• Pankreatitt (betennelse i bukspyttkjertelen)
• Pancreas-cancer (kreft i bukspyttkjertelen)
• MODY-diabetes (arvelig diabetes)

Tilknyttet følgende forskningsgrupper:

https://www.uib.no/diabetes

https://pancreas.w.uib.no

Vitenskapelig artikkel

• Inger Hals Kvinnsland; Keijo Aukusti Luukko; Inge Fristad et al. (2004). Glial cell line-derived neurotrophic factor (GDNF) from adult rat tooth serves a distinct population of large-sized trigeminal neurons. (ekstern lenke)
• Janniche Torsvik; Bente Berg Johansson; Monica Dalva et al. (2014). Endocytosis of secreted carboxyl ester lipase in a syndrome of diabetes and pancreatic exocrine dysfunction. (ekstern lenke)
• Karianne Fjeld; Frank Ulrich Weiss; Denise Lasher et al. (2015). A recombined allele of the lipase gene CEL and its pseudogene CELP confers susceptibility to chronic pancreatitis. (ekstern lenke)
• Kelly Velasco Pinto; Johanna Lüdeke St-Louis; Henrikke Nilsen Hovland et al. (2020). Functional evaluation of 16 SCHAD missense variants: Only amino acid substitutions causing congenital hyperinsulinism of infancy lead to loss-of-function phenotypes in vitro. (ekstern lenke)
• Khadija el Jellas; Petra Dušátková; Ingfrid S. Haldorsen et al. (2022). Two New Mutations in the CEL Gene Causing Diabetes and Hereditary Pancreatitis: How to Correctly Identify MODY8 Cases. (ekstern lenke)
• Anny Gravdal Svanbring; Steven J. Wilhelm; Ivan Abbedissen et al. (2025). The MODY-Causing Mutation of the Human Carboxyl Ester Lipase Gene (CEL) Triggers Chronic Pancreatitis But Not Diabetes in Mice. (ekstern lenke)
• Khadija el Jellas; Bente Berg Johansson; Karianne Fjeld et al. (2018). The mucinous domain of pancreatic carboxyl-ester lipase (CEL) contains core 1/core 2 O-glycans that can be modified by ABO blood group determinants. (ekstern lenke)
• Monica Dalva Valvatne; Ida Marie Kjærefjord Lavik; Khadija el Jellas et al. (2020). Pathogenic Carboxyl Ester Lipase (CEL) Variants Interact with the Normal CEL Protein in Pancreatic Cells. (ekstern lenke)
• Brett M. Cassidy; Sammy Zino; Karianne Fjeld et al. (2020). Single nucleotide polymorphisms in CEL-HYB1 increase risk for chronic pancreatitis through proteotoxic misfolding. (ekstern lenke)
• Ranveig Seim Brekke; Anny Gravdal Svanbring; Khadija el Jellas et al. (2024). Common single-base insertions in the VNTR of the carboxyl ester lipase (CEL) gene are benign and also likely to arise somatically in the exocrine pancreas. (ekstern lenke)
• Paivi Kettunen; Sigbjørn Suk Løes; Tomasz Michal Furmanek et al. (2005). Coordination of trigeminal axon navigation and patterning with tooth organ formation: epithelial-mesenchymal interactions, and epithelial Wnt4 and Tgfβ1 regulate semaphorin 3a expression in the dental mesenchyme. (ekstern lenke)
• Monica Dalva; Khadija el Jellas; Solrun Steine et al. (2017). Copy number variants and VNTR length polymorphisms of the carboxyl-ester lipase (CEL) gene as risk factors in pancreatic cancer. (ekstern lenke)
• Matthew J. Kolar; Siddhesh S. Kamat; William H. Parsons et al. (2016). Branched Fatty Acid Esters of Hydroxy Fatty Acids Are Preferred Substrates of the MODY8 Protein Carboxyl Ester Lipase. (ekstern lenke)
• Anja Ragvin; Karianne Fjeld; F. Ulrich Weiss et al. (2013). The number of tandem repeats in the carboxyl-ester lipase (CEL) gene as a risk factor in alcoholic and idiopathic chronic pancreatitis. (ekstern lenke)
• Karianne Fjeld; Paivi Kettunen; Tomasz Michal Furmanek et al. (2005). Dynamic expression of Wnt signaling-related Dickkopf1,-2, and-3 mRNAs in the developing mouse tooth. (ekstern lenke)
• Karianne Fjeld; Anny Gravdal Svanbring; Ranveig Seim Brekke et al. (2022). The genetic risk factor CEL-HYB1 causes proteotoxicity and chronic pancreatitis in mice. (ekstern lenke)
• Anny Gravdal Svanbring; Xunjun Xiao; Miriam Cnop et al. (2021). The position of single-base deletions in the VNTR sequence of the carboxyl ester lipase (CEL) gene determines proteotoxicity. (ekstern lenke)
• Keijo Luukko; Sigbjørn Suk Løes; Tomasz Furmanek et al. (2003). Identification of a novel putative signaling center, the tertiary enamel knot in the postnatal mouse molar tooth. (ekstern lenke)
• Xuguang Nie; Keijo Luukko; Karianne Fjeld et al. (2005). Developmental expression of Dkk1-3 and Mmp9 and apoptosis in cranial base of mice. (ekstern lenke)
• Inge Fristad; Vaska Vandevska-Radunovic; Karianne Fjeld et al. (2003). NK1-, NK2-, NK3-, and CGRP1-receptors identified in rat oral soft tissues, bone- and hard tissue cells. (ekstern lenke)
• Grzegorz Oracz; Aleksandra Anna Kujko; Karianne Fjeld et al. (2019). The hybrid allele 1 of carboxyl-ester lipase (CEL-HYB1) in Polish pediatric patients with chronic pancreatitis. (ekstern lenke)
• Keijo Aukusti Luukko; Sigbjorn Loes; Tomasz Furmanek et al. (2003). Identification of a novel putative signaling center, the tertiary enamel knot in the postnatal mouse molar tooth. (ekstern lenke)
• Bente Berg Johansson; Karianne Fjeld; Marie Holm Solheim et al. (2017). Nuclear import of glucokinase in pancreatic beta-cells is mediated by a nuclear localization signal and modulated by SUMOylation. (ekstern lenke)
• Henrik Underthun Irgens; Karianne Fjeld; Bente Berg Johansson et al. (2015). Glycogenin-2 is dispensable for liver glycogen synthesis and glucagon-stimulated glucose release. (ekstern lenke)
• Karianne Fjeld; Sebastian Beer; Marianne Johnstone et al. (2016). Length of variable numbers of tandem repeats in the carboxyl ester lipase (CEL) gene may confer susceptibility to alcoholic liver cirrhosis but not alcoholic chronic pancreatitis. (ekstern lenke)
• Erling Tjora; Anny Gravdal; Trond Engjom et al. (2021). Protein misfolding in combination with other risk factors in CEL-HYB1-mediated chronic pancreatitis. (ekstern lenke)
• Karianne Fjeld; Emmanuelle Masson; Jin-Huan Lin et al. (2020). Characterization of CEL-DUP2: Complete duplication of the carboxyl ester lipase gene is unlikely to influence risk of chronic pancreatitis. (ekstern lenke)
• Bente Berg Johansson; Janniche Torsvik; Lise Bjørkhaug et al. (2011). Diabetes and pancreatic exocrine dysfunction due to mutations in the carboxyl ester lipase gene-maturity onset diabetes of the young (CEL-MODY) A PROTEIN MISFOLDING DISEASE. (ekstern lenke)

Doktorgradsavhandling

• Karianne Fjeld; Paivi Kettunen; Keijo Luukko (2006). The Wnt pathway. Studies on Wnt signaling and regulation in the developing tooth. (ekstern lenke)

Fremhevet artikkel i media

• Karianne Fjeld; Anders Molven (2015). Du vet nesten ingenting om det, men dette er et av kroppens mest sentrale organer. (ekstern lenke)

Konferanseabstrakt

• Karianne Fjeld; Janniche Torsvik; Stefan Johansson et al. (2008). Structural changes in the repeated region of the carboxyl-ester lipase (CEL) gene and the development of diabetes. (ekstern lenke)
• Anders Molven; Janniche Torsvik; Bente Berg Johansson et al. (2013). Cellular re-uptake of secreted carboxyl-ester lipase protein in CEL-MODY, a syndrome of diabetes and pancreatic exocrine dysfunction. (ekstern lenke)

Masteroppgave

• Diego Iglesias Lopez; Anders Molven; Nils Henrik Halberg et al. (2024). Interplay of the proteotoxic CEL-MODY protein and oncogenic KRAS in pancreatic cancer development. (ekstern lenke)
• Karianne Fjeld (2000). The effect of Beta1-integrins on the invasive phenotype of human gliomas. (ekstern lenke)
• Karianne Fjeld (2000). The effect of beta1-integins on the phenotype of human gliomas. (ekstern lenke)

Vitenskapelig litteraturgjennomgang

• Bente Berg Johansson; Karianne Fjeld; Khadija el Jellas et al. (2018). The role of the carboxyl ester lipase (CEL) gene in pancreatic disease. (ekstern lenke)

Lederartikkel

• Anders Molven; Karianne Fjeld; Mark E. Lowe (2016). Lipase genetic variants in chronic pancreatitis: when the end is wrong, all's not well. (ekstern lenke)

Medieintervju

• Paivi Kettunen; Keijo Aukusti Luukko; Karianne Fjeld et al. (2004). Dyrking av det Perfekte Smil. (ekstern lenke)

Konferanseforedrag

• Karianne Fjeld; Paivi Johanna Kettunen; Keijo Aukusti Luukko et al. (2003). Wnt signaling in tooth morphogenesis. (ekstern lenke)
• Karianne Fjeld; Keijo Aukusti Luukko; Paivi Johanna Kettunen et al. (2003). Functions of SLIT1 in tooth morphogenesis. (ekstern lenke)

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