiktsartikkel/review

• Veeraragavan, Shibani; Johansen, Maria; Johnston, Iain (2024). Evolution and maintenance of mtDNA gene content across eukaryotes. (ekstern lenke)
• Chustecki, Joanna M.; Johnston, Iain George (2023). Collective mitochondrial dynamics resolve conflicting cellular tensions: From plants to general principles. (ekstern lenke)
• Autran, Daphné; Bassel, George W.; Chae, Eunyoung et al. (2021). What is quantitative plant biology?. (ekstern lenke)

Poster

• Kumar, Rajneesh; Johnston, Iain George (2023). Population Dynamics in Response to Environmental Stimuli. (ekstern lenke)
• Kumar, Rajneesh; Johnston, Iain George (2023). Stochastic and Deterministic Computation in the regulation of Decision – Making Genetic circuits by Energy Availability.. (ekstern lenke)

Leserinnlegg

• Johnston, Iain; Dingle, Kamaludin; Greenbury, Sam F. et al. (2022). Reply to Ocklenburg and Mundorf: The interplay of developmental bias and natural selection. (ekstern lenke)

Se en full oversikt over publikasjoner i Cristin

Alle artikkeler kan vises hos Google Scholar https://scholar.google.com/citations?user=PRw6LPwAAAAJ&hl=en 

MitoPhyto (NFR FRIPRO) -- mitochondria across species

TRUST-AI4D (Trond Mohn) -- diabetes disease progression

HyperEvol (Trond Mohn) -- learning pathways of antimicrobial resistance evolution

EvoConBiO (ERC StG) -- evolution and control of bioenergetic organelles

CAMRIA (Trond Mohn) -- combatting antimicrobial resistance with interdisciplinary approaches

QUINTUS (UK NERC) -- responses of forest ecosystems to elevated CO2

HyperTraPS (Alan Turing Institute) -- inferring pathways of evolution and disease progression

Iain also supervises researchers on projects funded by the UK BBSRC and Wellcome Trust, working on plant mitochondria, seed germination, and antimicrobial resistance.