Min hoved forskningsfokus er på sammenhengen mellom stress i ulike faser av livet og endringer i søvn og døgnrytmer i et translasjonelt prespektiv (dyremodeller og humane studier). Et av viktigste mål er å undersøke betydningen av ulike oppvekstbetingelser for helsemessige konsekvenser senere i livet (søvn, døgnrytmer, adferd, kognisjon, molekylære mekanismer), samt hvilke faktorer som kan moderere konsekvenser av negative tidlig livshendelser.

Et annet fokus er på konsekvenser av nattarbeid på søvn, døgnrytmer og våkenhetsfunksjon, samt hvordan eksponering til ulike lysforhold kan benyttes til å motvirke søvnighet og bedre kognitiv funksjon under nattarbeid.

 

Metoder:

Dyremodeller

• Objektive målinger av søvn og døgnrytmer
• Objektive målinger av våkenhetsfunksjon
• Elektrofysiologi​
• Polysomnografi
• Adferdstester

Humane studier

• Subjektive og objektive mål av søvn og døgnrytmer
• Subjektive og objektive målinger av våkenhetsfunksjon
• Polysomnografi
• Kognitive tester

Podcast episode

• Søvn og ernæring - hvordan henger dette sammen?

 

Artikler

• Kan vi spise oss til bedre søvn?, SØVN, 2018, 2:26-29
• Normal utvikling av hjernen, SØVN, 2013, 1:14-15
• Sommerskole i døgnrytmer og søvn, SØVN, 2017, 2:35-37
• Hva skjer med søvn hos ungdom og hvordan kan vi lære dem at søvn er viktig?, SØVN, 2016, 1:18-22

Emneansvarlig:

• Adferd og nevrovitenskap: Biologisk psykologi MAPSYK337

Andre kurs jeg underviser i:

• Biologisk psykologi PROPSY303
• Utviklings-, kognitiv og biologisk psykologi PSYK114
• Søvn, døgnrytmer og atferd PSYK115
• Adferd, helse og ernæring PSYK140
• Course in interdisciplinary neuroscience - IGSIN913

 

Noen tema jeg underviser i:

• Nevroanatomi/fysiologi
• Nervesystemets utvikling
• Ernæring og hjernefunksjon
• Søvn på tvers av arter
• Søvn og døgnrytmer gjennom livet
• Stressregulering

Vitenskapelig artikkel

• Torhild Thue Pedersen; Erlend Sunde; Jonathan P. Wisor et al. (2022). Sleep homeostasis and night work: a polysomnographic study of daytime sleep following three consecutive simulated night shifts. (ekstern lenke)
• Bjørn Bjorvatn; Jelena Mrdalj; Ingvild W. Saxvig et al. (2017). Age and sex differences in bedroom habits and bedroom preferences. (ekstern lenke)
• Janne Grønli; Peter Meerlo; Torhild Pedersen et al. (2016). A rodent model of night-shift work induces short-term and enduring sleep and electroencephalographic disturbances. (ekstern lenke)
• Iris Mulders Steine; Anne Marita Milde; Bjørn Bjorvatn et al. (2012). Forekomsten av seksuelle overgrep i et representativt befolkningsutvalg i Norge. (ekstern lenke)
• Jubayer Hossain; Lars Andreas Rømo Ystaas; Jelena Mrdalj et al. (2016). Lentiviral HSV-Tk.007-mediated suicide gene therapy is not toxic for normal brain cells. (ekstern lenke)
• Janne Grønli; Jelena Mrdalj (2018). Can night shift workers benefit from light exposure?. (ekstern lenke)
• Oda Bugge Kambestad; Kristine Sirevåg; Jelena Mrdalj et al. (2023). Physical Exercise and Serum BDNF Levels: Accounting for the Val66Met Polymorphism in Older Adults. (ekstern lenke)
• Anne Marie Kinn Rød; Robert Murison; Jelena Mrdalj et al. (2014). Effects of social defeat on sleep and behaviour: Importance of the confrontational behaviour. (ekstern lenke)
• Erlend Sunde; Jelena Mrdalj; Torhild Pedersen et al. (2020). Role of nocturnal light intensity on adaptation to three consecutive night shifts: a counterbalanced crossover study. (ekstern lenke)
• Erlend Sunde; Torhild Pedersen; Jelena Mrdalj et al. (2020). Blue-enriched white light improves performance but not subjective alertness and circadian adaptation during three consecutive simulated night shifts. (ekstern lenke)
• Erlend Sunde; Jelena Mrdalj; Torhild Thue Pedersen et al. (2022). Bright light exposure during simulated night work improves cognitive flexibility. (ekstern lenke)
• Jelena Mrdalj; Ståle Pallesen; Anne Marita Milde et al. (2013). Early and later life stress alter brain activity and sleep in rats. (ekstern lenke)
• Michael J. Rempe; Janne Grønli; Torhild Pedersen et al. (2018). Mathematical modeling of sleep state dynamics in a rodent model of shift work. (ekstern lenke)
• Andrea Rørvik Marti; Sudarshan Patil; Jelena Mrdalj et al. (2017). No escaping the rat race: simulated night shift work alters the time-of-day variation in BMAL1 translational activity in the prefrontal cortex. (ekstern lenke)
• Jelena Mrdalj; Åse Lundegaard Mattson; Robert Murison et al. (2014). Hypothermia after chronic mild stress exposure in rats with a history of postnatal maternal separations. (ekstern lenke)
• Iris Mulders Steine; Tetyana Zayats; Christine Stansberg et al. (2016). Implication of NOTCH1 Gene in Susceptibility to Anxiety and Depression among Sexual Abuse Victims. (ekstern lenke)
• Eliann Øines; Robert Murison; Jelena Mrdalj et al. (2012). Neonatal maternal separation in male rats increases intestinal permeability and affects behavior after chronic social stress. (ekstern lenke)
• Lars Ertesvåg Breivik; Erik Helgeland; Eva-Katrine Aarnes et al. (2011). Remote postconditioning by humoral factors in effluent from ischemic preconditioned rat hearts is mediated via PI3K/Akt-dependent cell-survival signaling at reperfusion. (ekstern lenke)
• Erlend Sunde; Torhild Pedersen; Jelena Mrdalj et al. (2020). Alerting and Circadian Effects of Short-Wavelength vs. Long-Wavelength Narrow-Bandwidth Light during a Simulated Night Shift. (ekstern lenke)
• Andrea Rørvik Marti; Torhild Pedersen; Jonathan P. Wisor et al. (2020). Cognitive function and brain plasticity in a rat model of shift work: role of daily rhythms, sleep and glucocorticoids. (ekstern lenke)
• Jelena Mrdalj; Robert Murison; Jonathan Soule et al. (2016). Mild daily stressors in adulthood may counteract behavioural effects after constant presence of mother during early life. (ekstern lenke)
• Andrea Rørvik Marti; Peter Meerlo; Janne Grønli et al. (2016). Shift in food intake and changes in metabolic regulation and gene expression during simulated night-shiftwork: A rat model. (ekstern lenke)

Medieintervju

• Jelena Mrdalj (2016). tips for å sovne raskere. (ekstern lenke)
• Jelena Mrdalj (2016). Derfor sover du dårlig første natten hjemmefra. (ekstern lenke)
• Jelena Mrdalj (2016). Om å sove ute. (ekstern lenke)
• Jelena Mrdalj (2016). Om det å sove ut i helgene. (ekstern lenke)
• Jelena Mrdalj (2016). Om lyse netter og søvn. (ekstern lenke)
• Jelena Mrdalj (2016). Om sene kvelder og lyse netter på sommeren. (ekstern lenke)
• Jelena Mrdalj (2016). Slik får du sove i ferien. (ekstern lenke)
• Jelena Mrdalj (2016). Om søvn i ferien hos barn. (ekstern lenke)

Masteroppgave

• Jelena Mrdalj; Boleslaw Srebro (2006). Meaning of motivation and spontaneous exploration for the firing properties of place cells in CA1 area of hippocampus: electrophysiological study in freely-moving rats. (ekstern lenke)

Konferanseabstrakt

• Bjørn Bjorvatn; Jelena Mrdalj; Ingvild W. Saxvig et al. (2016). Use of electronic media in bed and reading in bed after bedtime – Age and sex differences in a representative adult population.. (ekstern lenke)
• Michael J. Rempe; Torhild Thue Pedersen; Peter Meerlo et al. (2016). A rat model for shiftwork: Effects on sleep architecture and sleep homeostasis.. (ekstern lenke)
• Anne Marie Kinn Rød; Jelena Mrdalj; Anne Marita Milde et al. (2012). Sleep architecture, behaviour, corticosterone and acoustic startle response after double exposure to social defeat in rats. (ekstern lenke)
• Andrea Rørvik Marti; Jelena Mrdalj; Silje Skrede et al. (2016). Simulated night work alters clock gene expression in central and peripheral tissue in rats.. (ekstern lenke)

Konferanseposter

• Torhild Pedersen; Jelena Mrdalj; Ståle Pallesen et al. (2018). Daytime sleep following night shifts- impact of light intensity. (ekstern lenke)
• Janne Grønli; Anne Marita Milde; Robert Murison et al. (2012). Early life stress modulates responses to chronic stress later in life; affective and behavioural outcomes in rats. (ekstern lenke)
• Andrea Rørvik Marti; Silje Skrede; Jelena Mrdalj et al. (2018). Extending the photoperiod impacts circadian rhythmicity and gene expression in prefrontal cortex and retina- Impact of exposure to blue-enriched light.. (ekstern lenke)
• Andrea Rørvik Marti; jorrit waslander; Silje Skrede et al. (2018). Extended photoperiod alters circadian rhythmicity and expression of neuroplasticity markers. The impact of blue-enriched light.. (ekstern lenke)
• Jelena Mrdalj; Robert Murison; Anne Marita Milde et al. (2010). Altered Body Temperature Rhythm and Depression-like Symptoms following Early and Later Life Stress in Rats. (ekstern lenke)
• Janne Grønli; Robert Murison; Anne Marita Milde et al. (2011). Animal model of early and later life stress alters body temperature rhythm and induces depression-like symptoms. (ekstern lenke)
• Anne Marie Kinn; Jelena Mrdalj; Anne Marita Milde et al. (2011). Short- and long- term effects on sleep architecture, behaviour, corticosterone and acoustic startle response after two exposures to social defeat in rats. (ekstern lenke)
• Louise Haugen Bjerrum; Torhild Pedersen; Jelena Mrdalj et al. (2018). Prolonged photoperiod alters time in sleep and slow-wave activity. The impact of blue-enriched light.. (ekstern lenke)
• Torhild Pedersen; Jelena Mrdalj; Ståle Pallesen et al. (2018). Daytime sleep following bright light exposure during simulated night shift work.. (ekstern lenke)
• Eliann Øines; Robert Murison; Jelena Mrdalj et al. (2010). Chronic social stress increases colonic permeability in rats postnatally exposed to long maternal separation. (ekstern lenke)
• Michael J. Rempe; Torhild Thue Pedersen; Peter Meerlo et al. (2016). A rat model for shiftwork: Effects on sleep architecture and sleep homeostasis.. (ekstern lenke)
• Anne Marie Kinn Rød; Robert Murison; Jelena Mrdalj et al. (2013). Effects of Social Defeat on sleep and behaviour: The importance of the confrontational behaviour. (ekstern lenke)
• Janne Grønli; Andrea Rørvik Marti; jorrit waslander et al. (2018). Extended photoperiod alters sleep and expression of synaptic plasticity-associated genes. The impact of blue-enriched light.. (ekstern lenke)
• Jelena Mrdalj; Robert Murison; Anne Marita Milde et al. (2010). Chronic mild stress alters body temperature rhythm and induces depression-like symptoms in rats postnatally exposed to long maternal separations. (ekstern lenke)
• Anne Marie Kinn Rød; Jelena Mrdalj; Anne Marita Milde et al. (2012). Sleep Architecture, Behaviour, Corticosterone and Acoustic Startle Response after Double Exposure to Social Defeat in Rats. (ekstern lenke)
• Bjørn Bjorvatn; Jelena Mrdalj; Ingvild W. Saxvig et al. (2016). Use of electronic media in bed and reading in bed after bedtime – Age and sex differences in a representative adult population.. (ekstern lenke)
• Jelena Mrdalj; Erlend Sunde; Torhild Pedersen et al. (2018). Effects of bright light on sleepiness and cognitive performance during simulated night shift work.. (ekstern lenke)
• Anne Marie Kinn; Bjørn Bjorvatn; Jelena Mrdalj et al. (2010). A study of long-term effects on body temperature rhythm after two exposures to social defeat in rats. (ekstern lenke)
• Torhild Pedersen; Jelena Mrdalj; Ståle Pallesen et al. (2018). Bright light exposure during simulated night shift work- impact on daytime sleep.. (ekstern lenke)
• Jelena Mrdalj; Robert Murison; Anne Marita Milde et al. (2010). Chronic mild stress alters body temperature rhythm and induces depression-like symptoms in rats postnatally exposed to long maternal separation. (ekstern lenke)

Konferanseforedrag

• Jelena Mrdalj; Robert Murison; Anne Marita Milde et al. (2010). Early Life Stress and the effect on circadian rhythmicity. The mother - infant relationship in rats as model. (ekstern lenke)
• Jelena Mrdalj; Janne Grønli (2013). Early and later life stress in rats. Effects on sleep EEG and circadian rhythmicity. (ekstern lenke)
• Finn Konow Jellestad; Jelena Mrdalj; Anne Marie Kinn et al. (2011). Experiences with the 4ET transmitters in telemetric measurement of EEG, EMG, body temperature and motor activity in male rats exposed to early and later life stress. (ekstern lenke)
• Andrea Rørvik Marti; Jelena Mrdalj; Silje Skrede et al. (2016). Simulated night work alters clock gene expression in central and peripheral tissue in rats.. (ekstern lenke)
• Jelena Mrdalj; Torhild Thue Pedersen; Andrea Rørvik Marti et al. (2015). Night work - disturbances in sleep and circadian rhythm parameters. An animal model.. (ekstern lenke)
• Jelena Mrdalj; Anne Marita Milde; Janne Grønli (2009). Rhythms, sleep and biology after maternal separations. The mother – infant relationship. (ekstern lenke)
• Erlend Sunde; Jelena Mrdalj; Torhild Pedersen et al. (2019). Effects of Different Light Intensities on Adaptation to Simulated Night Shifts: A Randomized Counterbalanced Crossover Study. (ekstern lenke)
• Iris Mulders Steine; Tetyana Zayats; Christine Stansberg et al. (2016). Implication of NOTCH1 Gene in Comorbid Anxiety and Depression Symptoms in a Sample of Sexual Abuse Victims.. (ekstern lenke)
• Erlend Sunde; Jelena Mrdalj; Torhild Thue Pedersen et al. (2022). Reversal learning and working memory scanning task performance improve with bright light exposure during simulated night work: a counterbalanced crossover study. (ekstern lenke)
• Jelena Mrdalj; Ståle Pallesen; Anne Marita Milde et al. (2011). Early and later life stress leads to a lower brain activity during sleep and wakefulness in rats. (ekstern lenke)
• Jelena Mrdalj; Robert Murison; Finn Konow Jellestad et al. (2013). Hypothermia after chronic mild stress exposure in rats with ahistory of postnatal maternal separation. (ekstern lenke)
• Jelena Mrdalj; Ståle Pallesen; Anne Marita Milde et al. (2011). Lower brain activity during sleep and wakefullnes; induced by exposure to long maternal separation and chronic mild stress in rats. (ekstern lenke)
• Jelena Mrdalj; Ståle Pallesen; Anne Marita Milde et al. (2011). Chronic mild stress potentiates a lower brain activity during sleep and wakefulness in rats exposed to long maternal separation. (ekstern lenke)

Kapittel i fagbok

• Anne Marita Milde; Jelena Mrdalj (2021). Animal models for psychological disorders. (ekstern lenke)

Populærvitenskapelig artikkel

• Jelena Mrdalj (2016). Hva skjer med søvn hos ungdom og hvordan kan vi lære dem at søvn er viktig?. (ekstern lenke)
• Jelena Mrdalj (2016). Basalforskning på WorldSleep konferansen 2015. (ekstern lenke)
• Jelena Mrdalj (2016). Årets publikasjon 2015. (ekstern lenke)
• Jelena Mrdalj (2016). Basalforskning på ESRS 2016. (ekstern lenke)
• Jelena Mrdalj (2018). Kan man spise seg til bedre søvn?. (ekstern lenke)

Doktorgradsavhandling

• Jelena Mrdalj (2014). The early life condition: Importance for sleep, circadian rhythmicity, behaviour and response to later life challenges. (ekstern lenke)

Fagartikkel

• Jelena Mrdalj (2013). Normal utvikling av hjernen. (ekstern lenke)

Deltakelse i radio eller TV

• Kjersti Marie Blytt; Elisabeth Flo-Groeneboom; Jelena Mrdalj (2024). Søvn og ernæring - hvordan henger dette sammen?. (ekstern lenke)

Se en full oversikt over publikasjoner i Cristin

Publikasjonsliste i PubMed

• The early life condition - A translational study of affective and behavioral outcomes and genetic modulation
• Consequences of night shift simulation on waking performance, sleep, circadian rhythmicity and brain function
• Sleep dynamics in rats after exposure to long or short photoperiod