From 2026: MEDDOD1, MEDDOD2, BMED330 (cell communication and intracel. sign.), TPBAKBP (lab for oral hygenists)

Previously: ODPATIM2; immunology for dentists.

Se en full oversikt over publikasjoner i Cristin

12 chosen publications 10 last years (In total 87 publications)

2025 Single cell characterization of blood and expanded regulatory T cells in autoimmune polyendocrine syndrome type 1. Thea Sjøgren, Shahinul Islam#, Igor Filippov#, Adrianna Jebrzycka, André Sulen, Lars E. Breivik, Alexander Hellesen, Anders P. Jørgensen, Kari Lima, Liina Tserel, Kai Kisand, Pärt Peterson, Annamari Ranki, Eystein S. Husebye, Bergithe E. Oftedal, Anette S. B. Wolff (corr.author). Accepted iScience 25.03.24. DOI: 10.1016/j.isci.2024.109610

Here we describe the function and phenotype of regulatory T cells in patients with mutations in the Autoimmune Regulator gene using single cell sequencing, and mass and flow cytometry.

2024 Interferon autoantibodies as signals of a sick thymus. Bergithe E. Oftedal, Thea Sjøgren and Anette S. B. Wolff (corr.author). Review. Front Immunol. 2024 Feb 22;15:1327784. doi: 10.3389/fimmu.2024.1327784. IF 5.9.

A review describing different deficiencies of the thymus which co-occur with presence of cytokine autoantibodies. We further propose underlying mechanisms.

2024 Immune cell subsets in Autoimmune Polyendocrine Syndrome Type 1 Shahinul Islam, Bergithe E. Oftedal, Miriam Gjerdevik, Lars Breivik, Ellen C. Røyrvik, Kari Lima, Anders P. Jørgensen, Ifunanya Nwakwuo, Jørn Skavland, Eystein S. Husebye, Anette S. B. Wolff (corr.author). Sci Rep. 2025 Aug 4;15(1):28398. doi: 10.1038/s41598-025-12634-y.

In this work we characterised immune cell subsets in patients with mutations in the AIRE gene (N=19 patients). 

2023 Breakdown of tolerance to ameloblast-specific proteins results in tooth autoimmunity in APS1 and celiac patients.  Yael Gruper, Anette S. B. Wolff*, Liad Glanz, František Špoutil, Yonatan Herzig, Yael Goldfarb, Goretti A. Novaliches, Adriana Osičková, Jan Dobeš, Noam Kadouri, Osher Ben-Nun, Amit Binyamin, Bar Lavi, Tal Givony, Razi Khalaila, Tom Gome, Tomáš Wald, Blanka Mrázková, Carmel Shochen, Mihaela Cuida Marthinussen, Marine Besnard, Shifra Ben-Dor, Ester Feldmesser, Elisaveta M. Orlova, Carole Guillonneau, Csaba Hegedűs, István Lampé, Tamás Papp, Szabolcs Felszeghy, Dror Shouval, Noa Tal, Esti Davidovich, Raanan Shamir, Zsuzsa Szondy, Knut E.A. Lundin, Radim Osička, Jan Procházka, Eystein S. Husebye and Jakub Abramson* (Wolff joint corresponding author). Nature 23.10.23. DOI 10.1038/s41586-023-06776-0.

Open access: https://www.nature.com/articles/s41586-023-06776-0

Here, we describe a new disease syndrome, autoimmune amelogenesis imperfecta, affecting tooth enamel. We describe the same outcome for two autoimmune disorders and how tolerance may fail to cause autoimmunity against ameloblasts. I coordinated the patient-part on this study, both regarding APS-1 patients and celiac patients. I was involved in forming hypotheses, analyse samples and the whole writing process. I am corresponding author together with Abramson. 

2023 Vaccination prevents severe outcome of COVID-19 in patients with high levels of neutralizing type 1 interferon autoantibodies Anette S. B. Wolff (*), Lena Hansen, Marianne Aa. Grytaas, Bergithe E. Oftedal, Lars Breivik, Fan Zhou, Karl Ove Hufthammer, Thea Sjøgren, Jan Stefan Olofsson, Mai Chi Trieu, Anthony Meager, Anders P. Jørgensen, Kari Lima, Kristin G-I Mohn, Nina Langeland#, Rebecca Jane Cox# and Eystein S. Husebye#.(*). iScience 06.06.23. 

Open access Vaccination prevents severe COVID-19 outcome in patients with neutralizing type 1 interferon autoantibodies - PMC (nih.gov)

Here we have teamed up with the Cox/Langeland team at Haukeland and performed a study on SARS-CoV vaccination in patients with pre-existing autoantibodies against interferons, namely APS-1 patients. We also found that vaccination prevents severe COVID-19 course in these individuals. I came up with the idea, coordinated patient sampling and performed several of the analyses in the study.

2023 A polygenic risk score for autoimmune Addison’s disease estimates individual risk and identifies patients with monogenic adrenal insufficiency. Maribel Aranda-Guillén, Ellen Christine Røyrvik, Sara Ström, Haydee Artaza Alvarez, Ileana Botusan, Marianne Grytaas, Åsa Hallgren, Lars Breivik, Maria Pettersson, Anders P. Jørgensen, Anna Lindstrand, Elinor Vogt, The Norwegian Addison Registry Study Group, The Swedish Addison Registry Study Group, Eystein S. Husebye, Olle Kämpe, Anette S. Bøe Wolff, Sophie Bensing, Stefan Johansson, Daniel Eriksson. J Intern Med. 2023 May 8. doi: 10.1111/joim.13649. 

Open access

A polygenic risk score to help discriminate primary adrenal insufficiency of different etiologies - Aranda‐Guillén - 2023 - Journal of Internal Medicine - Wiley Online Library

In this multisenter study we performed a polygenic risk score to predict autoimmune Addison’s disease in risk individuals. I coordinated the Norwegian part of this study. 

2023 Systemic interferon type I and B cell regulation responses are impaired in autoimmune polyendocrine syndrome type 1. Bergithe E. Oftedal, Nicolas Delaleu, David Dolan, Anthony Meager, Eystein S. Husebye, Anette S. B. Wolff. (corr.author). FEBS Lett. 2023 Apr 13. doi: 10.1002/1873-3468.14625. 

Here we used several approaches to map molecular signal profiles in blood of patients with APS-1. We found impaired B cell and interferon responses. I came up with the hypotheses, performed several of the wet lab tasks and also analyses in the study. 

Open access

Systemic interferon type I and B cell responses are impaired in autoimmune polyendocrine syndrome type 1 - Oftedal - 2023 - FEBS Letters - Wiley Online Library

2022. Screening patients with autoimmune endocrine disorders for cytokine autoantibodies reveals monogenic immune deficiencies 

Thea Sjøgren, Eirik Bratland, Ellen C. Røyrvik, Marianne Grytaas, Andreas Benneche, Per M. Knappskog, Bergithe E. Oftedal, Eystein S.  Husebye and Anette S. B. Wolff(corr.author). J Autoimm. 2022 Dec;133:102917. 

Open access

https://www.sciencedirect.com/science/article/abs/pii/S0896841122001251?via%3Dihub

Here, my PhD student Thea (now Post.doc.) screened a large cohort of patients with adrenal failure and other autoimmune endocrine conditions and found several cases with autoantibodies against interferons who had mutations in genes encoding immune regulatory genes. This study is the initial part of a larger effort to describe cytokine autoantibodies as early risk markers of genetic impairments implicating failure of immune regulation culminating in autoimmunity. 

2021. Genome-wide association study links autoimmune Addison’s disease to break of central tolerance. Daniel Eriksson*, Ellen Christine Røyrvik*, Maribel Aranda-Guillén*, …, Anette Susanne Bøe Wolff, Sophie Bensing, Stefan Johansson§, Olle Kämpe§, Eystein S. Husebye§. Nat Commun.. 2021 Feb 11;12(1):959. doi: 10.1038/s41467-021-21015-8. 

The first ever GWAS on Addison’s disease. I coordinated this study from A to Z and was one of the senior authors. The study shows 9 genetic loci convincingly giving risk to Addison’s disease. All risk loci encode factors of adaptive immunity and the T cell pathway in specific. The results can be used to make polygenic risk scores to be able to predict risk for Addison’s disease in screening efforts. This again can lead to earlier diagnosis of patients, which in turn can save lives.

2021. The natural history of 21-hydroxylase autoantibodies in autoimmune Addison’s disease. Anette S. B. Wolff, Lars Breivik, Karl Ove Hufthammer, Marianne Grytaas, Eirik Bratland, Eystein S. Husebye, Bergithe E. Oftedal. EJE 2021. Volume 184: Issue 4. Page 607-15. https://doi.org/10.1530/EJE-20-1268 . 

We have here studied samples spanning 25 years from the largest registry and biobank of autoimmune Addison’s disease worldwide. I participated in the whole process.

2016 AIRE-Deficient Patients Harbor Unique High-Affinity Disease-Ameliorating Autoantibodies: Steffen Meyer, Martin Woodward, Christina Hertel, Philip Vlaicu, Yasmin Haque, Dimitri Fishman, Hedi Peterson, Jaanika Kärner, Kaja Metsküla, Raivo Uibo, Anette S. B. Wolff, APECED patient collaborative, Kai Krohn, Annamari Ranki, Pärt Peterson, Kai Kisand & Adrian Hayday. Cell Volume 166, Issue 3, p582–595, 28 July 2016. IF 41.5 (Citations 123).

Here we describe patients with APS-I having unique autoantibodies against a battery of proteins of the body, and that presence of these markers for autoimmunity may indeed be beneficial for not acquiring some components of APS-I, like type I diabetes, i.e. cytokine-autoantibodies may have protective roles. 

2015. Dominant Autoimmune Regulator mutations associated with common organ-specific autoimmune diseases: PhD Bergithe E. Oftedal, MSc Alexander Hellesen, MD PhD  Martina Moter Erichsen, PhD Eirik Bratland, MSc  Ayelet Vardi, MD PhD Jaakko Perheentupa, PhD E. Helen Kemp, MD PhD Torunn Fiskerstrand, PhD Marte K. Viken, MD PhD Anthony P. Weetman, PhD Sarel J. Fleishman, MD PhD Siddharth Banka, MD PhD William G. Newman, MD PhD W.A.C Sewell, MD Leila S. Sozaeva, MD PhD Tetyana Zayats,_, MD PHD Kristoffer Haugarvoll,PhD MD Elizaveta M. Orlova, PhD MD Jan Haavik, PhD Stefan Johansson, PhD Per M. Knappskog, MD PhD Kristian Løvås, PhD Anette S. B. Wolff, PhD Jakub Abramson, MD PhD Eystein S. Husebye. Immunity.2015 Jun 16;42(6):1185-96.  (Citations 108). 

In this paper, where I am one of the senior researchers, we describe and characterize novel dominant mutations in the autoimmune regulator (AIRE) gene, which could be a common susceptibility factor for autoimmune susceptibility.

• Cytokine autoantibodies in patients with autoimmune diseases and immunodeficiencies. Including genomics and functional genetics on germline and somatic immune gene variants.

  Funding; Norwegian Research council, Novo Nordisk Fonden, Western Norway Health Authorities.

  People: Thea Sjøgren (post.doc), Ivan Abbedissen (PhD student), Kristin Watnedal Olsen (PhD student), Julie Sølversen (Researcher), Alexander Hellesen (post.doc.), Mona Bjune (post.doc), Cecilie Gjerde (oral tissue), Kathrine Skarstein (biopsies, pathology), Ingvild Olerud (master student 2025-26), Victoria Olsvold (master student 2026-27), Elisabet Ognedal (genetic expert). Collaboration with Bergithe Oftedal, Harald Carlsen and Preben Boysen on mice studies.

  Biobanks/registries, ROAS (Registry and biobank for organ specific autoimmune disorders), Western Norway immune deficiency biobank, Norsk systemisk bindevevssykdom og vaskulittregister (NOSVAR), Norsk diabetesregister

• Autoimmune amelogenesis imperfecta and celiac disease

  People: Eystein Husebye, Nancy Bletsa, Mihaela C. Marthinussen, Erling Tjora (barn Haukeland), Rene Fjellander (voksne Haukeland), Birgitte Emken (voksne Haukeland), Ingvild Brusevold (UiO), Tove Wigen (UiO).

  Biobanks/registries, ROAS (Registry and biobank for organ specific autoimmune disorders), Biobank for enamel failure and celiac disease children at Haukeland. 

• Genetics in autoimmune Addison's disease

  Funding; Norwegian Research council, Western Norway Health Authorities

  People: Eystein S. Husebye, Marianne Grytaas, Ellen Røyrvik, Tetyana Zayats, Bergithe Oftedal, Julie Sølversen (researcher). Collaboration with Olle Kampe at KI, Sweden. 

  Biobank: Norway and Sweden Addison registry (Norway: ROAS)

• Natural course of Addison's disease

  People: Eystein Husebye, Marianne Øksnes, ROAS network, Grethe Ueland, Ann Elin Stokland, Eivind Ness-Jensen++

  Funding: Norwegian Research council, Western Norway Health Authorities

  Biobanks/registries, ROAS (Registry and biobank for organ specific autoimmune disorders), Norsk diabetesregister, HUNT Norway, DIPP Finland

Collaboration with the flow cytometry and genomic facility at UiB for all projects