- E-post
- tronstad@uib.no
- Telefonnummer
- +47 93221592
- +47 55586433
- Besøksadresse
-
Jonas Lies vei 91
5009 Bergen - Postadresse
-
Postboks 7804
5020 Bergen
Følg meg
Forskergrupper
Publikasjoner
Doktorgradsavhandling
Forelesning
Konferanseabstrakt
- L I H Nilsson; Julie Nikolaisen; Hanne Hagland et al. (2012). A mitochondrial reporter system for studies on NRF-1/AMPK activity and regulation in viable cells. (ekstern lenke)
- Martha Chekenya; Inger Anne Netland; Joost JC Verhoeff et al. (2010). NG2 PROMOTES RESISTANCE TO IONIZING RADIATION BY ELEVATED PEROXIREDOXIN-1 AND DNA DAMAGE RESPONSE IN GLIOBLASTOMA MULTIFORME. (ekstern lenke)
- Hanne Hagland; Julie Nikolaisen; Linn I. Hodneland et al. (2008). Mitochondrial function in cancer cell line models. (ekstern lenke)
- Bjarte Skoe Erikstein; Karl Johan Tronstad; Emmet Martin McCormack et al. (2007). Synergistic anti-leukemic effect of protein kinase a activator and PPAR7agonist is independent of Bcl-2 status. (ekstern lenke)
Konferanseforedrag
- Karl Johan Tronstad (2018). Cellular Energetics in ME/CFS. (ekstern lenke)
- Karl Johan Tronstad (2017). Defective energy metabolism in ME/CFS (Prosjektpresentasjon, NFR BehovME, 2017-2020). (ekstern lenke)
- Julie Nikolaisen; Linn I. Hodneland Nilsson; Hanne Røland Hagland et al. (2013). Mitochondrial function, biogenesis and morphology in cellular stress. (ekstern lenke)
- Julie Nikolaisen; Linn I. Nilsson Hodneland; Hanne Røland Hagland et al. (2012). Mitochondrial morphology and biogenesis in cellular stress. (ekstern lenke)
- Karl Johan Tronstad; Kjetil Berge; Odd Terje Brustugun et al. (1998). Metabolic effects of 3-thia fatty acid in cancer cells. (ekstern lenke)
Konferanseposter
- Tia Tidwell; Hanne Røland Hagland; Gro Vatne Røsland et al. (2018). Metabolic profiling of Colorectal cancer in 3D. (ekstern lenke)
- Ingrid Moen; Anne Margrete Øyan; Karl-Henning Kalland et al. (2009). Hyperoxic Treatment induces Mesenchymal-to-Epithelial Transition in a Rat Adenocarcinoma Model. (ekstern lenke)
- Therese Halvorsen Røst; Oddrun Anita Gudbrandsen; Karl Johan Tronstad et al. (2004). PPAR-delta activation in relation to reduction of adipose tissue. (ekstern lenke)
Leserbrev
- Karl Johan Tronstad; Øystein Fluge; Olav Mella (2018). Kronisk utmattelsessyndrom og pyruvat dehydrogenasefunksjon. (ekstern lenke)
- Karl Johan Tronstad; Øystein Fluge; Katarina Lien et al. (2017). Mer om pyruvat dehydrogenase og kronisk utmattelsessyndrom.. (ekstern lenke)
- Karl Johan Tronstad; Øystein Fluge; Olav Mella (2017). Chronic fatigue syndrome and pyruvate dehydrogenase function.. (ekstern lenke)
Masteroppgave
- Lea Francine J Longueville; Karl Johan Tronstad; Knut Teigen et al. (2024). Characterization of mutations detected in a family of severe cases of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). (ekstern lenke)
- Aina Van Der Meeren; Karl Johan Tronstad; Ina Katrine Nitschke Pettersen (2020). Hunting metabolic changes in ME/CFS by investigating cellular responses to applied stress and patient serum factors. (ekstern lenke)
- Anders Flataker Viken; Karl Johan Tronstad; Ina Katrine Nitschke Pettersen (2020). Exploring passive transfer of Myalgic Encephalopathy/Chronic Fatigue Syndrome (ME/CFS) metabolic disturbances on cultured mouse- and human muscle cells. (ekstern lenke)
- Silje Johannessen Hjellbrekke; Karl Johan Tronstad; Gro Vatne Røsland (2019). Alterations in cellular metabolism during development of cancer therapy resistance. (ekstern lenke)
- Hanan Ashrafi; Ina Katrine Nitschke Pettersen; Karl Johan Tronstad (2019). The role of pyruvate dehydrogenase kinases (PDKs) in rewiring of cell metabolism under energy stress. (ekstern lenke)
- Erna Irene Heggland; Trond Brattelid; Karl Johan Tronstad et al. (2015). The Role of Persistent Organic Pollutants in Induction of Endoplasmic Reticulum Stress in Hepatocytes in vitro and in vivo. (ekstern lenke)
- Carine Lindquist; Bodil Bjørndal; Karl Johan Tronstad (2014). The effect of tetradedecylthioacetic acid on insulin production and mitochondrial function in INS-1E β-cells. (ekstern lenke)
- Beate Hole Fosse; Anni Vedeler; Karl Johan Tronstad (2014). Effekt av hypoksia på Annexin A2 i mitokondrier fra HepG2- og PC12-celler. (ekstern lenke)
- Sissel Elisabeth Dyrstad; Karl Johan Tronstad; James Lorens (2013). Metabolic reprogramming in Slug and Twist overexpressing MCF10A cells. (ekstern lenke)
- Dina Manandar; Karl Johan Tronstad; James Lorens (2012). A study of mitochondrial function, ROS and signaling in Twist overexpressing cells. (ekstern lenke)
- Ina Katrine Nitschke Pettersen; Karl Johan Tronstad; Laurence Bindoff (2012). Mitochondrial function and metabolic stress tolerance in fibroblasts from patients with mutations in POLG. (ekstern lenke)
- Bina Qassem Ahmed; Karl Johan Tronstad; Linn I. Hodneland (2011). AMPK som regulator av mitokondriell biogenese i en ny reporter-cellemodell. (ekstern lenke)
- Ingunn Bergslien; Karl Johan Tronstad (2009). Mulige interaksjoner mellom tyrosin kinase reseptoren Axl, metabolisme og proliferasjon i brystkreftceller (MDA-MB-231). (ekstern lenke)
- Gisle Størseth Solhaug; Karl Johan Tronstad (2009). Possible interactions between EGFR vIII mediated regulation of proliferation and metabolism in glioma cells. (ekstern lenke)
- Anne K. Jonassen; Karl Johan Tronstad; Åshild Lien (2008). Growth Factors and Cardioprotection; - with special reference to insulin and IGF-II survival signalling at ischemic reperfusion. (ekstern lenke)
- Julie Nikolaisen; Karl Johan Tronstad (2007). Mitocondrial metabolism and tumor growth control. (ekstern lenke)
- Karl Johan Tronstad (1997). Proliferation of malignant rat glioma cells in reduced by the sulphur substituted fatty acid analogue tetradecylthioacetic acid; a stud on oxidative status (Cand. scient). (ekstern lenke)
Rettelse i tidsskrift
- Abdelnour Alhourani; Tia Tidwell; Ansooya Avinash Bokil et al. (2022). Author Correction: Metformin treatment response is dependent on glucose growth conditions and metabolic phenotype in colorectal cancer cells (Scientific Reports, (2021), 11, 1, (10487), 10.1038/s41598-021-89861-6). (ekstern lenke)
- Linn Iren Hodneland Nilsson; Ina Katrine Nitschke Pettersen; Julie Nikolaisen et al. (2016). Corrigendum: A new live-cell reporter strategy to simultaneously monitor mitochondrial biogenesis and morphology.. (ekstern lenke)
Vitenskapelig artikkel
- August Hoel; Fredrik Hoel; Sissel Dyrstad et al. (2026). Charting the circulating proteome in ME/CFS using cross-system profiling to uncover mechanistic insights. (ekstern lenke)
- Øystein Fluge; Ingrid Gurvin Rekeland; Kari Sørland et al. (2025). Plasma cell targeting with the anti-CD38 antibody daratumumab in myalgic encephalomyelitis/chronic fatigue syndrome—a clinical pilot study. (ekstern lenke)
- Sissel Dyrstad; Kimberley Joanne Hatfield; Endre Stigen et al. (2025). Mapping of Functional Metabolic Phenotypes in Acute Myeloid Leukemia. (ekstern lenke)
- Lena Elise Høyland; Magali R Van Linden; Marc Niere et al. (2024). Subcellular NAD+ pools are interconnected and buffered by mitochondrial NAD+. (ekstern lenke)
- Tia Tidwell; Gro Vatne Røsland; Karl Johan Tronstad et al. (2024). Comparing in vitro cytotoxic drug sensitivity in colon and pancreatic cancer using 2D and 3D cell models: Contrasting viability and growth inhibition in clinically relevant dose and repeated drug cycles. (ekstern lenke)
- Ingrid Gurvin Rekeland; Kari Sørland; Lisbeth Lykke Neteland et al. (2024). Six-year follow-up of participants in two clinical trials of rituximab or cyclophosphamide in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. (ekstern lenke)
- Dionysios C. Watson; Defne Bayik; Simon Humberto Storevik et al. (2023). GAP43-dependent mitochondria transfer from astrocytes enhances glioblastoma tumorigenicity. (ekstern lenke)
- Claire M. Larrieu; Simon Humberto Storevik; Joris Guyon et al. (2022). Refining the Role of Pyruvate Dehydrogenase Kinases in Glioblastoma Development. (ekstern lenke)
- Tia R. Tidwell; Gro Vatne Røsland; Karl Johan Tronstad et al. (2022). Metabolic flux analysis of 3D spheroids reveals significant differences in glucose metabolism from matched 2D cultures of colorectal cancer and pancreatic ductal adenocarcinoma cell lines. (ekstern lenke)
- Ingrid Gurvin Rekeland; Kari Sørland; Ove Bruland et al. (2022). Activity monitoring and patient-reported outcome measures in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome patients. (ekstern lenke)
- Sissel Elisabeth Dyrstad; Maria Lie Lotsberg; Tuan Zea Tan et al. (2021). Blocking aerobic glycolysis by targeting pyruvate dehydrogenase kinase in combination with EGFR TKI and ionizing radiation increases therapeutic effect in non-small cell lung cancer cells. (ekstern lenke)
- Fredrik Hoel; August Hoel; Ina Katrine Nitschke Pettersen et al. (2021). A map of metabolic phenotypes in patients with myalgic encephalomyelitis/chronic fatigue syndrome. (ekstern lenke)
- Jonas Walter; Silvia Bolognin; Suresh K. Poovathingal et al. (2021). The Parkinson's-disease-associated mutation LRRK2-G2019S alters dopaminergic differentiation dynamics via NR2F1. (ekstern lenke)
- August Hoel; Tarig Osman; Fredrik Hoel et al. (2021). Axl-inhibitor bemcentinib alleviates mitochondrial dysfunction in the unilateral ureter obstruction murine model. (ekstern lenke)
- Abdelnour Alhourani; Tia Tidwell; Ansooya Avinash Bokil et al. (2021). Metformin treatment response is dependent on glucose growth conditions and metabolic phenotype in colorectal cancer cells. (ekstern lenke)
- Ingrid Gurvin Rekeland; Alexander Fosså; Asgeir Lande et al. (2020). Intravenous Cyclophosphamide in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. An Open-Label Phase II Study. (ekstern lenke)
- Alexander Fosså; Knut Bjøro Smeland; Øystein Fluge et al. (2020). Metabolic analysis of amino acids and vitamin B6 pathways in lymphoma survivors with cancer related chronic fatigue. (ekstern lenke)
- Terje Sundstrøm; Lars Prestegarden; Francisco Azuaje et al. (2019). Inhibition of mitochondrial respiration prevents BRAF-mutant melanoma brain metastasis. (ekstern lenke)
- Jan-Inge Bjune; Laurence Dyer; Gro Vatne Røsland et al. (2019). The homeobox factor Irx3 maintains adipogenic identity. (ekstern lenke)
- Ina Katrine Nitschke Pettersen; Deusdedit Tusubira; Hanan Ashrafi et al. (2019). Upregulated PDK4 expression is a sensitive marker of increased fatty acid oxidation. (ekstern lenke)
- Gro Vatne Røsland; Sissel Elisabeth Dyrstad; Deusdedit Tusubira et al. (2019). Epithelial to mesenchymal transition (EMT) is associated with attenuation of succinate dehydrogenase (SDH) in breast cancer through reduced expression of SDHC.. (ekstern lenke)
- Jonas Walter; Silvia Bolognin; Paul M.A. Antony et al. (2019). Neural stem cells of Parkinson's disease patients exhibit aberrant mitochondrial morphology and functionality. (ekstern lenke)
- Tor-Christian Aase Johannessen; Md Mahdi Hasan-Olive; Huaiyang Zhu et al. (2018). Thioridazine inhibits autophagy and sensitizes glioblastoma cells to temozolomide. (ekstern lenke)
- Sissel Elisabeth Dyrstad; Deusdedit Tusubira; Stian Knappskog et al. (2018). Introducing nano-scale quantitative polymerase chain reaction. (ekstern lenke)
- Jui-Chih Chang; Fredrik Hoel; Ko-Hung Liu et al. (2017). Peptide-mediated delivery of donor mitochondria improves mitochondrial function and cell viability in human cybrid cells with the MELAS A3243G mutation. (ekstern lenke)
- Carine Lindquist; Bodil Bjørndal; Christine Renate Rossmann et al. (2017). Increased hepatic mitochondrial FA oxidation reduces plasma and liver TG levels and is associated with regulation of UCPs and APOC-III in rats. (ekstern lenke)
- Krishna Mukharji Talasila; Gro Vatne Røsland; Hanne Røland Hagland et al. (2017). The angiogenic switch leads to a metabolic shift in human glioblastoma. (ekstern lenke)
- Øystein Fluge; Olav Mella; Ove Bruland et al. (2016). Metabolic profiling indicates impaired pyruvate dehydrogenase function in myalgic encephalopathy/chronic fatigue syndrome.. (ekstern lenke)
- Jui-Chih Chang; Shey-Lin Wu; Fredrik Hoel et al. (2016). Far-infrared radiation protects viability in a cell model of Spinocerebellar Ataxia by preventing polyQ protein accumulation and improving mitochondrial function. (ekstern lenke)
- Linn I. Hodneland; Ina Katrine Nitschke Pettersen; Julie Nikolaisen et al. (2015). A new live-cell reporter strategy to simultaneously monitor mitochondrial biogenesis and morphology. (ekstern lenke)
- Magali R Van Linden; Christian Dölle; Ina Katrine Nitschke Pettersen et al. (2015). Subcellular distribution of NAD+ between cytosol and mitochondria determines the metabolic profile of human cells. (ekstern lenke)
- Julie Nikolaisen; Linn I. Hodneland; Ina Katrine Nitschke Pettersen et al. (2014). Automated quantification and integrative analysis of 2D and 3D mitochondrial shape and network properties. (ekstern lenke)
- Hanne Hagland; Linn I. Hodneland; Lena Burri et al. (2013). Induction of mitochondrial biogenesis and respiration is associated with mTOR regulation in hepatocytes of rats treated with the pan-PPAR activator tetradecylthioacetic acid (TTA). (ekstern lenke)
- Agnete Svendsen; Joost JC Verhoeff; Heike Immervoll et al. (2011). Expression of the progenitor marker NG2/CSPG4 predicts poor survival and resistance to ionising radiation in glioblastoma. (ekstern lenke)
- Bjarte Skoe Erikstein; Emmet Martin McCormack; Karl Johan Tronstad et al. (2010). Protein kinase A activators and the pan-PPAR agonist tetradecylthioacetic acid elicit synergistic anti-leukaemic effects in AML through CREB. (ekstern lenke)
- Bjarte Skoe Erikstein; Hanne Hagland; Julie Nikolaisen et al. (2010). Cellular stress induced by resazurin leads to autophagy and cell death via production of reactive oxygen species and mitochondrial impairment. (ekstern lenke)
- Ingrid Moen; Anne Margrete Øyan; Karl-Henning Kalland et al. (2009). Hyperoxic treatment induces mesenchymal to epithelial transition in a rat adenocarcinoma model. (ekstern lenke)
- Therese Bredholt; Elisabeth Anne Okumu Dimba; Hanne Hagland et al. (2009). Camptothecin and khat (Catha edulis Forsk.) induced distinct cell death phenotypes involving modulation of c-FLIPL, Mcl-1, procaspase-8 and mitochondrial function in acute myeloid leukemia cell lines. (ekstern lenke)
- Ingrid Moen; Karl Johan Tronstad; Odd Kolmannskog et al. (2009). Hyperoxia increases the uptake of 5-FU in mammary tumors independently of cganges in interstitial pressure and tumor stroma. (ekstern lenke)
- Hege Wergedahl; Kjetil Berge; Pavol Bohov et al. (2008). Long term treatment with tetradecylthioacetic acid improves the antioxidant status in obese Zucker (fa/fa) rats. (ekstern lenke)
- Per O. Iversen; Dag R. Sørensen; Karl Johan Tronstad et al. (2006). A bioactively modified fatty acid improves survival and impairs metastasis in preclinical models of acute leukemia. (ekstern lenke)
- Øystein Bruserud; Karl Johan Tronstad; Emmet Martin McCormack et al. (2006). Is targeted chemotherapy an alternative to immunotherapy in chronic lymphocytic leukemia?. (ekstern lenke)
- Rolf Kristian Berge; Karl Johan Tronstad; Kjetil Berge et al. (2005). The metabolic syndrome and the hepatic fatty acid drainage hypothesis. (ekstern lenke)
- Øystein Bruserud; Karl Johan Tronstad; Rolf Kristian Berge (2005). In vitro culture of human osteosarcoma cell lines: a comparison of functional characteristics for cell lines cultured in medium without and with fetal calf serum. (ekstern lenke)
- Johan Fernø; Maria Therese Barøy Ræder; Audun Osland Vik-Mo et al. (2005). Antipsychotic drugs activate SREBP-regulated expression of lipid biosynthetic genes in cultured human glioma cells: a novel mechanism of action?. (ekstern lenke)
- Karl Johan Tronstad; Kjetil Berge; Endre Dyrøy et al. (2001). Growth reduction in glioma cells after treatment with tetradecylthioacetic acid: changes in fatty acid metabolism and oxidative status. (ekstern lenke)
- Rolf Kristian Berge; Lise Madsen; Hege Vaagenes et al. (1999). In contrast with docosahexaenoic acid, eicosapentaenoic acid and hypolipidaemic derivatives decrease hepatic synthesis and secretion of triacyllycerol by decreased diacylglycerol acyltransferase activity and stimulation of fatty acid oxidation. (ekstern lenke)
Vitenskapelig kommentar
Vitenskapelig litteraturgjennomgang
- Øystein Fluge; Karl Johan Tronstad; Olav Mella (2021). Pathomechanisms and possible interventions in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). (ekstern lenke)
- Karl Johan Tronstad; Marco Nooteboom; Linn I. Hodneland et al. (2014). Regulation and quantification of cellular mitochondrial morphology and content. (ekstern lenke)
- Brynjar Foss; Karl Johan Tronstad; Øystein Bruserud (2010). Connexin-based signaling in acute myelogenous leukemia (AML). (ekstern lenke)
- Hanne Hagland; Julie Nikolaisen; Linn Iren Hodneland et al. (2007). Targeting mitochondria in the treatment of human cancer: a coordinated attack against cancer cell energy metabolism and signalling. (ekstern lenke)
- Øystein Bruserud; Camilla I Stapnes; Karl Johan Tronstad et al. (2006). Protein lysine acetylation in normal and leukaemic haematopoiesis: HDACs as possible therapeutic targets in adult AML. (ekstern lenke)