Tumor microenvironment and radiobiology research group

The Tumor microenvironment and radiobiology research group, led by Prof Per Øyvind Enger, is one of 5 labs that are integral nodes of the larger, dynamic Translational Cancer Research Group based at the Univesity of Bergen.

Affiliation

About the research group


Our research focus on cancer radiobiology, aiming to potentiate radiotherapy with radiosensitisers. We also investigate how tumor-stroma interactions impact on disease course and treatment response.

Publications

2022

The Styryl Benzoic Acid Derivative DC10 Potentiates Radiotherapy by Targeting the xCT-Glutathione Axis

 

 

 

2021

Structure-Activity-Relationship-Aided Design and Synthesis of xCT Antiporter Inhibitors

Meclofenamate causes loss of cellular tethering and decoupling of functional networks in glioblastoma 

2020

A simple score to estimate the likelihood of pseudoprogression vs. recurrence following stereotactic radiosurgery for brain metastases: The Bergen Criteria

2019

Platelet-derived growth factor receptor α/glial fibrillary acidic protein expressing peritumoral astrocytes associate with shorter median overall survival in glioblastoma patients

Bortezomib administered prior to temozolomide depletes MGMT, chemosensitizes glioblastoma with unmethylated MGMT promoter and prolongs animal survival

Astrocytes enhance glioblastoma growth

Pretreatment of Glioblastoma with Bortezomib Potentiates Natural Killer Cell Cytotoxicity through TRAIL/DR5 Mediated Apoptosis and Prolongs Animal Survival

2018

Microglia Induce PDGFRB Expression in Glioma Cells to Enhance Their Migratory Capacity

2017

Predictors of quality of life and survival following Gamma Knife surgery for lung cancer brain metastases: a prospective study

Drug repurposing in cancer

Membrane-Depolarizing Channel Blockers Induce Selective Glioma Cell Death by Impairing Nutrient Transport and Unfolded Protein/Amino Acid Responses

Tumour-associated glial host cells display a stem-like phenotype with a distinct gene expression profile and promote growth of GBM xenografts

Surgical debulking promotes recruitment of macrophages and triggers glioblastoma phagocytosis in combination with CD47 blocking immunotherapy

Quality of life is maintained using Gamma Knife radiosurgery: a prospective study of a brain metastases patient cohort

2016

EGFRvIII mutations can emerge as late and heterogenous events in glioblastoma development and promote angiogenesis through Src activation

People

Group manager

Per Øyvind Enger Professor

Bente Sandvei Skeie Associate Professor

Students

Sander Tennefoss Sørbø Forskerlinjestudent

Contact

For more information, contact the group leder, Prof Per Øyvind Enger

Phone number
+47 55586347
Emails
per.enger@uib.no