The Renal Research Group is an open forum for clinical and translational kidney research in Bergen. The group has traditionally combined human and animal models to study disease mechanisms with advanced molecular analyses of kidney biopsies and digital pathology. In addition, epidemiological studies on risk factors and the progression of chronic kidney disease are conducted, along with several ongoing clinical studies.

2020

• Øystein Solberg Eikrem; Nicolas Delaleu; Philipp Strauss et al. (2020). Systems Analyses of Renal Fabry Transcriptome and Response to Enzyme Replacement Therapy (ERT) Identifies a Cross-Validated and Druggable ERT-Resistant Module. (external link)
• Tarek Mazzawi; Øystein Solberg Eikrem; Gülen Arslan Lied et al. (2020). Abnormal Uroguanylin Immunoreactive Cells Density in the Duodenum of Patients with Diarrhea-Predominant Irritable Bowel Syndrome Changes following Fecal Microbiota Transplantation. (external link)

2016

• Lea Zoe Landolt; Hans-Peter Marti; Christian Beisland et al. (2016). RNA extraction for RNA sequencing of archival renal tissues. (external link)
• Lea Zoe Landolt; Øystein Solberg Eikrem; Gro Gausdal et al. (2016). Detection and Validation of Epithelial-to-Mesenchymal Transition(EMT) with Increased Expression of Axl and MMP-14 in Renal Cell Carcinoma. (external link)
• Øystein Solberg Eikrem; Andreas Scherer; Lea Zoe Landolt et al. (2016). Development and Confirmation of Gene Classifiers of Human Clear Cell Renal Cell Carcinoma Using Next-Generation Sequencing [Abstract].. (external link)
• Øystein Solberg Eikrem; Philipp Strauss; Christian Beisland et al. (2016). Development and confirmation of potential gene classifiers of human clear cell renal cell carcinoma using next-generation RNA sequencing. (external link)
• Lea Zoe Landolt; Philipp Strauss; Hans-Peter Marti et al. (2016). Next generation sequencing: A tool for this generation of nephrologists. (external link)
• Øystein Solberg Eikrem; Christian Beisland; Karin Margrethe Hjelle et al. (2016). Transcriptome sequencing (RNAseq) enables utilization of formalin-fixed, paraffin-embedded biopsies with clear cell renal cell carcinoma for exploration of disease biology and biomarker development. (external link)

2019

• Even Koch; Kenneth Finne; Øystein Solberg Eikrem et al. (2019). Transcriptome-proteome integration of archival human renal cell carcinoma biopsies enables identification of molecular mechanisms. (external link)
• Lea Zoe Landolt; Jessica Furriol; Janka Babickova et al. (2019). AXL targeting reduces fibrosis development in experimental unilateral ureteral obstruction. (external link)
• Philipp Strauss; Øystein Solberg Eikrem; Camilla Tøndel et al. (2019). Fabry Nephropathy: First mRNA-seq Findings from Kidney Biopsies Before and After Enzyme Replacement Therapy. (external link)
• Øystein Solberg Eikrem; Hans-Peter Marti (2019). New methods clear the dust off old biopsies. RNA sequencing of FFPE kidney biopsies. (external link)

2023

• Nicolas Delaleu; Hans Peter Marti; Philipp Strauss et al. (2023). Systems analyses of the Fabry kidney transcriptome and its response to enzyme replacement therapy identified and cross-validated enzyme replacement therapy-resistant targets amenable to drug repurposing. (external link)
• Ole Petter Nordbø; Lea Zoe Landolt; Øystein Solberg Eikrem et al. (2023). Transcriptomic analysis reveals partial epithelial–mesenchymal transition and inflammation as common pathogenic mechanisms in hypertensive nephrosclerosis and Type 2 diabetic nephropathy. (external link)
• Mariell Lossius Rivedal; Håvard Mikkelsen; Hans Peter Marti et al. (2023). Glomerular transcriptomics predicts long term outcome and identifies therapeutic strategies for patients with assumed benign IgA nephropathy. (external link)
• Hassan Osman Alhassan Elsaid; Mariell Lossius Rivedal; Eleni Skandalou et al. (2023). Proteomic analysis unveils Gb3-independent alterations and mitochondrial dysfunction in a gla ^−/− zebrafish model of Fabry disease. (external link)
• Philipp Strauss; Øystein Solberg Eikrem; Hans Peter Marti et al. (2023). From archival tissues to systems biology: Using transcriptomics to investigate the progression of kidney disease. (external link)
• Øystein Solberg Eikrem; Bjørnar Sandnes Lillefosse; Nicolas Delaleu et al. (2023). Network-Based Assessment of Minimal Change Disease Identifies Glomerular Response to IL-7 and IL-12 Pathways Activation as Innovative Treatment Target. (external link)
• Miroslav Sekulic; Ibrahim Batal; Satoru Kudose et al. (2023). Kidney Dysfunction and Pathology in the Setting of Hemophagocytic Lymphohistiocytosis. (external link)
• Fabian Braun; Ahmed Abed; Dominik Sellung et al. (2023). Accumulation of α-synuclein mediates podocyte injury in Fabry nephropathy. (external link)

2021

• Sigrid Nakken; Øystein Solberg Eikrem; Hans Peter Marti et al. (2021). AGAP2-AS1 as a prognostic biomarker in low-risk clear cell renal cell carcinoma patients with progressing disease. (external link)
• Fabian Braun; Ahmed Abed; Mathias Woidy et al. (2021). Synuclein Alpha Accumulation Drives Lysosomal Dysfunction in Fabry Podocytopathy. (external link)
• Øystein Solberg Eikrem; Spiros Kotopoulis; Mihaela-Lucia Popa et al. (2021). Ultrasound and Microbubbles Enhance Uptake of Doxorubicin in Murine Kidneys. (external link)

2017

• Lea Zoe Landolt; Øystein Solberg Eikrem; Philipp Strauss et al. (2017). Clear cell renal cell carcinoma is linked to epithelial-to-mesenchymal transition and to fibrosis. (external link)
• Einar Svarstad; Sabine Maria Leh; Rannveig Skrunes et al. (2017). Bedside stereomicroscopy of Fabry kidney biopsies: An easily available method for diagnosis and assessment of sphingolipid deposits. (external link)
• Øystein Solberg Eikrem; Rannveig Skrunes; Camilla Tøndel et al. (2017). Pathomechanisms of renal Fabry disease. (external link)

2025

• Tony Jialiang Chen; Eleni Skandalou; Katarina Fritz-Wallace et al. (2025). Serum proteome analysis detects early molecular signatures of disease progression in IgA nephropathy. (external link)
• Simen Femanger Pettersen; Eleni Skandalou; Jessica Furriol Palmer et al. (2025). Reconstruction of Single-Cell Spatial Transcriptomes in Archival Kidney Biopsies. (external link)
• Marius Altern Øvrehus; Knut Asbjørn Rise Langlo; Sabine Leh et al. (2025). Correction to: Norwegian kidney biopsy biobank (NorKiBB): organization, baseline characteristics, and generalizability of a low-cost national biobank (BMC Nephrology, (2025), 26, 1, (76), 10.1186/s12882-025-04007-4). (external link)
• Mariell Lossius Rivedal; Ole Petter Nordbø; Yngvar Lunde Haaskjold et al. (2025). Lifetime progression of IgA nephropathy: a retrospective cohort study with extended long-term follow-up. (external link)
• Ole Petter Nordbø; Øystein Solberg Eikrem; Philip A. Kalra et al. (2025). Longitudinal serum proteomics identifies inflammatory and metabolic pathways in hypertensive nephrosclerosis progression. (external link)
• Marius Altern Øvrehus; Knut Asbjørn Rise Langlo; Sabine Leh et al. (2025). Norwegian kidney biopsy biobank (NorKiBB): organization, baseline characteristics, and generalizability of a low-cost national biobank. (external link)

2022

• Håvard Mikkelsen; Bjørn Egil Vikse; Øystein Solberg Eikrem et al. (2022). Glomerular proteomic profiling of kidney biopsies with hypertensive nephropathy reveals a signature of disease progression. (external link)
• Hassan Osman Alhassan Elsaid; Håkon Tjeldnes; Mariell Lossius Rivedal et al. (2022). Gene Expression Analysis in gla-Mutant Zebrafish Reveals Enhanced Ca²⁺ Signaling Similar to Fabry Disease. (external link)
• Philipp Strauss; Mariell Rivedal; Andreas Scherer et al. (2022). A multiomics disease progression signature of low-risk ccRCC. (external link)

2018

• Øystein Solberg Eikrem; Tedd Christian Walther; Arnar Flatberg et al. (2018). Fine needle aspirates of kidneys: A promising tool for RNA sequencing in native and transplanted kidneys. (external link)
• Philipp Strauss; Hans-Peter Marti; Christian Beisland et al. (2018). Expanding the utilization of formalin-fixed, paraffin-embedded archives: Feasibility of miR-Seq for disease exploration and biomarker development from biopsies with clear cell renal cell Carcinoma. (external link)
• Even Evjen Koch; Øystein Solberg Eikrem; Arnar Flatberg et al. (2018). Fine needle aspirates of kidneys are usable for RNA sequencing like regular core biopsies. (external link)
• Philipp Strauss; Even Evjen Koch; Hans-Peter Marti et al. (2018). Expanding the utilization of formalin-fixed, paraffin-embedded archives: Feasability of miRNA-sequencing for disease exploration and biomarker development from biopsies with clear cell renal cell carcinoma. (external link)
• Øystein Solberg Eikrem; Even Evjen Koch; Thomas Knoop et al. (2018). Primary Membranous Nephropathy: Glomerular RNA Sequencing from Archival Kidney Biopsies. (external link)
• Øystein Solberg Eikrem; Hans-Peter Marti (2018). Klarcellet nyrekarsinom er knyttet til epitelial-til- mesenkymal overgang (EMT) og til fibrose. (external link)
• Øystein Solberg Eikrem; Philipp Strauss; Miroslav Sekulic et al. (2018). Fabry nephropathy: Transcriptome sequencing of microdissected renal compartments from archival kidney biopsies at baseline, and after 5 & 10 years of enzyme replacement therapy. (external link)

2024

• Mariell Lossius Rivedal; Yngvar Lunde Haaskjold; Øystein Solberg Eikrem et al. (2024). Use of corticosteroids in Norwegian patients with immunoglobulin a nephropathy progressing to end-stage kidney disease: a retrospective cohort study. (external link)

See a complete overview of publications in Cristin.