Protein-lipid interactions and their role in aging and neurodegeneration

The unit of life is the cell. It is bounded by the cell membrane, a thin barrier of just a few nanometers. This is not a solid barrier, but rather a semi-liquid oily affair. It is made up of lipids, molecules that resemble fats or oils, as well as proteins. There are also chains of sugar molecules attached to the membrane. The cell membrane allows some molecules to pass through it, but is impermeable to others. Many of the components of the cell membrane -- proteins, lipids and sugar molecules -- are well understood in terms of their individual properties and function. But in the complex and ever-changing environment of a cell membrane, it has so far been a challenge to understand how each component can affect each other. Understanding this interaction is crucial to understanding the molecular basis of the cell. An important question for my research is thus how lipids affect proteins and how proteins affect the integrity of the lipids that give the cell membrane its integrity as a barrier.

 

MOL310 Strukturell Molekylærbiologi

Målet for emnet er å gi studentene kunnskap om forholdet mellom biomakromolekylers struktur og funksjon. Dette kurset underviser jeg fra begynnelse til slutt.

MOL270 Bioetikk

Dette kurset underviser og organiserer jeg sammen med Anders Goksøyr og Gyri Haugland. 

MOL220

Som alle andre vitenskapelige ansatte ved MOL, har jeg en modul i dette kurset hvor jeg presenterer metoder og modelsystemer som er relevante for min forskning.

MOL210 Lipidbiokjemi

Dette kurset, som jeg underviser sammen med Aurelia Lewis, er ment å gi studenten en fordypning i lipiders kjemiske, cellulære og patologiske egenskaper.

MOL200 Metabolisme

Her underviser jeg i Aminosyremetabolisme.

MOL231 Prosjektoppgave i molekylærbiologi

Jeg har veiledet en lang rekke studenter i dette praktiske kurset.

Tidligere kurs:

MOL320 Avanserte Metoder i Biokjemi

Dette kurset gir studentene en praktisk innføring med noe tilhørende teori i biofysikalske metoder som er tilgjengelig ved Molekylærbiologis Institutt.  Kurset er modulbasert og bygget rundt praktisk laboratoriearbeid og dataanalyse. Eksempler på moduler som gis er: Surface Plasmon Resonance, Isothermal Calorimetry, Fluorescence og Protein NMR.

Mindre/eldre undervisningsbidrag:

2015: MBV 9520 (2x45 min forelesning i proteindynamikk, BIOSTRUCT-kurs på nasjonalt nivå)
2014, 16, 18, 20: MOL950 (en bitteliten praktisk NMR-modul, BIOSTRUCT-kurs på nasjonalt nivå)
2011-13: Forelesning (2x 45 min, biokjemi og kolloidkjemi) i BMED325 ‐ Nanobiokjemi
2012: Forelesning in Atomic Force Microscopy (1 x45 min, BIOSTRUCT-kurs på nasjonalt nivå)
2007‐11: Forelesninger og diskusjoner i BMED310 ‐ Vitenskapsfilosofi
1998‐2001: Statistikk (SOK33B) og Uorganisk Kjemi (K102)

2018

• Øyvind Halskau (2018). Contrasting cellular lipid states using quantitative 31P NMR and LC MS/MS. (ekstern lenke)
• Behdad Delavari; Fatemeh Mamashli; Bahareh Bigdeli et al. (2018). A biophysical study on the mechanism of interactions of DOX or PTX with α-lactalbumin as a delivery carrier. (ekstern lenke)
• Maxim Brilkov; Olena Dobrovolska; Rein Aasland et al. (2018). CW-domain of ASHH2 methyltransferase: structural basis of ligand binding and specificity. (ekstern lenke)
• Martin Jakubec; Øyvind Halskau; Astrid Elisabeth Mork-Jansson (2018). A novel exosome-like nanocarrier for treatment of refractory epilepsy. (ekstern lenke)
• Martin Jakubec; Øyvind Halskau; Damir Janigro et al. (2018). A novel exosome-like nanocarrier for treatment of refractory epilepsy. (ekstern lenke)
• Olena Dobrovolska; Maxim Brilkov; Øyvind Ødegård‑Fougner et al. (2018). 1H, 13C, and 15N resonance assignments of CW domain of the N-methyltransferase ASHH2 free and bound to the mono-, di- and tri-methylated histone H3 tail peptides. (ekstern lenke)
• Øyvind Halskau (2018). Proteiner og nevrodegenerative sykdommer. (ekstern lenke)
• Martin Jakubec; Georg Vinnit; Morten Andreas Govasli Larsen et al. (2018). Alpha-synuclein oligomerization in the presence of the cholesterol and glycerophosphoglycerol. (ekstern lenke)
• Martin Jakubec; Øyvind Halskau; Damir Janigro et al. (2018). A novel exosome-like nanocarrier for treatment of refractory epilepsy. (ekstern lenke)

2002

• Øyvind Halskau; Jarl Underhaug; Nils Å. Frøystein et al. (2002). Molten globule state of BLA bound to SDS micelles studied by NMR spectroscopy. (ekstern lenke)
• Øyvind Halskau; Knut Teigen; Rune Kleppe et al. (2002). Studying the interaction between 14-3-3 proteins and tryptophan hydroxylase using 3D-modelling and NMR spectroscopy. (ekstern lenke)
• Øyvind Halskau; Nils Å. Frøystein; Arturo Muga et al. (2002). The Membrane-bound Conformation of a-Lactalbumin Studied by NMR-monitored 1H Exchange. (ekstern lenke)
• Øyvind Halskau; Armelle, V. Agasøster; Aurora Martinez et al. (2002). Elucidating the membrane bound conformations of -lactalbumin in different lipid environments by CD, multidimensional NMR spectroscopy and fluorescence. (ekstern lenke)
• Øyvind Halskau; Nils Å. Frøystein; Matthias Thorolfsson et al. (2002). The membrane bound conformation of alpha-lactalbumin studied by NMR. (ekstern lenke)
• Øyvind Halskau; Nils Å. Frøystein; Aurora Martinez (2002). Detaljer i utilgjengelig systemer – membran-protein vekselvirkninger. (ekstern lenke)

2019

• Martin Jakubec; Øyvind Halskau (2019). Neuronal cell lipidomics and role of cholesterol in α-synuclein binding and aggregation. (ekstern lenke)
• Martin Jakubec; Espen Bariås; Fedor Kryuchkov et al. (2019). Fast and quantitative phospholipidomic analysis of SH-SY5Y neuroblastoma cell cultures using LC-MS/MS and 31P NMR. (ekstern lenke)
• Øyvind Halskau (2019). Misfolding i neurodegenerative sykdommer. (ekstern lenke)
• Øyvind Halskau (2019). Neurodegenerative sykdommer -- proteinkrøll gir hjernekrøll. (ekstern lenke)
• Morten Andreas Govasli Larsen; Pål Puntervoll; Øyvind Halskau (2019). From potent toxin to vaccine toxoid: Engineering the enterotoxigenic Escherichia coli heat-stable toxin into a subunit vaccine component. (ekstern lenke)

2016

• Samuel Robert Furse; Martin Jakubec; Michelle Victoria Hauge et al. (2016). Why is HAMLET more toxic to dividing cells?. (ekstern lenke)
• Øyvind Halskau (2016). Reversible protein membrane interactions by mobile peptides.. (ekstern lenke)
• Lene Hjortset; Øyvind Strømland; Ørjan Handegård et al. (2016). Characterization of protein-fatty acid complexe. (ekstern lenke)
• Øyvind Halskau (2016). Relevance of the protein, fatty acid and lipid component in early stages of HAMLET induced cell death. (ekstern lenke)
• Martin Jakubec; Øyvind Strømland; Samuel Robert Furse et al. (2016). Detection of misfolded protein aggregates from a clinical perspective. (ekstern lenke)
• Reed Lene Hjortset; Øyvind Halskau (2016). Molecular Characteristics of Peptide-Fatty Acid Complex Relevant for Tumoricidal HAMLET. (ekstern lenke)
• Øyvind Strømland; Martin Jakubec; Samuel Robert Furse et al. (2016). Detection of Misfolded Protein Aggregates from a Clinical Perspective. (ekstern lenke)
• Øyvind Halskau (2016). The protein, fatty acid and lipid components in early stages of PFA/HAMLET-induced cell death. (ekstern lenke)
• Christophe Louis Balin; Øyvind Halskau (2016). Expression and purification of misfolding peptides from E. coli for spectroscopic characterization. (ekstern lenke)

2017

• Samuel Robert Furse; Martin Jakubec; Frode Rise et al. (2017). Does the lipid fractio of Listeria innocua change as a function of the cell cycle?. (ekstern lenke)
• Samuel Robert Furse; Martin Jakubec; Frode Rise et al. (2017). Evidence that Listeria innocua modulates its membrane's stored curvature elastic stress, but not fluidity, through the cell cycle. (ekstern lenke)
• Øyvind Strømland; Ørjan Sele Handegård; Morten Andreas Govasli Larsen et al. (2017). Peptides derived from α-lactalbumin membrane binding helices oligomerize in presence of lipids and disrupt bilayers. (ekstern lenke)
• Øyvind Halskau (2017). Lecture on the Nobel Prize of Chemistry 2017 (Cryo-EM). (ekstern lenke)
• Øyvind Strømland; Ørjan S. Handegård; Morten Andreas Govasli Larsen et al. (2017). Spectroscopic and AFM characterization of polypeptide-surface interactions: Controls and lipid quantitative analyses. (ekstern lenke)

2013

• Hanzhen Wen; Wilhelm Glomm; Øyvind Halskau (2013). Cytotoxicity of bovine alpha-lactalbumin: Oleic acid complexes correlates with the disruption of lipid membranes. (ekstern lenke)
• Helene Heitmann Sandnes; Øyvind Halskau (2013). CREATING BAMLET USING ALPs AND INVESTIGATING THEIR EFFECT ON DIFFERENTIATED AND NONDIFFERENTIATED HUMAN BREAST CANCER CELLS. (ekstern lenke)
• Heli Havukainen; Daniel Münch; Anne Baumann et al. (2013). Vitellogenin recognizes cell damage through membrane binding and shields living cells from reactive oxygen species. (ekstern lenke)
• Sina Maria Lystvet; Sondre Volden; Gurvinder Singh et al. (2013). Tunable photophysical properties, conformation and function of nanosized protein–gold constructs. (ekstern lenke)
• Sina Maria Lystvet; Sondre Volden; Gurvinder Singh et al. (2013). Anticancer Activity from Gold-alpha-Lactalbumin Nanoconstructs?. (ekstern lenke)
• Sara Marie Øie Solbak; Tove Ragna Reksten; Friedrich Hahn et al. (2013). HIV-1 p6 - a structured to flexible multifunctional membrane-interacting protein. (ekstern lenke)

2023

• Espen Bariås; Martin Jakubec; Elise Førsund et al. (2023). Contrasting the phospholipid profiles of two neoplastic cell lines reveal a high PC:PE ratio for SH-SY5Y cells relative to A431 cells. (ekstern lenke)
• Mateu Montserrat Canals; Kilian Schnelle; Vilde Leipart et al. (2023). The high-resolution cryo-EM structure of vitellogenin from the hemolymph of the honey bee. (ekstern lenke)
• Nicolai Etwin Alsaker; Willy Nerdal; Bengt Erik Haug et al. (2023). Phospholipid membrane interactions of model peptides and depth of insertion investigated via solid-state NMR. (ekstern lenke)

2011

• Sina Maria Lystvet; Sondre Volden; Masahiro Yasuda et al. (2011). Emergent membrane-affecting properties of BSA-gold nanoparticle constructs. (ekstern lenke)
• Wilhelm Glomm; Sondre Volden; Marit-Helen Ese et al. (2011). Interactions of α-Lactalbumin and Cytochrome с with Langmuir Monolayers of Glycerophospholipids. (ekstern lenke)
• Hanzhen Wen; Ida M. Rundgren; Wilhelm Glomm et al. (2011). Benchmarking Different BAMLET-like Preparations with Resepct to Tryptophan Exposure, Interfacial Activity, and Effect on Cell Viability. (ekstern lenke)
• Helene Bustad Johannessen; Jarl Underhaug; Øyvind Halskau jr et al. (2011). The binding of 14-3-3 gamma to membranes studied by intrinsic fluorescence spectroscopy. (ekstern lenke)
• Heli Havukainen; Øyvind Halskau jr; Lars Skjærven et al. (2011). Deconstructing honeybee vitellogenin: novel 40 kDa fragment assigned to its N terminus. (ekstern lenke)
• Sina Maria Lystvet; Sondre Volden; Øyvind Halskau jr et al. (2011). Immobilizaton onto gold nanoparticles alters α-lactalbumin interaction with pure and mixed phospholipid monolayers. (ekstern lenke)
• Sondre Volden; Masahiro Yasuda; Øyvind Halskau jr et al. (2011). Mechanism for tunable protein deposition onto charged monodisperse polymer nanoparticles. (ekstern lenke)
• Heli Havukainen; Øyvind Halskau jr; Gro Vang Amdam (2011). Social pleiotropy and evolution of honey bee vitellogenin. (ekstern lenke)
• Sina Maria Lystvet; Sondre Volden; Masahiro Yasuda et al. (2011). Teaching old proteins new tricks. (ekstern lenke)

2005

• Øyvind Halskau; Jarl Underhaug; Nils Åge Frøystein et al. (2005). Conformational flexibility of alpha-lactalbumin related to its membrane binding capacity. (ekstern lenke)
• Ingunn Rødland; Øyvind Halskau; Aurora Martinez et al. (2005). α-Lactalbumin binding and membrane integrity – effect of charge and degree of unsaturation of glycerophospholipids. (ekstern lenke)
• Øyvind Halskau jr (2005). Structure and dynamics of the peripheral protein Lactalbumin in relation to its membrane binding capability. (ekstern lenke)
• Ingunn Rødland; Øyvind Halskau; Aurora Martinez et al. (2005). alpha-Lactalbumin binding and membrane integrity--effect of charge and degree of unsaturation of glycerophospholipids. (ekstern lenke)

2020

• Øyvind Halskau (2020). Conformational selection in histone binding – when being rigid fails. (ekstern lenke)
• Espen Bariås; Martin Jakubec; Øyvind Halskau (2020). Lipiders rolle i nevrodegenerative sykdommer. (ekstern lenke)
• Elise Førsund; Øyvind Halskau (2020). Senescence-Related Changes to the Lipid Composition of SH-SY5Y Cells with Implications for α-Synuclein Misfolding. (ekstern lenke)
• Olena Dobrovolska; Maxim Brilkov; Noëlly Madeleine et al. (2020). The Arabidopsis (ASHH2) CW domain binds monomethylated K4 of the histone H3 tail through conformational selection. (ekstern lenke)
• Martin Jakubec; Jodi Maple-Grødem; Saleha Akbari et al. (2020). Plasma-derived exosome-like vesicles are enriched in lyso-phospholipids and pass the blood-brain barrier. (ekstern lenke)
• Martin Jakubec; Christian Totland; Frode Rise et al. (2020). Bioactive metabolites of marine origin have unusual effects on model membrane systems. (ekstern lenke)
• Martin Jakubec; Espen Bariås; Samuel Robert Furse et al. (2020). Cholesterol-containing lipid nanodiscs promote an α-synuclein binding mode that accelerates oligomerization. (ekstern lenke)
• Trond-André Kråkenes; Fredrik Gullaksen Johannessen; Martin Jakubec et al. (2020). Phosphorylated TH hinges with vesicular membrane proteins for axonal transport. (ekstern lenke)
• Mette Ovesen; Øyvind Halskau (2020). The Attenuating Effects of 14-3-3eta in Parkinson’s Disease-Related alpha-Synuclein Aggregation. (ekstern lenke)

2012

• Anne Baumann; Anja Underhaug Gjerde; Ming Ying et al. (2012). HAMLET forms annular oligomers when deposited with phoshpolipid monolayers. (ekstern lenke)
• Svein Isungset Støve; Angele Abboud; Cédric Grauffel et al. (2012). An x-linked infantile lethal disorder caused by N-terminal acetyltransferase deficiency. (ekstern lenke)
• Heli Havukainen; Jarl Underhaug; Florian Wolschin et al. (2012). A vitellogenin polyserine cleavage site: highly disordered conformation protected from proteolysis by phosphorylation. (ekstern lenke)
• Sina Maria Lystvet; Sondre Volden; Øyvind Halskau jr et al. (2012). Interactions between BSA-gold nanoparticle constructs and a phospholipid monolayer. (ekstern lenke)
• Sondre Volden; Sina Maria Lystvet; Øyvind Halskau jr et al. (2012). Generally applicable procedure for in situ formation of fluorescent protein-gold nanoconstructs. (ekstern lenke)
• Anne-Sophie Schillinger; Cédric Grauffel; Øyvind Halskau et al. (2012). PR3 Interacts Directly to Lipid Bilayers: Evidence from MD Simulations and SPR Experiments. (ekstern lenke)
• Helene J. Bustad; Lars Skjærven; Ming Ying et al. (2012). The peripheral binding of 14-3-3gamma to membranes involves isoform-specific histidine residues. (ekstern lenke)
• Anne-Sophie Schillinger; Cédric Grauffel; Øyvind Halskau et al. (2012). PR3 Interacts Directly to Lipid Bilayers: Evidence from MD Simulations and SPR Experiments. (ekstern lenke)

2021

• Olena Dobrovolska; Øyvind Strømland; Ørjan Sele Handegård et al. (2021). Investigating the Disordered and Membrane-Active Peptide A-Cage-C Using Conformational Ensembles. (ekstern lenke)
• Vilde Leipart; Mateu Montserrat Canals; Eva Mariana de Sousa Cunha et al. (2021). Structure prediction of honey bee vitellogenin: a multi-domain protein important for insect immunity. (ekstern lenke)
• Milada Vitova; Vojtech Lanta; Maria Cizkova et al. (2021). The biosynthesis of phospholipids is linked to the cell cycle in a model eukaryote. (ekstern lenke)

2007

• Wilhelm R Glomm; Øyvind Halskau jr; Øyvind Halskau, Jr. et al. (2007). Adsorption Behavior of Acidic and Basic Proteins onto Citrate-Coated Au Surfaces Correlated to Their Native Fold, Stability, and pI. (ekstern lenke)
• G Saelensminde; Gisle Sælensminde; O Halskau et al. (2007). Structure-dependent relationships between growth temperature of prokaryotes and the amino acid frequency in their proteins. (ekstern lenke)

2015

• Hanzhen Wen; Øyvind Strømland; Øyvind Halskau (2015). α-lactalbumin: oleic acid complex spontaneously delivers oleic acid to artificial and erythrocyte membranes. (ekstern lenke)

2003

• Armelle, V. Agasøster; Øyvind Halskau; Edvin Fuglebakk et al. (2003). The interaction of peripheral proteins and membranes studied with alpha-lactalbumin and phospholipid bilayers of various compositions. (ekstern lenke)
• Øyvind Halskau; Jarl Underhaug; Nils Å. Frøystein et al. (2003). Direct and indirect NMR techniques applied on alpha-lactalbumin bound to different membrane-mimicking systems. (ekstern lenke)

2009

• Helene Bustad Johannessen; Øyvind Halskau jr; Aurora Martinez (2009). Exploring the Membrane Binding Capacity and Mechanism of 14-3-3γ. (ekstern lenke)
• Wilhelm Robert Glomm; Sondre Volden; O Halskau et al. (2009). Same System-Different Results: The Importance of Protein. Introduction Protocols in Langmuir-Monolayer Studies of Lipid-Protein Interactions. (ekstern lenke)
• Gisle Sælensminde; Øyvind Halskau jr; Inge Jonassen (2009). Amino acid contacts in proteins adapted to different temperatures: hydrophobic interactions and surface charges play a key role. (ekstern lenke)
• Øyvind Halskau jr; Arturo Muga; Aurora Martinez (2009). Linking new paradigms in protein chemistry to reversible membrane-protein interactions. (ekstern lenke)
• Øyvind Halskau jr; Ming Ying; Anne Baumann et al. (2009). Three-way interaction between 14-3-3 proteins, the N-terminal region of tyrosine hydroxylase and negatively charged membranes. (ekstern lenke)

2014

• Anne-Sophie Schillinger; Cédric Grauffel; Hanif Muhammad Khan et al. (2014). Two homologous neutrophil serine proteases bind to POPC vesicles with different affinities: When aromatic amino acids matter. (ekstern lenke)
• Åge Aleksander Skjevik; Mauro Mileni; Anne Baumann et al. (2014). The N-terminal sequence of tyrosine hydroxylase is a conformationally versatile motif that binds 14-3-3 proteins and membranes. (ekstern lenke)

2024

• Birta Ravdna Alexandersen Sarre; Olena Dobrovolska; Patrik Lundström et al. (2024). Structural dynamics of human deoxyuridine 5’-triphosphate nucleotidohydrolase (dUTPase). (ekstern lenke)
• Nicolai Etwin Alsaker; Øyvind Halskau; Bengt Erik Haug et al. (2024). Phospholipid Membrane Interactions of Model Ac-WL-X-LL-OH Peptides Investigated by Solid-State Nuclear Magnetic Resonance. (ekstern lenke)

2010

• Ann-Kristin Mossberg; Maja Puchades; Øyvind Halskau jr et al. (2010). HAMLET interacts with lipid membranes and perturbs their structure and integrity. (ekstern lenke)
• Øyvind Halskau jr; Sondre Volden; Ana C Calvo et al. (2010). Adsorption and bioactivity of tyrosine hydroxylase on gold surfaces and nanoparticles. (ekstern lenke)

2022

• Vilde Leipart; Øyvind Halskau; Gro Vang Amdam (2022). How Honey Bee Vitellogenin Holds Lipid Cargo: A Role for the C-Terminal. (ekstern lenke)
• Vilde Leipart; Øyvind Enger; Diana Cornelia Turcu et al. (2022). Resolving the zinc binding capacity of honey bee vitellogenin and locating its putative binding sites. (ekstern lenke)
• Maxim Bril'kov; Olena Dobrovolska; Øyvind Ødegård-Fougner et al. (2022). Binding Specificity of ASHH2 CW Domain Toward H3K4me1 Ligand Is Coupled to Its Structural Stability Through Its α1-Helix. (ekstern lenke)

2025

• Mateu Montserrat Canals; Kilian Schnelle; Vilde Leipart et al. (2025). Cryo-EM structure of native honey bee vitellogenin. (ekstern lenke)
• Julian Carolan; Martin Jakubec; Neubi F. Xavier et al. (2025). Anti-icing properties of polar bear fur. (ekstern lenke)

2000

• Øyvind Halskau; N.Å. Frøystein; Aurora Martinez et al. (2000). Conformation of alpha-lactalbumin bound to model membranes studied by NMR-monitored hydrogen exchange. (ekstern lenke)
• Øyvind Halskau (2000). The membrane bound conformation of bovine alpha-lactalbumin studied by NMR-monitored 1H-exchange. (ekstern lenke)

2008

• Gisle Sælensminde; Øyvind Halskau jr; Inge Jonassen (2008). Amino acid contacts in proteins adapted to different temperatures: hydrophobic interactions and surface charges play a key role. (ekstern lenke)
• Øyvind Halskau jr; Raul Perez-Jimenez; Beatriz Ibarra-Molero et al. (2008). Large-scale modulation of thermodynamic protein folding barriers linked to electrostatics. (ekstern lenke)

Se en full oversikt over publikasjoner i Cristin

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Under finner du  også publikasjonene mine i CRIStin. Det er stort overlapp mellom disse databasene, men de har litt forskjellige inklusjonskriterier og oppdateringsrutiner. 

2022-2023: UiB Idea Pre-project 2022-08 to present | Grant University of Bergen (Bergen, NO)

2022-2023: The senescent lipidome and its role in molecular maintenance and protein misfolding Nansenfondet (Oslo, Norway, NO)

2017-2021: Verdens første vaksinasjonsprogram for honningbier The Research Council of Norway (Oslo, NO) URL: https://grants.uberresearch.com/501100005416/262137/The-worlds-first-vaccination-for-honeybees Part of GRANT_NUMBER: grant.262137

2016-24: BioCat -- PhD-School in Catalysis Norges Forskningsråd (Oslo, NO) URL: https://site.uit.no/biocat/ Part of GRANT_NUMBER: 249023

2014:The membrane as a catalyst of damaging protein misfolding events (Research Council of Norway grant #240063)

2013: The Norwegian NMR Platform (Research Council of Norway Infrastructure grant 226244 / F50, with Finn Achmann, Frode Ride, Willy Nerdal).

2009: Interfaces as folding templates for polypetides (With associate professor Wilhelm Glomm)

2008: From details to drugs – a thorough structural and dynamic analysis of 14-3-3, tyrosine hydroxylase and membranes (Lie and Jensens fund/Norwegian Cancer Society, grant #58240001, with Professor Aurora Martínez)

2007: Dissecting molecular properties of honey bee vitellogenin (Research Council of Norway, grant #185306, with Professor Gro Vang Amdam)

2006: Linking new paradigms in protein chemistry to membrane-protein interaction, apoptosis and signalling (Norwegian Cancer Society, grant #06109/01, with Professor Aurora Martínez)

2002: Structural characterization of protein folding variants that induce apoptosis in tumor cells (Research Council of Norway, grant #149117, with Professor Aurora Martínez)