Craniofacial Developmental Biology and Regeneration
The aim of the group is to analyze general molecular signaling mechanisms regulating embryonic organ development in craniofacial and oral tissues.
About the research group
We use mouse as a model system in order to understand how the mammalian cells form, organize, maintain, regenerate and repair the proper three-dimensional structures of tissues and organs. Knowledge of the molecular regulation of normal development forms a basis for understanding abnormal behavior of cells, for example malignant growth in adult mammalian systems. Our research provides also basic information for engineering biological tissues and organs to replace congenitally missing, damaged or removed cells, tissues or organs in man in the future.
Publications
Selected Publications
Integration of tooth morphogenesis and innervation by local tissue interactions, signaling networks, and semaphorin 3A. Luukko K, Kettunen P. Cell Adh Migr. 2016 Nov;10(6):618-626. Epub 2016 Aug 9. Review.
Sema3A chemorepellant regulates the timing and patterning of dental nerves during development of incisor tooth germ. Shrestha A, Moe K, Luukko K, Taniguchi M, Kettunen P. Cell Tissue Res. 2014 Jul;357(1):15-29. doi: 10.1007/s00441-014-1839-3.
Semaphorin 3A controls timing and patterning of the dental pulp innervation. Moe K, Sijaona A, Shrestha A, Kettunen P, Taniguchi M, Luukko K. Differentiation. 2012 Dec;84(5):371-9. doi: 10.1016/j.diff.2012.09.003. Epub 2012 Nov 7.
Coordination of trigeminal axon navigation and patterning with tooth organ formation: epithelial-mesenchymal interactions, and epithelial Wnt4 and Tgfbeta1 regulate semaphorin 3a expression in the dental mesenchyme. Kettunen P, Løes S, Furmanek T, Fjeld K, Kvinnsland IH, Behar O, Yagi T, Fujisawa H, Vainio S, Taniguchi M, Luukko K. Development. 2005 Jan;132(2):323-34. Epub 2004 Dec 16.
Localization of putative stem cells in dental epithelium and their association with Notch and FGF signaling. Harada H, Kettunen P, Jung HS, Mustonen T, Wang YA, Thesleff I. J Cell Biol. 1999 Oct 4;147(1):105-20.
People
Group manager
Päivi Kettunen Professor
Contact
For more information, contact the group leader, Professor Päivi Kettunen
- Phone number
- +47 55586364
- Emails
- Paivi.Kettunen@uib.no