Lake Atitlán Lung Health Study, Guatemala

This project brings together occupational health and epigenetic experts, anthropologists and local organizations, aiming to generate actionable knowledge on occupational and environmental exposures in indigenous communities in Guatemala and impact on the workers and their offspring’s respiratory health; and explore epigenetic mechanisms for transfer of exposure effects to offspring; with a research governance approach that builds trust and partnership with communities and stakeholders to ensure the research results can be acted upon. We study indigenous families in traditional Mayan villages in Guatemala.

Occupational and environmental exposure to dusts, endotoxins and chemical exposures (dyes, pesticides, plastic chemicals etc.) are measured in environmental samples, urine and blood. We will analyse how such exposures are associated with respiratory health of the workers, and how mothers and fathers’ exposures relate to growth/ height and respiratory health of their offspring. Epidemiological analyses will be supported and guided by mechanistic studies, of how parental exposures relate to offspring DNA methylation and to miRNA in sperm (fathers).

Citizens-led approaches are being applied to raise awareness among families while shaping policy processes at the local, national and global levels. This unique interdisciplinary project with a two-generation study in neglected population, unprecedented mechanistic work in humans and key partnerships, has the potential to generate high-level insights, relevant to policy and practice on all levels.