The Renal Research Group

A project to establish a platform for omics-related analyses of kidney biopsies of IgA nephropathy.

This project aims to investigate formalin-fixed, paraffin-embedded (FFPE) kidney biopsies from patients with assumed benign IgA nephropathy utilizing mRNA sequencing in conjunction with immunohistochemistry of complement factors (e.g. C3, C4, MAC).
Patients with minimal change nephropathy and membranous nephropathy can be included as comparators. Biopsies will be obtained from the Norwegian Kidney Biopsy Registry (NKBR) and our respective transcriptomic/IHC results will be correlated with histological IgAN classification, clinical & biochemical findings, such as renal outcome, kidney function (eGFR) and proteinuria. The group members of our group had a previous experience with the latter. Key parameters will be also investigated in serum samples of IgAN patients.

New Paper published:
Glomerular transcriptomics predicts long term outcome and identifies therapeutic strategies for patients with assumed benign IgA nephropathy 

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Collaborative projects with the Department of Pathology - Haukeland University Hospital

The following projects are running in collaboration with the Department of Pathology, Haukeland University Hospital:

1. Collaborative projects with the Department of Pathology, Haukeland University Hospital, Bergen
Pathology services in the Western Norway Health Region "Patologi i Vest"): a centre for applied digitization. 

Increasing​g workload and labour shortages constitute a major challenge for pathology departments in the Western Norwegian Health Region. At the same time, digitization is revolutionizing the field of pathology. Never before has so much data been produced in pathology laboratories. Our project will develop methods to transform this data into meaningful clinical information and implement the results in practical applications. One of our focus areas is chronic kidney disease with the 2 sub-projects:

a. Quantification of kidney fibrosis

Any chronic kidney disease will develop fibrosis, an increase of connective tissue, over time. Fibrosis is a key prognostic marker. Quantification of fibrosis is therefore crucial to assess prognosis and to guide therapy. More information about the project.

People: Nazanin Mola (PhD candidate), Hrafn Weishaupt (Computer Scientist), Erlend Hodneland, Sabine Leh (Associate Professor)

b. Automatic classification of glomerular lesions

Glomeruli are capillary tufts filtering waste products from the blood and forming urine together with the tubular system. Glomeruli can be affected by a multitude of diseases and show very diverse lesions. Several deep-learning strategies will be evaluated for e.g., the detection, segmentation, clustering, and classification of glomerular structures from biopsy images. More information about the project.

People: Hrafn Weishaupt (Computer Scientist), Justinas Besusparis (Pathologist), Nazanin Mola (PhD candidate), Sabine Leh (Associate Professor)

2. Polyvinylpyrrolidone deposition disease

Intravenous use of an oral methadone syrup containing PVP K90 has led to PVP deposition in patients with opioid addiction and IVDU, in some patients likely resulting in severe disease and fatal outcomes. The project investigates the pathological and clinical findings of 33 patients with PVP deposition. A specific focus is PVP-related chronic kidney disease.

Funding: Helse Vest PhD grant

People: Ida Stalund (PhD candidate), Einar Svarstad, Friedemann Leh, Heidi Grønseth, Hans-Peter Marti, Sabine Leh

Publications:

Kristoffersen, A. H., T. K. Bjanes, S. Jordal, S. Leh, F. Leh and E. Svarstad (2016). "Polyvinylpyrrolidone induced artefactual prolongation of activated partial thromboplastin times in intravenous drug users with renal failure." J Thromb Haemost 14(5): 936-939.

Stalund, I. V., G. N. Riise, F. Leh, T. K. Bjånes, L. Riise, E. Svarstad and S. Leh (2021). "Case Report: Polyvinylpyrrolidone deposition disease from repeated injection of opioid substitution drugs: report of a case with a fatal outcome." F1000Res 10: 300.

Leh, F., I. V. Stalund, T. K. Bjånes, C. Ohldieck, E. Svarstad and S. Leh (2021). "Polyvinylpyrrolidone deposition disease in patients with intravenous opioid use: a case series." Hum Pathol 116: 102-111.

Stalund, I. V., H. Grønseth, F. P. Reinholt, E. Svarstad, H. P. Marti and S. Leh (2022). "Chronic Kidney Disease from Polyvinylpyrrolidone Deposition in Persons with Intravenous Drug Use." Clin J Am Soc Nephrol 17(4): 518-526.

3. Complement C5b-9 activation in kidney disease

Complement activation represents a well-described key pathogenic mechanism underlying inflammatory diseases affecting the kidney. In order to learn more about the significance of C5b-9 deposition, we evaluate the expression of C5b-9 in formalin-fixed, paraffin embedded (FFPE) non-neoplastic kidney biopsies with both glomerular, tubulointerstitial and vascular diseases by means of immunohistochemistry and quantitative image analysis.

People: Ole Petter Nordbø (PhD candidate), Ga Kei Tam, Sabine Leh, Hans-Peter Marti

4. Kidney Biopsy Codes for Pathologists KBC

Website

Information gathered in kidney biopsy registries benefits research, teaching and policy-making. Nowadays registries are mainly using locally developed classifications (sometimes with corresponding codes) for registration of pathology diagnoses. Because of the variety in classifications and codes, comparison, exchange or accumulation of data is hampered. Consequently, there is a great need for a more standardized, universally applicable terminology and interoperable coding for kidney biopsy codes. The KBC project aims to provide a complete and structured list of terminology and codes applicable to kidney biopsies.

People: Amélie Dendooven (Belgium), Sabine Leh (Norway)

Publications:

Dendooven, A., H. Peetermans, M. Helbert, T. Q. Nguyen, N. Marcussen, M. Nagata, L. Gesualdo, A. Perkowska-Ptasinska, C. Capusa, J. M. Lopez-Gomez, C. Geddes, M. A. Abdul-Hamid, M. Segelmark, R. Yahya, M. Garau, R. Villanueva, A. Dorman, S. Barbour, R. Cornet, H. Hopfer, K. Amann and S. Leh (2021). "Coding practice in national and regional kidney biopsy registries." BMC Nephrol 22(1): 193.

Leh, S. and A. Dendooven (2022). "Systematic reporting of medical kidney biopsies." Clin Kidney J 15(1): 21-30.

Leh, S., Dendooven, A. „Kidney biopsy codes for pathologists“. Nephrologie 17, 376–385 (2022).


Related persons:
Hans Peter Marti
Professor, Professor of Nephrology I
Department of Clinical Medicine
+4794030929
Hans-Peter.Marti@uib.no

Sabine Leh
Associate Professor
Department of Clinical Medicine
Sabine.Leh@uib.no


Key figures:

• Acronym: PiV (the Norwegian title is "Patologi i Vest")
• Duration: 2020 – 2024
• Funding: 20 Mill. NOK.
• Strategic investment Western Norway Health Authority

PET-based GFR measurement in animals and humans:
Olav Tenstad

Measurement of GFR in children:
Camilla Tøndel

Birthweights role in GFR and CKD risk:
Bjørn Egil Vikse

.

This project focuses on the utilization of newly developed technology for transcriptomic analysis of archival kidney biopsies and investigates which molecular features of HN increase biopsy accuracy and/or can be recovered in serum and urine specimens. Then, statistical machine learning methods will be developed to integrate these omics-based findings with routine clinical and laboratory patient features to define diagnostic and/or prognostic panels. Individual panel factors will also serve as novel drug targets for the identification of drugs that we can repurpose to treat HN. We will evaluate the biological effect of these drugs in vitro using the new kidney-on-chip technology, which we will refine to better simulate HN. We will further investigate the drugs with the best in vitro effect for their capability to attenuate the progression of HN in silico using pharmacometrics disease progression modelling. Finally, we will design a clinical trial that will begin after this project.

This project will deliver patient-tailored management of HN by improving the accuracy of renal biopsy, developing a non-invasive diagnostic/prognostic HN test allowing early diagnosis and sequential disease monitoring of disease course, and by identifying novel medical therapy.

Three subprojects are running on Fabrys disease:

Observational follow-up studies on Fabry's disease:

Fabry register LINK (CRISTIN)

Staff:

Camilla Tøndel, Rannveig Skrunes, Sabine Leh and Einar Svarstad

Funding:

Details of funding are here 

Publications:

1. Burlina A, Brand E, Hughes D, Kantola I, Krӓmer J, Nowak A, Tøndel C, Wanner C, Spada M. An expert consensus on the recommendations for the use of biomarkers in Fabry disease. Mol Genet Metab. 2023 Jun;139(2):107585. doi: 10.1016/j.ymgme.2023.107585. Epub 2023 Apr 17. PMID: 37207471.
2. Najafian B, Silvestroni A, Sokolovskiy A, Tøndel C, Svarstad E, Obrisca B, Ismail G, Holida MD, Mauer M. A novel unbiased method reveals progressive podocyte globotriaosylceramide accumulation and loss with age in females with Fabry disease. Kidney Int. 2022 Jul;102(1):173-182. doi: 10.1016/j.kint.2022.03.023. Epub 2022 Apr 26. PMID: 35483528; PMCID: PMC9233139.
3. Najafian B, Tøndel C, Svarstad E, Gubler MC, Oliveira JP, Mauer M. Accumulation of Globotriaosylceramide in Podocytes in Fabry Nephropathy Is Associated with Progressive Podocyte Loss. J Am Soc Nephrol. 2020 Apr;31(4):865-875. doi: 10.1681/ASN.2019050497. Epub 2020 Mar 3. PMID: 32127409; PMCID: PMC7191924.
4. Wanner C, Arad M, Baron R, Burlina A, Elliott PM, Feldt-Rasmussen U, Fomin VV, Germain DP, Hughes DA, Jovanovic A, Kantola I, Linhart A, Mignani R, Monserrat L, Namdar M, Nowak A, Oliveira JP, Ortiz A, Pieroni M, Spada M, Tylki-Szymańska A, Tøndel C, Viana-Baptista M, Weidemann F, Hilz MJ. European expert consensus statement on therapeutic goals in Fabry disease. Mol Genet Metab. 2018 Jul;124(3):189-203. doi: 10.1016/j.ymgme.2018.06.004. Epub 2018 Jun 12. PMID: 30017653.
5. Spada M, Baron R, Elliott PM, Falissard B, Hilz MJ, Monserrat L, Tøndel C, Tylki-Szymańska A, Wanner C, Germain DP. The effect of enzyme replacement therapy on clinical outcomes in paediatric patients with Fabry disease - A systematic literature review by a European panel of experts. Mol Genet Metab. 2019 Mar;126(3):212-223. doi: 10.1016/j.ymgme.2018.04.007. Epub 2018 Apr 26. PMID: 29785937.
6. Svarstad E, Leh S, Skrunes R, Kampevold Larsen K, Eikrem Ø, Tøndel C. Bedside Stereomicroscopy of Fabry Kidney Biopsies: An Easily Available Method for Diagnosis and Assessment of Sphingolipid Deposits. Nephron. 2018;138(1):13-21. doi: 10.1159/000479751. Epub 2017 Aug 26. PMID: 28848191.
7. Skrunes R, Tøndel C, Leh S, Larsen KK, Houge G, Davidsen ES, Hollak C, van Kuilenburg ABP, Vaz FM, Svarstad E. Long-Term Dose-Dependent Agalsidase Effects on Kidney Histology in Fabry Disease. Clin J Am Soc Nephrol. 2017 Sep 7;12(9):1470-1479. doi: 10.2215/CJN.01820217. Epub 2017 Jun 16. PMID: 28625968; PMCID: PMC5586567.
8. Suntjens E, Dreschler WA, Hess-Erga J, Skrunes R, Wijburg FA, Linthorst GE, Tøndel C, Biegstraaten M. Hearing loss in children with Fabry disease. J Inherit Metab Dis. 2017 Sep;40(5):725-731. doi: 10.1007/s10545-017-0051-5. Epub 2017 May 31. PMID: 28567540; PMCID: PMC5579138.
9. Eikrem Ø, Skrunes R, Tøndel C, Leh S, Houge G, Svarstad E, Marti HP. Pathomechanisms of renal Fabry disease. Cell Tissue Res. 2017 Jul;369(1):53-62. doi: 10.1007/s00441-017-2609-9. Epub 2017 Apr 12. PMID: 28401309.
10. Schiffmann R, Hughes DA, Linthorst GE, Ortiz A, Svarstad E, Warnock DG, West ML, Wanner C; Conference Participants. Screening, diagnosis, and management of patients with Fabry disease: conclusions from a "Kidney Disease: Improving Global Outcomes" (KDIGO) Controversies Conference. Kidney Int. 2017 Feb;91(2):284-293. doi: 10.1016/j.kint.2016.10.004. Epub 2016 Dec 18. PMID: 27998644.
11. Skrunes R, Svarstad E, Kampevold Larsen K, Leh S, Tøndel C. Reaccumulation of globotriaosylceramide in podocytes after agalsidase dose reduction in young Fabry patients. Nephrol Dial Transplant. 2017 May 1;32(5):807-813. doi: 10.1093/ndt/gfw094. PMID: 27190352.
12. Najafian B, Tøndel C, Svarstad E, Sokolovkiy A, Smith K, Mauer M. One Year of Enzyme Replacement Therapy Reduces Globotriaosylceramide Inclusions in Podocytes in Male Adult Patients with Fabry Disease. PLoS One. 2016 Apr 15;11(4):e0152812. doi: 10.1371/journal.pone.0152812. PMID: 27081853; PMCID: PMC4833322.
13. Biegstraaten M, Arngrímsson R, Barbey F, Boks L, Cecchi F, Deegan PB, Feldt-Rasmussen U, Geberhiwot T, Germain DP, Hendriksz C, Hughes DA, Kantola I, Karabul N, Lavery C, Linthorst GE, Mehta A, van de Mheen E, Oliveira JP, Parini R, Ramaswami U, Rudnicki M, Serra A, Sommer C, Sunder-Plassmann G, Svarstad E, Sweeb A, Terryn W, Tylki-Szymanska A, Tøndel C, Vujkovac B, Weidemann F, Wijburg FA, Woolfson P, Hollak CE. Recommendations for initiation and cessation of enzyme replacement therapy in patients with Fabry disease: the European Fabry Working Group consensus document. Orphanet J Rare Dis. 2015 Mar 27;10:36. doi: 10.1186/s13023-015-0253-6. PMID: 25885911; PMCID: PMC4383065.
14. Tøndel C, Kanai T, Larsen KK, Ito S, Politei JM, Warnock DG, Svarstad E. Foot process effacement is an early marker of nephropathy in young classic Fabry patients without albuminuria. Nephron. 2015;129(1):16-21. doi: 10.1159/000369309. Epub 2014 Dec 17. PMID: 25531941.
15. Mauer M, Glynn E, Svarstad E, Tøndel C, Gubler MC, West M, Sokolovskiy A, Whitley C, Najafian B. Mosaicism of podocyte involvement is related to podocyte injury in females with Fabry disease. PLoS One. 2014 Nov 11;9(11):e112188. doi: 10.1371/journal.pone.0112188. PMID: 25386848; PMCID: PMC4227696.
16. van der Tol L, Cassiman D, Houge G, Janssen MC, Lachmann RH, Linthorst GE, Ramaswami U, Sommer C, Tøndel C, West ML, Weidemann F, Wijburg FA, Svarstad E, Hollak CE, Biegstraaten M. Uncertain diagnosis of fabry disease in patients with neuropathic pain, angiokeratoma or cornea verticillata: consensus on the approach to diagnosis and follow-up. JIMD Rep. 2014;17:83-90. doi: 10.1007/8904_2014_342. Epub 2014 Sep 16. PMID: 25224312; PMCID: PMC4241201.
17. van der Tol L, Svarstad E, Ortiz A, Tøndel C, Oliveira JP, Vogt L, Waldek S, Hughes DA, Lachmann RH, Terryn W, Hollak CE, Florquin S, van den Bergh Weerman MA, Wanner C, West ML, Biegstraaten M, Linthorst GE. Chronic kidney disease and an uncertain diagnosis of Fabry disease: approach to a correct diagnosis. Mol Genet Metab. 2015 Feb;114(2):242-7. doi: 10.1016/j.ymgme.2014.08.007. Epub 2014 Aug 20. PMID: 25187469.
18. Linthorst GE, Burlina AP, Cecchi F, Cox TM, Fletcher JM, Feldt-Rasmussen U, Giugliani R, Hollak CE, Houge G, Hughes D, Kantola I, Lachmann R, Lopez M, Ortiz A, Parini R, Rivera A, Rolfs A, Ramaswami U, Svarstad E, Tondel C, Tylki-Szymanska A, Vujkovac B, Waldek S, West M, Weidemann F, Mehta A. Recommendations on reintroduction of agalsidase Beta for patients with fabry disease in europe, following a period of shortage. JIMD Rep. 2013;8:51-6. doi: 10.1007/8904_2012_160. Epub 2012 Jul 14. PMID: 23430520; PMCID: PMC3565660.
19. Tøndel C, Bostad L, Larsen KK, Hirth A, Vikse BE, Houge G, Svarstad E. Agalsidase benefits renal histology in young patients with Fabry disease. J Am Soc Nephrol. 2013 Jan;24(1):137-48. doi: 10.1681/ASN.2012030316. PMID: 23274955; PMCID: PMC3537211.
20. Bertelsen AK, Tøndel C, Krohn J, Bull N, Aarseth J, Houge G, Mellgren SI, Vedeler CA. Small fibre neuropathy in Fabry disease. J Neurol. 2013 Mar;260(3):917-9. doi: 10.1007/s00415-012-6800-3. Epub 2012 Dec 21. PMID: 23263
21. Houge G, Tøndel C, Kaarbøe O, Hirth A, Bostad L, Svarstad E. Fabry or not Fabry--a question of ascertainment. Eur J Hum Genet. 2011 Nov;19(11):1111. doi: 10.1038/ejhg.2011.87. Epub 2011 May 18. PMID: 21587323; PMCID: PMC3198147.
22. Najafian B, Svarstad E, Bostad L, Gubler MC, Tøndel C, Whitley C, Mauer M. Progressive podocyte injury and globotriaosylceramide (GL-3) accumulation in young patients with Fabry disease. Kidney Int. 2011 Mar;79(6):663-670. doi: 10.1038/ki.2010.484. Epub 2010 Dec 15. PMID: 21160462; PMCID: PMC3640823.
23. Guest JF, Jenssen T, Houge G, Aaseboe W, Tøndel C, Svarstad E. Modelling the resource implications of managing adults with Fabry disease in Norway favours home infusion. Eur J Clin Invest. 2010 Dec;40(12):1104-12. doi: 10.1111/j.1365-2362.2010.02363.x. Epub 2010 Sep 9. PMID: 21070219.
24. Tøndel C, Ramaswami U, Aakre KM, Wijburg F, Bouwman M, Svarstad E. Monitoring renal function in children with Fabry disease: comparisons of measured and creatinine-based estimated glomerular filtration rate. Nephrol Dial Transplant. 2010 May;25(5):1507-13. doi: 10.1093/ndt/gfp658. Epub 2009 Dec 27. PMID: 20038520.
25. Aakre KM, Tøndel C, Brun A, Svarstad E. The MDRD equation may mask decline of glomerular filtration rate in Fabry patients with normal or nearly normal kidney function. Clin Nephrol. 2009 Feb;71(2):118-24. doi: 10.5414/cnp71118. PMID: 19203503.
26. Tøndel C, Bostad L, Hirth A, Svarstad E. Renal biopsy findings in children and adolescents with Fabry disease and minimal albuminuria. Am J Kidney Dis. 2008 May;51(5):767-76. doi: 10.1053/j.ajkd.2007.12.032. Epub 2008 Mar 20. Erratum in: Am J Kidney Dis. 2009 Mar;53(3):567. PMID: 18436087.
27. Svarstad E, Bostad L, Kaarbøe O, Houge G, Tøndel C, Lyngdal PT, Iversen BM. Focal and segmental glomerular sclerosis (FSGS) in a man and a woman with Fabry's disease. Clin Nephrol. 2005 May;63(5):394-401. doi: 10.5414/cnp63394. PMID: 15909601.
28. Tøndel C, Laegreid LM, Hirth A, Houge G, Månsson JE, Søvik O. Intravenøs enzymsubstitusjonsbehandling ved Fabrys sykdom hos barn [Intravenous enzyme substitution therapy in children with Fabry's disease]. Tidsskr Nor Laegeforen. 2003 Dec 4;123(23):3388-90. Norwegian. PMID: 14713976.

Clinical interventional studies Fabry's disease:
Staff:

Camilla Tøndel, Rannveig Skrunes and Øystein Eikrem

Funding:

Publications:

1. Hopkin RJ, Cabrera GH, Jefferies JL, Yang M, Ponce E, Brand E, Feldt-Rasmussen U, Germain DP, Guffon N, Jovanovic A, Kantola I, Karaa A, Martins AM, Tøndel C, Wilcox WR, Yoo HW, Burlina AP, Mauer M. Clinical outcomes among young patients with Fabry disease who initiated agalsidase beta treatment before 30 years of age: An analysis from the Fabry Registry. Mol Genet Metab. 2023 Feb;138(2):106967. doi: 10.1016/j.ymgme.2022.106967. Epub 2022 Nov 30. PMID: 36709533.
2. Tøndel C, Thurberg BL, DasMahapatra P, Lyn N, Maski M, Batista JL, George K, Patel H, Hariri A. Clinical relevance of globotriaosylceramide accumulation in Fabry disease and the effect of agalsidase beta in affected tissues. Mol Genet Metab. 2022 Dec;137(4):328-341. doi: 10.1016/j.ymgme.2022.10.005. Epub 2022 Oct 29. PMID: 36334424.
3. van der Veen SJ, Körver S, Hirsch A, Hollak CEM, Wijburg FA, Brands MM, Tøndel C, van Kuilenburg ABP, Langeveld M. Early start of enzyme replacement therapy in pediatric male patients with classical Fabry disease is associated with attenuated disease progression. Mol Genet Metab. 2022 Feb;135(2):163-169. doi: 10.1016/j.ymgme.2021.12.004. Epub 2021 Dec 17. PMID: 35033446.
4. Moreno-Martinez D, Aguiar P, Auray-Blais C, Beck M, Bichet DG, Burlina A, Cole D, Elliott P, Feldt-Rasmussen U, Feriozzi S, Fletcher J, Giugliani R, Jovanovic A, Kampmann C, Langeveld M, Lidove O, Linhart A, Mauer M, Moon JC, Muir A, Nowak A, Oliveira JP, Ortiz A, Pintos-Morell G, Politei J, Rozenfeld P, Schiffmann R, Svarstad E, Talbot AS, Thomas M, Tøndel C, Warnock D, West ML, Hughes DA. Standardising clinical outcomes measures for adult clinical trials in Fabry disease: A global Delphi consensus. Mol Genet Metab. 2021 Apr;132(4):234-243. doi: 10.1016/j.ymgme.2021.02.001. Epub 2021 Feb 20. PMID: 33642210.
5. Ramaswami U, Bichet DG, Clarke LA, Dostalova G, Fainboim A, Fellgiebel A, Forcelini CM, An Haack K, Hopkin RJ, Mauer M, Najafian B, Scott CR, Shankar SP, Thurberg BL, Tøndel C, Tylki-Szymanska A, Bénichou B, Wijburg FA. Low-dose agalsidase beta treatment in male pediatric patients with Fabry disease: A 5-year randomized controlled trial. Mol Genet Metab. 2019 May;127(1):86-94. doi: 10.1016/j.ymgme.2019.03.010. Epub 2019 Apr 3. PMID: 30987917.
6. Wijburg FA, Bénichou B, Bichet DG, Clarke LA, Dostalova G, Fainboim A, Fellgiebel A, Forcelini C, An Haack K, Hopkin RJ, Mauer M, Najafian B, Scott CR, Shankar SP, Thurberg BL, Tøndel C, Tylki-Szymańska A, Ramaswami U. Characterization of early disease status in treatment-naive male paediatric patients with Fabry disease enrolled in a randomized clinical trial. PLoS One. 2015 May 8;10(5):e0124987. doi: 10.1371/journal.pone.0124987. PMID: 25955246; PMCID: PMC4425695.
    

Translational studies Fabry's disease:
Different subprojects included (CRISTIN links): 

• PB-102-F60 An open-label extension study to assess the long-term safety and efficacy of pegunigalsidase alfa (PRX-102) in patients with Fabry disease.  LINK
• LPS15919 - A randomized, open comparative study to evaluate glycosphingolipid removal and clinical effects of agalsidase beta (Fabrazyme®) in male Fabry patients who have switched treatment from migalastat (Galafold®) LINK
• Clinical Trial: A randomized, open-label study to evaluate glycosphingolipid (GL-3) removal and clinical effects of switching treatment to agalsidase beta (Fabrazyme) versus continuing treatment with agalsidase alfa (Replagal) in male patients with Fabry disease LINK
• Lucerastat-long-term treatment-ID-069A302 LINK
• MODIFY - Placebo-controlled study with oral Lucerastat monotherapy in Fabry disease LINK
• Phase 1/2 gene therapy study with AVV vector in Fabry disease LINK
• PB-102-F50:  A phase 3 open-label switch study to assess the safety, efficacy, and pharmacokinetics of pegunigalsidase alfa 2 mg/kg administered intravenously every 4 weeks for 52 weeks in patients with Fabry disease currently treated with enzyme replacement therapy. BRIGHT LINK
• PB-102-F51 Long-term treatment with Unigal every 4 weeks LINK
• Protalix PB-102-F30 An open-label study of the safety and efficacy of PRX-102 in patients with Fabry disease treated with Replagal (agalsidase alfa) LINK
• PB-102-F20 - A randomized, double-blind, active-controlled study of the safety and efficacy of PRX-102 compared with agalsidase beta on renal function in patients with Fabry disease previously treated with agalsidase beta LINK
• Fabry register [TC2] LINK
• Venglustat for neuropathic and abdominal pain in men and women with Fabry disease - EFC17045 LINK

Staff:

Hans-Peter Marti, Øystein Eikrem, Jessica Furriol and Philipp Strauss

Funding:

Publications:

1. Lillås BS, Tøndel C, Melsom T, Eriksen BO, Marti HP, Vikse BE. Response to Birth Weight and Renal Functional Reserve in Adults. Kidney Int Rep. 2023 Jun 17;8(8):1700-1701. doi: 10.1016/j.ekir.2023.06.012. PMID: 37547517; PMCID: PMC10403668.
2. Lillås BS, Tøndel C, Melsom T, Eriksen BO, Marti HP, Vikse BE. Renal Functional Response-Association With Birth Weight and Kidney Volume. Kidney Int Rep. 2023 Feb 20;8(5):1034-1042. doi: 10.1016/j.ekir.2023.02.1079. PMID: 37180504; PMCID: PMC10166784.
3. Lillås BS, Tøndel C, Aßmus J, Vikse BE. Low birthweight is associated with lower glomerular filtration rate in middle-aged mainly healthy women. Nephrol Dial Transplant. 2021 Dec 31;37(1):92-99. doi: 10.1093/ndt/gfaa306. PMID: 33313893; PMCID: PMC8719610.
4. Gjerde A, Skrunes R, Reisæter AV, Marti HP, Vikse BE. Familial Contributions to the Association Between Low Birth Weight and Risk of CKD in Adult Life. Kidney Int Rep. 2021 May 30;6(8):2151-2158. doi: 10.1016/j.ekir.2021.05.032. PMID: 34386664; PMCID: PMC8343716.
5. Gjerde A, Reisæter AV, Skrunes R, Marti HP, Vikse BE. Intrauterine Growth Restriction and Risk of Diverse Forms of Kidney Disease during the First 50 Years of Life. Clin J Am Soc Nephrol. 2020 Oct 7;15(10):1413-1423. doi: 10.2215/CJN.04080320. Epub 2020 Aug 17. PMID: 32816833; PMCID: PMC7536758.
6. Gjerde A, Lillås BS, Marti HP, Reisæter AV, Vikse BE. Intrauterine growth restriction, preterm birth and risk of end-stage renal disease during the first 50 years of life. Nephrol Dial Transplant. 2020 Jul 1;35(7):1157-1163. doi: 10.1093/ndt/gfaa001. PMID: 32040151; PMCID: PMC7417009.
7. Lillås BS, Tøndel C, Gjerde A, Vikse BE. Measurement of renal functional response using iohexol clearance-a study of different outpatient procedures. Clin Kidney J. 2019 Nov 26;14(1):181-188. doi: 10.1093/ckj/sfz167. PMID: 33564417; PMCID: PMC7857819.
    

Leaders:

Camilla Tøndel
Professor, Head of Teaching
Department of Clinical Science
camilla.tondel@uib.no

Øystein Eikrem
Associate Professor
Department of Clinical Medicine
oystein.eikrem@uib.no

Hans Peter Marti
Professor, Professor of Nephrology I
Department of Clinical Medicine
+4794030929
Hans-Peter.Marti@uib.no

Different subProjects related to kidney cancer:

Prognostic biomarkers in human renal cancer:
Hans-Peter Marti, Øystein Eikrem, Jessica Furriol and Christian Beisland. Helse Vest grant.

Caveolin expression in human renal cancer:
Jessica Furriol

Hyperion - Image mass cytometry tissue analyses:
Responsible people: Tarig Osman and Tony Chen

Image Mass Cytometry (Hyprion) identification of kidney cancer biomarkers
Pilot Study: Hyperion Imaging System is a reliable tool for simultaneous detection of multiple markers in archival kidney biopsies.

The HyperionTM Imaging System is a high-parameter imaging system that enables the simultaneous detection of
up to 40 protein markers using metal-tagged antibodies. It allows measurements of antigen
abundances at sub-cellular resolution and exploration of cell-cell interactions and can potentially
increase the diagnostic and pathophysiological yield of archival biopsies.
This project aimed to investigate this technique's applicability on archival formalin-fixed paraffin-embedded (FFPE) kidney biopsies.

Based on our first pilot study, further processing and data analysis would be needed to enable the exploration of the cell-cell interactions.


Interventional animal studies (Axl inhibitor)):
Lea Landolt
 

We are collaborating on different multidisciplinary projects as follows: 

Manifestations and pathogeneisis of Sjögren’s syndrome:
Kathrine Skarstein, Hanne Borge, Hans-Peter Marti.

SGLT2 expression in diabetes mellitus after kidney transplantation:
Jessica Furriol, Hans-Peter Marti.

Role of peroxidasin CKD:
Hans-Peter Marti and Tony Chen.

A pilot study of the application of microbubbles to mouse kidneys:
Øystein Eikrem.

Nutritional assessment of CKD, HD and transplant patients:
Hans-Peter Marti.

Hans-Peter Marti
Einar Svarstad
Bjørn Egil Vikse
Olav Tenstad
Bjørneklett Rune
Tøndel Camilla (Pubmed link)
Sabine Leh
Igegjerd Sekse
Rolf Christiansen
Kristin Kampevold Larsen
Thomas Knoop
Rannveig Skrunes
Janka Babickova
Jessica Furriol Palmer
Tarig Osman
Mohammad Madani Ibrahim
Øystein Solberg Eikrem
Lea Zoe Landolt

1. Marti HP, Pavía López AA, Schwartzmann P. Safety and tolerability of β-blockers: importance of cardioselectivity. Curr Med Res Opin. 2024;40(sup1):55-62. doi: 10.1080/03007995.2024.2317433. Epub 2024 Apr 10.
2. Rivedal M, Mikkelsen H, Marti HP, Liu L, Kiryluk K, Knoop T, Bjørneklett R, Haaskjold YL, Furriol J, Leh S, Paunas F, Bábíčková J, Scherer A, Serre C, Eikrem O, Strauss P. Glomerular transcriptomics predicts long term outcome and identifies therapeutic strategies for patients with assumed benign IgA nephropathy. Kidney Int. 2024 Apr;105(4):717-730. doi: 10.1016/j.kint.2023.12.010. Epub 2023 Dec 26.
3. Sekulic M, Batal I, Kudose S, Santoriello D, Stokes MB, Jim B, Marti HP, Eikrem Ø, Radhakrishnan J, D'Agati VD, Markowitz GS. Kidney Dysfunction and Pathology in the Setting of Hemophagocytic Lymphohistiocytosis. Kidney Int Rep. 2023 Nov 7;9(2):410-422. doi: 10.1016/j.ekir.2023.10.033. eCollection 2024 Feb.
4. Samodova D, Hoel A, Hansen TH, Clausen L, Telléus GK, Marti HP, Pedersen O, Støving RK, Deshmukh AS. Plasma proteome profiling reveals metabolic and immunologic differences between Anorexia Nervosa subtypes. Metabolism. 2024 Mar;152:155760. doi: 10.1016/j.metabol.2023.155760. Epub 2023 Dec 15.
5. Rivedal M, Haaskjold YL, Eikrem Ø, Bjørneklett R, Marti HP, Knoop T. Use of corticosteroids in Norwegian patients with immunoglobulin a nephropathy progressing to end-stage kidney disease: a retrospective cohort study. BMC Nephrol. 2024 Jan 29;25(1):42. doi: 10.1186/s12882-024-03481-6.
6. Smerkous D, Mauer M, Tøndel C, Svarstad E, Gubler MC, Nelson RG, Oliveira JP, Sargolzaeiaval F, Najafian B. Development of an automated estimation of foot process width using deep learning in kidney biopsies from patients with Fabry, minimal change, and diabetic kidney diseases. Kidney Int. 2024 Jan;105(1):165-176. doi: 10.1016/j.kint.2023.09.011. Epub 2023 Sep 27. 

1. Rivedal M, Haaskjold YL, Berge H, Knoop T. Antiglomerular Basement Membrane Disease Possibly Triggered by Undiagnosed Renal Cell Carcinoma: A Case Report. Kidney Med. 2023 Aug 9;5(10):100709. doi: 10.1016/j.xkme.2023.100709.
2. Elsaid HOA, Rivedal M, Skandalou E, Svarstad E, Tøndel C, Birkeland E, Eikrem Ø, Babickova J, Marti HP, Furriol J. Proteomic analysis unveils Gb3-independent alterations and mitochondrial dysfunction in a gla^-/- zebrafish model of Fabry disease. J Transl Med. 2023 Sep 5;21(1):591. doi: 10.1186/s12967-023-04475-y.
3. Kristiansen CK, Furriol J, Chen A, Sullivan GJ, Bindoff LA, Liang KX. Deoxyribonucleoside treatment rescues EtBr-induced mtDNA depletion in iPSC-derived neural stem cells with POLG mutations. FASEB J. 2023 Sep;37(9):e23139. doi: 10.1096/fj.202300650RR.PMID: 37584631
4. Kipp A, Marti HP, Babickova J, Nakken S, Leh S, Halden TAS, Jenssen T, Vikse BE, Åsberg A, Spagnoli G, Furriol J. Glomerular proteomic profiling reveals early differences between preexisting and de novo type 2 diabetes in human renal allografts. BMC Nephrol. 2023 Aug 25;24(1):254. doi: 10.1186/s12882-023-03294-z.
5. O'Keeffe M, Oterhals Å, Weishaupt H, Leh S, Ulvik A, Ueland PM, Halstensen A, Marti HP, Gudbrandsen OA. A diet containing cod backbone proteins attenuated the development of mesangial sclerosis and tubular dysfunction in male obese BTBR ob/ob mice. Eur J Nutr. 2023 Aug 7. doi: 10.1007/s00394-023-03227-4.
6. Lillås BS, Tøndel C, Melsom T, Eriksen BO, Marti HP, Vikse BE. Kidney Response to Birth Weight and Renal Functional Reserve in Adults. Int Rep. 2023 Jun 17;8(8):1700-1701. doi: 10.1016/j.ekir.2023.06.012.
7. Malicki S, Książek M, Sochaj Gregorczyk A, Kamińska M, Golda A, Chruścicka B, Mizgalska D, Potempa J, Marti HP, Kozieł J, Wieczorek M, Pieczykolan J, Mydel P, Dubin G. Identification and characterization of aptameric inhibitors of human neutrophil elastase. J Biol Chem. 2023 Aug;299(8):104889. doi: 10.1016/j.jbc.2023.104889.
8. Åsberg A, Hovd M, Kjellevold SA, Stenehjem AE, Wien TN, Broch LU, Reier-Nielsen M, Qvale TH, Marti HP, Heldal K, Bitter J, Hagelsteen Kvien E, Vaage JT, Lund-Johansen F, Midtvedt K. Humoral Response After 6 or More Successive Doses of SARS-CoV-2 mRNA Vaccines in Kidney Transplant Recipients-Should We Keep Vaccinating? Transplantation. 2023 Jul 27. doi: 10.1097/TP.0000000000004732.
9. Delaleu N, Marti HP, Strauss P, Sekulic M, Osman T, Tøndel C, Skrunes R, Leh S, Svarstad E, Nowak A, Gaspert A, Rusu E, Kwee I, Rinaldi A, Flatberg A, Eikrem O. Systems analyses of the Fabry kidney transcriptome and its response to enzyme replacement therapy identified and cross-validated enzyme replacement therapy-resistant targets amenable to drug repurposing. Kidney Int. 2023 Jul 5:S0085-2538(23)00487-8. doi: 10.1016/j.kint.2023.06.029.
10. Braun F, Abed A, Sellung D, Rogg M, Woidy M, Eikrem O, Wanner N, Gambardella J, Laufer SD, Haas F, Wong MN, Dumoulin B, Rischke P, Mühlig A, Sachs W, von Cossel K, Schulz K, Muschol N, Gersting SW, Muntau AC, Kretz O, Hahn O, Rinschen MM, Mauer M, Bork T, Grahammer F, Liang W, Eierhoff T, Römer W, Hansen A, Meyer-Schwesinger C, Iaccarino G, Tøndel C, Marti HP, Najafian B, Puelles VG, Schell C, Huber TB. Accumulation of α-synuclein mediates podocyte injury in Fabry nephropathy. J Clin Invest. 2023 Jun 1;133(11):e157782. doi: 10.1172/JCI157782.
11. Haaskjold YL, Lura NG, Bjørneklett R, Bostad L, Bostad LS, Knoop T. Validation of two IgA nephropathy risk-prediction tools using a cohort with a long follow-up. Nephrol Dial Transplant. 2023 May 4;38(5):1183-1191. doi: 10.1093/ndt/gfac225.
12. Lillås BS, Tøndel C, Melsom T, Eriksen BO, Marti HP, Vikse BE. Renal Functional Response-Association With Birth Weight and Kidney Volume. Kidney Int Rep. 2023 Feb 20;8(5):1034-1042. doi: 10.1016/j.ekir.2023.02.1079.
13. Gjerstad AC, Skrunes R, Tøndel C, Åsberg A, Leh S, Klingenberg C, Døllner H, Hammarstrøm C, Bjerre AK. Kidney biopsy diagnosis in childhood in the Norwegian Kidney Biopsy Registry and the long-term risk of kidney replacement therapy: a 25-year follow-up. Pediatr Nephrol. 2023 Apr;38(4):1249-1256. doi: 10.1007/s00467-022-05706-y.
14. Dahl H, Meyer K, Sandnes K, Welland NL, Arnesen I, Marti HP, Dierkes J, Lysne V. Cystatin C proteoforms in chronic kidney disease. PLoS One. 2023 Feb 1;18(2):e0269436. doi: 10.1371/journal.pone.0269436.
15. Krendel M, Leh S, Garone ME, Edwards-Richards A, Lin JJ, Brackman D, Knappskog P, Mikhailov A. Focal segmental glomerulosclerosis and proteinuria associated with Myo1E mutations: novel variants and histological phenotype analysis. Pediatr Nephrol. 2023 Feb;38(2):439-449. doi: 10.1007/s00467-022-05634-x.
16. Eikrem Ø, Lillefosse B, Delaleu N, Strauss P, Osman T, Vikse BE, Debiec H, Ronco P, Sekulic M, Koch E, Furriol J, Leh SM, Marti HP. Network-Based Assessment of Minimal Change Disease Identifies Glomerular Response to IL-7 and IL-12 Pathways Activation as Innovative Treatment Target. Biomedicines. 2023 Jan 16;11(1):226. doi: 10.3390/biomedicines11010226.
17. Mikkelsen H, Vikse BE, Eikrem O, Scherer A, Finne K, Osman T, Marti HP. Glomerular proteomic profiling of kidney biopsies with hypertensive nephropathy reveals a signature of disease progression. Hypertens Res. 2023 Jan;46(1):144-156. doi: 10.1038/s41440-022-01066-0.
18. Wallace EL, Goker-Alpan O, Wilcox WR, Holida M, Bernat J, Longo N, Linhart A, Hughes DA, Hopkin RJ, Tøndel C, Langeveld M, Giraldo P, Pisani A, Germain DP, Mehta A, Deegan PB, Molnar MJ, Ortiz D, Jovanovic A, Muriello M, Barshop BA, Kimonis V, Vujkovac B, Nowak A, Geberhiwot T, Kantola I, Knoll J, Waldek S, Nedd K, Karaa A, Brill-Almon E, Alon S, Chertkoff R, Rocco R, Sakov A, Warnock DG. Head-to-head trial of pegunigalsidase alfa versus agalsidase beta in patients with Fabry disease and deteriorating renal function: results from the 2-year randomised phase III BALANCE study. J Med Genet. 2023 Nov 8:jmg-2023-109445. doi: 10.1136/jmg-2023-109445. Online ahead of print.PMID: 37940383
19. Linhart A, Dostálová G, Nicholls K, West ML, Tøndel C, Jovanovic A, Giraldo P, Vujkovac B, Geberhiwot T, Brill-Almon E, Alon S, Chertkoff R, Rocco R, Hughes D. Safety and efficacy of pegunigalsidase alfa in patients with Fabry disease who were previously treated with agalsidase alfa: results from BRIDGE, a phase 3 open-label study. Orphanet J Rare Dis. 2023 Oct 21;18(1):332. doi: 10.1186/s13023-023-02937-6.
20. Smerkous D, Mauer M, Tøndel C, Svarstad E, Gubler MC, Nelson RG, Oliveira JP, Sargolzaeiaval F, Najafian B. Development of an automated estimation of foot process width using deep learning in kidney biopsies from patients with Fabry, minimal change, and diabetic kidney diseases. Kidney Int. 2024 Jan;105(1):165-176. doi: 10.1016/j.kint.2023.09.011. Epub 2023 Sep 27.
21. Bichet DG, Hopkin RJ, Aguiar P, Allam SR, Chien YH, Giugliani R, Kallish S, Kineen S, Lidove O, Niu DM, Olivotto I, Politei J, Rakoski P, Torra R, Tøndel C, Hughes DA. Consensus recommendations for the treatment and management of patients with Fabry disease on migalastat: a modified Delphi study. Front Med (Lausanne). 2023 Sep 1;10:1220637. doi: 10.3389/fmed.2023.1220637. eCollection 2023.
22. Bradley JS, Makieieva N, Tøndel C, Roilides E, Kelly MS, Patel M, Vaddady P, Maniar A, Zhang Y, Paschke A, Chen LF. Pharmacokinetics, Safety, and Tolerability of Imipenem/Cilastatin/Relebactam in Children with Confirmed or Suspected Gram-Negative Bacterial Infections: A Phase 1b, Open-Label, Single-Dose Clinical Trial. J Clin Pharmacol. 2023 Dec;63(12):1387-1397. doi: 10.1002/jcph.2334. Epub 2023 Sep 2.
23. Bansal A, Trieu MC, Mohn KGI, Madsen A, Olofsson JS, Sandnes HH, Sævik M, Søyland H, Hansen L, Onyango TB, Tøndel C, Brokstad KA; Bergen COVID-19 research group; Syre H, Riis ÅG, Langeland N, Cox RJ. Risk assessment and antibody responses to SARS-CoV-2 in healthcare workers. Front Public Health. 2023 Jul 21;11:1164326. doi: 10.3389/fpubh.2023.1164326. eCollection 2023.
24. Salvador CL, Flemmen PTK, Tøndel C, Bliksrud YT, Tsui EFF, Brun A, Bjerre A, Mørkrid L. Renal function, sex and age influence purines and pyrimidines in urine and could lead to diagnostic misinterpretation. Mol Genet Metab. 2023 Nov;140(3):107649. doi: 10.1016/j.ymgme.2023.107649. Epub 2023 Jul 5.
25. Burlina A, Brand E, Hughes D, Kantola I, Krӓmer J, Nowak A, Tøndel C, Wanner C, Spada M. An expert consensus on the recommendations for the use of biomarkers in Fabry disease. Mol Genet Metab. 2023 Jun;139(2):107585. doi: 10.1016/j.ymgme.2023.107585. Epub 2023 Apr 17.
26. Hopkin RJ, Cabrera GH, Jefferies JL, Yang M, Ponce E, Brand E, Feldt-Rasmussen U, Germain DP, Guffon N, Jovanovic A, Kantola I, Karaa A, Martins AM, Tøndel C, Wilcox WR, Yoo HW, Burlina AP, Mauer M. Clinical outcomes among young patients with Fabry disease who initiated agalsidase beta treatment before 30 years of age: An analysis from the Fabry Registry. Mol Genet Metab. 2023 Feb;138(2):106967. doi: 10.1016/j.ymgme.2022.106967. Epub 2022 Nov 30.
27. Hansen L, Brokstad KA, Bansal A, Zhou F, Bredholt G, Onyango TB, Sandnes HH, Elyanow R, Madsen A, Trieu MC, Sævik M, Søyland H, Olofsson JS, Vahokoski J, Ertesvåg NU, Fjelltveit EB, Shafiani S, Tøndel C, Chapman H, Kaplan I, Mohn KGI, Langeland N, Cox RJ. Durable immune responses after BNT162b2 vaccination in home-dwelling old adults. Vaccine X. 2023 Apr;13:100262. doi: 10.1016/j.jvacx.2023.100262. Epub 2023 Jan 10.
28. Fjelltveit EB, Blomberg B, Kuwelker K, Zhou F, Onyango TB, Brokstad KA, Elyanow R, Kaplan IM, Tøndel C, Mohn KGI, Özgümüş T, Cox RJ, Langeland N; Bergen COVID-19 Research Group. Symptom Burden and Immune Dynamics 6 to 18 Months Following Mild Severe Acute Respiratory Syndrome Coronavirus 2 Infection (SARS-CoV-2): A Case-control Study. Clin Infect Dis. 2023 Feb 8;76(3):e60-e70. doi: 10.1093/cid/ciac655.
29. Smeets NJL, Teunissen EMM, van der Velden K, van der Burgh MJP, Linders DE, Teesselink E, Moes DAR, Tøndel C, Ter Heine R, van Heijst A, Schreuder MF, de Wildt SN. Glomerular filtration rate in critically ill neonates and children: creatinine-based estimations versus iohexol-based measurements. Pediatr Nephrol. 2023 Apr;38(4):1087-1097. doi: 10.1007/s00467-022-05651-w. Epub 2022 Aug 2.

1. Dahl H, Rosendahl-Riise H, Marti HP, Dierkes J. The Association of Sarcopenia and Central Obesity with Mortality Risk in Patients with Chronic Kidney Disease - a 2-Year Observational Study. Curr Dev Nutr. 2022 Dec 22;7(1):100014. doi: 10.1016/j.cdnut.2022.100014.
2. Elsaid HOA, Tjeldnes H, Rivedal M, Serre C, Eikrem Ø, Svarstad E, Tøndel C, Marti HP, Furriol J, Babickova J. Gene Expression Analysis in gla-Mutant Zebrafish Reveals Enhanced Ca²⁺ Signaling Similar to Fabry Disease. Int J Mol Sci. 2022 Dec 26;24(1):358. doi: 10.3390/ijms24010358.
3. Haaskjold YL, Knoop T. [Y.L. Haaskjold and T. Knoop respond]. Tidsskr Nor Laegeforen. 2022 Dec 12;142(18). doi: 10.4045/tidsskr.22.0740.
4. Haaskjold YL, Knoop T. [IgA nephropathy]. Tidsskr Nor Laegeforen. 2022 Nov 7;142(16). doi: 10.4045/tidsskr.22.0146.
5. Vildmyren I, Oterhals Å, Leh S, Samuelsen TA, Halstensen A, Marti HP, Gudbrandsen OA. Intake of residuals from Atlantic cod attenuated blood pressure increase but did not delay development of kidney damage in obese Zucker fa/fa rats. Food Nutr Res. 2022 Oct 11;66. doi: 10.29219/fnr.v66.8708
6. Binder V, Chruścicka-Smaga B, Bergum B, Jaisson S, Gillery P, Sivertsen J, Hervig T, Kaminska M, Tilvawala R, Nemmara VV, Thompson PR, Potempa J, Marti HP, Mydel P. Carbamylation of Integrin α _IIb β ₃: The Mechanistic Link to Platelet Dysfunction in ESKD. J Am Soc Nephrol. 2022 Oct;33(10):1841-1856. doi: 10.1681/ASN.2022010013.
7. Dahl H, Sandblost SRT, Welland NL, Sandnes K, Sekse I, Sæle K, Marti HP, Holst L, Dierkes J. Medication Prescription, Common Side-effects, and Nutritional Status are Associated in Patients With Chronic Kidney Disease. J Ren Nutr. 2022 Sep;32(5):520-528. doi: 10.1053/j.jrn.2021.10.008.
8. Strauss P, Rivedal M, Scherer A, Eikrem Ø, Nakken S, Beisland C, Bostad L, Flatberg A, Skandalou E, Beisvåg V, Furriol J, Marti HP. A multiomics disease progression signature of low-risk ccRCC. Sci Rep. 2022 Aug 5;12(1):13503. doi: 10.1038/s41598-022-17755-2.
9. Apeland T, Ushakova A, Mansoor MA, Furriol J, Jonsson G, Marti HP. Association of redox and inflammation-related biomarkers with prognosis in IgA nephropathy: A prospective observational study. Free Radic Biol Med. 2022 Aug 1;188:62-70. doi: 10.1016/j.freeradbiomed.2022.06.224.
10. Malicki S, Pucelik B, Żyła E, Benedyk-Machaczka M, Gałan W, Golda A, Sochaj-Gregorczyk A, Kamińska M, Encarnação JC, Chruścicka B, Marti HP, Chen TJ, Magiera-Mularz K, Zięba B, Holak TA, Dąbrowski JM, Czarna A, Kozieł J, Mydel P, Dubin G. Imaging of Clear Cell Renal Carcinoma with Immune Checkpoint Targeting Aptamer-Based Probe. Pharmaceuticals (Basel). 2022 Jun 1;15(6):697. doi: 10.3390/ph15060697.
11. Elsaid HOA, Furriol J, Blomqvist M, Diswall M, Leh S, Gharbi N, Anonsen JH, Babickova J, Tøndel C, Svarstad E, Marti HP, Krause M. Reduced α-galactosidase A activity in zebrafish (Danio rerio) mirrors distinct features of Fabry nephropathy phenotype. Mol Genet Metab Rep. 2022 Feb 17;31:100851. doi: 10.1016/j.ymgmr.2022.100851.
12. Dahl H, Warz SI, Welland NL, Arnesen I, Marti HP, Dierkes J. Factors associated with nutritional risk in patients receiving haemodialysis assessed by Nutritional Risk Screening 2002 (NRS2002). J Ren Care. 2022 Jun;48(2):112-118. doi: 10.1111/jorc.12374.
13. Landolt L, Spagnoli GC, Hertig A, Brocheriou I, Marti HP. Fibrosis and cancer: shared features and mechanisms suggest common targeted therapeutic approaches. Nephrol Dial Transplant. 2022 May 25;37(6):1024-1032. doi: 10.1093/ndt/gfaa301.
14. Stalund IV, Grønseth H, Reinholt FP, Svarstad E, Marti HP, Leh S. Chronic Kidney Disease from Polyvinylpyrrolidone Deposition in Persons with Intravenous Drug Use. Clin J Am Soc Nephrol. 2022 Apr;17(4):518-526. doi: 10.2215/CJN.13681021.
15. Paunas FTI, Finne K, Leh S, Marti HP, Berven F, Vikse BE. Proteomic signature of tubulointerstitial tissue predicts prognosis in IgAN. BMC Nephrol. 2022 Mar 24;23(1):118. doi: 10.1186/s12882-022-02736-4.
16. Schem BC, Pfeffer F, Ott MA, Wiig JN, Sletteskog N, Frøystein T, Myklebust MP, Leh S, Dahl O, Mella O. Long-Term Outcome in a Phase II Study of Regional Hyperthermia Added to Preoperative Radiochemotherapy in Locally Advanced and Recurrent Rectal Adenocarcinomas. Cancers (Basel). 2022 Jan 29;14(3):705. doi: 10.3390/cancers14030705
17. Haaskjold YL, Bjørneklett R, Bostad L, Bostad LS, Lura NG, Knoop T. Utilizing the MEST score for prognostic staging in IgA nephropathy. BMC Nephrol. 2022 Jan 11;23(1):26. doi: 10.1186/s12882-021-02653-y.
18. Tøndel C, Thurberg BL, DasMahapatra P, Lyn N, Maski M, Batista JL, George K, Patel H, Hariri A. Clinical relevance of globotriaosylceramide accumulation in Fabry disease and the effect of agalsidase beta in affected tissues. Mol Genet Metab. 2022 Dec;137(4):328-341. doi: 10.1016/j.ymgme.2022.10.005. Epub 2022 Oct 29.
19. Syre H, Obreque MEB, Dalen I, Riis ÅG, Berg Å, Löhr IH, Sundal J, Kleppe LK, Vadla MS, Lenning OB, Olofsson JS, Mohn KG, Tøndel C, Blomberg B, Trieu MC, Langeland N, Cox RJ. The Performances of Three Commercially Available Assays for the Detection of SARS-CoV-2 Antibodies at Different Time Points Following SARS-CoV-2 Infection. Viruses. 2022 Oct 5;14(10):2196. doi: 10.3390/v14102196.
20. Gjerstad AC, Skrunes R, Tøndel C, Åsberg A, Leh S, Klingenberg C, Døllner H, Hammarstrøm C, Bjerre AK. Kidney biopsy diagnosis in childhood in the Norwegian Kidney Biopsy Registry and the long-term risk of kidney replacement therapy: a 25-year follow-up. Pediatr Nephrol. 2023 Apr;38(4):1249-1256. doi: 10.1007/s00467-022-05706-y. Epub 2022 Aug 22.
21. Smeets NJL, Teunissen EMM, van der Velden K, van der Burgh MJP, Linders DE, Teesselink E, Moes DAR, Tøndel C, Ter Heine R, van Heijst A, Schreuder MF, de Wildt SN. Glomerular filtration rate in critically ill neonates and children: creatinine-based estimations versus iohexol-based measurements. Pediatr Nephrol. 2023 Apr;38(4):1087-1097. doi: 10.1007/s00467-022-05651-w. Epub 2022 Aug 2.
22. Najafian B, Silvestroni A, Sokolovskiy A, Tøndel C, Svarstad E, Obrisca B, Ismail G, Holida MD, Mauer M. A novel unbiased method reveals progressive podocyte globotriaosylceramide accumulation and loss with age in females with Fabry disease. Kidney Int. 2022 Jul;102(1):173-182. doi: 10.1016/j.kint.2022.03.023. Epub 2022 Apr 26.
23. Tøndel C, Marti HP. Cardiovascular changes in young renal failure patients. Clin Kidney J. 2021 Nov 11;15(2):183-185. doi: 10.1093/ckj/sfab223. eCollection 2022 Feb.

1. Tøndel C, Marti HP. Cardiovascular changes in young renal failure patients. Clin Kidney J. 2021 Nov 11;15(2):183-185. doi: 10.1093/ckj/sfab223.
2. Leh S, Dendooven A. Systematic reporting of medical kidney biopsies. Clin Kidney J. 2021 Jul 23;15(1):21-30. doi: 10.1093/ckj/sfab140.
3. Nakken S, Eikrem Ø, Marti HP, Beisland C, Bostad L, Scherer A, Flatberg A, Beisvag V, Skandalou E, Furriol J, Strauss P. Cancer Cell Int. 2021 Dec 20;21(1):690. doi: 10.1186/s12935-021-02395-9.
4. Strauss P, Mikkelsen H, Furriol J. Variable expression of eighteen common housekeeping genes in human non-cancerous kidney biopsies. PLoS One. 2021 Dec 9;16(12):e0259373. doi: 10.1371/journal.pone.0259373.
5. Chen TJ, Mydel P, Benedyk-Machaczka M, Kamińska M, Kalucka U, Blø M, Furriol J, Gausdal G, Lorens J, Osman T, Marti HP. AXL targeting by a specific small molecule or monoclonal antibody inhibits renal cell carcinoma progression in an orthotopic mice model. Physiol Rep. 2021 Dec;9(23):e15140. doi: 10.14814/phy2.15140.
6. Eikrem O, Kotopoulis S, Popa M, Mayoral Safont M, Fossan KO, Leh S, Landolt L, Babickova J, Gudbrandsen OA, Gilja OH, Riedel B, Schjøtt J, McCormack E, Marti HP. Ultrasound and Microbubbles Enhance Uptake of Doxorubicin in Murine Kidneys. Pharmaceutics. 2021 Nov 29;13(12):2038. doi: 10.3390/pharmaceutics13122038.
7. Fraggetta F, L'Imperio V, Ameisen D, Carvalho R, Leh S, Kiehl TR, Serbanescu M, Racoceanu D, Della Mea V, Polonia A, Zerbe N, Eloy C. Best Practice Recommendations for the Implementation of a Digital Pathology Workflow in the Anatomic Pathology Laboratory by the European Society of Digital and Integrative Pathology (ESDIP). Diagnostics (Basel). 2021 Nov 22;11(11):2167. doi: 10.3390/diagnostics11112167.
8. Hervig T, Tvedt THA, Knoop T, Sandnes M, Reikvam H. [A young woman with dyspnoea and proteinuria]. Tidsskr Nor Laegeforen. 2021 Nov 8;141(16). doi: 10.4045/tidsskr.21.0171.
9. Mohamed N, Litlekalsøy J, Ahmed IA, Martinsen EMH, Furriol J, Javier-Lopez R, Elsheikh M, Gaafar NM, Morgado L, Mundra S, Johannessen AC, Osman TA, Nginamau ES, Suleiman A, Costea DE. Analysis of Salivary Mycobiome in a Cohort of Oral Squamous Cell Carcinoma Patients From Sudan Identifies Higher Salivary Carriage of Malassezia as an Independent and Favorable Predictor of Overall Survival. Front Cell Infect Microbiol. 2021 Oct 12;11:673465. doi: 10.3389/fcimb.2021.673465.
10. Niederhauser C, Tinguely C, Dreier J, Vollmer T, Marti HP, Nickel B, Klemens JM, Warnecke JM, Gowland P. Comparison of a New IgG-EIA for the Detection of Anti-Plasmodium Antibodies with Two Currently Used Assays. Transfus Med Hemother. 2021 May 26;48(5):265-271. doi: 10.1159/000515842.
11. Leh F, Stalund IV, Bjånes TK, Ohldieck C, Svarstad E, Leh S. Polyvinylpyrrolidone deposition disease in patients with intravenous opioid use: a case series. Hum Pathol. 2021 Oct;116:102-111. doi: 10.1016/j.humpath.2021.07.009.
12. Hoel F, Hoel A, Pettersen IK, Rekeland IG, Risa K, Alme K, Sørland K, Fosså A, Lien K, Herder I, Thürmer HL, Gotaas ME, Schäfer C, Berge RK, Sommerfelt K, Marti HP, Dahl O, Mella O, Fluge Ø, Tronstad KJ. A map of metabolic phenotypes in patients with myalgic encephalomyelitis/chronic fatigue syndrome. JCI Insight. 2021 Aug 23;6(16):e149217. doi: 10.1172/jci.insight.149217.
13. Gjerde A, Skrunes R, Reisæter AV, Marti HP, Vikse BE. Familial Contributions to the Association Between Low Birth Weight and Risk of CKD in Adult Life. Kidney Int Rep. 2021 May 30;6(8):2151-2158. doi: 10.1016/j.ekir.2021.05.032.
14. Hoel A, Osman T, Hoel F, Elsaid H, Chen T, Landolt L, Babickova J, Tronstad KJ, Lorens JB, Gausdal G, Marti HP, Furriol J. Axl-inhibitor bemcentinib alleviates mitochondrial dysfunction in the unilateral ureter obstruction murine model. J Cell Mol Med. 2021 Aug;25(15):7407-7417. doi: 10.1111/jcmm.16769.
15. Midtvedt K, Tran T, Parker K, Marti HP, Stenehjem AE, Gøransson LG, Mørkve Soldal K, Madsen C, Smedbråten J, Vaage EB, Lund-Johansen F, Åsberg A. Low Immunization Rate in Kidney Transplant Recipients Also After Dose 2 of the BNT162b2 Vaccine: Continue to Keep Your Guard up! Transplantation. 2021 Aug 1;105(8):e80-e81. doi: 10.1097/TP.0000000000003856.
16. Steinfeld PF, Knoop T, Trovik LH, Gjelberg HK, Haslerud TM, Reikvam H. Kidney Failure and Abdominal Discomfort as Initial Signs of Extramedullary Acute Myelogenous Leukemia. Clin Pract. 2021 Jul 22;11(3):459-466. doi: 10.3390/clinpract11030061.
17. Dendooven A, Peetermans H, Helbert M, Nguyen TQ, Marcussen N, Nagata M, Gesualdo L, Perkowska-Ptasinska A, Capusa C, López-Gómez JM, Geddes C, Abdul-Hamid MA, Segelmark M, Yahya R, Garau M, Villanueva R, Dorman A, Barbour S, Cornet R, Hopfer H, Amann K, Leh S; Kidney Biopsy Codes for Pathologists project (www.kibico.org). Coding practice in national and regional kidney biopsy registries. BMC Nephrol. 2021 May 24;22(1):193. doi: 10.1186/s12882-021-02365-3.
18. Kelly DM, Anders HJ, Bello AK, Choukroun G, Coppo R, Dreyer G, Eckardt KU, Johnson DW, Jha V, Harris DCH, Levin A, Lunney M, Luyckx V, Marti HP, Messa P, Mueller TF, Saad S, Stengel B, Vanholder RC, Weinstein T, Khan M, Zaidi D, Osman MA, Ye F, Tonelli M, Okpechi IG, Rondeau E; ISN Western Europe Regional Board International Society of Nephrology Global Kidney Health Atlas: structures, organization, and services for the management of kidney failure in Western Europe. Kidney Int Suppl (2011). 2021 May;11(2):e106-e118. doi: 10.1016/j.kisu.2021.01.007.
19. Rossi F, Svarstad E, Elsaid H, Binaggia A, Roggero L, Auricchio S, Marti HP, Pieruzzi F. Elevated Ambulatory Blood Pressure Measurements are Associated with a Progressive Form of Fabry Disease. High Blood Press Cardiovasc Prev. 2021 May;28(3):309-319. doi: 10.1007/s40292-021-00450-0.
20. Stalund IV, Riise GN, Leh F, Bjånes TK, Riise L, Svarstad E, Leh S. Case Report: Polyvinylpyrrolidone deposition disease from repeated injection of opioid substitution drugs: report of a case with a fatal outcome. F1000Res. 2021 Apr 19;10:300. doi: 10.12688/f1000research.51927.2.
21. Haaskjold YL, Nylund K, Skrunes R. A Rare Case of Unilateral Renal Cortical Necrosis. Case Rep Nephrol Dial. 2021 Feb 12;11(1):63-68. doi: 10.1159/000512228.
22. Rossi F, L'Imperio V, Marti HP, Svarstad E, Smith A, Bolognesi MM, Magni F, Pagni F, Pieruzzi F. Proteomics for the study of new biomarkers in Fabry disease: State of the art.. Mol Genet Metab. 2021 Feb;132(2):86-93. doi: 10.1016/j.ymgme.2020.10.006.
23. van der Veen SJ, Körver S, Hirsch A, Hollak CEM, Wijburg FA, Brands MM, Tøndel C, van Kuilenburg ABP, Langeveld M. Early start of enzyme replacement therapy in pediatric male patients with classical Fabry disease is associated with attenuated disease progression. Mol Genet Metab. 2022 Feb;135(2):163-169. doi: 10.1016/j.ymgme.2021.12.004. Epub 2021 Dec 17.
24. Eide TT, Hufthammer KO, Brun A, Brackman D, Svarstad E, Tøndel C. Accuracy of single intravenous access iohexol GFR in children is hampered by marker contamination. Sci Rep. 2021 Dec 1;11(1):23224. doi: 10.1038/s41598-021-02759-1.
25. Casabona G, Habib MA, Povey M, Riise Bergsaker MA, Flodmark CE, Espnes KA, Tøndel C, Silfverdal SA. Randomised controlled trial showed long-term efficacy, immunogenicity and safety of varicella vaccines in Norwegian and Swedish children. Acta Paediatr. 2022 Feb;111(2):391-400. doi: 10.1111/apa.16136. Epub 2021 Oct 28.
26. Blomberg B, Mohn KG, Brokstad KA, Zhou F, Linchausen DW, Hansen BA, Lartey S, Onyango TB, Kuwelker K, Sævik M, Bartsch H, Tøndel C, Kittang BR; Bergen COVID-19 Research Group; Cox RJ, Langeland N. Long COVID in a prospective cohort of home-isolated patients. Nat Med. 2021 Sep;27(9):1607-1613. doi: 10.1038/s41591-021-01433-3. Epub 2021 Jun 23.
27. Baka-Ostrowska M, Bolong DT, Persu C, Tøndel C, Steup A, Lademacher C, Martin N. Efficacy and safety of mirabegron in children and adolescents with neurogenic detrusor overactivity: An open-label, phase 3, dose-titration study. Neurourol Urodyn. 2021 Aug;40(6):1490-1499. doi: 10.1002/nau.24657. Epub 2021 May 31.
28. Kuwelker K, Zhou F, Blomberg B, Lartey S, Brokstad KA, Trieu MC, Bansal A, Madsen A, Krammer F, Mohn KG, Tøndel C, Linchausen DW, Cox RJ, Langeland N; Bergen COVID-19 research group. Attack rates amongst household members of outpatients with confirmed COVID-19 in Bergen, Norway: A case-ascertained study. Lancet Reg Health Eur. 2021 Apr;3:100014. doi: 10.1016/j.lanepe.2020.100014. Epub 2021 Mar 31.
29. Arrieta AC, Ang JY, Espinosa C, Fofanov O, Tøndel C, Chou MZ, De Anda CS, Kim JY, Li D, Sabato P, Sears PS, Bradley JS. Pharmacokinetics and Safety of Single-dose Tedizolid Phosphate in Children 2 to <12 Years of Age. Pediatr Infect Dis J. 2021 Apr 1;40(4):317-323. doi: 10.1097/INF.0000000000003030.
30. Moreno-Martinez D, Aguiar P, Auray-Blais C, Beck M, Bichet DG, Burlina A, Cole D, Elliott P, Feldt-Rasmussen U, Feriozzi S, Fletcher J, Giugliani R, Jovanovic A, Kampmann C, Langeveld M, Lidove O, Linhart A, Mauer M, Moon JC, Muir A, Nowak A, Oliveira JP, Ortiz A, Pintos-Morell G, Politei J, Rozenfeld P, Schiffmann R, Svarstad E, Talbot AS, Thomas M, Tøndel C, Warnock D, West ML, Hughes DA. Standardising clinical outcomes measures for adult clinical trials in Fabry disease: A global Delphi consensus. Mol Genet Metab. 2021 Apr;132(4):234-243. doi: 10.1016/j.ymgme.2021.02.001. Epub 2021 Feb 20.
31. Lillås BS, Tøndel C, Aßmus J, Vikse BE. Low birthweight is associated with lower glomerular filtration rate in middle-aged mainly healthy women. Nephrol Dial Transplant. 2021 Dec 31;37(1):92-99. doi: 10.1093/ndt/gfaa306.
32. Trieu MC, Bansal A, Madsen A, Zhou F, Sævik M, Vahokoski J, Brokstad KA, Krammer F, Tøndel C, Mohn KGI, Blomberg B, Langeland N, Cox RJ; Bergen COVID-19 Research Group. SARS-CoV-2-Specific Neutralizing Antibody Responses in Norwegian Health Care Workers After the First Wave of COVID-19 Pandemic: A Prospective Cohort Study. J Infect Dis. 2021 Feb 24;223(4):589-599. doi: 10.1093/infdis/jiaa737.
33. Lillås BS, Tøndel C, Gjerde A, Vikse BE. Measurement of renal functional response using iohexol clearance-a study of different outpatient procedures. Clin Kidney J. 2019 Nov 26;14(1):181-188. doi: 10.1093/ckj/sfz167. eCollection 2021 Jan.

1. Pichler Sekulic S, Marti HP, Sekulic M. The Case | Kidney injury in a patient receiving nivolumab. Kidney Int. 2020 Nov;98(5):1359-1360. doi: 10.1016/j.kint.2020.06.006.
2. Liang KX, Kristiansen CK, Mostafavi S, Vatne GH, Zantingh GA, Kianian A, Tzoulis C, Høyland LE, Ziegler M, Perez RM, Furriol J, Zhang Z, Balafkan N, Hong Y, Siller R, Sullivan GJ, Bindoff LA. Disease-specific phenotypes in iPSC-derived neural stem cells with POLG mutations. EMBO Mol Med. 2020 Oct 7;12(10):e12146. doi: 10.15252/emmm.202012146.
3. Gjerde A, Reisæter AV, Skrunes R, Marti HP, Vikse BE. Intrauterine Growth Restriction and Risk of Diverse Forms of Kidney Disease during the First 50 Years of Life. Clin J Am Soc Nephrol. 2020 Oct 7;15(10):1413-1423. doi: 10.2215/CJN.04080320.
4. Apeland T, Mansoor MA, Furriol J, Ushakova A, Jonsson G, Stangeland KW, Marti HP. Circulating inflammation-related factors are correlated with systemic redox status in IgA nephropathy; a case-control study. Free Radic Biol Med. 2020 Aug 1;155:10-18. doi: 10.1016/j.freeradbiomed.2020.05.005.
5. Gjerde A, Lillås BS, Marti HP, Reisæter AV, Vikse BE. Intrauterine growth restriction, preterm birth and risk of end-stage renal disease during the first 50 years of life. Nephrol Dial Transplant. 2020 Jul 1;35(7):1157-1163. doi: 10.1093/ndt/gfaa001.
6. Svarstad E, Marti HP. The Changing Landscape of Fabry Disease. Clin J Am Soc Nephrol. 2020 Apr 7;15(4):569-576. doi: 10.2215/CJN.09480819
7. Mohn KG, Brokstad KA, Islam S, Oftung F, Tøndel C, Aarstad HJ, Cox RJ. Early Induction of Cross-Reactive CD8+ T-Cell Responses in Tonsils After Live-Attenuated Influenza Vaccination in Children. J Infect Dis. 2020 Apr 7;221(9):1528-1537. doi: 10.1093/infdis/jiz583.
8. Najafian B, Tøndel C, Svarstad E, Gubler MC, Oliveira JP, Mauer M. Accumulation of Globotriaosylceramide in Podocytes in Fabry Nephropathy Is Associated with Progressive Podocyte Loss. J Am Soc Nephrol. 2020 Apr;31(4):865-875. doi: 10.1681/ASN.2019050497. Epub 2020 Mar 3.
9. Thorsteinsdottir H, Salvador CL, Mjøen G, Lie A, Sugulle M, Tøndel C, Brun A, Almaas R, Bjerre A. Growth Differentiation Factor 15 in Children with Chronic Kidney Disease and after Renal Transplantation. Dis Markers. 2020 Feb 6;2020:6162892. doi: 10.1155/2020/6162892. eCollection 2020.
10. Rittig S, Baka-Ostrowska M, Tøndel C, Walle JV, Kjaeer B, Passier P, Bosman B, Stroosma O, Tannenbaum S. The pharmacokinetics, safety, and tolerability of mirabegron in children and adolescents with neurogenic detrusor overactivity or idiopathic overactive bladder and development of a population pharmacokinetic model-based pediatric dose estimation. J Pediatr Urol. 2020 Feb;16(1):31.e1-31.e10. doi: 10.1016/j.jpurol.2019.10.009. Epub 2019 Oct 22.
11. Rossi F, L'Imperio V, Marti HP, Svarstad E, Smith A, Bolognesi MM, Magni F, Pagni F, Pieruzzi F. Proteomics for the study of new biomarkers in Fabry disease: State of the art. Mol Genet Metab. 2021 Feb;132(2):86-93. doi: 10.1016/j.ymgme.2020.10.006. Epub 2020 Oct 14. 

1. Knoop T, Larsen KK, Leh F, Hemsing AL, Teigen IA, Reikvam H. Severe nephritis as initial sign of Waldenström's macroglobulinemia. Clin Pract. 2019 Dec 19;9(4):1184. doi: 10.4081/cp.2019.1184.
2. Paunas FTI, Finne K, Leh S, Osman TA, Marti HP, Berven F, Vikse BE. Characterization of glomerular extracellular matrix in IgA nephropathy by proteomic analysis of laser-captured microdissected glomeruli. BMC Nephrol. 2019 Nov 14;20(1):410. doi: 10.1186/s12882-019-1598-1.
3. Marti HP, Serebruany V, Atar D. Challenging Anticoagulation in Advanced Renal Failure. Am J Med. 2019 Nov;132(11):1258-1259. doi: 10.1016/j.amjmed.2019.07.002.
4. Hodneland E, Keilegavlen E, Hanson EA, Andersen E, Monssen JA, Rorvik J, Leh S, Marti HP, Lundervold A, Svarstad E, Nordbotten JM. In Vivo Detection of Chronic Kidney Disease Using Tissue Deformation Fields From Dynamic MR Imaging. IEEE Trans Biomed Eng. 2019 Jun;66(6):1779-1790. doi: 10.1109/TBME.2018.2879362.
5. Landolt L, Furriol J, Babickova J, Ahmed L, Eikrem Ø, Skogstrand T, Scherer A, Suliman S, Leh S, Lorens JB, Gausdal G, Marti HP, Osman T. AXL targeting reduces fibrosis development in experimental unilateral ureteral obstruction. Physiol Rep. 2019 May;7(10):e14091. doi: 10.14814/phy2.14091.
6. Becirovic-Agic M, Jönsson S, Tveitarås MK, Skogstrand T, Karlsen TV, Lidén Å, Leh S, Ericsson M, Nilsson SK, Reed RK, Hultström M. Time course of decompensation after angiotensin II and high-salt diet in Balb/CJ mice suggests pulmonary hypertension-induced cardiorenal syndrome. Am J Physiol Regul Integr Comp Physiol. 2019 May 1;316(5):R563-R570. doi: 10.1152/ajpregu.00373.2018.
7. Koch E, Finne K, Eikrem Ø, Landolt L, Beisland C, Leh S, Delaleu N, Granly M, Vikse BE, Osman T, Scherer A, Marti HP. Transcriptome-proteome integration of archival human renal cell carcinoma biopsies enables identification of molecular mechanisms. Am J Physiol Renal Physiol. 2019 May 1;316(5):F1053-F1067. doi: 10.1152/ajprenal.00424.2018.
8. Jönsson S, Becirovic-Agic M, Isackson H, Tveitarås MK, Skogstrand T, Narfström F, Karlsen TV, Lidén Å, Leh S, Ericsson M, Nilsson SK, Reed RK, Hultström M. Angiotensin II and salt-induced decompensation in Balb/CJ mice is aggravated by fluid retention related to low oxidative stress. Am J Physiol Renal Physiol. 2019 May 1;316(5):F914-F933. doi: 10.1152/ajprenal.00483.2018.
9. Rondeau E, Luyckx VA, Anders HJ, Eckardt KU, Florquin S, Marti HP, Ølgaard K, Harden P; members of the Western Europe Regional Board, International Society of Nephrology Challenges and opportunities for nephrology in Western Europe. Kidney Int. 2019 May;95(5):1037-1040. doi: 10.1016/j.kint.2018.09.028.
10. Nylund K, Sævik F, Leh S, Pfeffer F, Hausken T, Gilja OH. Interobserver Analysis of CEUS-Derived Perfusion in Fibrotic and Inflammatory Crohn's Disease. Ultraschall Med. 2019 Feb;40(1):76-84. doi: 10.1055/s-0044-100492.
11. Hodneland E, Keilegavlen E, Hanson EA, Andersen E, Monssen JA, Rorvik J, Leh S, Marti HP, Lundervold A, Svarstad E, Nordbotten JM. In Vivo Detection of Chronic Kidney Disease Using Tissue Deformation Fields From Dynamic MR Imaging. IEEE Trans Biomed Eng. 2019 Jun;66(6):1779-1790. doi: 10.1109/TBME.2018.2879362.
12. Nylund K, Sævik F, Leh S, Pfeffer F, Hausken T, Gilja OH. Interobserver Analysis of CEUS-Derived Perfusion in Fibrotic and Inflammatory Crohn's Disease. Ultraschall Med. 2019 Feb;40(1):76-84. doi: 10.1055/s-0044-100492.
13. Lillås BS, Tøndel C, Gjerde A, Vikse BE. Measurement of renal functional response using iohexol clearance-a study of different outpatient procedures. Clin Kidney J. 2019 Nov 26;14(1):181-188. doi: 10.1093/ckj/sfz167. eCollection 2021 Jan.
14. Ramaswami U, Bichet DG, Clarke LA, Dostalova G, Fainboim A, Fellgiebel A, Forcelini CM, An Haack K, Hopkin RJ, Mauer M, Najafian B, Scott CR, Shankar SP, Thurberg BL, Tøndel C, Tylki-Szymanska A, Bénichou B, Wijburg FA. Low-dose agalsidase beta treatment in male pediatric patients with Fabry disease: A 5-year randomized controlled trial. Mol Genet Metab. 2019 May;127(1):86-94. doi: 10.1016/j.ymgme.2019.03.010. Epub 2019 Apr 3.
15. Salvador CL, Tøndel C, Rowe AD, Bjerre A, Brun A, Brackman D, Mørkrid L. Estimating glomerular filtration rate in children: evaluation of creatinine- and cystatin C-based equations. Pediatr Nephrol. 2019 Feb;34(2):301-311. doi: 10.1007/s00467-018-4067-3. Epub 2018 Aug 31.
16. Spada M, Baron R, Elliott PM, Falissard B, Hilz MJ, Monserrat L, Tøndel C, Tylki-Szymańska A, Wanner C, Germain DP. The effect of enzyme replacement therapy on clinical outcomes in paediatric patients with Fabry disease - A systematic literature review by a European panel of experts. Mol Genet Metab. 2019 Mar;126(3):212-223. doi: 10.1016/j.ymgme.2018.04.007. Epub 2018 Apr 26.

1. Dierkes J, Dahl H, Welland NL, Sandnes K, Sæle K, Sekse I, Marti HP. Correction to: High rates of central obesity and sarcopenia in CKD irrespective of renal replacement therapy - an observational cross-sectional study. BMC Nephrol. 2018 Dec 24;19(1):375. doi: 10.1186/s12882-018-1149-1.
2. Ruggajo P, Leh S, Svarstad E, Marti HP, Vikse BE Low birth weight associates with glomerular area in young male IgA nephropathy patients. BMC Nephrol. 2018 Oct 22;19(1):287. doi: 10.1186/s12882-018-1070-7.
3. Dierkes J, Dahl H, Lervaag Welland N, Sandnes K, Sæle K, Sekse I, Marti HP. High rates of central obesity and sarcopenia in CKD irrespective of renal replacement therapy - an observational cross-sectional study. BMC Nephrol. 2018 Oct 11;19(1):259. doi: 10.1186/s12882-018-1055-6.
4. Eikrem Ø, Walther TC, Flatberg A, Beisvag V, Strauss P, Farstad M, Beisland C, Koch E, Mueller TF, Marti HP. Fine needle aspirates of kidneys: a promising tool for RNA sequencing in native and transplanted kidneys. BMC Nephrol. 2018 Sep 5;19(1):221. doi: 10.1186/s12882-018-1012-4.
5. Tariq A, Mansoor MA, Marti HP, Jonsson G, Slettan A, Weeraman P, Apeland T. Systemic redox biomarkers and their relationship to prognostic risk markers in autosomal dominant polycystic kidney disease and IgA nephropathy. Clin Biochem. 2018 Jun;56:33-40. doi: 10.1016/j.clinbiochem.2018.04.010.
6. Vikøren LA, Drotningsvik A, Mwakimonga A, Leh S, Mellgren G, Gudbrandsen OA. Diets containing salmon fillet delay development of high blood pressure and hyperfusion damage in kidneys in obese Zucker fa/fa rats. J Am Soc Hypertens. 2018 Apr;12(4):294-302. doi: 10.1016/j.jash.2018.01.006.
7. Strauss P, Marti HP, Beisland C, Scherer A, Lysne V, Leh S, Flatberg A, Koch E, Beisvag V, Landolt L, Skogstrand T, Eikrem Ø. Expanding the Utilization of Formalin-Fixed, Paraffin-Embedded Archives: Feasibility of miR-Seq for Disease Exploration and Biomarker Development from Biopsies with Clear Cell Renal Cell Carcinoma. Int J Mol Sci. 2018 Mar 10;19(3):803. doi: 10.3390/ijms19030803.
8. Svarstad E, Leh S, Skrunes R, Kampevold Larsen K, Eikrem Ø, Tøndel C. Bedside Stereomicroscopy of Fabry Kidney Biopsies: An Easily Available Method for Diagnosis and Assessment of Sphingolipid Deposits. Nephron. 2018;138(1):13-21. doi: 10.1159/000479751.
9. Wanner C, Arad M, Baron R, Burlina A, Elliott PM, Feldt-Rasmussen U, Fomin VV, Germain DP, Hughes DA, Jovanovic A, Kantola I, Linhart A, Mignani R, Monserrat L, Namdar M, Nowak A, Oliveira JP, Ortiz A, Pieroni M, Spada M, Tylki-Szymańska A, Tøndel C, Viana-Baptista M, Weidemann F, Hilz MJ. European expert consensus statement on therapeutic goals in Fabry disease. Mol Genet Metab. 2018 Jul;124(3):189-203. doi: 10.1016/j.ymgme.2018.06.004. Epub 2018 Jun 12.
10. Tøndel C, Salvador CL, Hufthammer KO, Bolann B, Brackman D, Bjerre A, Svarstad E, Brun A. Iohexol plasma clearance in children: validation of multiple formulas and single-point sampling times. Pediatr Nephrol. 2018 Apr;33(4):683-696. doi: 10.1007/s00467-017-3841-y. Epub 2017 Nov 13.

1. Nowak A, Koch G, Huynh-Do U, Siegenthaler M, Marti HP, Pfister M. Disease Progression Modeling to Evaluate the Effects of Enzyme Replacement Therapy on Kidney Function in Adult Patients with the Classic Phenotype of Fabry Disease. Kidney Blood Press Res. 2017 Feb 28;42(1):1-15. doi: 10.1159/000464312. [Epub ahead of print]
2. Schiffmann R, Hughes DA, Linthorst GE, Ortiz A, Svarstad E, Warnock DG, West ML, Wanner C; Conference Participants. Screening, diagnosis, and management of patients with Fabry disease: conclusions from a "Kidney Disease: Improving Global Outcomes" (KDIGO) Controversies Conference. Kidney Int. 2017 Feb;91(2):284-293. doi: 10.1016/j.kint.2016.10.004
3. Tøndel C, Bolann B, Salvador CL, Brackman D, Bjerre A, Svarstad E, Brun A. Iohexol plasma clearance in children: validation of multiple formulas and two-point sampling times. Pediatr Nephrol. 2017 Feb;32(2):311-320. doi: 10.1007/s00467-016-3436-z. Erratum in: Pediatr Nephrol. 2017 Feb;32(2):375-376
4. Tøndel C, Bolann B, Salvador CL, Brackman D, Bjerre A, Svarstad E, Brun A. Erratum to: Iohexol plasma clearance in children: validation of multiple formulas and two-point sampling times. Pediatr Nephrol. 2017 Feb;32(2):375-376. doi: 10.1007/s00467-016-3479-1. No abstract available.
5. Brackman D, Sartz L, Leh S, Kristoffersson AC, Bjerre A, Tati R, Frémeaux-Bacchi V, Karpman D. Thrombotic microangiopathy mimicking membranoproliferative glomerulonephritis. Nephrol Dial Transplant. 2017 Mar 1;32(3):584. doi: 10.1093/ndt/gfx013. No abstract available
6. Skrunes R, Svarstad E, Kampevold Larsen K, Leh S, Tøndel C. Reaccumulation of globotriaosylceramide in podocytes after agalsidase dose reduction in young Fabry patients. Nephrol Dial Transplant. 2017 May 1;32(5):807-813
7. Low Birth Weight and Nephron Number Working Group. The Impact of Kidney Development on the Life Course: A Consensus Document for Action. Nephron. 2017;136(1):3-49. doi: 10.1159/000457967. Epub 2017 Mar 21
8. Suntjens E, Dreschler WA, Hess-Erga J, Skrunes R, Wijburg FA, Linthorst GE, Tøndel C, Biegstraaten M. Hearing loss in children with Fabry disease. J Inherit Metab Dis. 2017 May 31. doi: 10.1007/s10545-017-0051-5. [Epub ahead of print]
9. Landolt L, Eikrem Ø, Strauss P, Scherer A, Lovett DH, Beisland C, Finne K, Osman T, Ibrahim MM, Gausdal G, Ahmed L, Lorens JB, Thiery JP, Tan TZ, Sekulic M, Marti HP. Clear Cell Renal Cell Carcinoma is linked to Epithelial-to-Mesenchymal Transition and to Fibrosis. Physiol Rep. 2017 Jun;5(11). pii: e13305. doi: 10.14814/phy2.13305
10. Luyckx VA, Perico N, Somaschini M, Manfellotto D, Valensise H, Cetin I, Simeoni U, Allegaert K, Vikse BE, Steegers EA, Adu D, Montini G, Remuzzi G, Brenner BM; writing group of the Low Birth Weight and Nephron Number Working Group. A developmental approach to the prevention of hypertension and kidney disease: a report from the Low Birth Weight and Nephron Number Working Group. Lancet. 2017 Jul 22;390(10092):424-428.
11. Norby GE, Mjøen G, Bjørneklett R, Vikse BE, Holdaas H, Svarstad E, Aasarød K. Outcome in biopsy-proven Lupus nephritis: Evaluation of biopsies from the Norwegian Kidney Biopsy Registry. Lupus. 2017 Jul;26(8):881-885
12. Midtvedt K, Bergan S, Reisæter AV, Vikse BE, Åsberg A. Exposure to Mycophenolate and Fatherhood. Transplantation. 2017 Jul;101(7):e214-e217
13. Eikrem Ø, Skrunes R, Tøndel C, Leh S, Houge G, Svarstad E, Marti HP. Pathomechanisms of renal Fabry disease. Cell Tissue Res. 2017 Jul;369(1):53-62
14. Skrunes R, Tøndel C, Leh S, Larsen KK, Houge G, Davidsen ES, Hollak C, van Kuilenburg ABP, Vaz FM, Svarstad E  Long-Term Dose-Dependent Agalsidase Effects on Kidney Histology in Fabry Disease. Clin J Am Soc Nephrol. 2017 Sep 7;12(9):1470-1479
15. Paunas TIF, Finne K, Leh S, Marti HP, Mollnes TE, Berven F, Vikse BE. Glomerular abundance of complement proteins characterized by proteomic analysis of laser-captured microdissected glomeruli associates with progressive disease in IgA nephropathy. Clin Proteomics. 2017 Aug 14;14:30. doi: 10.1186/s12014-017-9165-x. eCollection 2017
16. Svarstad E, Leh S, Skrunes R, Kampevold Larsen K, Eikrem Ø, Tøndel C. Bedside Stereomicroscopy of Fabry Kidney Biopsies: An Easily Available Method for Diagnosis and Assessment of Sphingolipid Deposits. Nephron. 2017 Aug 26. doi: 10.1159/000479751. [Epub ahead of print]
17. Egeland GM, Skurtveit S, Sakshaug S, Daltveit AK, Vikse BE, Haugen M. Low Calcium Intake in Midpregnancy Is Associated with Hypertension Development within 10 Years after Pregnancy: The Norwegian Mother and Child Cohort Study. J Nutr. 2017 Sep;147(9):1757-1763
18. Salvador CL, Tøndel C, Rowe AD, Bjerre A, Brun A, Brackman D, Bolstad N, Mørkrid L. Renal Function Influences Diagnostic Markers in Serum and Urine: A Study of Guanidinoacetate, Creatine, Human Epididymis Protein 4, and Neutrophil Gelatinase-Associated Lipocalin in Children. J Appl Lab Med. 2017 Nov 1;2(3):297-308. doi: 10.1373/jalm.2016.022145.  

1. Finne K, Marti HP, Leh S, Skogstrand T, Vethe H, Tenstad O, Berven FS, Scherer A, Vikse BE. Proteomic Analysis of Minimally Damaged Renal Tubular Tissue from Two-Kidney-One-Clip Hypertensive Rats Demonstrates Extensive Changes Compared to Tissue from Controls. Nephron. 2016;132(1):70-80. doi: 10.1159/000442825. Epub 2016 Jan 9.
2. Ruggajo P, Skrunes R, Svarstad E, Skjærven R, Reisæther AV, Vikse BE. Familial Factors, Low Birth Weight, and Development of ESRD: A Nationwide Registry Study. Am J Kidney Dis. 2016 Apr;67(4):601-8. doi: 10.1053/j.ajkd.2015.11.015. Epub 2015 Dec 31.
3. Eikrem O, Beisland C, Hjelle K, Flatberg A, Scherer A, Landolt L, Skogstrand T, Leh S, Beisvag V, Marti HP. Transcriptome Sequencing (RNAseq) Enables Utilization of Formalin-Fixed, Paraffin-Embedded Biopsies with Clear Cell Renal Cell Carcinoma for Exploration of Disease Biology and Biomarker Development.PLoS One. 2016 Feb 22;11(2):e0149743. doi: 10.1371/journal.pone.0149743. eCollection 2016.
4. Kristoffersen AH, Bjånes TK, Jordal S, Leh S, Leh F, Svarstad E. Polyvinylpyrrolidone induced artefactual prolongation of activated partial thromboplastin times in intravenous drug users with renal failure. J Thromb Haemost. 2016 Feb 26. doi: 10.1111/jth.13299.
5. Havre RF, Leh SM, Gilja OH, Ødegaard S, Waage JE, Baatrup G, Nesje LB. Differentiation of Metastatic and Non-Metastatic Mesenteric Lymph Nodes by Strain Elastography in Surgical Specimens. Ultraschall Med. 2016 Apr 12.
6. Najafian B, Tøndel C, Svarstad E, Sokolovkiy A, Smith K, Mauer M. One Year of Enzyme Replacement Therapy Reduces Globotriaosylceramide Inclusions in Podocytes in Male Adult Patients with Fabry Disease. PLoS One. 2016 Apr 15;11(4):e0152812. doi: 10.1371/journal.pone.0152812. eCollection 2016.
7. Ruggajo P, Svarstad E, Leh S, Marti HP, Reisæther AV, Vikse BE. Low Birth Weight and Risk of Progression to End Stage Renal Disease in IgA Nephropathy-A Retrospective Registry-Based Cohort Study. PLoS One. 2016 Apr 19;11(4):e0153819. doi: 10.1371/journal.pone.0153819. eCollection 2016.
8. Mohn KG, Brokstad KA, Pathirana RD, Bredholt G, Jul-Larsen Å, Trieu MC, Lartey SL, Montomoli E, Tøndel C, Aarstad HJ, Cox RJ. 
   Live Attenuated Influenza Vaccine in Children Induces B-Cell Responses in Tonsils. J Infect Dis. 2016 Sep 1;214(5):722-31. doi: 10.1093/infdis/jiw230. Epub 2016 May 30. 

1. Tøndel C, Kanai T, Larsen KK, Ito S, Politei JM, Warnock DG, Svarstad E. Foot Process Effacement Is an Early Marker of Nephropathy in Young Classic Fabry Patients without Albuminuria. AbstractNephron 2015;129:16-21 (DOI:10.1159/000369309)
2. Vethe H, Finne K, Skogstrand T, Vaudel M, Vikse BE, Hultström M, Placier S, Scherer A, Tenstad O, Marti HP. Distinct protein signature of hypertension-induced damage in the renal proteome of the two-kidney, one-clip rat model. J Hypertens. 2015 Jan;33(1):126-35
3. van der Tol L, Svarstad E, Ortiz A, Tøndel C, Oliveira JP, Vogt L, Waldek S, Hughes DA, Lachmann RH, Terryn W, Hollak CE, Florquin S, van den Bergh Weerman MA, Wanner C, West ML, Biegstraaten M, Linthorst GE.Chronic kidney disease and an uncertain diagnosis of Fabry disease: approach to a correct diagnosis. Mol Genet Metab. 2015 Feb;114(2):242-7. doi: 10.1016/j.ymgme.2014.08.007. Epub 2014 Aug 20
4. Skogstrand T, Leh S, McClure J, Dashti M, Iversen BM, Graham D, McBride MW, Hultström M. Identification of a common molecular pathway in hypertensive renal damage: comparison of rat and human gene expression profiles. J Hypertens. 2015 Mar;33(3):584-96
5. Sriskandarajah S, Aasarød K, Skrede S, Knoop T, Reisæter AV, Bjørneklett R. Improved prognosis in Norwegian patients with glomerulonephritis associated with anti-neutrophil cytoplasmic antibodies. Nephrol Dial Transplant. 2015 30: i67-i75 [Epub ahead of print]
6. Eikefjord E, Andersen E, Hodneland E, Zöllner F, Lundervold A, Svarstad E, Rørvik J. Use of 3D DCE-MRI for the Estimation of Renal Perfusion and Glomerular Filtration Rate: An Intrasubject Comparison of FLASH and KWIC With a Comprehensive Framework for Evaluation. AJR Am J Roentgenol. 2015 Mar;204(3):W273-81. doi: 10.2214/AJR.14.13226
7. Marti HP, Dörje C, Strøm EH. Bedeutung und Management der Rezidive von Glomerulonephritiden im Nierentransplantat. Ther Umsch. 2015 Mar;72(3):199-206. doi: 10.1024/0040-5930/a000665. German
8. Biegstraaten M, Arngrímsson R, Barbey F, Boks L, Cecchi F, Deegan PB, Feldt-Rasmussen U, Geberhiwot T, Germain DP, Hendriksz C, Hughes DA, Kantola I, Karabul N, Lavery C, Linthorst GE, Mehta A, van de Mheen E, Oliveira JP, Parini R, Ramaswami U, Rudnicki M, Serra A, Sommer C, Sunder-Plassmann G, Svarstad E, Sweeb A, Terryn W, Tylki-Szymanska A, Tøndel C, Vujkovac B, Weidemann F, Wijburg FA, Woolfson P, Hollak CE.Recommendations for initiation and cessation of enzyme replacement therapy in patients with Fabry disease: the European Fabry Working Group consensus document. Orphanet J Rare Dis. 2015 Mar 27;10:36. doi: 10.1186/s13023-015-0253-6
9. Knoop T, Vågane AM, Vikse BE, Svarstad E, Magnúsdóttir BT, Leh S, Varberg Reisæter A, Bjørneklett R. Addition of eGFR and Age Improves the Prognostic Absolute Renal Risk-Model in 1,134 Norwegian Patients with IgA Nephropathy. Am J Nephrol. 2015;41(3):210-9. doi: 10.1159/000381403. Epub 2015 Apr 9
10. Wijburg FA, Bénichou B, Bichet DG, Clarke LA, Dostalova G, Fainboim A, Fellgiebel A, Forcelini C, An Haack K, Hopkin RJ, Mauer M, Najafian B, Scott CR, Shankar SP, Thurberg BL, Tøndel C, Tylki-Szymańska A, Ramaswami U. Characterization of early disease status in treatment-naive male paediatric patients with Fabry disease enrolled in a randomized clinical trial. PLoS One. 2015 May 8;10(5):e0124987. doi: 10.1371/journal.pone.0124987. eCollection 2015
11. Mohn KG, Bredholt G, Brokstad KA, Pathirana RD, Aarstad HJ, Tøndel C, Cox RJ. Longevity of B-cell and T-cell responses after live attenuated influenza vaccination in children. J Infect Dis. 2015 May 15;211(10):1541-9
12. Wójtowicz A, Lecompte TD, Bibert S, Manuel O, Rüeger S, Berger C, Boggian K, Cusini A, Garzoni C, Hirsch H, Khanna N, Mueller NJ, Meylan PR, Pascual M, van Delden C, Bochud PY; Swiss Transplant Cohort Study. PTX3 Polymorphisms and Invasive Mold Infections After Solid Organ Transplant. Clin Infect Dis. 2015 Aug 15;61(4):619-22
13. Pesce F, Diciolla M, Binetti G, Naso D, Ostuni VC, Di Noia T, Vågane AM, Bjørneklett R, Suzuki H, Tomino Y, Di Sciascio E, Schena FP. Clinical decision support system for end-stage kidney disease risk estimation in IgA nephropathy patients. Nephrol Dial Transplant. 2015 Jun 4. pii: gfv232. [Epub ahead of print]
14. Haaskjold YL, Drotningsvik A, Leh S, Marti HP, Svarstad E. Renal failure due to excessive intake of almonds in the absence of Oxalobacter Formigenes. Am J Med. 2015 Jul 30. pii: S0002-9343(15)00682-8. doi: 10.1016/j.amjmed.2015.07.010. [Epub ahead of print] No abstract available
15. Øvrehus MA, Zürbig P, Vikse BE, Hallan SI. Urinary proteomics in chronic kidney disease: diagnosis and risk of progression beyond albuminuria. Clin Proteomics. 2015 Aug 7;12(1):21. doi: 10.1186/s12014-015-9092-7. eCollection 2015
16. den Hoedt CH, Grooteman MP, Bots ML, Blankestijn PJ, van der Tweel I, van der Weerd NC, Penne EL, Mazairac AH, Levesque R, ter Wee PM, Nubé MJ, van den Dorpel MA; CONTRAST investigators. The Effect of Online Hemodiafiltration on Infections: Results from the CONvective TRAnsport STudy. PLoS One. 2015 Aug 19;10(8):e0135908. doi: 10.1371/journal.pone.0135908. eCollection 2015
17. Diciolla M, Binetti G, Di Noia T, Pesce F, Schena FP, Vågane AM, Bjørneklett R, Suzuki H, Tomino Y, Naso D. Patient classification and outcome prediction in IgA nephropathy. Comput Biol Med. 2015 Nov 1;66:278-86
18. Quteineh L, Bochud PY, Golshayan D, Crettol S, Venetz JP, Manuel O, Kutalik Z, Treyer A, Lehmann R, Mueller NJ, Binet I, van Delden C, Steiger J, Mohacsi P, Dufour JF, Soccal PM, Pascual M, Eap CB; and The Swiss Transplant Cohort Study. CRTC2 polymorphism as a risk factor for the incidence of metabolic syndrome in patients with solid organ transplantation. Pharmacogenomics J. 2015 Dec 8. doi: 10.1038/tpj.2015.82. [Epub ahead of print]
19. Salvador CL, Tøndel C, Mørkrid L, Bjerre A, Brun A, Bolann B, Brackman D, Bergan S. Glomerular filtration rate measured by iohexol clearance: A comparison of venous samples and capillary blood spots. Scand J Clin Lab Invest. 2015 Dec;75(8):710-6
20. Fredrick FF, Ruggajo PJ, Basu G, Svarstad E, Langeland N. Global collaboration bears fruit: Tanzania report. Kidney Int. 2015 Dec;88(6):1211-1214
21. Tveitarås MK, Skogstrand T, Leh S, Helle F, Iversen BM, Chatziantoniou C, Reed RK, Hultström M. Matrix Metalloproteinase-2 Knockout and Heterozygote Mice Are Protected from Hydronephrosis and Kidney Fibrosis after Unilateral Ureteral Obstruction. PLoS One. 2015 Dec 16;10(12):e0143390. doi: 10.1371/journal.pone.0143390. eCollection 2015.
22. Ruggajo P, Skrunes R, Svarstad E, Skjærven R, Reisæther AV, Vikse BE. Familial Factors, Low Birth Weight, and Development of ESRD: A Nationwide Registry Study. Am J Kidney Dis. 2015 Dec 31. pii: S0272-6386(15)01434-1.doi:10.1053/j.ajkd.2015.11.015. [Epub ahead of print]

1. den Hoedt CH, Bots ML, Grooteman MP, van der Weerd NC, Penne EL, Mazairac AH, Levesque R, Blankestijn PJ, Nubé MJ, ter Wee PM, van den Dorpel MA; CONTRAST Investigators. Clinical predictors of decline in nutritional parameters over time in ESRD. Clin J Am Soc Nephrol. 2014 Feb;9(2):318-25. doi: 10.2215/CJN.04470413. Epub 2014 Jan 23
2. Hirt-Minkowski P, Marti HP, Hönger G, Grandgirard D, Leib SL, Amico P, Schaub S. Correlation of serum and urinary matrix metalloproteases/tissue inhibitors of metalloproteases with subclinical allograft fibrosis in renal transplantation. Transpl Immunol. 2014 Jan;30(1):1-6. doi: 10.1016/j.trim.2013.11.004. Epub 2013 Nov 27
3. den Hoedt CH, Bots ML, Grooteman MP, van der Weerd NC, Mazairac AH, Penne EL, Levesque R, ter Wee PM, Nubé MJ, Blankestijn PJ, van den Dorpel MA; CONTRAST Investigators. Online hemodiafiltration reduces systemic inflammation compared to low-flux hemodialysis. Kidney Int. 2014 Aug;86(2):423-32. doi: 10.1038/ki.2014.9. Epub 2014 Feb 19.
4. Marti HP, Fuscoe JC, Kwekel JC, Anagnostopoulou A, Scherer A. Metzincins and related genes in experimental renal ageing: towards a unifying fibrosis classifier across species. Nephrol Dial Transplant. 2014 Jun;29(6):1177-85. doi: 10.1093/ndt/gfu027. Epub 2014 Feb 24
5. Sandvik LF, Skarstein K, Sviland L, Svarstad E, Nilsen AE, Leivestad T, Jonsson R, Appel S. CD11c(+) dendritic cells rather than Langerhans cells are reduced in normal skin of immunosuppressed renal transplant recipients. Acta Derm Venereol. 2014 Mar;94(2):173-8. doi: 10.2340/00015555-1679
6. Aakre KM, Røraas T, Petersen PH, Svarstad E, Sellevoll H, Skadberg O, Sæle K, Sandberg S. Weekly and 90-minute biological variations in cardiac troponin T and cardiac troponin I in hemodialysis patients and healthy controls. Clin Chem. 2014 Jun;60(6):838-47. doi: 10.1373/clinchem.2013.216978. Epub 2014 Mar 11
7. van der Weerd NC, Den Hoedt CH, Blankestijn PJ, Bots ML, van den Dorpel MA, Lévesque R, Mazairac AH, Nubé MJ, Penne EL, ter Wee PM, Grooteman MP; CONTRAST Investigators. Resistance to erythropoiesis stimulating agents in patients treated with online hemodiafiltration and ultrapure low-flux hemodialysis: results from a randomized controlled trial (CONTRAST). PLoS One. 2014 Apr 17;9(4):e94434. doi: 10.1371/journal.pone.0094434. eCollection 2014
8. Skrunes R, Svarstad E, Reisæter AV, Vikse BE. Familial Clustering of ESRD in the Norwegian Population. Clin J Am Soc Nephrol. 2014 Aug 4. pii: CJN.01680214. [Epub ahead of print]
9. Finne K, Vethe H, Skogstrand T, Leh S, Dahl TD, Tenstad O, Berven FS, Reed RK, Vikse BE. Proteomic analysis of formalin-fixed paraffin-embedded glomeruli suggests depletion of glomerular filtration barrier proteins in two-kidney one-clip hypertensive rats. Nephrol Dial Transplant. 2014 Dec;29(12):2217-27. doi: 10.1093/ndt/gfu268. Epub 2014 Aug 16
10. van der Tol L, Svarstad E, Ortiz A, Tøndel C, Oliveira JP, Vogt L, Waldek S, Hughes DA, Lachmann RH, Terryn W, Hollak CE, Florquin S, van den Bergh Weerman MA, Wanner C, West ML, Biegstraaten M, Linthorst GE. Chronic kidney disease and an uncertain diagnosis of Fabry disease: Approach to a correct diagnosis. Mol Genet Metab. 2014 Aug 20. pii: S1096-7192(14)00261-3. doi: 10.1016/j.ymgme.2014.08.007. [Epub ahead of print]
11. van der Tol L, Cassiman D, Houge G, Janssen MC, Lachmann RH, Linthorst GE, Ramaswami U, Sommer C, Tøndel C, West ML, Weidemann F, Wijburg FA, Svarstad E, Hollak CE, Biegstraaten M. Uncertain Diagnosis of Fabry Disease in Patients with Neuropathic Pain, Angiokeratoma or Cornea Verticillata: Consensus on the Approach to Diagnosis and Follow-Up. JIMD Rep. 2014 Sep 16. [Epub ahead of print]
12. Vethe H, Finne K, Skogstrand T, Vaudel M, Vikse BE, Hultström M, Placier S, Scherer A, Tenstad O, Marti HP. Distinct protein signature of hypertension-induced damage in the renal proteome of the two-kidney, one-clip rat model. J Hypertens. 2014 Oct 9. [Epub ahead of print]
13. Mauer M, Glynn E, Svarstad E, Tøndel C, Gubler MC, West M, Sokolovskiy A, Whitley C, Najafian B. Mosaicism of podocyte involvement is related to podocyte injury in females with fabry disease. PLoS One. 2014 Nov 11;9(11):e112188. doi: 10.1371/journal.pone.0112188. eCollection 2014
14. Skogstrand T, Leh S, McClure J, Dashti M, Iversen BM, Graham D, McBride MW, Hultström M. Identification of a common molecular pathway in hypertensive renal damage: comparison of rat and human gene expression profiles. J Hypertens. 2014 Nov 6. [Epub ahead of print]
15. Tøndel C, Kanai T, Larsen K.K, Ito S, Politei JM, Warnock DG, Svarstad E. Foot Process Effacement Is an Early Marker of Nephropathy in Young Classic Fabry Patients without Albuminuria. Nephron Online First, E-pub Dec 18. 2013. DOI:10.1159/000369309

1. Tøndel C, Bostad L, Larsen KK, Hirth A, Vikse BE, Houge G, Svarstad E.Agalsidase benefits renal histology in young patients with fabry disease. J Am Soc Nephrol. 2013 Jan;24(1):137-48. doi: 10.1681/ASN.2012030316

2. Skogstrand T, Leh S, Paliege A, Reed RK, Vikse BE, Bachmann S, Iversen BM Late, Hultström M. Arterial damage precedes the development of interstitial damage in the nonclipped kidney of two-kidney, one-clip hypertensive rats. J Hypertens. 2013 Jan;31(1):152-9. doi: 10.1097/HJH.0b013e32835a5d4e

3. Mazairac AH, de Wit GA, Grooteman MP, Penne EL, van der Weerd NC, den Hoedt CH, Lévesque R, van den Dorpel MA, Nubé MJ, ter Wee PM, Bots ML, Blankestijn PJ; CONTRAST Investigators. Effect of hemodiafiltration on quality of life over time. Clin J Am Soc Nephrol. 2013 Jan;8(1):82-9. doi: 10.2215/CJN.00010112. Epub 2012 Nov 2

4. Helle F, Karlsen TV, Tenstad O, Titze J, Wiig H. High-salt diet increases hormonal sensitivity in skin pre-capillary resistance vessels. Acta Physiol (Oxf). 2013 Mar;207(3):577-81. doi: 10.1111/apha.12049. Epub 2013 Jan 10

5. Linthorst GE, Burlina AP, Cecchi F, Cox TM, Fletcher JM, Feldt-Rasmussen U, Giugliani R, Hollak CE, Houge G, Hughes D, Kantola I, Lachmann R, Lopez M, Ortiz A, Parini R, Rivera A,Rolfs A, Ramaswami U, Svarstad E, Tondel C, Tylki-Szymanska A, Vujkovac B, Waldek S, West M, Weidemann F, Mehta A. Recommendations on reintroduction of agalsidase Beta for patients with fabry disease in europe, following a period of shortage. JIMD Rep. 2013;8:51-6. doi: 10.1007/8904_2012_160. Epub 2012 Jul 14

6. Åsberg A, Apeland T, Reisaeter AV, Foss A, Leivestad T, Heldal K, Thorud LO, Eriksen BO, Hartmann A; NILS Study Group. Long-term outcomes after cyclosporine or mycophenolate withdrawal in kidney transplantation - results from an aborted trial. Clin Transplant. 2013 Mar-Apr;27(2):E151-6. doi: 10.1111/ctr.12076. Epub 2013 Jan 27

7. Bertelsen AK, Tøndel C, Krohn J, Bull N, Aarseth J, Houge G, Mellgren SI, Vedeler CA. Small fibre neuropathy in Fabry disease. J Neurol. 2013 Mar;260(3):917-9. doi: 10.1007/s00415-012-6800-3. Epub 2012 Dec 21. No abstract available

8. Helle F, Skogstrand T, Schwartz IF, Schwartz D, Iversen BM, Palm F, Hultström M. Nitric oxide in afferent arterioles after uninephrectomy depends on extracellular L-arginine. Am J Physiol Renal Physiol. 2013 Apr 15;304(8):F1088-98. doi: 10.1152/ajprenal.00665.2011. Epub 2013 Feb 13.

9. den Hoedt CH, Bots ML, Grooteman MP, Mazairac AH, Penne EL, van der Weerd NC, Ter Wee PM, Nubé MJ, Levesque R, Blankestijn PJ, van den Dorpel MA; CONTRAST investigators. Should we still focus that much on cardiovascular mortality in end stage renal disease patients? The CONvective TRAnsport STudy. PLoS One. 2013 Apr 19;8(4):e61155. doi: 10.1371/journal.pone.0061155. Print 2013

10.  Villa L, Boor P, Konieczny A, Kunter U, van Roeyen CR, Denecke B, Gan L, Neusser MA, Cohen CD; ERCB Consortium;, Eitner F, Scholl T, Ostendorf T, Floege J. Late angiotensin II receptor blockade in progressive rat mesangioproliferative glomerulonephritis: new insights into mechanisms. J Pathol. 2013 Apr;229(5):672-84. doi: 10.1002/path.4151. Epub 2013 Mar 5

11.  Koller MT, van Delden C, Müller NJ, Baumann P, Lovis C, Marti HP, Fehr T, Binet I, De Geest S, Bucher HC, Meylan P, Pascual M, Steiger J. Design and methodology of the Swiss Transplant Cohort Study (STCS): a comprehensive prospective nationwide long-term follow-up cohort. Eur J Epidemiol. 2013 Apr;28(4):347-55. doi: 10.1007/s10654-012-9754-y. Epub 2013 Apr 2

12.  Najafian B, Mauer M, Hopkin RJ, Svarstad E. Renal complications of Fabry disease in children. Pediatr Nephrol. 2013 May;28(5):679-87. doi: 10.1007/s00467-012-2222-9. Epub 2012 Aug 17.

13.  Vikse BE. Pre-eclampsia and the risk of kidney disease. Lancet. 2013 Jul 13;382(9887):104-6. doi: 10.1016/S0140-6736(13)60741-2. Epub 2013 May 31

14.  Sandvik MK, Hallan S, Svarstad E, Vikse BE. Preeclampsia and Prevalence of Microalbuminuria 10 Years Later. Clin J Am Soc Nephrol. 2013 Jul;8(7):1126-34. doi: 10.2215/CJN.10641012. Epub 2013 May 30.

15.  Luyckx VA, Bertram JF, Brenner BM, Fall C, Hoy WE, Ozanne SE, Vikse BE.Effect of fetal and child health on kidney development and long-term risk of hypertension and kidney disease. Lancet. 2013 Jul 20;382(9888):273-83. doi: 10.1016/S0140-6736(13)60311-6. Epub 2013 May 31. Review.

16.  Mazairac AH, Blankestijn PJ, Grooteman MP, Penne EL, van der Weerd NC, den Hoedt CH, Buskens E, van den Dorpel MA, ter Wee PM, Nubé MJ, Bots ML, de Wit GA; CONTRAST investigators. The cost-utility of haemodiafiltration versus haemodialysis in the Convective Transport Study. Nephrol Dial Transplant. 2013 Jul;28(7):1865-73. doi: 10.1093/ndt/gft045. Epub 2013 Jun 13

17.  Sandvik LF, Skarstein K, Sviland L, Svarstad E, Nilsen AE, Leivestad T, Jonsson R, Appel S. CD11c+ Dendritic Cells Rather than Langerhans Cells are Reduced in Normal Skin of Immunosuppressed Renal Transplant Recipients. Acta Derm Venereol. 2013 Aug 27. doi: 10.2340/00015555-1679. [Epub ahead of print]

18.  Schartum-Hansen H, Ueland PM, Pedersen ER, Meyer K, Ebbing M, Bleie Ø, Svingen GF, Seifert R, Vikse BE, Nygård O. Assessment of urinary betaine as a marker of diabetes mellitus in cardiovascular patients. PLoS One. 2013 Aug 6;8(8):e69454. doi: 10.1371/journal.pone.0069454. Print 2013

19.  Knoop T, Vikse BE, Svarstad E, Leh S, Reisæter AV, Bjørneklett R. Mortality in Patients With IgA Nephropathy. Am J Kidney Dis. 2013 Nov;62(5):883-90. doi: 10.1053/j.ajkd.2013.04.019. Epub 2013 Jun 21

20.  Hirt-Minkowski P, Marti HP, Hönger G, Grandgirard D, Leib SL, Amico P, Schaub S. Correlation of serum and urinary matrix metalloproteases/tissue inhibitors of metalloproteases with subclinical allograft fibrosis in renal transplantation. Transpl Immunol. 2013 Nov 27. pii: S0966-3274(13)00100-7. doi: 10.1016/j.trim.2013.11.004. [Epub ahead of print]

21.  Aakre KM, Røraas T, Petersen PH, Svarstad E, Sæle K, Sandberg S. Week-to-Week Biological Variation in the N-terminal Prohormone of Brain Natriuretic Peptide in Hemodialysis Patients and Healthy Individuals. Clin Chem. 2013 Dec;59(12):1813-4. doi: 10.1373/clinchem.2013.209353. Epub 2013 Sep 16

22.  Sandvik MK, Leirgul E, Nygård O, Ueland PM, Berg A, Svarstad E, Vikse BE.Preeclampsia in healthy women and endothelial dysfunction 10 years later. Am J Obstet Gynecol. 2013 Dec;209(6):569.e1-569.e10. doi: 10.1016/j.ajog.2013.07.024. Epub 2013 Jul 27

23. Tøndel C. Markers of nephropathy in young Fabry disease patients; role of kidney biopsies and functional measurement: PhD-thesis, University of Bergen 2013 (ISBN 978-82-308-2256-2), UiB

24. Sandvik MK. Renal disease and cardiovascular risk factors after preeclampsia: PhD-thesis, University of Bergen 2013 (ISBN 978-82-308-2297-5), UiB

25. Skogstrand T. Renal hypertensive fibrosis in the rat: PhD-thesis, University of Bergen 2013 (ISBN 978-82-308-2226-5), UiB

Warnock DG, Ortiz A, Mauer M, Linthorst GE, Oliveira JP, Serra AL, Maródi L, Mignani R, Vujkovac B, Beitner-Johnson D, Lemay R, Cole JA, Svarstad E, Waldek S, Germain DP, Wanner C; Fabry Registry. Renal outcomes of agalsidase beta treatment for Fabry disease: role of proteinuria and timing of treatment initiation. Nephrol Dial Transplant. 2012 Mar;27(3):1042-9. Epub 2011 Jul 29

Hultström M, Leh S, Paliege A, Bachmann S, Skogstrand T, Iversen BM. Collagen-binding proteins in age-dependent changes in renal collagen turnover: microarray analysis of mRNA expression. Physiol Genomics. 2012 May 1;44(10):576-86. Epub 2012 Mar 27

Olstad HD, Svarstad E. [A women in her 50s with leg pain and renal failure]. Tidsskr Nor Laegeforen. 2012 Apr 30;132(8):960-1. Norwegian. No abstract available

Bjørneklett R, Vikse BE, Bostad L, Leivestad T, Iversen BM. Long-term risk of ESRD in IgAN; validation of Japanese prognostic model in a Norwegian cohort. Nephrol Dial Transplant. 2012 Apr;27(4):1485-91. Epub 2011 Aug 5

Grooteman MP, van den Dorpel MA, Bots ML, Penne EL, van der Weerd NC, Mazairac AH, den Hoedt CH, van der Tweel I, Lévesque R, Nubé MJ, ter Wee PM, Blankestijn PJ; CONTRAST Investigators. Effect of online hemodiafiltration on all-cause mortality and cardiovascular outcomes. J Am Soc Nephrol. 2012 Jun;23(6):1087-96. Epub 2012 Apr 26

Tøndel C, Vikse BE, Bostad L, Svarstad E. Safety and Complications of Percutaneous Kidney Biopsies in 715 Children and 8573 Adults in Norway 1988-2010. Clin J Am Soc Nephrol. 2012; 7: 1591-7

Rui PO, Svarstad E, Bostad L, Vikse BE. [A man in his fifties with fever, cough and anuria]. Tidsskr Nor Laegeforen. 2012 Aug 7;132(14):1621-4. Norwegian. No abstract available

Najafian B, Mauer M, Hopkin RJ, Svarstad E. Renal complications of Fabry disease in children. Pediatr Nephrol. 2012 Aug 17. [Epub ahead of print]

Vikse BE, Irgens LM, Karumanchi SA, Thadhani R, Varberg Reisæter A, Skjærven R. Familial Factors in the Association between Pre-Eclampsia and Later ESRD. Clin J Am Soc Nephrol. 2012 Nov;7(11):1819-1826. Epub 2012 Sep 6

Skogstrand T, Leh S, Paliege A, Reed RK, Vikse BE, Bachmann S, Iversen BM Late, Hultström M. Arterial damage precedes the development of interstitial damage in the nonclipped kidney of two-kidney, one-clip hypertensive rats. J Hypertens. 2013 Jan;31(1):152-159. [2012 Oct 17. Epub ahead of print]

Zöllner FG, Svarstad E, Munthe-Kaas AZ, Schad LR, Lundervold A, Rørvik J. Assessment of Kidney Volumes From MRI: Acquisition and Segmentation Techniques. AJR Am J Roentgenol. 2012 Nov;199(5):1060-9. doi: 10.2214/AJR.12.8657

Skjaerven R, Wilcox AJ, Klungsøyr K, Irgens LM, Vikse BE, Vatten LJ, Lie RT. Cardiovascular mortality after pre-eclampsia in one child mothers: prospective, population based cohort study. BMJ. 2012 Nov 27;345:e7677. doi: 10.1136/bmj.e7677

Tøndel C, Bostad L, Kampevold Larsen K, Hirth A, Vikse BE, Houge G, Svarstad E. Agalsidase Benefits Renal Histology in Young Patients with Fabry Disease. JASN December 28, 2012 24: 137-148; doi:10.1681/ASN.2012030316

Bjørneklett RO. Long-term prognosis in chronic primary glomerulonephritides: PhD-thesis, University of Bergen 2012 (ISBN 978-82-308-1972-2), HAUKELAND UiB

Leh S. Progression of renal disease – pathogenetic aspects and treatment options: PhD-thesis, University of Bergen 2012 (ISBN 978-82-308-1953-1), HAUKELAND UiB

Verbeke F, Van Biesen W, Honkanen E, Wikström B, Jensen PB, Krzesinski JM, Rasmussen M, Vanholder R, Rensma PL; CORD Study Investigators. Prognostic value of aortic stiffness and calcification for cardiovascular events and mortality in dialysis patients: outcome of the calcification outcome in renal disease (CORD) study. Clin J Am Soc Nephrol 2011; 6: 153-159

Najafian B, Svarstad E, Bostad L, Gubler M-C, Tøndel C, Whitley C, Mauer M.Podocyte Injury and GL-3 accumulation are progressive in young patients with Fabry disease. Kidney Int 2011; 79: 663-670. [Advance online publication, December 15, 2010; doi:10.1038/ki.2010.484]

Dahl TD, Hultström M, Iversen BM, Helle F. Adenosine sensitization after angiotensin II stimulation in afferent arterioles from normal rats does not occur during two-kidney, one-clip hypertension. Acta Physiol (Oxf). 2011 Feb;201(2):289-94. doi: 10.1111/j.1748-1716.2010.02177.x

Penne EL, van der Weerd NC, Grooteman MP, Mazairac AH, van den Dorpel MA, Nubé MJ, Bots ML, Lévesque R, ter Wee PM, Blankestijn PJ; CONTRAST investigators. Role of residual renal function in phosphate control and anemia management in chronic hemodialysis patients. Clin J Am Soc Nephrol. 2011Feb;6(2):281-9. [Epub 2010 Oct 28] 

Aakre KM, Thue G, Svarstad E, Skadberg Ø, Sandberg S. Laboratory investigation and follow-up of chronic kidney disease stage 3 in primary care. Clin Chim Acta.2011 Mar 8. [Epub ahead of print]

Bjørneklett R, Vikse BE, Smerud HK, Bostad L, Leivestad T, Hartmann A, Iversen BM. Pre-transplant course and risk of kidney transplant failure in IgA nephropathy patients. Clin Transplant. 2011 May;25(3):E356-65. doi: 10.1111/j.1399-0012.2011.01424.x. [Epub 2011 Mar 9]

Boulos N, Helle F, Dussaule JC, Placier S, Milliez P, Djudjaj S, Guerrot D, Joutel A, Ronco P, Boffa JJ, Chatziantoniou C. Notch3 Is Essential for Regulation of the Renal Vascular Tone. Hypertension. 2011 Apr 25. [Epub ahead of print]
 

Houge G, Kaarbø Ø, Bostad L, Tøndel C, Hirth A, Svarstad E.  Fabry or not Fabry – a question of ascertainment. Eur J Hum Genet 2011 May 18. [Epub ahead of print]

Bjørneklett R, Vikse BE, Smerud HK, Bostad L, Leivestad T, Hartmann A, Iversen BM. Pre-transplant course and risk of kidney transplant failure in IgA nephropathy patients. Clin Transplant. 2011 May;25(3):E356-65. doi: 10.1111/j.1399-0012.2011.01424.x. Epub 2011 Mar 9

Christiansen RE, Fiskerstrand T, Leh S, Haukanes BI, Singh AK, Fervenza FC, Svarstad E. A mother and daughter with unexplained renal failure. Nephron Clin Pract 2011;119:c1–c9 [Published online: May 27, 2011, DOI: 10.1159/000327428]

Leh S, Hultström M, Rosenberger C, Iversen BM. Afferent arteriolopathy and glomerular collapse but not segmental sclerosis induce tubular atrophy in old spontaneously hypertensive rats. Virchows Arch. 2011 Jul;459(1):99-108. Epub 2011 Jun 10

Warnock DW, Ortiz A, Mauer M, Linthorst GE, Oliveira JP, Serra AL, Maródi L, Mignani R, Vujkovac B, Beitner-Johnson D, Lemay R, J. Cole A, Svarstad E, Waldek S, Germain DP,  and Wanner C, on behalf of the Fabry Registry. Renal Outcomes of Agalsidase Beta Treatment for Fabry Disease: Role of Proteinuria and Timing of Treatment Initiation. Nephrol Dial Transplant (2011) 0: 1–8. doi: 10.1093/ndt/gfr420 [Advance Access published July 29, 2011]

Bjørneklett R, Vikse BE, Bostad L, Leivestad T, Iversen BM. Long-term risk of ESRD in IgAN; validation of Japanese prognostic model in a Norwegian cohort.Nephrol Dial Transplant. 2011 Aug 5. [Epub ahead of print]
 

Holdaas H, Rostaing L, Serón D, Cole E, Chapman J, Fellstrøm B, Strom EH, Jardine A, Midtvedt K, Machein U, Ulbricht B, Karpov A, O'Connell PJ; ASCERTAIN Investigators. Conversion of long-term kidney transplant recipients from calcineurin inhibitor therapy to everolimus: a randomized, multicenter, 24-month study. Transplantation. 2011 Aug 27;92(4):410-8. Erratum in: Transplantation. 2011 Nov 27;92(10):e61. multiple investigator names added.

Bivol, Liliana-Monica; Berge, Rolf Kristian; Iversen, Bjarne Magnus.

Tetradecylthioacetic acid prevents the inflammatory response in two-kidney, one-clip hypertension. American Journal of Physiology. Regulatory Integrative and Comparative Physiology 2008 ;Volum 294.(2) s. R438-R447
UiB

Bivol, Liliana-Monica; Hultström, Michael; Gudbrandsen, Oddrun Anita; Berge, Rolf Kristian; Iversen, Bjarne Magnus. 
Tetradecylthioacetic acid downregulates cyclooxygenase 2 in the renal cortex of two-kidney, one-clip hypertensive rats. American Journal of Physiology. Regulatory Integrative and Comparative Physiology 2008 ;Volum 295.(6) s. R1866-R1873
UiB

Christiansen, Rolf E.F.; Kolmannskog, Odd; Leh, Sabine; Iversen, Bjarne Magnus; Tenstad, Olav. 
Glomerular charge barrier and development of proteinuria in passive Heymann nephritis. Kidney and Blood Pressure Research 2008 ;Volum 31.(3) s. 203-209
UiB

Hultström, Michael; Leh, Sabine; Skogstrand, Trude; Iversen, Bjarne Magnus. 
Upregulation of tissue inhibitor of metalloproteases-1 (TIMP-1) and procollagen-N-peptidase in hypertension-induced renal damage. Nephrology, Dialysis and Transplantation 2008 ;Volum 23.(3) s. 896-903
UiB

Svendsen, Elisabeth Berge; Christiansen, Rolf E.F.; Svarstad, Einar; Aase, Steinar Torbjørn.

En kvinne med kronisk nyresvikt, progredierende hudforkalkninger og sepsis.Tidsskrift for Den norske lægeforening 2008 ;Volum 128. UiB

Tøndel, Camilla; Bostad, Leif; Hirth, Asle; Svarstad, Einar. 
Renal biopsy findings in children and adolescents with Fabry disease and minimal albuminuria. American Journal of Kidney Diseases 2008 ;Volum 51.(5) s. 767-776
UiB

Tøndel, Camilla; Bostad, Leif; Lægreid, Liv Marie; Houge, Gunnar; Svarstad, Einar.

Prominence of glomerular and vascular changes in renal biopsies in children and adolescents with Fabry disease and microalbuminuria. Clinical Therapeutics 2008 ;Volum 30. Suppl. 2 s. S42-S42

UiB

Vikse, Bjørn Egil; Irgens, Lorentz; Leivestad, Torbjørn; Hallan, Stein; Iversen, Bjarne Magnus. 
Low birth weight increases risk for end-stage renal disease. Journal of the American Society of Nephrology 2008 ;Volum 19.(1) s. 151-157
UiB

Vikse, Bjørn Egil; Irgens, Lorentz M.; Leivestad, Torbjørn; Skjaerven, Rolv; Iversen, Bjarne Magnus. 
Preeclampsia and the risk of end-stage renal disease. New England Journal of Medicine 2008 ;Volum 359.(8) s. 800-809
UiB

Bivol, Liliana-Monica; Berge, Rolf Kristian; Iversen, Bjarne Magnus. 
Differential effect of tetradecythioacetic acid on the renin-angiotensin system and blood pressure in SHR and 2-kidney, 1-clip hypertension. American Journal of Physiology - Renal Physiology 2007 ;Volum F293.(3) s. F839-845
UiB

Bjørneklett, Rune Oskar; Vikse, Bjørn Egil; Svarstad, Einar; Aasarød, Knut; Bostad, Leif; Langmark, Frøydis; Iversen, Bjarne Magnus. 
Long-term risk of cancer in membranous nephropathy patients. American Journal of Kidney Diseases 2007 ;Volum 50. s. 396-403
UiB

Hultström, Michael; Skogstrand, Trude; Helle, Frank; Iversen, Bjarne Magnus. 
The mRNA expression of eNOS, iNOS and L-arginine transporters in the afferent arterioles (AA) of 2K1C hypertensive rats. The FASEB Journal 2007 ;Volum 21.(6) s. A899-A899
UiB

Skogstrand, Trude; Hultström, Michael; Leh, Sabine; Iversen, Bjarne Magnus. 
Protein expression of factors involved in the development of renal interstitial fibrosis in old SHR. The FASEB Journal 2007 ;Volum 21.(6) s. A899-A899
UiB

Stormark, Tor Andre; Strømmen, Kenneth; Iversen, Bjarne Magnus; Matre, Knut.
Three-dimensional ultrasonography can detect the modulation of kidney volume in two-kidney, one-clip hypertensive rats. Ultrasound in Medicine and Biology 2007 ;Volum 33.(12) s. 1882-1888
UiB

Vågnes, Kari Stave; Vågnes, Øyvind Brune; Bakken, Vidar. 
Sera from mice immunized with DNA encoding Porphyromonas gingivalis catalytic or adhesin part of HRgpA inhibit degradation of human fibronectin by HRgpA. Oral Microbiology and Immunology 2007 ;Volum 22.(1) s. 46-51
UiB

Vågnes, Øyvind Brune; Iversen, Bjarne Magnus; Arendshorst, William J.. 
Short-term ANG II produces renal vasoconstriction independent of TP receptor activation and TxA(2)/isoprostane production. American Journal of Physiology - Renal Physiology 2007 ;Volum 293.(3) s. F860-F867
UiB

Helle, Frank; Vågnes, Øyvind Brune; Iversen, Bjarne Magnus. 
Angiotensin II-induced calcium signaling in the afferent arteriole from rats with two-kidney, one-clip hypertension. American Journal of Physiology - Renal Physiology 2006 ;Volum 291.(1) s. F140-F147
UiB

Vikse, Bjørn Egil; Irgens, Lorentz; Bostad, Leif; Iversen, Bjarne Magnus. 
Adverse perinatal outcome and later kidney biopsy in the mother. Journal of the American Society of Nephrology 2006 ;Volum 17.(3) s. 837-845
UiB

Svarstad, Einar; Bostad, Leif; Kaarbøe, Øyvind; Houge, Gunnar; Tøndel, Camilla; Lyngdal, Per Tore; Iversen, Bjarne Magnus. 
Focal and segmental glomerular sclerosis (FSGS) in a man and a woman with Fabry's disease. Clinical Nephrology 2005 ;Volum 63.(5) s. 394-401
UiB 

Bivol, Liliana-Monica; Vågnes, Øyvind Brune; Iversen, Bjarne Magnus. 
The renal vascular response to ANG II injection is reduced in the nonclipped kidney of two-kidney, one-clip hypertension. American Journal of Physiology - Renal Physiology 2005 ;Volum 289. s. F393-F400
UiB

Hansen, Frank Helle; Vågnes, Øyvind Brune; Iversen, Bjarne Magnus. 
Enhanced response to AVP in the interlobular artery from the spontaneously hypertensive rat. American Journal of Physiology - Renal Physiology 2005 ;Volum 288. s. F1023-F1031
UiB

Svarstad, Einar; Bostad, Leif; Kaarbøe, Øyvind; Houge, Gunnar; Tøndel, Camilla; Lyngdal, Per Tore; Iversen, Bjarne Magnus. 
Focal and segmental glomerular sclerosis (FSGS) in a man and a woman with Fabry's disease. Clinical Nephrology 2005 ;Volum 63.(5) s. 394-401
UiB

Svarstad, Einar; Urheim, Lasse; Iversen, Bjarne Magnus. 
Critical renal artery stenoses may cause a spectrum of cardiorenal failure and associated thromboembolic events. Clinical Nephrology 2005 ;Volum 63.(6) s. 487-492
UiB

Vågnes, Øyvind Brune; Hansen, Frank Helle; Feng, JJ; Iversen, Bjarne Magnus; Arendshorst, WJ. 
Enhanced Ca2+ response to AVP in preglomerular vessels from rats with genetic hypertension during different hydration states. American Journal of Physiology - Renal Physiology 2005 ;Volum 288. s. F1249-F1256
UiB

Christiansen, Rolf E.; Tenstad, Olav; Leh, Sabine; Iversen, Bjarne Magnus. 
Glomerular charge selectivity is impaired in hypertensive nephropathy. Nephrology, Dialysis and Transplantation 2004 ;Volum 19. s. 1083-1091
UiB

Hansen, Frank; Vågnes, Øyvind Brune; Iversen, Bjarne Magnus; Forslund, Terje.
Enhanced response to arginine vasopressin (AVP) in the interlobular artery (ILA) from the spontaneously hypertensive rat (SHR). American Journal of Physiology - Renal Physiology 2004 
UiB

Leh, Sabine; Vågnes, Øyvind Brune; Margolin, Solomon B.; Iversen, Bjarne Magnus; Forslund, Terje. 
Pirfenidone and candesartan ameliorate morphological damage in mild chronic anti-GBM nephritis in rats. Nephrology, Dialysis and Transplantation 2004 
UiB

Strømmen, Kenneth; Stormark, Tor A.; Iversen, Bjarne Magnus; Matre, Knut. 
Volume estimation of small phantoms and rat kidneys using three-dimensional ultrasonography and a position sensor. Ultrasound in Medicine and Biology 2004 ;Volum 30.(9) s. 1109-1117
UiB

Svarstad, Einar; Iversen, Bjarne Magnus. 
Renal artery thrombosis and acute renal failure after ACE inhibition. Nephrology, Dialysis and Transplantation 2004 s. 565-
UiB

Svarstad, Einar; Iversen, Bjarne Magnus; Bostad, Leif. 
Bedside stereomicroscopy of renal biopsies may lead to a rapid diagnosis of Fabry's disease. Nephrology, Dialysis and Transplantation 2004 ;Volum 19. s. 3202-3203
UiB

Vågnes, Kari Stave; Vågnes, Øyvind Brune; Vasstrand, Endre N.; Bakken, Vidar. 
Expression of the beta-adhesin part of HRgpA in Sprague Dawley rats induces a specific antibody response. Oral Microbiology and Immunology 2004 ;Volum 19.(2) s. 77-82
UiB

Vågnes, Øyvind Brune; Hansen, Frank; Christiansen, Rolf E.; Gjerstad, C.; Iversen, Bjarne Magnus. 
Age regulation of the V1a receptor in rats with genetic hypertension. American Journal of Physiology - Renal Physiology 2004 ;Volum 286. s. F997-F1003
UiB

Midtvedt, Karsten; Fauchald, Per; Bergan, Stein; Høieggen, Aud; Hallan, Stein; Svarstad, Einar; Bergrem, Harald; Eriksen, Bjørn; Pfeffer, Per; Dalen, Ingvild; Leivestad, Torbjørn. 
C2 monitoring in maintenance renal transplant recipients: is it worthwhile?.Transplantation 2003 ;Volum 76.(8) s. 1236-1238
UiB

Vikse, Bjørn E; Aasarød, Knut Ivar; Bostad, L.; Iversen, B.M.. 
Clinical prognostic factors in biopsy-proven benign nephrosclerosis. Nephrology, Dialysis and Transplantation 2003 ;Volum 18. s. 517-523
UiB

Vikse, Bjørn Egil; Aasarød, Knut; Bostad, Leif; Iversen, Bjarne Magnus. 
Clinical prognostic factors in biopsy-proven benign nephrosclerosis. Nephrology, Dialysis and Transplantation 2003 ;Volum 18. s. 517-523
UiB

Vågnes, Øyvind B.; Hansen, Frank Helle; Christiansen, Rolf E.F.; Gjerstad, Camilla; Iversen, Bjarne Magnus. 
Age-dependent regulation of vasopressin V1a receptors in preglomerular vessels from the spontaneously hypertensive rat. American Journal of Physiology - Renal Physiology 2003 
UiB

Aaserød, Knut; Iversen, Bjarne Magnus; Hammerstrøm, Jan; Bostad, Leif; Jørstad, Størker. 
Clinical outcome in patients with Wegners granulomatosis treated with plasmapheresis. Blood Purification 2002 ;Volum 20.(2) s. 167-173
UiB

Christiansen, Rolf E.F.; Roald, Anca Beatrice; Tenstad, Olav; Iversen, Bjarne Magnus. 
Renal hemodynamics during development of hypertension in young spontaneously hypertensive rats. Kidney and Blood Pressure Research 2002 ;Volum 25. s. 322-328
UiB

Svarstad, Einar; Hultstrøm, Dieter; Jensen, Dag; Jenssen, Geir. 
Renal artery thrombosis with acute renal failure after withdrawal of angiotensin converting enzyme inhibitor: a case report. Nephrology, Dialysis and Transplantation2002 ;Volum 17.(4) s. 687-689
UiB

Svarstad, Einar; Myking, Ole Langeland; Ofstad, Jarle; Iversen, Bjarne Magnus. 
Effect of light excercise on renal hemodynamics in patients with hypertension and chronic renal disease. Scandinavian Journal of Urology and Nephrology 2002 ;Volum 36.(6) s. 464-473
UiB

Surgery 2002 ;Volum 12.(3) s. 312-318
UiB

Svarstad, Einar; Hultstrøm, Dieter; Jensen, Dag; Jenssen, Geir. 
Renal artery thrombosis with acute renal failure after withdrawal of angiotensin converting enzyme inhibitor: a case report. Nephrology, Dialysis and Transplantation2002 ;Volum 17.(4) s. 687-689
UiB

 Vabø, Anne-Lisbeth; Leh, Sabine; Forslund, Terje. 
Interstitial nephritis, acute renal failure in a patient with non-fulminant hepatitis A infection. Clinical Nephrology 2002 ;Volum 57.(2) s. 149-153
UiB

Vikse, Bjørn E; Bostad, Leif; Aasarød, Knut Ivar; Lysebo, Dag Einar; Iversen, Bjarne M.. 
Prognostic factors in mesangioproliferative glomerulonephritis. Nephrology, Dialysis and Transplantation 2002 ;Volum 17. s. 1603-1613
UiB

Vikse, Bjørn Egil; Bostad, Leif; Aasarød, Knut; Lysebo, Dag Einar; Iversen, Bjarne Magnus. 
Prognostic factors in mesangioproliferative glomerulonephritis. Nephrology, Dialysis and Transplantation 2002 ;Volum 17. s. 1603-1613
UiB

Aasarød, Knut; Bostad, Leif; Hammerstrøm, Jan; Jørstad, Størker; Iversen, Bjarne Magnus. 
Renal histopathology and clinical course in 94 patients with Wegners granulomatosis. Nephrology, Dialysis and Transplantation 2001 ;Volum 16.(5) s. 953-960
UiB

Aasarød, Knut; Bostad, Leif; Hammerstrøm, Jan; Jørstad, Størker; Iversen, Bjarne Magnus. 
Wegners ganulomatosis: Inflammatory cells and markers of repair and fibrosis in renal biopsies. A clinicopathological study. Scandinavian Journal of Urology and Nephrology 2001 ;Volum 35.(5) s. 401-410
UiB

Dale, Astrid; Iversen, Bjarne Magnus. 
Ambulatory blood pressure in patients with mesangioproliferative glomerulonephritis. Blood Pressure 2001 ;Volum 10. s. 150-155
UiB

Ellingsen, Ivar; Florvaag, Erik; Andreassen, Anders; Iversen, Bjarne Magnus; Irgens, Ågot; Matre, Roald. 
Plasmapheresis in the treatment of steroid-dependent bronchial asthma. Allergy. European Journal of Allergy and Clinical Immunology 2001 ;Volum 56. s. 1202-1205
UiB

Gøransson, Lasse G.; Bergrem, Harald. 
Consequences of late referral of patients with end-stage renal disease. Journal of Internal Medicine 2001 ;Volum 250.(2) s. 154-159
UiB

Leiva, Rafael Alexander; Svarstad, Einar; Iversen, Bjarne Magnus. 
Akutt dialysebehandling ved Haukeland Sykehus i 1999. Tidsskrift for Den norske lægeforening 2001 ;Volum 121.(15) s. 1774-1779
UiB

Svarstad, Einar; Gerdts, Eva; Omvik, Per; Ofstad, Jarle; Iversen, Bjarne Magnus. 
Renal hemodynamic effects of captopril and doxazosin during slight physical activity in hypertensive patients with type-1 diabetes mellitus. Kidney and Blood Pressure Research 2001 ;Volum 24. s. 64-70
UiB

Svarstad, Einar; Hultstrøm, Dieter; Jensen, Dag; Jenssen, Guttorm; Gravendeel, Joost; Iversen, Bjarne Magnus. 
Akutt nyresvikt, nyrearteriestenose og angiotensinkonvertase (ACE)-hemmer.Tidsskrift for Den norske lægeforening 2001 ;Volum 121.(15) s. 1784-1788
UiB

Svarstad, Einar; Myking, Ole Langeland; Ofstad, Jarle; Iversen, Bjarne Magnus. 
Sympathetic nervous system overactivity in hypertensive patients with chronic renal failure. Role of upright body position. Scandinavian Journal of Urology and Nephrology2001 ;Volum 35. s. 393-400
UiB

Svarstad, Einar. 
ACE-hemmere og nyresvikt. Vårmøte Norsk Nyremedisinsk Forening; 2001-06-07
UiB

Svarstad, Einar. 
Akutt nyresvikt, epidemiologi og nyreerstattende behandling. Grunnkurs anestesiologi; 2001-05-11
UiB

Svarstad, Einar. 
Akutt nyresvikt (forekomst, diagnostikk, dialyseindikasjon). Grunnkurs i nyresykdommer; 2001-11-07
UiB

Svarstad, Einar. 
Renal hemodynamics in ambulatory patients with chronic renal disease. : Universitetet i Bergen 2001 Dr.med.
UiB

Svarstad, Einar. 
Ultralyd og Doppler av nyrer. Grunnkurs i gastroenterologisk ultralyd; 2001-11-20
UiB

 Svarstad, Einar; Sundal, E.. 
A simplified therapy regimen with epoetin alfa is sufficient in most HD-patients. ASN; 2001-10-14 - 2001-10-17
UiB

Vikse, Bjørn E; Aasarød, Knut Ivar; Bostad, Leif; Iversen, Bjarne M.. 
Clinical prognostic factors in patients with membranoproliferative glomerulonephritis (MPG) and benign nephrosclerosis (BN). Journal of the American Society of Nephrology2001 ;Volum 12. s. 128A-
UiB

Christiansen, Rolf EF; Roald, Anca B; Tenstad, Olav; Iversen, Bjarne M. 
Renal Hemodynamics in Young Spontaneously Hypertensive Rats (SHR) during Development of Hypertension. Journal of the American Society of Nephrology 2000 ;Volum 11. s. 332A-
UiB

Forslund, Terje; Iversen, Bjarne M. 
Akvaporiner. Tidsskrift for Den norske lægeforening 2000 ;Volum 120. s. 2129-2134
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Kvam, Fred I; Ofstad, Jarle; Iversen, Bjarne M. 
Effect of NO-inhibition in SHR with nefron loss. Kidney and Blood Pressure Research2000 ;Volum 23. s. 376-384
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Vågnes, Øyvind; Feng, Jian J.; Iversen, Bjarne Magnus; Arendshorst, William J.. 
Upregulation of V1 receptors in renal resistance vessels of rats developing genetic hypertension. American Journal of Physiology - Renal Physiology 2000 ;Volum 278.(6) s. F940-F948
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