Målet med min forskning innen analytisk kjemi er å maksimere informasjonen som kan hentes fra analytisk instrumentering ved bruk av kjemometri. 

Aktivitetene for å oppnå dette målet kan deles inn i følgende kategorier:

• Ekstraksjon av informasjon fra spektra og kromatogrammer for bruk til kvantifisering og identifikasjon. Dette inkluderer teknikker som støyreduksjon, spektral sammenligning og oppløsning av overlappende signaler.
• Prediksjon av kromatografisk retensjon og retensjonsbaserte metoder for identifikasjon.
• Optimalisering og standardisering av kromatografiske betingelser ved hjelp av responsflate-metodikk.

I tillegg utvikler jeg også Matlab-basert programvare for kromatografi og massespektrometri som brukes i vår undervisning og forskning. Jeg vedlikeholder også en samling med kromatografiske og massespektrometriske data for fettsyre-metylestre.

Kurs

Jeg underviser i emnet KJEM/FARM250 (Analytisk Kjemi), KJEM350 (Kvantitativ organisk analyse) og EMQAL AM15. 

Masteroppgaver

Masteroppgaver innen kjemometri eller analytisk kjemi tilbys til studenter på masterprogrammene i kjemi og medisinsk teknologi
 
Mange av oppgavene utføres på eksterne laboratorier, typisk på Haukeland Sykehus eller Havforskningstinstituttet.

 

Vitenskapelig artikkel

• Nakken, Charlotte L.; Berntssen, Marc HG; Meier, Sonnich et al. (2024). Exposure of Polycyclic Aromatic Hydrocarbons (PAHs) and Crude Oil to Atlantic Haddock (Melanogrammus aeglefinus): A Unique Snapshot of the Mercapturic Acid Pathway. (ekstern lenke)
• Rimmen, Eira V.; Mjøs, Svein Are; Søfteland, Eirik et al. (2024). Intake of herring oil, but not of anchovy oil, resulted in a lower serum cholesterol concentration in male Zucker Diabetic Sprague Dawley rats. (ekstern lenke)
• Chhaganlal, Milan Narendra; Mjøs, Svein Are; Underhaug, Jarl (2023). Evaluation of NMR predictors for accuracy and ability to reveal trends in ¹H NMR spectra of fatty acids. (ekstern lenke)
• Zeng, Yingxu; Deng, Baichuan; Kang, Zixin et al. (2023). Tissue accumulation of polystyrene microplastics causes oxidative stress, hepatopancreatic injury and metabolome alterations in Litopenaeus vannamei. (ekstern lenke)
• Laroche, Olivier; Meier, Sonnich; Mjøs, Svein Are et al. (2022). Suspension-feeding benthic species’ physiological and microbiome response to salmon farming and associated environmental changes. (ekstern lenke)
• Laroche, Olivier; Meier, Sonnich; Mjøs, Svein A. et al. (2021). Effects of fish farm activities on the sponge Weberella bursa, and its associated microbiota. (ekstern lenke)
• Drotningsvik, Aslaug; Oterhals, Åge; Mjøs, Svein Are et al. (2020). Effects of intact and hydrolysed blue whiting proteins on blood pressure and markers of kidney function in obese Zucker fa/fa rats. (ekstern lenke)
• Lin, Chenchen; Sengee, Amarjargal; Mjøs, Svein Are (2020). Minor compounds and potential interferents in gas chromatographic analyses of human serum fatty acids. (ekstern lenke)
• Hovland, Ida Heir; Leikanger, Ingrid Sande; Stokkeland, Oddbjørg et al. (2019). Effects of low doses of fish and milk proteins on glucose regulation and markers of insulin sensitivity in overweight adults: a randomised, double blind study. (ekstern lenke)
• Drotningsvik, Aslaug; Vikøren, Linn Anja Slåke; Mjøs, Svein Are et al. (2018). Water-soluble fish protein intake led to lower serum and liver cholesterol concentrations in obese zucker fa/fa rats. (ekstern lenke)
• Vikøren, Linn Anja Slåke; Drotningsvik, Aslaug; Mjøs, Svein Are et al. (2018). Salmon fillet intake led to higher serum triacylglycerol in obese zucker Fa/Fa rats but not in normolipidemic Long-Evans rats. (ekstern lenke)
• Waktola, Habtewold Deti; Mjøs, Svein Are (2018). Chromatographic efficiency of polar capillary columns applied for the analysis of fatty acid methyl esters by gas chromatography. (ekstern lenke)
• Steinrücken, Pia; Prestegard, Siv Kristin; de Vree, Jeroen Hendrik et al. (2018). Comparing EPA production and fatty acid profiles of three Phaeodactylum tricornutum strains under western Norwegian climate conditions. (ekstern lenke)
• Vikøren, Linn Anja Slåke; Drotningsvik, Aslaug; Bergseth, Marthe Tønder et al. (2018). Intake of baked cod fillet resulted in lower serum cholesterol and higher long chain n-3 PUFA concentrations in serum and tissues in hypercholesterolemic obese Zucker fa/fa rats. (ekstern lenke)
• Steinrücken, Pia; Mjøs, Svein Are; Prestegard, Siv Kristin et al. (2018). Enhancing EPA Content in an Arctic Diatom: A Factorial Design Study to Evaluate Interactive Effects of Growth Factors. (ekstern lenke)
• Steinrücken, Pia; Erga, Svein Rune; Mjøs, Svein Are et al. (2017). Bioprospecting North Atlantic microalgae with fast growth and high polyunsaturated fatty acid (PUFA) content for microalgae-based technologies. (ekstern lenke)
• Hvidsten, Ina; Mjøs, Svein Are; Bødtker, Gunhild et al. (2017). Lipids of Dietzia sp. A14101. Part II: A study of the dynamics of the release of surface active compounds by Dietzia sp. A14101 into the medium. (ekstern lenke)
• Vikøren, Linn Anja Slåke; Drotningsvik, Aslaug; Bergseth, Marthe Tønder et al. (2017). Effects of baked and raw salmon fillet on lipids and n-3 PUFAs in serum and tissues in Zucker fa/fa rats. (ekstern lenke)
• Helland, Anita; Bratlie, Marianne; Hagen, Ingrid Valheim et al. (2017). High intake of fatty fish, but not of lean fish, improved postprandial glucose regulation and increased the n-3 PUFA content in the leucocyte membrane in healthy overweight adults: A randomised trial. (ekstern lenke)
• Hvidsten, Ina; Mjøs, Svein Are; Holmelid, Bjarte et al. (2017). Lipids of Dietzia sp. A14101. Part I: A study of the production dynamics of surface-active compounds. (ekstern lenke)
• Sørensen, Lisbet; Meier, Sonnich; Mjøs, Svein Are (2016). Application of gas chromatography/tandem mass spectrometry to determine a wide range of petrogenic alkylated polycyclic aromatic hydrocarbons in biotic samples. (ekstern lenke)
• Zeng, Yingxu; Mjøs, Svein Are; Araujo, Pedro et al. (2016). An LC–MS-based lipidomics approach for studying the impact of dietary eicosapentaenoic acid on modulating methylmercury toxicity in mice. (ekstern lenke)
• Prestegard, Siv Kristin; Erga, Svein Rune; Steinrücken, Pia et al. (2016). Specific metabolites in a Phaeodactylum tricornutum strain isolated from Western Norwegian fjord water. (ekstern lenke)
• Lin, Chenchen; Andersen, John Roger; Våge, Villy et al. (2016). Intensive lifestyle intervention provides rapid reduction of serum fatty acid levels in women with severe obesity without lowering omega-3 to unhealthy levels. (ekstern lenke)
• Drotningsvik, Aslaug; Mjøs, Svein Are; Pampanin, Daniela Maria et al. (2016). Dietary fish protein hydrolysates containing bioactive motifs affect serum and adipose tissue fatty acid compositions, serum lipids, postprandial glucose regulation and growth in obese Zucker fa/fa rats.. (ekstern lenke)
• Rajalahti, Tarja; Lin, Chenchen; Mjøs, Svein Are et al. (2016). Changes in serum fatty acid and lipoprotein subclass concentrations from prepuberty to adulthood and during aging. (ekstern lenke)
• Araujo, Pedro; Zhu, Han; Breivik, Joar Fjørtoft et al. (2016). Plackett-Burman design and fragmentation studies to assist the 1 comparison of techniques used to extract phospholipids prior to regiospecific characterization by liquid chromatography mass spectrometry. (ekstern lenke)
• Zeng, Yingxu; Mjøs, Svein Are; David, Fabrice et al. (2016). Extension of least squares spectral resolution algorithm to high-resolution lipidomics data. (ekstern lenke)
• Zeng, Yingxu; Du, Zhen-yu; Mjøs, Svein Are et al. (2016). Methylmercury Increases and Eicosapentaenoic Acid Decreases the Relative Amounts of Arachidonic Acid-Containing Phospholipids in Mouse Brain. (ekstern lenke)
• Lin, Chenchen; Rajalahti, Tarja; Mjøs, Svein Are et al. (2016). Predictive associations between serum fatty acids and lipoproteins in healthy non-obese Norwegians: implications for cardiovascular health. (ekstern lenke)
• Rajalahti, Tarja; Lin, Chenchen; Mjøs, Svein Are et al. (2016). Serum fatty acid and lipoprotein subclass concentrations and their associations in prepubertal healthy Norwegian children. (ekstern lenke)
• Mjøs, Svein Are; Waktola, Habtewold D. (2015). Optimizing the relationship between chromatographic efficiency and retention times in temperature-programmed gas chromatography. (ekstern lenke)
• Hvidsten, Ina; Mjøs, Svein Are; Bødtker, Gunhild et al. (2015). Data on pigments and long-chain fatty compounds identified in Dietzia sp. A14101 grown on simple and complex hydrocarbons. (ekstern lenke)
• Giskeødegård, Guro F.; Hansen, Ailin Falkmo; Bertilsson, Helena et al. (2015). Metabolic markers in blood can separate prostate cancer from benign prostatic hyperplasia. (ekstern lenke)
• Hvidsten, Ina; Mjøs, Svein Are; Bødtker, Gunhild et al. (2015). Fatty acids in bacterium Dietzia sp grown on simple and complex hydrocarbons determined as FAME by GC-MS. (ekstern lenke)
• Lin, Chenchen; Våge, Villy; Mjøs, Svein Are et al. (2015). Changes in Serum Fatty Acid Levels During the First Year After Bariatric Surgery. (ekstern lenke)
• Apablaza, Patricia; Brevik, Øyvind Jakobsen; Mjøs, Svein Are et al. (2015). Variable Number of Tandem Repeats (VNTR) analysis of Flavobacterium psychrophilum from salmonids in Chile and Norway. (ekstern lenke)
• Drotningsvik, Aslaug; Mjøs, Svein Are; Høgøy, Ingmar Johan et al. (2014). A low dietary intake of cod protein is sufficient to increase growth, improve serum and tissue fatty acid compositions, and lower serum postprandial glucose and fasting non-esterified fatty acid concentrations in obese Zucker fa/fa rats. (ekstern lenke)
• Gudbrandsen, Oddrun Anita; Kodama, Yosuke; Mjøs, Svein Are et al. (2014). Effects of duodenal switch alone or in combination with sleeve gastrectomy on body weight and lipid metabolism in rats. (ekstern lenke)
• Lin, Chenchen; Wasta, Ziar Miran; Mjøs, Svein Are (2014). Evaluation of the retention pattern on ionic liquid columns for gas chromatographic analyses of fatty acid methyl esters. (ekstern lenke)
• Chhaganlal, Milan; Skartland, Liv Kjersti; Mjøs, Svein Are (2014). Transfer of retention patterns in gas chromatography by means of response surface methodology. (ekstern lenke)
• Bekhit, Michael Yemane; Grung, Bjørn; Mjøs, Svein Are (2014). Determination of Omega-3 Fatty Acids in Fish Oil Supplements Using Vibrational Spectroscopy and Chemometric Methods . (ekstern lenke)
• Samuelsen, Tor Andreas; Mjøs, Svein Are; Oterhals, Åge (2014). Influence of type of raw material on fishmeal physicochemical properties, the extrusion process, starch gelatinization and physical quality of fish feed. (ekstern lenke)
• Samuelsen, Tor Andreas; Mjøs, Svein Are; Oterhals, Åge (2013). Impact of variability in fishmeal physicochemical properties on the extrusion process, starch gelatinization and pellet durability and hardness. (ekstern lenke)
• Kousoulaki, Katerina; Rønnestad, Ivar; Olsen, Hanne Jorun et al. (2013). Krill hydrolysate free amino acids responsible for feed intake stimulation in Atlantic salmon (Salmo salar). (ekstern lenke)
• Zeng, Yingxu; Mjøs, Svein Are; Meier, Sonnich et al. (2013). Least squares spectral resolution of liquid chromatography-mass spectrometry data of glycerophospholipids. (ekstern lenke)
• Wasta, Ziar Miran; Mjøs, Svein Are (2013). A database of chromatographic properties and mass spectra of fatty acid methyl esters from omega-3 products. (ekstern lenke)
• Kousoulaki, Katerina; Olsen, Hanne Jorun; Albrektsen, Sissel et al. (2012). High growth rates in Atlantic salmon (Salmo salar L.) fed 7.5% fish meal in the diet. Micro-, ultra- and nano-filtration of stickwater and effects of different fractions and compounds on pellet quality and fish performance. (ekstern lenke)
• Xiao, Liping; Mjøs, Svein Are; Haugsgjerd, Bjørn Ole (2012). Efficiencies of three common lipid extraction methods evaluated by calculating mass balances of the fatty acids. (ekstern lenke)
• Sciotto, Caterina; Mjøs, Svein Are (2012). Trans isomers of EPA and DHA in Omega-3 products on the European market. (ekstern lenke)
• Skartland, Liv Kjersti; Mjøs, Svein Are; Grung, Bjørn (2011). Experimental designs for modeling retention patterns and separation efficiency in analysis of fatty acid methyl esters by gas chromatography-mass spectrometry. (ekstern lenke)
• Mjøs, Svein Are; Haugsgjerd, Bjørn Ole (2011). Trans Fatty Acid Analyses in Samples of Marine Origin: The Risk of False Positives. (ekstern lenke)
• Zhang, Liangxiao; Mjøs, Svein Are; Meier, Sonnich et al. (2010). The vector of calibration ratios: A simple transfer method for mass spectra. (ekstern lenke)
• Mjøs, Svein Are; Grung, Bjørn (2009). A Rank annihilation approach to reducing the scan-effect in gas chromatography-mass spectrometry data. (ekstern lenke)
• Mjøs, Svein Are (2008). Retention behavior of trans isomers of eicosapentaenoic and docosahexaenoic acid methyl esters on a polyethylene glycol stationary phase. (ekstern lenke)
• Boitsov, Stepan; Mjøs, Svein Are; Meier, Sonnich (2007). Identification of estrogen-like alkylphenols in produced water from offshore oil installations. (ekstern lenke)
• Mjøs, Svein Are; Meier, Sonnich; Boitsov, Stepan (2006). Alkylphenol retention indices. (ekstern lenke)
• Mjøs, Svein Are; Meier, Sonnich; Grahl-Nielsen, Otto (2006). Geometrical isomerisation of double bonds in acid catalysed preparation of fatty acid methyl esters. (ekstern lenke)
• Mjøs, Svein Are; Solvang, Marianne (2006). Patterns in volatile components over heated fish powders. (ekstern lenke)
• Mjøs, Svein Are; Solvang, Marianne (2006). Geometrical isomerisation of EPA and DHA at high temperatures. (ekstern lenke)
• Meier, Sonnich; Mjøs, Svein Are; Joensen, Horaldur et al. (2006). Validation of a one-step extraction/methylation method for determination of fatty acids and cholesterol in marine tissues. (ekstern lenke)
• Mjøs, Svein Are (2006). Prediction of equivalent chain lengths from two-dimensional fatty acid retention indices. (ekstern lenke)
• Mjøs, Svein Are (2005). Properties of trans isomers of eicosapentaenoic acid and eicosahexaenoic acid methyl esters on cyanopropyl stationary phases. (ekstern lenke)
• Mjøs, Svein Are (2004). Two-dimensional fatty acid retention indices. (ekstern lenke)
• Mjøs, Svein Are (2004). Quantification of linolenic acid isomers by gas chromatography-mass spectrometry and deconvolution of overlapping chromatographic peaks. (ekstern lenke)
• Mjøs, Svein Are (2004). The prediction of fatty acid structure from selected ions in electron impact mass spectra of fatty acid methyl esters. (ekstern lenke)
• Mjøs, Svein Are (2003). Spectral transformations for deconvolution methods applied on gas chromatography–mass spectrometry data. (ekstern lenke)
• Mjøs, Svein Are; Pettersen, Jan (2003). Determination of trans double bonds in polyunsaturated fatty acid methyl esters from their electron impact mass spectra. (ekstern lenke)
• Mjøs, Svein Are; Pettersen, jan (2003). A rapid method for the analysis of hydrogenated fats by GC with IR detection. (ekstern lenke)
• Mjøs, Svein Are (2003). Identification of fatty acids in gas chromatography by application of different temperature and pressure programs on a single capillary column. (ekstern lenke)

Doktorgradsavhandling

• Steinrücken, Pia; Erga, Svein Rune; Prestegard, Siv Kristin et al. (2018). High-value fatty acids from microalgae. Bioprospecting and outdoor cultivation at northern latitudes. (ekstern lenke)
• Zeng, Yingxu; Mjøs, Svein Are (2015). Application of liquid chromatographymass spectrometry and chemometrics in the automated characterization of molecular lipid species. (ekstern lenke)
• Samuelsen, Tor Andreas; Oterhals, Åge; Mjøs, Svein Are (2015). Fishmeal physicochemical properties – Impact on the fish feed extrusion process, phase transitions and physical pellet quality. (ekstern lenke)
• Mjøs, Svein Are (2006). Interpretation of chromatographic and mass spectrometric data from analyses of fatty acid methyl esters – Application of multivariate methods. (ekstern lenke)

Se en full oversikt over publikasjoner i Cristin

Utvalgte publikasjoner:

M.N. Chhaganlal, J. Underhaug, S.A. Mjøs*, Evaluation of NMR predictors for accuracy and ability to reveal trends in 1H NMR spectra of fatty acids, MAGNETIC RESONANCE IN CHEMISTRY 61 (2023) 318-332. DOI: 10.1002/mrc.5336

C.C. Lin, A. Sengee, S.A. Mjøs*, Minor compounds and potential interferents in gas chromatographic analyses of human serum fatty acids. JOURNAL OF CHROMATOGRAPHY B 1138 (2020) 121963. DOI: 10.1016/j.jchromb.2019.121963

H.D. Waktola, S.A. Mjøs*, Chromatographic efficiency of polar capillary columns applied for the analysis of fatty acid methyl esters by gas chromatography, JOURNAL OF SEPARATION SCIENCE 41 (2018) 1582-1592. DOI: 10.1002/jssc.201700908

Y. Zeng, S.A. Mjøs*, F.P.A. David, A.W. Schmid, Extension of least squares spectral resolution algorithm to high-resolution lipidomics data. ANALYTICA CHIMICA ACTA 914 (2016) 35-46. DOI: 10.1016/j.aca.2016.02.002

S.A. Mjøs*, H.D. Waktola, Optimizing the relationship between chromatographic efficiency and retention times in temperature-programmed gas chromatography. JOURNAL OF SEPARATION SCIENCE 38 (2015) 3014-3027. DOI: 10.1002/jssc.201500364

M. Chhaganlal, L.K. Skartland, S.A. Mjøs*, Transfer  of retention patterns in gas chromatography by means of response surface  methodology, JOURNAL OF CHROMATOGRAPHY A 1332 (2014) 64-72. DOI: 10.1016/j.chroma.2014.01.039

Z. Wasta, S.A. Mjøs*, A database of chromatographic properties and mass spectra of fatty acid methyl esters from omega-3 products. JOURNAL OF CHROMATOGRAPHY A 1299 (2013) 94-102. DOI: 10.1016/j.chroma.2013.05.056

Y. Zeng, S.A. Mjøs*, S. Meier, C. Lin, R. Vadla, Least squares spectral resolution of liquid chromatography-mass  spectrometry data of glycerophospholipids. JOURNAL OF CHROMATOGRAPHY A  1280 (2013) 23-34. DOI: 10.1016/j.chroma.2012.12.070

C. Sciotto, S.A. Mjøs*, Trans isomers of EPA and DHA in omega-3 products on the European market. LIPIDS 47 (2012) 659-667. DOI: 10.1007/s11745-012-3672-3

L.K. Skartland, S.A. Mjøs*, B. Grung, Experimental designs for modeling retention patterns and separation efficiency in analysis of fatty acid methyl esters by gas chromatography-mass spectrometry. JOURNAL OF CHROMATOGRAPHY A 1218 (2011) 6823-6831. DOI: 10.1016/j.chroma.2011.07.077

S.A. Mjøs*, B. Grung, A Rank annihilation approach to reducing the scan-effect in gas chromatography-mass spectrometry data. ANALYTICA CHIMICA ACTA 640 (2009) 33-39. DOI: 10.1016/j.aca.2009.03.011

S. Meier*, S.A. Mjøs, H. Joensen, O. Grahl-Nielsen, Validation of a one-step extraction/methylation method for determination of fatty acids and cholesterol in marine tissues. JOURNAL OF CHROMATOGRAPHY A 1104 (2006) 291-298. DOI: 10.1016/j.chroma.2005.11.045

S.A. Mjøs, S. Meier, S. Boitsov*, Alkylphenol retention indices. JOURNAL OF CHROMATOGRAPHY A 1123 (2006) 98-105. DOI: 10.1016/j.chroma.2006.05.002

S.A. Mjøs*, O. Grahl-Nielsen, Prediction of gas chromatographic retention of polyunsaturated fatty acid methyl esters. JOURNAL OF CHROMATOGRAPHY A 1110 (2006) 171-180. DOI: 10.1016/j.chroma.2006.01.092

S.A. Mjøs*, The prediction of fatty acid structure from selected ions in electron impact mass spectra of fatty acid methyl esters. EUROPEAN JOURNAL OF LIPID SCIENCE AND TECHNOLOGY 106 (2004) 550-560. DOI: 10.1002/ejlt.200401013

S.A. Mjøs*, Two-dimensional fatty acid retention indices. JOURNAL OF CHROMATOGRAPHY A 1061 (2004) 201-209. DOI: 10.1016/j.chroma.2004.11.025

S.A. Mjøs*, Identification of fatty acids in gas  chromatography by application of different temperature and pressure programs  on a single capillary column. JOURNAL OF CHROMATOGRAPHY A 1015 (2003)  151-161. DOI: 10.1016/S0021-9673(03)01240-8

S.A. Mjøs*, Spectral transformations for deconvolution methods applied on gas chromatography-mass spectrometry data. ANALYTICA CHIMICA ACTA 488 (2003) 231-241. DOI: 10.1016/S0003-2670(03)00679-2

S.A. Mjøs*, J. Pettersen, A rapid method for the analysis of hydrogenated  fats by GC with IR detection. JOURNAL OF THE AMERICAN OIL CHEMISTS  SOCIETY 80 (2003) 839-846. DOI: 10.1007/s11746-003-0783-0

Alle publikasjoner i Christin: