The Tropical Infectious Diseases Group
We focus on researching diseases caused by enteric and blood parasites, antimicrobial resistance and microbial causes of diarrhea and severe infections in resource-poor settings.
About the research group
Our interdisciplinary team collaborates with global partners to improve health outcomes and promote sustainable healthcare practices. Through cutting-edge research, we aim to develop innovative solutions to combat diseases. Join us in our mission to make a significant impact on global health.
Featured
Projects
Probiotics against antimicrobial resistance
- Probiotics as adjunct preventive therapy for childhood diarrhea and antimicrobial resistance in Africa (PRoRota)
- Probiotic treatment of newborns to reduce colonization and disease caused by resistant bacteria (ProRIDE).
Bloodstream infections and antimicrobial resistance
- Surveillance and metagenomic tracking of antimicrobial resistance genes in environmental and clinical samples using machine learning approaches (MARGIN).
- Learning and predicting the pathways of antimicrobial resistance evolution using hypercubic transition path sampling, computational and mathematical approach to learn evolutionary pathways using large-scale biological data (HyperEvol)
- Risk communication and perception of antimicrobial resistance in the public and among healthcare workers: Knowledge needed to develop new policies and interventions (Media and AMR).
- Antimicrobial stewardship in hospitals, resistance selection and transfer in a One Health context (STRESST).
- Consequences of antibiotic resistance after preventive treatment with cotrimoxazole in HIV patients (CoTrimResist).
- Innate and adaptive immunity within the early versus late BCG vaccination in HIV-1 exposed infants (BCGI).
- Bloodstream infections and antibiotic resistance among patients in Tanzania.
- Development of methods for detection of the malaria parasite’s genetic material.
Diarrhea
- Immune reasponse against Giardia in humans.
- Detection and prevalence of intestinal parasites in Norway, including genotyping of circulating Giardia and Cryptosporidium variants (TaDiGe).
- Improved diagnostics for Cryptosporidium in low-income countries (Crypto-POC, CryptoT&T).
- Exposure study to enterotoxigenic Escherichia coli bacteria and vaccine development (ETEC).
- Causes of diarrhea among children under five years of age in Tanzania.
Ebola
- Investigation of the protocols for supportive treatment in Ebola treatment centers in Sierra Leone and other affected countries.
- Evaluation of the efficacy of a post-exposure prophylaxis strategy in contacts at high risk of developing Ebola virus disease.
Other projects
- Bacterial strain colonization in fecal microbiota transfer therapy in patients with irritable bowel syndrome (STRACOL).
- Prevention of long covid-19 in Norway by treatment with Paxlovid (PANORAMIC).
- The significance of blood volume in blood cultures in children: evaluation of weight- and age-adjusted volumes for growth of pathogenic microbes and microbial contamination.
Completed projects
- Developing vaccines against diarrhea caused by enterotoxigenic Shigella (EntVac)
- Developing vaccines against diarrhea caused by enterotoxigenic Escherichia coli (ETECVac)
- Transplantation of intestinal microbiota in primary Clostridioides difficile infections (COLONIZE)
- Gastrointestinal complaints and fatigue among patients and a control group after the giardiasis outbreak in Bergen in 2004.
Publications
Key publications
This is a selection of the Group's key publications. For detailed lists please refer to individual project pages.
- Evaluation of rectal swab compared with bulk stool sampling for detection of Cryptosporidium infection by light-emitting diode auramine-phenol microscopy in young children with diarrhoea. (2025)
- Cryptosporidium species and subtypes in Norway: predominance of C. parvum and emergence of C. mortiferum. (2024)
- Gut microbiota patterns associated with duration of diarrhea in children under five years of age in Ethiopia. (2024)
- Dynamics of circulating lymphocytes responding to human experimental enterotoxigenic Escherichia coli infection. (2023)
- Performance and operational feasibility of two diagnostic tests for cryptosporidiosis in children (CRYPTO-POC): a clinical, prospective, diagnostic accuracy study. (2020)
- Irritable bowel syndrome and chronic fatigue six years after Giardia infection: a controlled prospective cohort study. (2014)
Doctoral dissertations
- Annette Onken: Bloodstream infections and antimicrobial resistance in Zanzibar, Tanzania, with special focus on typhoid fever and malaria. (2024)
- Øystein Haarklau Johansen: Cryptosporidiosis in low-resource healthcare settings. (2023)
- Joel Manyahi: Molecular characterization of antibiotic resistant bacteria in newly HIV diagnosed adults in a community setting in Tanzania. Implications for infection prevention and control in HIV. (2022)
- Christina Skår Saghaug: Genetic variability of proteins involved in metronidazole metabolism and detoxification in Giardia lamblia. (2021)
- Thandile Nkosi: Severe anemia in Malawian children: Risk factors, mortality and malaria chemoprevention. (2021)
- Sunniva Todnem Sakkestad: Enterotoxigenic Escherichia coli infection and diarrhoea - experimental infection studies and immunological characterisation to guide vaccine development. (2021)
- Sabrina Moyo: Viral diarrhoea in children under two years of age in Dar es Salaam, Tanzania. (2014)
- Gro Elizabeth Ann Strøm: Diagnosing pediatric malaria in Dar es Salaam, Tanzania. Clinical and laboratorial perspectives. (2014)
- Kurt Hanevik: Post-giardiasis functional gastrointestinal disorders and chronic fatigue syndrome – clinical symptoms, inflammation and immune responses. (2012)
- Kristine Mørch: Giardiasis : with emphasis on treatment and post-infectious manifestations. (2010)
- Bjørn Blomberg: Antimicrobial resistance in bacterial infections in urban and rural Tanzania (2007)
People
Group manager
Nina Langeland Professor
Group members
Kristine Mørch Associate Professor, Head National Center for Tropical Infectious Diseases, Haukeland University Hospital
Kurt Hanevik Professor
Bjørn Blomberg Professor
Audun Helge Nerland Emeritus
Sabrina Moyo Researcher
Joel Manyahi Researcher
Asnake Simieneh Tamru PhD candidate
Elin Hoffmann Dahl PhD candidate
Jahid Hasan Tipu PhD candidate
Jepsy Grace Yango Wa Yango PhD candidate
Nikolai Norevik Myklebust PhD candidate
Oda Vedøy PhD candidate
Saman Riaz PhD candidate
Sehee Rim PhD candidate
Tewachew Awoke Dejenie PhD candidate
Trygve Kristiansen PhD candidate
Tori Friis Study Nurse
Helene Heitmann Sandnes Laboratory engineer
Olivera Bozickovic Laboratory engineer
Internal collaborators
Anne Lise Fimreite Head of Department of Government
Lise H. Rykkja Professor, Department of Government
Iain Johnston Professor, Department of Mathematics
Guttorm Alendal Professor, Department of Mathematics
Eivind Valen Professor, Department of Informatics
Amani Thomas Mori Researcher, Institute for Global Public Health and Primary Care
Randi Jacobsen Bertelsen Professor, Department of Clinical Science
Iren Høyland Löhr Associate Professor, Department of Clinical Science
Ingrid Smith Department of Research and Development, Haukeland University Hospital
Birgitte Berentsen Jacobsen Associate Professor, Department of Clinical Medicine
Eline Hillestad PhD candidate
Audun Sivertsen Department of Microbiology, Haukeland University Hospital
External collaborators
Adam Roberts Liverpool School of Tropical Medicine, United Kingdom
Anani Badjé University of Bordeaux, France | ANRS, Ivory Coast
Kamija Samuel Phiri Training and Research Unit of Excellence, Malawi | Kamuzu University of Health Sciences
Kristian Andersen Scripps Research Translational Institute, USA
Nono-Raymond Kuispond-Swar National Institute of Biomedical Research, Congo | University of Kinshasa, Congo
Placide Mbala-Kingebeni National Institute of Biomedical Research, Congo | University of Kinshasa, School of Medicine, Congo
Pål Aukrust Oslo University Hospital, Norway
Stein Emil Vollset Norwegian Institute of Public Health
Christian Klotz Robert Koch Institute, Berlin, Germany
Rasmus Goll Department of Clinical Medicine, UiT - The Arctic University of Norway
James Fleckenstein John T. Milliken Department of Medicine, University of Washington, USA
Alumni
Gro Elizabeth Ann Strøm PhD graduate
Sunniva Todnem Sakkestad PhD graduate
Thandile Nkosi PhD graduate
Christina Skår Saghaug PhD graduate
Øystein Haarklau Johansen PhD graduate
Anette Onken PhD graduate