ImSignal

This is a new project inspired by previous work of the group where proximity ligation assay (PLA) based detection of PD1-PDL1 interactions was found to provide a more refined patient stratification than PD-L1 protein alone (Lindberg et al., in preparation).

Highly multiplex detection of active immune checkpoint interactions

Aiming to gather better insights into the resistance mechanisms towards immunotherapy in breast cancer, the ImSignal project intends to perform a highly multiplex detection of active immune checkpoint interactions in tissue samples by adapting the PLA to the Hyperion mass imager.

Last updated: 23.06.2025