My research interests are in the fields of toxicology, environmental toxicology, microplastics, biomarkers, endocrine disruptors, toxicogenomics, environmental genomics, proteomics, and systems toxicology focusing on marine organisms such as fish and marine mammals.

2016-2021: Project leader of "dCod 1.0: decoding the systems toxicology of Atlantic cod (Gadus morhua)" (dcod.no), a large interdisciplinary project under the Digital Life Norway network, funded by the BIOTEK 2021 programme of the Research Council of Norway.

2023-2027: Project leader of Marma-detox - Whales and polar bear in a petri dish: decoding marine mammal toxicology through in vitro and in silico approaches, funded by the Research Council of Norway. https://www.digitallifenorway.org/research/marma-detox/index.html

 

BIO 216 Toxicology, BIO 316 Selected topics in environmental toxicology, MOL270 Bioethics

2024

• Goksøyr, Anders; Søderstrøm, Sofie Karin (2024). Isbjørn og hval i en petriskål. (external link)
• Jossey, Sushma; Haddrath, Oliver; Loureiro, Livia et al. (2024). Population structure and history of North Atlantic Blue whales (Balaenoptera musculus musculus) inferred from whole genome sequence analysis. (external link)
• Goksøyr, Siri Øfsthus; Yadetie, Fekadu; Johansen, Christine et al. (2024). Interaction of Bisphenol A and Its Analogs with Estrogen and Androgen Receptor from Atlantic Cod (Gadus morhua). (external link)
• Brun, Nadja Rebecca; Yadetie, Fekadu; Liestøl, Hanna Todal et al. (2024). Transcriptome responses to benzo[a]pyrene in liver slices of sub-arctic fish species. (external link)

2023

• Eide, Marta; Goksøyr, Anders; Yadetie, Fekadu et al. (2023). Integrative omics-analysis of lipid metabolism regulation by peroxisome proliferator-activated receptor a and b agonists in male Atlantic cod. (external link)
• Olsvik, Pål Asgeir; Meier, Sonnich; Zhang, Xiaokang et al. (2023). Environmentally realistic concentrations of chlorinated, brominated, and fluorinated persistent organic pollutants induce the unfolded protein response as a shared stress pathway in the liver of Atlantic cod (Gadus morhua). (external link)
• Donald, Carey; Sørhus, Elin; Perrichon, Prescilla et al. (2023). Co-Exposure of Phenanthrene and the cyp-Inducer 3-Methylchrysene Leads to Altered Biotransformation and Increased Toxicity in Fish Egg and Larvae. (external link)
• Strople, Leah C.; Vieweg, Ireen; Yadetie, Fekadu et al. (2023). Spawning time in adult polar cod (Boreogadus saida) altered by crude oil exposure, independent of food availability. (external link)
• Bjørneset, J.; Blévin, P.; Bjørnstad, P.M. et al. (2023). Establishment of killer whale (Orcinus orca) primary fibroblast cell cultures and their transcriptomic responses to pollutant exposure. (external link)
• Eze, Chukwuebuka ThankGod; Otitoloju, Adebayo Akeem; Eze, Obianuju Oluchukwu et al. (2023). West African e-waste-soil assessed with a battery of cell-based bioassays. (external link)

2022

• Toto, Benuarda; Refosco, Alice; O'Keeffe, Maria et al. (2022). Intestinal permeability and gene expression after polyethylene and polyamide microplastic ingestion in Wistar rats. (external link)
• Yadetie, Fekadu; Brun, Nadja Rebecca; Giebichenstein, Julia et al. (2022). Transcriptome responses in copepods Calanus finmarchicus, Calanus glacialis and Calanus hyperboreus exposed to phenanthrene and benzo[a]pyrene. (external link)
• Goksøyr, Anders; Kaiser, Matthias (2022). Hva gjør et rykte om kvikksølv i norsk fisk med sjømatnasjonen?. (external link)
• Söderström, Sofie Karin; Lille-Langøy, Roger; Yadetie, Fekadu et al. (2022). Agonistic and potentiating effects of perfluoroalkyl substances (PFAS) on the Atlantic cod (Gadus morhua) peroxisome proliferator-activated receptors (Ppars). (external link)
• Dale, Karina; Yadetie, Fekadu; Horvli, Torill et al. (2022). Single PFAS and PFAS mixtures affect nuclear receptor- and oxidative stress-related pathways in precision-cut liver slices of Atlantic cod (Gadus morhua). (external link)
• Aranguren Abadía, Libe; Yadetie, Fekadu; Donald, Carey et al. (2022). Photo-enhanced toxicity of crude oil on early developmental stages of Atlantic cod (Gadus morhua). (external link)

2021

• Routti, Heli Anna Irmeli; Harju, Mikael; Lühmann, Katharina et al. (2021). Concentrations and endocrine disruptive potential of phthalates in marine mammals from the Norwegian Arctic. (external link)
• Stenseth, Nils Christian; Baalsrud, Helle Tessand; Jakobsen, Kjetill Sigurd et al. (2021). Havgenomet – bevaring og bærekraftig bruk av marine genetiske ressurser i Norge. (external link)
• Yadetie, Fekadu; Brun, Nadja Rebecca; Vieweg, Ireen et al. (2021). Transcriptome responses in polar cod (Boreogadus saida) liver slice culture exposed to benzo[a]pyrene and ethynylestradiol: insights into anti-estrogenic effects. (external link)
• Eide, Marta; Zhang, Xiaokang; Karlsen, Odd André et al. (2021). The chemical defensome of five model teleost fish. (external link)
• Zhang, Xiaokang; Jonassen, Inge; Goksøyr, Anders (2021). Machine Learning Approaches for Biomarker Discovery Using Gene Expression Data. (external link)
• Goksøyr, Siri Øfsthus; Sørensen, Helene; Grøsvik, Bjørn Einar et al. (2021). Toxicity assessment of urban marine sediments from Western Norway using a battery of stress-activated receptors and cell-based bioassays from fish. (external link)
• Goksøyr, Anders (2021). Hunnsnegl med penis og hannfisk med egg. (external link)
• Lille-Langøy, Roger; Jørgensen, Kåre Bredeli; Goksøyr, Anders et al. (2021). Substituted Two- To Five-Ring Polycyclic Aromatic Compounds Are Potent Agonists of Atlantic Cod (Gadus morhua) Aryl Hydrocarbon Receptors Ahr1a and Ahr2a. (external link)
• Strobel, Anneli; Lille-Langøy, Roger; Segner, Helmut et al. (2021). Xenobiotic metabolism and its physiological consequences in high-Antarctic Notothenioid fishes. (external link)
• Goksøyr, Siri Øfsthus; Goldstone, Jed; Lille-Langøy, Roger et al. (2021). Polycyclic aromatic hydrocarbons modulate the activity of Atlantic cod (Gadus morhua) vitamin D receptor paralogs in vitro. (external link)

2020

• Hanna, Eileen Marie; Zhang, Xiaokang; Eide, Marta et al. (2020). ReCodLiver0.9: Overcoming Challenges in Genome-Scale Metabolic Reconstruction of a Non-model Species. (external link)
• Lühmann, Katharina; Lille-Langøy, Roger; Øygarden, Lene Eidsvik et al. (2020). Environmental pollutants modulate transcriptional activity of nuclear receptors of whales in vitro. (external link)
• Aranguren Abadía, Libe; Donald, Carey; Eilertsen, Mariann et al. (2020). Expression and localization of the aryl hydrocarbon receptors and cytochrome P450 1A during early development of Atlantic cod (Gadus morhua). (external link)
• Dale, Karina; Yadetie, Fekadu; Müller, Mette Helen Bjørge et al. (2020). Proteomics and lipidomics analyses reveal modulation of lipid metabolism by perfluoroalkyl substances in liver of Atlantic cod (Gadus morhua). (external link)
• Aranguren-Abadía, Libe; Lille-Langøy, Roger; Madsen, Alexander Klevedal et al. (2020). Molecular and Functional Properties of the Atlantic Cod (Gadus morhua) Aryl Hydrocarbon Receptors Ahr1a and Ahr2a. (external link)
• Khan, Essa Ahsan; Zhang, Xiaokang; Hanna, Eileen Marie et al. (2020). Quantitative transcriptomics, and lipidomics in evaluating ovarian developmental effects in Atlantic cod (Gadus morhua) caged at a capped marine waste disposal site. (external link)
• Khan, Essa Ahsan; Zhang, Xiaokang; Hanna, Eileen Marie et al. (2020). Application of quantitative transcriptomics in evaluating the ex vivo effects of per- and polyfluoroalkyl substances on Atlantic cod (Gadus morhua) ovarian physiology. (external link)

2019

• Dale, Karina; Müller, Mette Bjørge; Tairova, Zhanna et al. (2019). Contaminant accumulation and biological responses in Atlantic cod (Gadus morhua) caged at a capped waste disposal site in Kollevåg, Western Norway. (external link)
• Routti, Heli Anna Irmeli; Berg, Mari Katrine; Lille-Langøy, Roger et al. (2019). Environmental contaminants modulate the transcriptional activity of polar bear (Ursus maritimus) and human peroxisome proliferator-activated receptor alpha (PPARA). (external link)
• Görbitz, Carl Henrik; Jakobsen, Kjetill Sigurd; Sandve, Simen Rød et al. (2019). Den sjette masseutryddelse og Jordens DNA. (external link)
• Olsvik, Pål Asgeir; Larsen, Anett Kristin; Berntssen, Marc et al. (2019). Effects of agricultural pesticides in aquafeeds on wild fish feeding on leftover pellets near fish farms. (external link)
• Goksøyr, Anders (2019). Se torsken! Om torsk, miljøgifter og torskens genom.. (external link)
• Khan, Essa Ahsan; Bertotto, Luisa B.; Dale, Karina et al. (2019). Modulation of neuro-dopamine homeostasis in juvenile female Atlantic cod (Gadus morhua) exposed to polycyclic aromatic hydrocarbons and perfluoroalkyl substances. (external link)

2018

• Ahmed , Kareem Eldin Mohammed ; Frøysa, Håvard G; Karlsen, Odd Andre et al. (2018). Effects of defined mixtures of POPs and endocrine disruptors on the steroid metabolome of the human H295R adrenocortical cell line. (external link)
• Kareem Eldin, Mohammed Adhmed Abdel Ghafar; Frøysa, Håvard G; Karlsen, Odd Andre et al. (2018). LC-MS/MS based profiling and dynamic modelling of the steroidogenesis pathway in adrenocarcinoma H295R cells. (external link)
• Eide, Marta; Rydbeck, Halfdan; Tørresen, Ole K. et al. (2018). Independent losses of a xenobiotic receptor across teleost evolution. (external link)
• Lille-Langøy, Roger; Karlsen, Odd Andre; Myklebust, Line Merethe et al. (2018). Sequence variations in pxr (nr1i2) from Zebrafish (Danio rerio) strains affect nuclear receptor function. (external link)
• Yadetie, Fekadu; Zhang, Xiaokang; Hanna, Eileen Marie et al. (2018). RNA-Seq analysis of transcriptome responses in Atlantic cod (Gadus morhua) precision-cut liver slices exposed to benzo[a]pyrene and 17α-ethynylestradiol. (external link)
• Blanco, Maria; Perez-Albaladejo, Elisabet; Pina, Benjamin et al. (2018). Assessing the environmental quality of sediments from Split coastal area (Croatia) with a battery of cell-based bioassays. (external link)

2017

• Yadetie, Fekadu; Oveland, Eystein; Døskeland, Anne Marie Simonne et al. (2017). Quantitative proteomics analysis reveals perturbation of lipid metabolic pathways in the liver of Atlantic cod (Gadus morhua) treated with PCB 153. (external link)
• Tartu, Sabrina; Lille-Langøy, Roger; Størseth, Trond Røvik et al. (2017). Multiple-stressor effects in an apex predator: combined influence of pollutants and sea ice decline on lipid metabolism in polar bears. (external link)

2016

• Bizarro, Cristina; Eide, Marta; Hitchcock, Daniel James et al. (2016). Single and mixture effects of aquatic micropollutants studied in precision-cut liver slices of Atlantic cod (Gadus morhua). (external link)
• Yadetie, Fekadu; Bjørneklett, Silje; Garberg, Hilde Kristin et al. (2016). Quantitative analyses of the hepatic proteome of methylmercury-exposed Atlantic cod (Gadus morhua) suggest oxidative stress-mediated effects on cellular energy metabolism. (external link)
• Perez-Albaladejo, Elisabet; Rizzi, Juliane; Fernandes, Denise et al. (2016). Assessment of the environmental quality of coastal sediments by using a combination of in vitro bioassays. (external link)
• Routti, Heli Anna Irmeli; Lille-Langøy, Roger; Berg, Mari Katrine et al. (2016). Environmental chemicals modulate polar bear (Ursus maritimus) Peroxisome Proliferator-Activated Receptor Gamma (PPARG) and adipogenesis in vitro. (external link)

2015

• Lille-Langøy, Roger; Goldstone, Jared V.; Rusten, Marte et al. (2015). Environmental contaminants activate human and polar bear (Ursus maritimus) pregnane X receptors (PXR, NR1I2) differently. (external link)
• Ruzzin, Jérôme; Bethune, Claudette; Goksøyr, Anders et al. (2015). Comment on "Contaminant levels in Norwegian farmed Atlantic salmon (Salmo salar) in the 13-year period from 1999 to 2011" by Nøstbakken et al.. (external link)

2014

• Eide, Marta; Karlsen, Odd Andre; Kryvi, Harald et al. (2014). Precision-cut liver slices of Atlantic cod (Gadus morhua): An in vitro system for studying the effects of environmental contaminants. (external link)
• Yadetie, Fekadu; Karlsen, Odd Andre; Eide, Marta et al. (2014). Liver transcriptome analysis of Atlantic cod (Gadus morhua) exposed to PCB 153 indicates effects on cell cycle regulation and lipid metabolism. (external link)
• Eide, Marta; Rusten, Marte; Male, Rune et al. (2014). A characterization of the ZFL cell line and primary hepatocytes as in vitro liver cell models for the zebrafish (Danio rerio). (external link)
• Castelli, Martina Galatea; Rusten, Marte; Goksøyr, Anders et al. (2014). MRNA expression of genes regulating lipid metabolism in ringed seals (Pusa hispida) from differently polluted areas. (external link)
• Karlsen, Odd Andre; Sheehan, David; Goksøyr, Anders (2014). Alterations in the atlantic COD (Gadus morhua) hepatic thiol-proteome after methylmercury exposure. (external link)

2013

• Bainy, Alfonso C.D.; Kubota, Akira; Goldstone, Jared V. et al. (2013). Functional characterization of a full length pregnane X receptor, expression in vivo, and identification of PXR alleles, in Zebrafish (Danio rerio). (external link)
• Yadetie, Fekadu; Karlsen, Odd Andre; Lanzén, Anders et al. (2013). Global transcriptome analysis of Atlantic cod (Gadus morhua) liver after in vivo methylmercury exposure suggests effects on energy metabolism pathways. (external link)

2012

• Karlsen, Odd Andre; Puntervoll, Pål; Goksøyr, Anders (2012). Mass spectrometric analyses of microsomal cytochrome P450 isozymes isolated from beta-naphthoflavone-treated Atlantic cod (Gadus morhua) liver reveal insights into the cod CYPome. (external link)
• Nøstbakken, Ole Jakob; Goksøyr, Anders; Martin, Samuel A.M. et al. (2012). Marine n-3 fatty acids alter the proteomic response to methylmercury in Atlantic salmon kidney (ASK) cells. (external link)
• Yadetie, Fekadu; Butcher, Stephen; Førde, Hilde Elise Sundsøy et al. (2012). Conservation and divergence of chemical defense system in the tunicate Oikopleura dioica revealed by genome wide response to two xenobiotics. (external link)

2011

• Berg, Karin; Puntervoll, Pål; Klungsøyr, Jarle et al. (2011). Brain proteome alterations of Atlantic cod (Gadus morhua) exposed to PCB 153. (external link)
• Karlsen, Odd Andre; Bjørneklett, Silje; Berg, Karin et al. (2011). Integrative Environmental Genomics of Cod (Gadus morhua): The Proteomics Approach. (external link)
• Olsvik, Pål Asgeir; Brattås, Marianne; Lie, Kai Kristoffer et al. (2011). Transcriptional responses in juvenile Atlantic cod (Gadus morhua) after exposure to mercury-contaminated sediments obtained near the wreck of the German WW2 submarine U-864, and from Bergen Harbor, Western Norway. (external link)
• Goksøyr, Anders (2011). 3rd Norwegian Environmental Toxicology Symposium: Emerging Solutions for Emerging Challenges. (external link)
• Sletten, Einar; Goksøyr, Anders (2011). Kystverket dekker til problema. (external link)
• Schwesig, David; Borchers, Ulrich; Chancerelle, Laure et al. (2011). A harmonized European framework for method validation to support research on emerging pollutants. (external link)

2010

• BERNTSSEN, MARC; Olsvik, Pål Asgeir; TORSTENSEN, BENTE ELISABETH et al. (2010). Reducing persistent organic pollutants while maintaining long chain omega-3 fatty acid in farmed Atlantic salmon using decontaminated fish oils for an entire production cycle. (external link)
• Berg, Karin; Puntervoll, Pål; Valdersnes, Stig et al. (2010). Responses in the brain proteome of Atlantic cod (Gadus morhua) exposed to methylmercury. (external link)
• Meier, Sonnich; Morton, Craig H.; Nyhammer, Gunnar et al. (2010). Development of Atlantic cod (Gadus morhua) exposed to produced water during early life stages: Effects on embryos, larvae, and juvenile fish. (external link)
• Kjersem, Anneli Bohne; Bache, Nicolai; Meier, Sonnich et al. (2010). Biomarker candidate discovery in Atlantic cod (Gadus morhua) continuously exposed to North Sea produced water from egg to fry. (external link)
• Marteil, Gaëlle; D'Inca, Romain; Pascal, Aude et al. (2010). EP45 accumulates in growing Xenopus laevis oocytes and has oocyte-maturation-enhancing activity involved in oocyte quality. (external link)

2009

• Olsvik, Pål Asgeir; LIE, KAI KRISTOFFER; Goksøyr, Anders et al. (2009). Are atlantic cod in Store Lungegårdsvann, a seawater recipient in Bergen, affected by environmental contaminants? A qRT-PCR survey. (external link)
• Kjersem, Anneli Bohne; Skadsheim, Arnfinn; Goksøyr, Anders et al. (2009). Candidate biomarker discovery in plasma of juvenile cod (Gadus morhua) exposed to crude North Sea oil, alkyl phenols and polycyclic aromatic hydrocarbons (PAHs). (external link)
• Nahrgang, Jasmine Magali; Camus, Lionel; Camus, Lionel et al. (2009). PAH biomarker responses in polar cod (Boreogadus saida) exposed to benzo(a)pyrene. (external link)
• Goksøyr, Anders; Tollefsen, Knut Erik; Grung, Merete et al. (2009). Balsa raft crossing the Pacific finds low contaminant levels. (external link)
• Goksøyr, Anders; Tollefsen, Knut-Erik; Grung, M et al. (2009). Balsa Raft Crossing the Pacific Finds Low Contaminant Levels. (external link)

2008

• Sanchez, Wilfried; Goin, Carolyne; Brion, Francois et al. (2008). A new ELISA for the three-spined stickleback (Gasterosteus aculeatus L.) spiggin, using antibodies against synthetic peptide. (external link)
• Viganò, Luigi; Benfenati, Emilio; van Cauwenberge, Anne et al. (2008). Estrogenicity profile and estrogenic compounds determined in river sediments by chemical analysis, ELISA and yeast assays. (external link)
• Gunawickrama, S.H. Nandana P.; Aarsæther, Niels; Orbea, Amaia et al. (2008). PCB77 (3,3 ',4,4 '-tetrachlorobiphenyl) co-exposure prolongs CYP1A induction, and sustains oxidative stress in B(a)P-exposed turbot, Scophthalmus maximus, in a long-term study. (external link)

2007

• Goksøyr, Anders; Strand, Roger (2007). Pest eller kolera?. (external link)
• Carvan, Michael J.; Gallagher, Evan; Goksøyr, Anders et al. (2007). Roundtable discussion: Fish models in toxicology. (external link)
• Goksøyr, Anders (2007). DNA - det mystiske arvestoffet. (external link)
• Kleivdal, Hans; Kristiansen, Sven inge; Mona V., Nilsen et al. (2007). Determination of domoic acid toxins in shellfish by Biosense ASP ELISA - A direct competitive enzyme-linked immunosorbent assay: Collaborative study. (external link)

2006

• Goksøyr, Anders (2006). Hormonforstyrrende stoffer i miljøet - hva er det som skjer?. (external link)
• Goksøyr, Anders (2006). Hormonforstyrrende stoffer i miljøet - hva er det som skjer?. (external link)
• Scott, A.P.; Kristiansen, Sven inge; Katsiadiki, I et al. (2006). Assessment of estrogen exposure in cod (Gadus morhua) and saithe (Pollachius virens) in relation to their proximity to an oil field. (external link)
• Tollefsen, Knut Erik; Goksøyr, Anders; Hylland, Ketil (2006). Assessment of cytotoxic, CYP1A inducing and oestrogen activity in waters from the German Bight and the Statfjord area of the North Sea by a suite of fish in vitro bioassays. (external link)
• Jonsson, Henrik; Schiedek, Doris; Goksøyr, Anders et al. (2006). Expression of cytoskeletal proteins, cross-reacting with anti-CYP1A, in Mytilus sp exposed to organic contaminants. (external link)
• Goksøyr, Anders; Male, Rune (2006). Endocrine disrupters and the aquatic environment: studies on mechanims of toxicity and influence on nuclear receptor signalling pathways in fish. (external link)
• Grøsvik, Bjørn Einar; Jonsson, Henrik; Rodriguez-Ortega, Manuel J. et al. (2006). CYP1A-immunopositive proteins in bivalves identified as cytoskeletal and major vault proteins. (external link)
• Jonsson, Henrik; Schiedek, Doris; Grøsvik, Bjørn Einar et al. (2006). Protein responses in blue mussels (Mytilus edulis) exposed to organic pollutants: A combined CYP-antibody/proteomic approach. (external link)
• Goksøyr, Anders (2006). Endocrine disruptors in the marine environment: Mechanisms of toxicity and their influence on reproductive processes in fish. (external link)
• Eidem, Janne K.; Kleivdal, Hans; Kroll, Kevin et al. (2006). Development and validation of a direct homologous quantitative sandwich ELISA for fathead minnow (Pimephales promelas) vitellogenin. (external link)
• Grøsvik, Bjørn Einar; Tolfsen, Christina C; Goksøyr, Anders (2006). Studies of protein pattern in digestive gland of blue mussel (Mytilus edulis) deployed in cages in vicinity of the Statfjord oil field. (external link)

2005

• Goksøyr, Anders (2005). DNA - det mystiske arvestoffet. (external link)
• Al-Arabi, Syed A.M.; Adolfsson-Erici, M; Waagbø, Rune et al. (2005). Contaminant accumulation and biomarker responses in caged fish exposed to effluents from anthropogenic sources in the Karnaphuly River, Bangladesh. (external link)
• Mandich, Alberta; Benfenati, Emilio; Cronin, Marc TD et al. (2005). Environmental agent susceptibility assessment using existing and novel biomarkers as rapid noninvasive testing methods. (external link)

See a complete overview of publications in Cristin.

http://publicationslist.org/anders.goksoyr

Whales and polar bear in a petri dish: decoding marine mammal toxicology through in vitro and in silico approaches

https://www.digitallifenorway.org/research/marma-detox/index.html