Genetiske og epigenetiske variantar som påvirkar kreftrisiko

I tillegg til variantar som endrar den genetiske koden for eit gen, kan kreftrisiko bli endra av variasjonar i korleis gen vert regulert, td. ved at det vert slått av via metylering i genet sitt regulatoriske område (promoter).  Vi studerer slik regulering av BRCA1 genet, og har funne at dette genet er metylert i løpet av fosterlivet hos omlag 10% av jenter, noko som forårsaker ein 2-4 gongar auka risiko for bryst og eggstokkreft seinare i livet.

Tidligare har vi fullført fleire større prosjekt som har fokusert på genetiske endringar i promoteren for MDM2 genet. Her har vi funne at ein særskilt variant (SNP285) reduserer risiko for brystkreft med 37% og risikoen for eggstokkreft med 39% i nokre subgrupper av Europeiske kvinner. 

 

Nøkkel-publikasjonar:

Lønning et al. JAMA Oncology, 2022

Lønning et al. Annals of Internal Medicine, 2018

Knappskog et al. European Journal of Cancer 2012

Knappskog et al. Cancer Cell, 2011

 

Genetiske mekanismar som gir resistens mot behandling hos kreftpasientar

Nokon kreftpasientar opplever dårlig effekt av behandlinga. Vår forsking fokuserer på genetiske og molekylære mekanismar som gjer at enkelt-svulstar ikkje responderer på ulike kreft-medikament. Målet med er å identifisere genetiske mekanismar som kan nyttast som såkalla prediktive biomarkørar, dvs markørar som kan indikere kva for type cellegift som vil være mest nyttig for kvar enkelt pasient.

 

Nøkkel-publikasjonar:

Venizelos et al. Genome Medicine, 2022

Eikesdal et al. Annals of Oncology, 2021

Knappskog et al. Molecular Oncology, 2015

Knappskog et al. Breast Cancer Research, 2012

 

Kreftheterogenitet og evolusjon

Mange kreftsvulstar er heterogene, og er bygd opp av subklonar som er genetisk ulike. Vår forsking fokuserer på korleis ulike subklonar vekst og ter seg gjennom sjukdomsforløpet. Dette inkluderer kva som skjer når sjukdommen spreier seg i kroppen, og kva som skjer når pasienten får behandling med ulike typar medikament.

 

Nøkkel-publikasjonar:

Birkeland et al. Nature Communications, 2018

Yates et al. Cancer Cell, 2017

Yates et al. Nature Medicine, 2015

 

Gjest i podcast frå Bioteknologirådet (2024.09.25)

https://www.bioteknologiradet.no/podkast/kreftens-genetikk/

 

Avisreportasje om ny årsak til brystkreft (2024.01.16)

https://www.ba.no/caroline-fikk-den-mest-aggressive-formen-for-brystkreft-haper-ny-forskning-vil-gi-svar/s/5-8-2494856

 

Avisreportasje om ny årsak til brystkreft (2023.12.)

https://www.vg.no/forbruker/helse/i/Kn5z04/studie-aarsaken-til-brystkreft-kan-oppstaa-i-fosterlivet

 

Innslag i Dagsrevyen om funn i PETREMAC-studien (2021.04.15)

Åse vart kreftfri etter «umogeleg» behandling – NRK Vestland

 

Avisreportasje om nytt sekvenseringsinstrument (2019.10.02)

https://www.bt.no/nyheter/lokalt/i/6jeX98/kreftforskerne-vet-ikke-hvorfor-noen-svulster-ikke-reagerer-paa-behandl

 

Avisreportasjer om forskingsfunn og publikasjon  (2018.01.16)

https://www.vg.no/forbruker/helse/i/G1QO46/norske-forskere-med-internasjonalt-gjennombrudd-kan-pavise-kreftrisiko-i-ufodte-barn

https://www.bt.no/nyheter/innenriks/i/oR617R/Norske-forskere-kan-pavise-kreftrisiko-hos-ufodte-barn

 

Avisreportasjer om forskingsfunn og publikasjon  (2017.08.14)

http://www.vg.no/nyheter/innenriks/helse-og-medisin/norske-forskere-med-nytt-gjennombrudd-kan-gi-bedre-behandling-av-brystkreft/a/24115097/

https://www.ba.no/helse/haukeland-universitetssykehus/nyheter/bergensforskere-med-kreftgjennombrudd/s/5-8-631593

 

Avisreportasje om Ung Forsker-pris ved Onkologisk Forum (2016.11.18)

https://www.dagensmedisin.no/artikler/2016/11/18/stian-knappskog-far-ung-forsker-prisen-2016/?acceptCookies=true

 

TV-innslag om ny klinisk studie - PETREMAC (2016.07.03)

http://www.tv2.no/a/8421737/

 

TV-innslag om ny klinisk studie - PETREMAC (2016.07.05)

http://www.tv2.no/a/8428791/

 

Avisreportasje om forsking finansiert av Rosa sløyfe-aksjonen (2015.10.29)

http://www.ba.no/nyheter/helsevesen/medisin-og-helse/her-gar-midlene-fra-rosa-sloyfe/s/5-8-183805

 

TV intervju om donasjon frå Mohn (2014.12.23)

https://tv.nrk.no/sok?q=Stian%20Knappskog&filter=rettigheter

 

Film for Kreftforeningen angåande Rosa sløyfe-aksjonen (2013.09.20)

https://www.youtube.com/watch?v=Sr4qk4RKz3I

 

Avisreportasje om oppdaging av genvariant som reduserer kreftrisiko (2011.02.15)

http://www.vg.no/nyheter/innenriks/helse-og-medisin/fant-supergen-som-beskytter-mot-kreft/a/10038307/

http://www.forskningsradet.no/prognett-kreftsatsing/Nyheter/Genvariant_reduserer_kreftrisiko/1253964771715&lang=no

 

 

2024

• Elvebakken, Hege; Venizelos, Andreas; Perren, Aurel et al. (2024). Treatment outcome according to genetic tumour alterations and clinical characteristics in digestive high-grade neuroendocrine neoplasms. (ekstern lenke)
• Yndestad, Synnøve; Haugland, Hans Kristian; Goplen, Dorota Katarzyna Pazdyk et al. (2024). Germline variants in patients diagnosed with pediatric soft tissue sarcoma. (ekstern lenke)
• Lønning, Per Eystein; Nikolaienko, Oleksii; Knappskog, Stian (2024). Constitutional BRCA1 Epimutations: A Key for Understanding Basal-Like Breast and High-Grade Serous Ovarian Cancer. (ekstern lenke)

2023

• Yuan, Yuan; Ju, Young Seok; Kim, Youngwook et al. (2023). Publisher Correction: Comprehensive molecular characterization of mitochondrial genomes in human cancers (Nature Genetics, (2020), 52, 3, (342-352), 10.1038/s41588-019-0557-x). (ekstern lenke)
• Nikolaienko, Oleksii; Eikesdal, Hans Petter; Berge, Elisabet Ognedal et al. (2023). Prenatal BRCA1 epimutations contribute significantly to triple-negative breast cancer development. (ekstern lenke)
• Nikolaienko, Oleksii; Lønning, Per Eystein; Knappskog, Stian (2023). epialleleR: an R/Bioconductor package for sensitive allele-specific methylation analysis in NGS data. (ekstern lenke)
• Thomsen, Liv Cecilie Vestrheim; Honore, Alfred; Gjertsen, Bjørn Tore et al. (2023). A prospective non-randomized phase I trial of dendritic cell–based cryoimmunotherapy combined with checkpoint inhibitors in mCRPC.. (ekstern lenke)
• Alexandrov, Ludmil B.; Kim, Jaegil; Haradhvala, Nicholas J. et al. (2023). Author Correction: The repertoire of mutational signatures in human cancer (Nature, (2020), 578, 7793, (94-101), 10.1038/s41586-020-1943-3). (ekstern lenke)
• Yndestad, Synnøve; Engebrethsen, Christina; Herencia-Ropero, A. et al. (2023). Homologous Recombination Deficiency Across Subtypes of Primary Breast Cancer. (ekstern lenke)
• Rheinbay, Esther; Nielsen, Morten Muhlig; Abascal, Federico et al. (2023). Author Correction: Analyses of non-coding somatic drivers in 2,658 cancer whole genomes (Nature, (2020), 578, 7793, (102-111), 10.1038/s41586-020-1965-x). (ekstern lenke)
• Yuan, Yuan; Ju, Young Seok; Kim, Youngwook et al. (2023). Author Correction: Comprehensive molecular characterization of mitochondrial genomes in human cancers (Nature Genetics, (2020), 52, 3, (342-352), 10.1038/s41588-019-0557-x). (ekstern lenke)
• Gerstung, Moritz; Jolly, Clemency; Leshchiner, Ignaty et al. (2023). Author Correction: The evolutionary history of 2,658 cancers (Nature, (2020), 578, 7793, (122-128), 10.1038/s41586-019-1907-7). (ekstern lenke)
• Thomsen, Liv Cecilie Vestrheim; Honore, Alfred; Reisæter, Lars Anders Rokne et al. (2023). Survival and biomarkers in a prospective non-randomized phase I trial of dendritic cell-based cryoimmunotherapy combined with checkpoint inhibitors in metastatic castration-resistant prostate cancer (mCRPC). (ekstern lenke)
• Li, Yilong; Roberts, Nicola D.; Wala, Jeremiah A. et al. (2023). Author Correction: Patterns of somatic structural variation in human cancer genomes (Nature, (2020), 578, 7793, (112-121), 10.1038/s41586-019-1913-9). (ekstern lenke)
• Knappskog, Stian; Grob, Tobias; Venizelos, Andreas et al. (2023). Mutation Spectrum in Liquid Versus Solid Biopsies From Patients With Advanced Gastroenteropancreatic Neuroendocrine Carcinoma. (ekstern lenke)
• Yakneen, Sergei; Waszak, Sebastian Martin; Aminou, Brice et al. (2023). Author Correction: Butler enables rapid cloud-based analysis of thousands of human genomes (Nature Biotechnology, (2020), 38, 3, (288-292), 10.1038/s41587-019-0360-3). (ekstern lenke)
• Calabrese, Claudia; Davidson, Natalie R.; Demircioğlu, Deniz et al. (2023). Author Correction: Genomic basis for RNA alterations in cancer (Nature, (2020), 578, 7793, (129-136), 10.1038/s41586-020-1970-0). (ekstern lenke)
• Sørbye, Halfdan; Knappskog, Stian; Elvebakken, Hege et al. (2023). Mutation Spectrum in Liquid Versus Solid Biopsies From Patients With Advanced Gastroenteropancreatic Neuroendocrine Carcinoma. (ekstern lenke)
• Sorbye, H.; Knappskog, Stian; Elvebakken, Hege et al. (2023). Germline pathogenic variants in patients with high-grade gastroenteropancreatic neuroendocrine neoplasms. (ekstern lenke)
• Venizelos, Andreas; Sorbye, Halfdan; Elvebakken, Hege et al. (2023). Germline pathogenic variants in patients with high-grade gastroenteropancreatic neuroendocrine neoplasms. (ekstern lenke)
• Zapatka, Marc; Borozan, Ivan; Brewer, Daniel S. et al. (2023). Author Correction: The landscape of viral associations in human cancers (Nature Genetics, (2020), 52, 3, (320-330), 10.1038/s41588-019-0558-9). (ekstern lenke)
• Rodriguez-Martin, Bernardo; Alvarez, Eva G.; Baez-Ortega, Adrian et al. (2023). Author Correction: Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition (Nature Genetics, (2020), 52, 3, (306-319), 10.1038/s41588-019-0562-0). (ekstern lenke)
• Thomsen, Liv Cecilie Vestrheim; Honore, Alfred; Reisæter, Lars Anders Rokne et al. (2023). A phase I prospective, non-randomized trial of autologous dendritic cell-based cryoimmunotherapy in patients with metastatic castration-resistant prostate cancer. (ekstern lenke)
• Torkildsen, Cecilie Fredvik; Thomsen, Liv Cecilie Vestrheim; Sande, Ragnar et al. (2023). Molecular and phenotypic characteristics influencing the degree of cytoreduction in high-grade serous ovarian carcinomas. (ekstern lenke)
• Cortés-Ciriano, Isidro; Lee, Jake June-Koo; Xi, Ruibin et al. (2023). Author Correction: Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing (Nature Genetics, (2020), 52, 3, (331-341), 10.1038/s41588-019-0576-7). (ekstern lenke)
• Akdemir, Kadir C.; Le, Victoria T.; Chandran, Sahaana et al. (2023). Author Correction: Disruption of chromatin folding domains by somatic genomic rearrangements in human cancer (Nature Genetics, (2020), 52, 3, (294-305), 10.1038/s41588-019-0564-y). (ekstern lenke)
• Yuan, Yuan; Ju, Young Seok; Kim, Youngwook et al. (2023). Author Correction: Comprehensive molecular characterization of mitochondrial genomes in human cancers (Nature Genetics, (2020), 52, 3, (342-352), 10.1038/s41588-019-0557-x). (ekstern lenke)
• Nguyen, Ha-Linh; Geukens, Tatjana; Maetens, Marion et al. (2023). Obesity-associated changes in molecular biology of primary breast cancer. (ekstern lenke)
• Aaltonen, Lauri A.; Abascal, Federico; Abeshouse, Adam et al. (2023). Author Correction: Pan-cancer analysis of whole genomes (Nature, (2020), 578, 7793, (82-93), 10.1038/s41586-020-1969-6). (ekstern lenke)
• Thomsen, Liv Cecilie Vestrheim; Honore, Alfred; Reisæter, Lars Anders Rokne et al. (2023). Survival and biomarkers in a prospective non-randomized phase I trial of dendritic cell-based cryoimmunotherapy combined with checkpoint inhibitors in metastatic castration-resistant prostate cancer (mCRPC) . (ekstern lenke)

2022

• Liu, Xiaozheng; Rulina, Anastasiia; Choi, Man Hung et al. (2022). C/EBPB-dependent adaptation to palmitic acid promotes tumor formation in hormone receptor negative breast cancer. (ekstern lenke)
• Bhandari, Vinayak; Li, Constance H.; Bristow, Robert G. et al. (2022). Author Correction: Divergent mutational processes distinguish hypoxic and normoxic tumours (Nature Communications, (2020), 11, 1, (737), 10.1038/s41467-019-14052-x). (ekstern lenke)
• Rubanova, Yulia; Shi, Ruian; Harrigan, Caitlin F. et al. (2022). Author Correction: Reconstructing evolutionary trajectories of mutation signature activities in cancer using TrackSig (Nature Communications, (2020), 11, 1, (731), 10.1038/s41467-020-14352-7). (ekstern lenke)
• Sieverling, Lina; Hong, Chen; Koser, Sandra D. et al. (2022). Author Correction: Genomic footprints of activated telomere maintenance mechanisms in cancer (Nature Communications, (2020), 11, 1, (733), 10.1038/s41467-019-13824-9). (ekstern lenke)
• Paczkowska, Marta; Barenboim, Jonathan; Sintupisut, Nardnisa et al. (2022). Author Correction: Integrative pathway enrichment analysis of multivariate omics data (Nature Communications, (2020), 11, 1, (735), 10.1038/s41467-019-13983-9). (ekstern lenke)
• Shuai, Shimin; Abascal, Federico; Amin, Samirkumar B. et al. (2022). Author Correction: Combined burden and functional impact tests for cancer driver discovery using DriverPower (Nature Communications, (2020), 11, 1, (734), 10.1038/s41467-019-13929-1). (ekstern lenke)
• Jiao, Wei; Atwal, Gurnit; Polak, Paz et al. (2022). Author Correction: A deep learning system accurately classifies primary and metastatic cancers using passenger mutation patterns (Nature Communications, (2020), 11, 1, (728), 10.1038/s41467-019-13825-8). (ekstern lenke)
• Reyna, Matthew A.; Haan, David; Paczkowska, Marta et al. (2022). Author Correction: Pathway and network analysis of more than 2500 whole cancer genomes (Nature Communications, (2020), 11, 1, (729), 10.1038/s41467-020-14367-0). (ekstern lenke)
• Zhang, Yiqun; Chen, Fengju; Fonseca, Nuno A. et al. (2022). Author Correction: High-coverage whole-genome analysis of 1220 cancers reveals hundreds of genes deregulated by rearrangement-mediated cis-regulatory alterations (Nature Communications, (2020), 11, 1, (736), 10.1038/s41467-019-13885-w). (ekstern lenke)
• Cmero, Marek; Yuan, Ke; Ong, Cheng Soon et al. (2022). Author Correction: Inferring structural variant cancer cell fraction (Nature Communications, (2020), 11, 1, (730), 10.1038/s41467-020-14351-8). (ekstern lenke)
• Sofiyeva, Nigar; Krakstad, Camilla; Halle, Mari Kyllesø et al. (2022). APOBEC3A/B deletion polymorphism and endometrial cancer risk. (ekstern lenke)
• Batalini, Felipe; Gulhan, Doga C.; Mao, Victor et al. (2022). Mutational Signature 3 Detected from Clinical Panel Sequencing is Associated with Responses to Olaparib in Breast and Ovarian Cancers. (ekstern lenke)
• Pedersen, Christine Aaserød; Cao, Maria Dung; Fleischer, Thomas et al. (2022). DNA methylation changes in response to neoadjuvant chemotherapy are associated with breast cancer survival. (ekstern lenke)
• Lønning, Per Eystein; Nikolaienko, Oleksii; Pan, Kathy et al. (2022). Constitutional BRCA1 methylation and risk of incident triple-negative breast cancer and high-grade serous ovarian cancer. (ekstern lenke)
• Knappskog, Stian; Sorbye, Halfdan; Grob, Tim et al. (2022). Mutation spectrum in liquid versus solid biopsies from advanced digestive neuroendocrine carcinoma patients. (ekstern lenke)
• Nikolaienko, Oleksii; Lønning, Per Eystein; Knappskog, Stian (2022). ramr: an R/Bioconductor package for detection of rare aberrantly methylated regions. (ekstern lenke)
• Rahman, Mohummad Aminur; Engelsen, Agnete ; Sarowar, Shahin et al. (2022). Bortezomib abrogates temozolomide-induced autophagic flux through an ATG5 dependent pathway. (ekstern lenke)
• Venizelos, Andreas; Engebrethsen, Christina; Deng, Wei et al. (2022). Clonal evolution in primary breast cancers under sequential epirubicin and docetaxel monotherapy. (ekstern lenke)

2021

• Venizelos, Andreas; Elvebakken, Hege; Perren, Aurel et al. (2021). The molecular characteristics of high-grade gastroenteropancreatic neuroendocrine neoplasms. (ekstern lenke)
• Gansmo, Liv Beathe; Sofiyeva, Nigar; Bjørnslett, Merete Pauline et al. (2021). Impact of the APOBEC3A/B deletion polymorphism on risk of ovarian cancer. (ekstern lenke)
• Helwa, Reham; Gansmo, Liv Beathe; Bjørnslett, Merete Pauline et al. (2021). Impact of MDM2 promoter SNP55 (rs2870820) on risk of endometrial and ovarian cancer. (ekstern lenke)
• Sorbye, Halfdan; Venizelos, Andreas; Elvebakken, Hege et al. (2021). Molecular characteristics of high-grade gastroenteropancreatic neuroendocrine neoplasms. (ekstern lenke)
• Gansmo, Liv Beathe; Lie, Benedicte Alexandra; Mæhlen, Marthe Thoresen et al. (2021). Polymorphisms in the TP53-MDM2-MDM4-axis in patients with rheumatoid arthritis. (ekstern lenke)

2020

• Bailey, Matthew H.; Meyerson, William U.; Dursi, L. Jonathan et al. (2020). Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples. (ekstern lenke)
• Li, Constance H.; Prokopec, Stephenie D.; Sun, Ren X. et al. (2020). Sex differences in oncogenic mutational processes. (ekstern lenke)
• ICGC/TCGA Pan-Cancer Analysis, of Whole Genomes Consortium; Campbell, Peter J.; Getz, Gad et al. (2020). Pan-cancer analysis of whole genomes. (ekstern lenke)
• Pedersen, Line; Panahandeh, Pouda; Siraji, Muntequa Ishtiaq et al. (2020). Golgi-Localized PAQR4 Mediates Antiapoptotic Ceramidase Activity in Breast Cancer. (ekstern lenke)
• Poduval, Deepak; Sichmanovà, Zuzana; Straume, Anne Hege et al. (2020). The novel microRNAs hsa-miR-nov7 and hsamiR- nov3 are over-expressed in locally advanced breast cancer. (ekstern lenke)
• Poduval, Deepak; Berge, Elisabet Ognedal; Sichmanovà, Zuzana et al. (2020). Assessment of tumor suppressor promoter methylation in healthy individuals. (ekstern lenke)
• Eikesdal, Hans Petter; Yndestad, Synnøve; Elzawahry, Asmaa et al. (2020). Olaparib monotherapy as primary treatment in unselected triple negative breast cancer. (ekstern lenke)
• Cortés-Ciriano, Isidro; Lee, Jake June-Koo; Xi, Ruibin et al. (2020). Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing. (ekstern lenke)
• Zapatka, Marc; Borozan, Ivan; Brewer, Daniel S. et al. (2020). The landscape of viral associations in human cancers. (ekstern lenke)
• Yuan, Yuan; Ju, Young Seok; Kim, Youngwook et al. (2020). Comprehensive molecular characterization of mitochondrial genomes in human cancers. (ekstern lenke)
• Rodriguez-Martin, Bernardo; Alvarez, Eva G.; Baez-Ortega, Adrian et al. (2020). Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition. (ekstern lenke)
• Akdemir, Kadir C.; Le, Victoria T.; Chandran, Sahaana et al. (2020). Disruption of chromatin folding domains by somatic genomic rearrangements in human cancer. (ekstern lenke)
• Zhang, Yiqun; Chen, Fengju; Fonseca, Nuno A. et al. (2020). High-coverage whole-genome analysis of 1220 cancers reveals hundreds of genes deregulated by rearrangement-mediated cis-regulatory alterations. (ekstern lenke)
• Bhandari, Vinayak; Li, Constance H.; Bristow, Robert G. et al. (2020). Divergent mutational processes distinguish hypoxic and normoxic tumours. (ekstern lenke)
• Jiao, Wei; Atwal, Gurnit; Polak, Paz et al. (2020). A deep learning system accurately classifies primary and metastatic cancers using passenger mutation patterns. (ekstern lenke)
• Cmero, Marek; Yuan, Ke; Ong, Cheng Soon et al. (2020). Inferring structural variant cancer cell fraction. (ekstern lenke)
• Sieverling, Lina; Hong, Chen; Koser, Sandra D. et al. (2020). Genomic footprints of activated telomere maintenance mechanisms in cancer. (ekstern lenke)
• Cmero, Marek; Yuan, Ke; Ong, Cheng Soon et al. (2020). Inferring structural variant cancer cell fraction. (ekstern lenke)
• Rubanova, Yulia; Shi, Ruian; Harrigan, Caitlin F. et al. (2020). Reconstructing evolutionary trajectories of mutation signature activities in cancer using TrackSig. (ekstern lenke)
• Bailey, Matthew H.; Meyerson, William U.; Dursi, Lewis Jonathan et al. (2020). Author Correction: Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples (Nature Communications, (2020), 11, 1, (4748), 10.1038/s41467-020-18151-y). (ekstern lenke)

2019

• Choi, Man Hung; Mejlænder-Andersen, Eline ; Manueldas, Sophia et al. (2019). Mutation analysis by deep sequencing of pancreatic juice from patients with pancreatic ductal adenocarcinoma. (ekstern lenke)
• Lønning, Per Eystein; Eikesdal, Hans Petter; Løes, Inger Marie et al. (2019). Constitutional mosaic epimutations - A hidden cause of cancer?. (ekstern lenke)
• Bischof, Katharina; Bjørge, Line; Gjertsen, Bjørn Tore et al. (2019). Rethinking Gynecological High- Grade Serous Carcinoma. Portraying the p53 isoform landscape and development of a new preclinical for optical imaging in xenograft models. (ekstern lenke)
• Bischof, Katharina; Knappskog, Stian; Hjelle, Sigrun Margrethe et al. (2019). Influence of p53 isoform expression on survival in high-grade serous ovarian cancers. (ekstern lenke)
• Røsland, Gro Vatne; Dyrstad, Sissel Elisabeth; Tusubira, Deusdedit et al. (2019). Epithelial to mesenchymal transition (EMT) is associated with attenuation of succinate dehydrogenase (SDH) in breast cancer through reduced expression of SDHC.. (ekstern lenke)
• Smid, Marcel; Wilting, Saskia M.; Uhr, Katharina et al. (2019). The circular RNome of primary breast cancer. (ekstern lenke)
• Aasen, Synnøve Nymark; Parajuli, Himalaya; Hoang, Tuyen et al. (2019). Effective treatment of metastatic melanoma by combining mapk and pi3k signaling pathway inhibitors. (ekstern lenke)
• Eikesdal, Hans Petter; Yndestad, Synnøve; Blix, Egil Støre et al. (2019). Neoadjuvant olaparib monotherapy in primary triple negative breast cancer. (ekstern lenke)
• Eikesdal, Hans Petter; Clausen, Christina; Blix, Egil Støre et al. (2019). Neoadjuvant endocrine therapy with palbociclib in patients with high-risk breast cancer. (ekstern lenke)
• Forthun, Rakel Brendsdal; Hovland, Randi; Schuster, Cornelia et al. (2019). ctDNA detected by ddPCR reveals changes in tumour load in metastatic malignant melanoma treated with bevacizumab. (ekstern lenke)
• Nik-Zainal, Serena; Davies, Helen; Staaf, Johan et al. (2019). Correction to: Landscape of somatic mutations in 560 breast cancer whole-genome sequences (Nature, (2016), 534, 7605, (47-54), 10.1038/nature17676). (ekstern lenke)

2018

• Birkeland, Einar Elvbakken; Lønning, Per Eystein; Knappskog, Stian (2018). Genomic evolution and therapy resistance in melanoma and breast cancer. (ekstern lenke)
• Lønning, Per Eystein; Knappskog, Stian (2018). BRCA1 methylation in newborns: Genetic disposition, maternal transfer, environmental influence, or by chance only?. (ekstern lenke)
• Bischof, Katharina; Knappskog, Stian; Stefansson, Ingunn et al. (2018). High expression of the p53 isoform ? is associated with reduced progression-free survival in uterine serous carcinoma. (ekstern lenke)
• Knappskog, Stian; Gansmo, Liv Beathe; Lønning, Per Eystein (2018). Association of rs2279744 and rs117039649 promoter polymorphism with the risk of gynaecological cancer: A meta-analysis of case-control studies . (ekstern lenke)
• Dyrstad, Sissel Elisabeth; Tusubira, Deusdedit; Knappskog, Stian et al. (2018). Introducing nano-scale quantitative polymerase chain reaction. (ekstern lenke)
• Lønning, Per Eystein; Berge, Elisabet Ognedal; Bjørnslett, Merete Pauline et al. (2018). White blood cell BRCA1 promoter methylation status and ovarian cancer risk. (ekstern lenke)
• Birkeland, Einar Elvbakken; Zhang, Shan; Poduval, Deepak et al. (2018). Patterns of genomic evolution in advanced melanoma. (ekstern lenke)

2017

• Yates, Lucy R.; Knappskog, Stian; Wedge, David et al. (2017). Genomic evolution of breast cancer metastasis and relapse. (ekstern lenke)
• Yndestad, Synnøve; Austreid, Eilin; Svanberg, Ida et al. (2017). Activation of Akt characterizes estrogen receptor positive human breast cancers which respond to anthracyclines. (ekstern lenke)
• Ju, Young Seok; Martincorena, Inigo; Gerstung, Moritz et al. (2017). Somatic mutations reveal asymmetric cellular dynamics in the early human embryo. (ekstern lenke)
• Huun, Johanna; Gansmo, Liv Beathe; Mannsåker, Bård et al. (2017). Impact of the MDM2 splice-variants MDM2-A, MDM2-B and MDM2-C on cytotoxic stress response in breast cancer cells. (ekstern lenke)
• Huun, Johanna; Lønning, Per Eystein; Knappskog, Stian (2017). Effects of concomitant inactivation of p53 and pRb on response to doxorubicin treatment in breast cancer cell lines.. (ekstern lenke)
• Gansmo, Liv Beathe; Romundstad, Pål Richard; Hveem, Kristian et al. (2017). APOBEC3A/B deletion polymorphism and cancer risk.. (ekstern lenke)
• Gansmo, Liv Beathe; Bjørnslett, Merete Pauline; Halle, Mari Kyllesø et al. (2017). MDM2 promoter polymorphism del1518 (rs3730485) and its impact on endometrial and ovarian cancer risk. (ekstern lenke)
• Yndestad, Synnøve; Austreid, Eilin; Knappskog, Stian et al. (2017). High PTEN gene expression is a negative prognostic marker in human primary breast cancers with preserved p53 function. (ekstern lenke)
• Helwa, Reham; Heller, Anette; Knappskog, Stian et al. (2017). Tumor cells interact with red blood cells via galectin-4 - a short report. (ekstern lenke)
• Huun, Johanna; Gansmo, Liv Beathe; Mannsåker, Bård et al. (2017). The Functional roles of the MDM2 splice variants P2-MDM2-10 and MDM2-∆5 in breast cancer cells. (ekstern lenke)

2016

• Knappskog, Stian; Leirvaag, Beryl; Gansmo, Liv Beathe et al. (2016). Prevalence of the CHEK2 R95* germline mutation. (ekstern lenke)
• Sveen, Anita; Løes, Inger Marie; Alagaratnam, Sharmini et al. (2016). Intra-patient inter-metastatic genetic heterogeneity in colorectal cancer as a key determinant of survival after curative liver resection. (ekstern lenke)
• Gansmo, Liv Beathe; Bjørnslett, Merete Pauline; Halle, Mari Kyllesø et al. (2016). The MDM4 SNP34091 (rs4245739) C-allele is associated with increased risk of ovarian—but not endometrial cancer. (ekstern lenke)
• Eskilsson, Eskil; Røsland, Gro Vatne; Talasila, Krishna Mukharji et al. (2016). EGFRvIII mutations can emerge as late and heterogenous events in glioblastoma development and promote angiogenesis through Src activation. (ekstern lenke)
• Smid, Marcel; Rodríguez-González, F. Germán; Sieuwerts, Anieta M. et al. (2016). Breast cancer genome and transcriptome integration implicates specific mutational signatures with immune cell infiltration. (ekstern lenke)
• Helwa, Reham; Gansmo, Liv Beathe; Romundstad, Pål Richard et al. (2016). MDM2 promoter SNP55 (rs2870820) affects risk of colon cancer but not breast-, lung-, or prostate cancer. (ekstern lenke)
• Flågeng, Marianne Hauglid; Larionov, Alexey; Geisler, Jürgen et al. (2016). Treatment with aromatase inhibitors stimulates the expression of epidermal growth factor receptor-1 and neuregulin 1 in ER positive/HER-2/neu non-amplified primary breast cancers. (ekstern lenke)
• Løes, Inger Marie; Immervoll, Heike; Sorbye, Halfdan et al. (2016). Impact of KRAS, BRAF, PIK3CA, TP53 status and intraindividual mutation heterogeneity on outcome after liver resection for colorectal cancer metastases. (ekstern lenke)
• Nik-Zainal, Serena; Davies, Helen; Staaf, Johan et al. (2016). Landscape of somatic mutations in 560 breast cancer whole-genome sequences. (ekstern lenke)
• Gansmo, Liv Beathe; Vatten, Lars Johan; Romundstad, Pål Richard et al. (2016). Associations between the MDM2 promoter P1 polymorphism del1518 (rs3730485) and incidence of cancer of the breast, lung, colon and prostate. (ekstern lenke)
• Helwa, Reham; Ramadan, Mohamed; Abdel-Wahab, Abdel-Hady A. et al. (2016). Promoter SNPs rs116896264 and rs73933062 form a distinct haplotype and are associated with galectin-4 overexpression in colorectal cancer. (ekstern lenke)

2015

• Ju, Young Seok; Tubio, José M.C.; Mifsud, William et al. (2015). Frequent somatic transfer of mitochondrial DNA into the nuclear genome of human cancer cells. (ekstern lenke)
• Yates, Lucy R.; Gerstung, Moritz; Knappskog, Stian et al. (2015). Subclonal diversification of primary breast cancer revealed by multiregion sequencing. (ekstern lenke)
• Flågeng, Marianne Hauglid; Knappskog, Stian; Gjerde, Jennifer et al. (2015). Estrogens correlate with PELP1 expression in ER positive breast cancer. (ekstern lenke)
• Knappskog, Stian; Berge, Elisabet Ognedal; Chrisanthar, Ranjan et al. (2015). Concomitant inactivation of the p53- and pRB- functional pathways predicts resistance to DNA damaging drugs in breast cancer in vivo. (ekstern lenke)
• Gansmo, Liv Beathe; Knappskog, Stian; Romundstad, Pål Richard et al. (2015). Influence of MDM2 SNP309 and SNP285 status on the risk of cancer in the breast, prostate, lung and colon. (ekstern lenke)
• Løes, Inger Marie; Immervoll, Heike ; Angelsen, Jon-Helge et al. (2015). Performance comparison of three BRAF V600E detection methods in malignant melanoma and colorectal cancer specimen. (ekstern lenke)
• Gansmo, Liv Beathe; Romundstad, Pål Richard; Birkeland, Einar Elvbakken et al. (2015). MDM4 SNP34091 (rs4245739) and its effect on breast-, colon-, lung-, and prostate cancer risk. (ekstern lenke)

2014

• Eikesdal, Hans Petter; Knappskog, Stian; Aas, Turid et al. (2014). TP53 status predicts long-term survival in locally advanced breast cancer after primary chemotherapy. (ekstern lenke)
• Knappskog, Stian; Lønning, Per Eystein (2014). MDM2 SNP309 and risk of endometrial cancer. (ekstern lenke)
• Nik-Zainal, Serena; Wedge, David C.; Alexandrov, Ludmil B. et al. (2014). Association of a germline copy number polymorphism of APOBEC3A and APOBEC3B with burden of putative APOBEC-dependent mutations in breast cancer. (ekstern lenke)
• Tubio, José M.C.; Li, Yilong; Ju, Young Seok et al. (2014). Extensive transduction of nonrepetitive DNA mediated by L1 retrotransposition in cancer genomes. (ekstern lenke)
• Knappskog, Stian; Lønning, Per Eystein (2014). MDM2 SNP309 and risk of cervical cancer. (ekstern lenke)
• Knappskog, Stian; Gansmo, Liv Beathe; Dibirova, Khadizha et al. (2014). Population distribution and ancestry of the cancer protective MDM2 SNP285 (rs117039649). (ekstern lenke)
• Straume, Anne Hege; Knappskog, Stian; Lønning, Per Eystein (2014). Effects of SNP variants in the 17β-HSD2 and 17β-HSD7 genes and 17β-HSD7 copy number on gene transcript and estradiol levels in breast cancer tissue. (ekstern lenke)
• Knappskog, Stian; Lønning, Per Eystein (2014). MDM2 SNP309 and risk of cervical cancer. (ekstern lenke)

2013

• Berge, Elisabet Ognedal; Huun, Johanna; Lillehaug, Johan R. et al. (2013). Functional characterisation of p53 mutants identified in breast cancers with suboptimal responses to anthracyclines or mitomycin. (ekstern lenke)
• Knappskog, Stian; Lønning, Per Eystein (2013). MDM2 SNP309 and risk of endometrial cancer. (ekstern lenke)
• Alexandrov, Ludmil B.; Nik-Zainal, Serena; Wedge, David C. et al. (2013). Signatures of mutational processes in human cancer. (ekstern lenke)
• Flågeng, Marianne Hauglid; Knappskog, Stian; Haynes, Ben P. et al. (2013). Inverse regulation of EGFR/HER1 and HER2-4 in normal and malignant human breast tissue. (ekstern lenke)
• Birkeland, Einar Elvbakken; Busch, Christian; Berge, Elisabet Ognedal et al. (2013). Low BRAF and NRAS expression levels are associated with clinical benefit from DTIC therapy and prognosis in metastatic melanoma. (ekstern lenke)
• Astori, Audrey; Fredly, Hanne Kristin; Aloysius, Thomas Aquinas et al. (2013). CXXC5 (retinoid-inducible nuclear factor, RINF) is a potential therapeutic target in high-risk human acute myeloid leukemia. (ekstern lenke)
• Arnesen, Thomas; Glomnes, Nina; Strømsøy, Siri S. et al. (2013). Outcome after surgery for primary hyperaldosteronism may depend on KCNJ5 tumor mutation status: a population-based study from Western Norway. (ekstern lenke)
• Lønning, Per Eystein; Knappskog, Stian (2013). Mapping genetic alterations causing chemoresistance in cancer: identifying the roads by tracking the drivers. (ekstern lenke)

2012

• McCormack, Emmet Martin; Haaland, Ingvild; Venås, Gurid et al. (2012). Synergistic induction of p53 mediated apoptosis by valproic acid and nutlin-3 in acute myeloid leukemia. (ekstern lenke)
• Knappskog, Stian; Trovik, Jone; Marcickiewicz, Janusz et al. (2012). SNP285C modulates oestrogen receptor/Sp1 binding to the MDM2 promoter and reduces the risk of endometrial but not prostatic cancer. (ekstern lenke)
• Ånensen, Nina; Hjelle, Sigrun Margrethe; Van, Belle Werner et al. (2012). Correlation analysis of p53 protein isoforms with NPM1/FLT3 mutations and therapy response in acute myeloid leukemia. (ekstern lenke)
• Straume, Anne Hege; Knappskog, Stian; Lønning, Per Eystein (2012). Effect of CYP19 rs6493497 and rs7176005 haplotype status on in vivo aromatase transcription, plasma and tissue estrogen levels in postmenopausal women. (ekstern lenke)
• Knappskog, Stian; Lønning, Per Eystein (2012). P53 and its molecular basis to chemoresistance in breast cancer. (ekstern lenke)
• Straume, Anne Hege; Løvås, Kristian; Miletic, Hrvoje et al. (2012). Elevated levels of the steroidogenic factor 1 are associated with over-expression of CYP19 in an oestrogen-producing testicular Leydig cell tumour. (ekstern lenke)
• Knappskog, Stian (2012). Re: Murine double minute 2 promoter SNP309 polymorphism and prostate cancer risk: a meta-analysis. (ekstern lenke)
• Lønning, Per Eystein; Knappskog, Stian (2012). Chemosensitivity and p53; new tricks by an old dog. (ekstern lenke)
• Bjørnslett, Merete Pauline; Knappskog, Stian; Lønning, Per Eystein et al. (2012). Effect of the MDM2 promoter polymorphisms SNP309T>G and SNP285G>C on the risk of ovarian cancer in BRCA1 mutation carriers. (ekstern lenke)
• Knappskog, Stian; Gansmo, Liv Beathe; Romundstad, Pål Richard et al. (2012). MDM2 Promoter SNP344T>A (rs1196333) Status Does Not Affect Cancer Risk. (ekstern lenke)
• Knappskog, Stian; Chrisanthar, Ranjan; Løkkevik, Erik et al. (2012). Low expression levels of ATM may substitute for CHEK2/TP53 mutations predicting resistance towards anthracycline and mitomycin chemotherapy in breast cancer. (ekstern lenke)

2011

• Knappskog, Stian; Bjørnslett, Merete Pauline; Myklebust, Line Merethe et al. (2011). The MDM2 Promoter SNP285C/309G Haplotype Diminishes Sp1 Transcription Factor Binding and Reduces Risk for Breast and Ovarian Cancer in Caucasians. (ekstern lenke)
• Flågeng, Marianne Hauglid; Knappskog, Stian; Lønning, Per Eystein et al. (2011). The nuclear receptor coactivator PELP1/MNAR is positively correlated with estrogen levels in breast cancer patients. (ekstern lenke)
• Knappskog, Stian; Myklebust, Line Merethe; Busch, Christian et al. (2011). RINF (CXXC5) is overexpressed in solid tumors and is an unfavorable prognostic factor in breast cancer(dagger). (ekstern lenke)
• Welin, Staffan; Sørbye, Halfdan; Sebjørnsen, Sigrunn et al. (2011). Clinical effect of Temozolomide-based chemotherapy in poorly differentiated endocrine carcinoma after progression on first-line chemotherapy. (ekstern lenke)
• Berge, Elisabet Ognedal; Knappskog, Stian; Lillehaug, Johan R. et al. (2011). Alterations of the retinoblastoma gene in metastatic breast cancer. (ekstern lenke)
• Knappskog, Stian; Lønning, Per Eystein (2011). MDM2 promoter SNP285 and SNP309; phylogeny and impact on cancer risk. (ekstern lenke)
• Lønning, Per Eystein; Haynes, Ben P.; Straume, Anne Hege et al. (2011). Recent data on intratumor estrogens in breast cancer. (ekstern lenke)
• Lønning, Per Eystein; Haynes, Ben P.; Straume, Anne Hege et al. (2011). Exploring breast cancer estrogen disposition: The basis for endocrine manipulation. (ekstern lenke)
• Chrisanthar, Ranjan; Knappskog, Stian; Løkkevik, Erik et al. (2011). Predictive and Prognostic Impact of TP53 Mutations and MDM2 Promoter Genotype in Primary Breast Cancer Patients Treated with Epirubicin or Paclitaxel. (ekstern lenke)
• Knappskog, Stian; Lønning, Per Eystein (2011). Effects of the MDM2 promoter SNP285 and SNP309 on Sp1 transcription factor binding and cancer risk. (ekstern lenke)

2010

• Torsvik, Anja; Røsland, Gro Vatne; Svendsen, Agnete et al. (2010). Spontaneous Malignant Transformation of Human Mesenchymal Stem Cells Reflects Cross-Contamination: Putting the Research Field on Track - Letter. (ekstern lenke)
• Berge, Elisabet Ognedal; Knappskog, Stian; Geisler, Stephanie et al. (2010). Identification and characterization of retinoblastoma gene mutations disturbing apoptosis in human breast cancers. (ekstern lenke)
• Busch, Christian; Geisler, Jürgen; Knappskog, Stian et al. (2010). Alterations in the p53 Pathway and p16INK4a Expression Predict Overall Survival in Metastatic Melanoma Patients Treated with Dacarbazine. (ekstern lenke)
• Flågeng, Marianne Hauglid; Knappskog, Stian; Larionov, Alexey et al. (2010). Epidermal growth factor receptors (ErbB/HER) and the ligand Neuregulin 1 (NRG1) increase in breast tumors during short time treatment with aromatase inhibitors. (ekstern lenke)
• Jönsson, Göran; Busch, Christian; Knappskog, Stian et al. (2010). Gene Expression Profiling-Based Identification of Molecular Subtypes in Stage IV Melanomas with Different Clinical Outcome. (ekstern lenke)

2008

• Chrisanthar, Ranjan; Knappskog, Stian; Løkkevik, Erik et al. (2008). CHEK2 mutations affecting kinase activity together with mutations in TP53 indicate a functional pathway associated with resistance to epirubicin in primary breast cancer. (ekstern lenke)

2007

• Chrisanthar, Ranjan; Knappskog, Stian; Staalesen, Vidar et al. (2007). P21/waf1 mutation and drug resistance to paclitaxel in locally advanced breast cancer. (ekstern lenke)
• Lønning, Per Eystein; Chrisanthar, Ranjan; Staalesen, Vidar et al. (2007). Adjuvant treatment: the contribution of expression microarrays. (ekstern lenke)
• Lønning, Per Eystein; Knappskog, Stian; Staalesen, Vidar et al. (2007). Breast cancer prognostication and prediction in the postgenomic era. (ekstern lenke)
• Knappskog, Stian (2007). Germline Genetic Alterations Affecting CDKN2A, MDM2 and CDKN1A in Melanoma and Breast Cancer Patients. (ekstern lenke)
• Staalesen, Vidar; Knappskog, Stian; Chrisanthar, Ranjan et al. (2007). The MDM2 SNP309 G/T promoter polymorphism is associated with chemoresistance in primary breast cancers harbouring mutations in the TP53 gene. (ekstern lenke)
• Stern, Beate; Gjerdrum, Christine; Knappskog, Stian et al. (2007). UTRech tm: Exploiting mRNA Targeting To Increase Protein Secetion From Mammalian Cells. (ekstern lenke)
• Knappskog, Stian; Ravneberg, Hanne; Gjerdrum, Christine et al. (2007). The level of synthesis and secretion of Gaussia princeps luciferase in transfected CHO cells is heavily dependent on the choice of signal peptide. (ekstern lenke)
• Knappskog, Stian; Chrisanthar, Ranjan; Staalesen, Vidar et al. (2007). Mutations and polymorphisms of the p21B transcript in breast cancer. (ekstern lenke)

2006

• Stålesen, Vidar; Staalesen, Vidar; Knappskog, Stian et al. (2006). The novel p21 polymorphism p21(G251A) is associated with locally advanced breast cancer. (ekstern lenke)
• Knappskog, Stian; Geisler, Jürgen; Arnesen, Thomas et al. (2006). A novel type of deletion in the CDKN2A gene identified in a melanoma-prone family. (ekstern lenke)
• Berge, Elisabet Ognedal; Knappskog, Stian; Lillehaug, Johan et al. (2006). Functional characterisation of novel p53 mutants. (ekstern lenke)

2005

• Staalesen, Vidar; Knappskog, Stian; Geisler, Stephanie et al. (2005). The SNP309HDM2 polymorphism is associated with chemoresistance and poor survival in breast cancers harboring mutations in the TP53 gene. (ekstern lenke)

Se en full oversikt over publikasjoner i Cristin

Publikasjonar lista i PubMed:

https://www.ncbi.nlm.nih.gov/pubmed/?term=knappskog+s

 

Publikasjonar lista i Cristin: